DK1115693T3 - Substituerede polycykliske aryl- og heteroaryl-Si(tertiære)-heteroalkylaminer der er egnede til inhibering af cholesteryl-esther-transferproteinaktivitet - Google Patents
Substituerede polycykliske aryl- og heteroaryl-Si(tertiære)-heteroalkylaminer der er egnede til inhibering af cholesteryl-esther-transferproteinaktivitetInfo
- Publication number
- DK1115693T3 DK1115693T3 DK99969710T DK99969710T DK1115693T3 DK 1115693 T3 DK1115693 T3 DK 1115693T3 DK 99969710 T DK99969710 T DK 99969710T DK 99969710 T DK99969710 T DK 99969710T DK 1115693 T3 DK1115693 T3 DK 1115693T3
- Authority
- DK
- Denmark
- Prior art keywords
- transfer protein
- heteroaryl
- heteroalkylamines
- esther
- tertiary
- Prior art date
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
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- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10166398P | 1998-09-25 | 1998-09-25 | |
PCT/US1999/022119 WO2000018721A1 (en) | 1998-09-25 | 1999-09-23 | Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1115693T3 true DK1115693T3 (da) | 2007-07-23 |
Family
ID=22285787
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99948429T DK1115695T3 (da) | 1998-09-25 | 1999-09-23 | (R)-Chirale, halogenerede 1-substituerede amino-(n+1)-alkanoler til inhibering af cholesterylesteroverförselsproteinaktivitet |
DK99969710T DK1115693T3 (da) | 1998-09-25 | 1999-09-23 | Substituerede polycykliske aryl- og heteroaryl-Si(tertiære)-heteroalkylaminer der er egnede til inhibering af cholesteryl-esther-transferproteinaktivitet |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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DK99948429T DK1115695T3 (da) | 1998-09-25 | 1999-09-23 | (R)-Chirale, halogenerede 1-substituerede amino-(n+1)-alkanoler til inhibering af cholesterylesteroverförselsproteinaktivitet |
Country Status (11)
Country | Link |
---|---|
EP (3) | EP1115695B1 (de) |
JP (4) | JP3955180B2 (de) |
AT (2) | ATE296796T1 (de) |
AU (2) | AU6160899A (de) |
CA (2) | CA2345103C (de) |
DE (3) | DE69925612T2 (de) |
DK (2) | DK1115695T3 (de) |
ES (2) | ES2286909T3 (de) |
GE (1) | GEP20094661B (de) |
PT (2) | PT1115693E (de) |
WO (2) | WO2000018721A1 (de) |
Families Citing this family (33)
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DE69925612T2 (de) * | 1998-09-25 | 2006-03-16 | Monsanto Co., Chicago | (r)-chirale halogenierte 1-substituierte amino-(n+1)-alkanolen für die hemmung der aktivität des cholesteryl-ester-transfer-proteins |
US7115279B2 (en) | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
EP1404302B1 (de) | 2001-06-22 | 2010-11-03 | Pfizer Products Inc. | Pharmazeutische zusammensetzungen, enthaltend adsorbate eines arzneimittels in amorpher form |
ES2333645T3 (es) | 2001-06-22 | 2010-02-25 | Bend Research, Inc. | Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros. |
EP1269994A3 (de) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten |
DE10155064A1 (de) * | 2001-11-09 | 2003-05-28 | Covion Organic Semiconductors | Rhodium- und Iridium-Komplexe |
WO2003053359A2 (en) | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
MXPA04005864A (es) | 2001-12-19 | 2004-10-29 | Atherogenics Inc | Derivados de charcona y su uso para tratar enfermedades. |
KR20040083493A (ko) | 2002-02-01 | 2004-10-02 | 화이자 프로덕츠 인크. | 콜레스테릴 에스테르 전달 단백질 억제제의 제어 방출형제약상 제형 |
AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
CA2474838C (en) | 2002-02-01 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
KR100634195B1 (ko) * | 2002-08-30 | 2006-10-16 | 니뽄 다바코 산교 가부시키가이샤 | 디벤질아민 화합물 및 그 의약 용도 |
JP2006506383A (ja) | 2002-10-21 | 2006-02-23 | カイロン コーポレイション | グリコーゲンシンターゼキナーゼ3のインヒビター |
ES2310676T3 (es) | 2002-12-20 | 2009-01-16 | Pfizer Products Inc. | Formas de dosificacion que comprenden un inhibidor de cetp y un inhibidor de hmg-coa reductasa. |
MXPA05009976A (es) | 2003-03-17 | 2005-11-04 | Japan Tobacco Inc | Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo]. |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
BRPI0413277A (pt) | 2003-08-04 | 2006-10-10 | Pfizer Prod Inc | composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas |
SG146695A1 (en) | 2003-09-26 | 2008-10-30 | Japan Tobacco Inc | Method of inhibiting remnant lipoprotein production |
US7417040B2 (en) | 2004-03-01 | 2008-08-26 | Bristol-Myers Squibb Company | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
CN1934066A (zh) * | 2004-03-22 | 2007-03-21 | 默克公司 | 有丝分裂驱动蛋白抑制剂 |
EP1737811B1 (de) * | 2004-04-13 | 2016-08-10 | Merck Sharp & Dohme Corp. | Cetp-inhibitoren |
CN1993323B (zh) * | 2004-08-05 | 2011-04-20 | 霍夫曼-拉罗奇有限公司 | 吲哚,吲唑或二氢吲哚衍生物 |
