DK1104409T3 - Fremgangsmåde til fremstilling af piperazinsyre og omdannelse deraf til N-acylerede bicykliske ringe, der indeholder N,N-bindinger, hvilke forbindelser er nyttige som mellemprodukter for caspaseinhibitorer - Google Patents

Fremgangsmåde til fremstilling af piperazinsyre og omdannelse deraf til N-acylerede bicykliske ringe, der indeholder N,N-bindinger, hvilke forbindelser er nyttige som mellemprodukter for caspaseinhibitorer

Info

Publication number
DK1104409T3
DK1104409T3 DK99943814T DK99943814T DK1104409T3 DK 1104409 T3 DK1104409 T3 DK 1104409T3 DK 99943814 T DK99943814 T DK 99943814T DK 99943814 T DK99943814 T DK 99943814T DK 1104409 T3 DK1104409 T3 DK 1104409T3
Authority
DK
Denmark
Prior art keywords
intermediates
useful
bonds
compounds
conversion
Prior art date
Application number
DK99943814T
Other languages
English (en)
Inventor
Andrea L C Robidoux
Jeffrey Douglas Wilson
Petra Dieterich
Neil Storer
Stefania Leonardi
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/136,339 external-priority patent/US6201118B1/en
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of DK1104409T3 publication Critical patent/DK1104409T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK99943814T 1998-08-19 1999-08-19 Fremgangsmåde til fremstilling af piperazinsyre og omdannelse deraf til N-acylerede bicykliske ringe, der indeholder N,N-bindinger, hvilke forbindelser er nyttige som mellemprodukter for caspaseinhibitorer DK1104409T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/136,339 US6201118B1 (en) 1998-08-19 1998-08-19 Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US09/235,894 US6177565B1 (en) 1998-08-19 1999-01-22 Process for synthesizing piperazic acid

Publications (1)

Publication Number Publication Date
DK1104409T3 true DK1104409T3 (da) 2004-09-13

Family

ID=26834217

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99943814T DK1104409T3 (da) 1998-08-19 1999-08-19 Fremgangsmåde til fremstilling af piperazinsyre og omdannelse deraf til N-acylerede bicykliske ringe, der indeholder N,N-bindinger, hvilke forbindelser er nyttige som mellemprodukter for caspaseinhibitorer

Country Status (9)

Country Link
US (1) US6177565B1 (da)
EP (1) EP1104409B1 (da)
AT (1) ATE267815T1 (da)
AU (1) AU5684099A (da)
DE (1) DE69917648T2 (da)
DK (1) DK1104409T3 (da)
ES (1) ES2221430T3 (da)
PT (1) PT1104409E (da)
WO (1) WO2000010979A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2777889B1 (fr) * 1998-04-27 2004-07-09 Hoechst Marion Roussel Inc Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
US6492170B1 (en) 2000-09-11 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 9 expression
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression
FR2853901B1 (fr) * 2003-04-16 2005-06-17 Isochem Sa Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) * 2003-06-26 2005-03-31 Honeywell Specialty Chemicals Seelze Gmbh Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
DE10328888A1 (de) * 2003-06-26 2005-01-20 Honeywell Specialty Chemicals Seelze Gmbh Verbessertes Verfahren zur Herstellung von 1,2-disubstituierten Hexahydropyridazin-3-carbonsäuren und deren Estern
CN100404516C (zh) * 2004-02-13 2008-07-23 大连绿源药业有限责任公司 六氢哒嗪三羧酸酯的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ATE182892T1 (de) 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
GB9223739D0 (en) 1992-11-12 1992-12-23 Univ London Process for the preparation of (3r) and (3s) piperazic acid derivatives
US5716929A (en) 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
FR2777889B1 (fr) 1998-04-27 2004-07-09 Hoechst Marion Roussel Inc Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
FR2777888B1 (fr) 1998-04-27 2004-07-16 Hoechst Marion Roussel Inc Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments

Also Published As

Publication number Publication date
AU5684099A (en) 2000-03-14
ATE267815T1 (de) 2004-06-15
EP1104409A1 (en) 2001-06-06
DE69917648D1 (de) 2004-07-01
DE69917648T2 (de) 2005-06-09
EP1104409B1 (en) 2004-05-26
WO2000010979A1 (en) 2000-03-02
PT1104409E (pt) 2004-09-30
ES2221430T3 (es) 2004-12-16
US6177565B1 (en) 2001-01-23

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