US8617604B2 (en) | 2005-02-03 | 2013-12-31 | Bend Research, Inc. | Pharmaceutical compositions with enhanced performance |
AU2006217630A1 (en) * | 2005-02-23 | 2006-08-31 | Pfizer Products Inc. | Substituted 1,1,1-trifluoro-3-[(benzyl)-(pyrimidin-2-yl)-amino]-prop an-2-ol compounds |
WO2006098394A1 (ja) * | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | 脂質吸収抑制方法および脂質吸収抑制剤 |
US7572823B2 (en) * | 2006-02-07 | 2009-08-11 | Hoffmann-La Roche Inc. | Heteroaryl carboxamide compounds |
EP2049517B1 (de) | 2006-07-20 | 2013-11-27 | Novartis AG | Aminopiperidinderivate als cetp-hemmer |
SI2207775T1 (sl) | 2007-11-05 | 2012-05-31 | Novartis Ag | benzilamino karboksiacil piperidinski derivati kot inhibitorji CETP uporabni za zdravljenje bolezni kot je hiperlipidemija ali arterioskleroza |
CA2707651A1 (en) | 2007-12-03 | 2009-06-11 | Novartis Ag | 1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis |
MX2012009149A (es) | 2010-02-19 | 2012-09-28 | Boehringer Ingelheim Int | Derivados de piridina triciclicos, medicamentos que contienen tales compuestos, su uso y proceso para su preparacion. |
EP2675811A1 (de) | 2011-02-17 | 2013-12-25 | Boehringer Ingelheim International GmbH | Tricyclische pyridinderivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür |
US9150583B2 (en) | 2011-08-17 | 2015-10-06 | Boehringer Ingelheim International Gmbh | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
US20140303198A1 (en) | 2011-11-29 | 2014-10-09 | Kowa Company, Ltd. | Agent for inhibiting expression of npc1l1 and/or lipg mrna and agent for preventing and/or treating obesity |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US2700686A (en) * | 1951-02-15 | 1955-01-25 | Eastman Kodak Co | Hydroxy substituted polyfluorinated compounds |
JPH0959155A (ja) * | 1995-08-23 | 1997-03-04 | Kaken Pharmaceut Co Ltd | コレステリルエステル転送反応阻害剤 |
JPH0978277A (ja) * | 1995-09-14 | 1997-03-25 | Kanegafuchi Chem Ind Co Ltd | 3−アミノ−2−ヒドロキシ−1,1,1−トリフルオロメチル化合物の製造法 |
GB2305665A (en) * | 1995-09-26 | 1997-04-16 | Merck & Co Inc | Selective ß3 agonists for the treatment of diabetes aand obesity |
DE19610932A1 (de) * | 1996-03-20 | 1997-09-25 | Bayer Ag | 2-Aryl-substituierte Pyridine |
EP0801060A1 (de) * | 1996-04-09 | 1997-10-15 | Pfizer Inc. | Heterocyclische Beta-3 adrenergische Angonisten |
DE19627431A1 (de) * | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
JP3290962B2 (ja) * | 1997-02-12 | 2002-06-10 | 日本たばこ産業株式会社 | Cetp活性阻害剤 |
DE19709125A1 (de) * | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
DE19741399A1 (de) * | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
DE69925612T2 (de) * | 1998-09-25 | 2006-03-16 | Monsanto Co., Chicago | (r)-chirale halogenierte 1-substituierte amino-(n+1)-alkanolen für die hemmung der aktivität des cholesteryl-ester-transfer-proteins |
-
1999
- 1999-09-23 DE DE69925612T patent/DE69925612T2/de not_active Expired - Lifetime
- 1999-09-23 AU AU61608/99A patent/AU6160899A/en not_active Abandoned
- 1999-09-23 EP EP99948429A patent/EP1115695B1/de not_active Expired - Lifetime
- 1999-09-23 AT AT99948429T patent/ATE296796T1/de active
- 1999-09-23 CA CA2345103A patent/CA2345103C/en not_active Expired - Fee Related
- 1999-09-23 PT PT99969710T patent/PT1115693E/pt unknown
- 1999-09-23 WO PCT/US1999/022119 patent/WO2000018721A1/en active IP Right Grant
- 1999-09-23 DK DK99948429T patent/DK1115695T3/da active
- 1999-09-23 CA CA2345118A patent/CA2345118C/en not_active Expired - Fee Related
- 1999-09-23 JP JP2000572186A patent/JP3955180B2/ja not_active Expired - Fee Related
- 1999-09-23 AT AT99969710T patent/ATE361273T1/de not_active IP Right Cessation
- 1999-09-23 AU AU60594/99A patent/AU6059499A/en not_active Abandoned
- 1999-09-23 ES ES99969710T patent/ES2286909T3/es not_active Expired - Lifetime
- 1999-09-23 DE DE69935992T patent/DE69935992T4/de not_active Expired - Lifetime
- 1999-09-23 JP JP2000572183A patent/JP3924124B2/ja not_active Expired - Lifetime
- 1999-09-23 WO PCT/US1999/022120 patent/WO2000018724A1/en active IP Right Grant
- 1999-09-23 EP EP99969710A patent/EP1115693B9/de not_active Expired - Lifetime
- 1999-09-23 ES ES99948429T patent/ES2244216T3/es not_active Expired - Lifetime
- 1999-09-23 DE DE69935992A patent/DE69935992D1/de not_active Expired - Lifetime
- 1999-09-23 GE GEAP199910720A patent/GEP20094661B/en unknown
- 1999-09-23 EP EP05011025A patent/EP1589000A3/de not_active Withdrawn
- 1999-09-23 DK DK99969710T patent/DK1115693T3/da active
- 1999-09-23 PT PT99948429T patent/PT1115695E/pt unknown
-
2006
- 2006-11-10 JP JP2006305077A patent/JP2007112804A/ja active Pending
- 2006-11-10 JP JP2006305973A patent/JP2007126460A/ja active Pending
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