MXPA05009976A - Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo]. - Google Patents

Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo].

Info

Publication number
MXPA05009976A
MXPA05009976A MXPA05009976A MXPA05009976A MXPA05009976A MX PA05009976 A MXPA05009976 A MX PA05009976A MX PA05009976 A MXPA05009976 A MX PA05009976A MX PA05009976 A MXPA05009976 A MX PA05009976A MX PA05009976 A MXPA05009976 A MX PA05009976A
Authority
MX
Mexico
Prior art keywords
methylpropanethioate
ethylbutyl
cyclohexyl
carbonyl
phenyl
Prior art date
Application number
MXPA05009976A
Other languages
English (en)
Inventor
Tomohiro Ishikawa
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of MXPA05009976A publication Critical patent/MXPA05009976A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion esta dirigida a un metodo para incrementar la biodisponibilidad de la forma activa del 2-metilpropantioato de S-[2-([[1-(2-etilbutil)ciclohexil]carbonil]amino)fenilo], mediante la administracion de una cantidad terapeuticamente efectiva del farmaco con alimento; la invencion tambien proporciona un equipo que comprende una composicion farmaceutica que comprende una cantidad terapeuticamente efectiva de 2-metilpropantioato de S-[2-([[1-(2-etilbutil)ciclohexil]carbonil]amino)fenilo] y un portador farmaceuticamente aceptable, informacion para prescribir incluye aconsejar al paciente con respecto a la administracion del farmaco con alimento, para mejorar la biodisponibilidad.
MXPA05009976A 2003-03-17 2004-03-17 Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo]. MXPA05009976A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45529303P 2003-03-17 2003-03-17
US46052103P 2003-04-04 2003-04-04
US47720203P 2003-06-10 2003-06-10
PCT/JP2004/003589 WO2004082675A1 (en) 2003-03-17 2004-03-17 Method for increasing the oral bioavailability of s-[2- ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate

Publications (1)

Publication Number Publication Date
MXPA05009976A true MXPA05009976A (es) 2005-11-04

Family

ID=33033150

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009976A MXPA05009976A (es) 2003-03-17 2004-03-17 Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo].

Country Status (11)

Country Link
US (2) US7276536B2 (es)
EP (1) EP1603554A1 (es)
JP (1) JP2006520810A (es)
KR (1) KR20050110017A (es)
AU (1) AU2004222436A1 (es)
BR (1) BRPI0408442A (es)
CA (1) CA2519458A1 (es)
CO (1) CO5700729A2 (es)
MX (1) MXPA05009976A (es)
NO (1) NO20054739L (es)
WO (1) WO2004082675A1 (es)

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US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
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US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
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US20100179215A1 (en) * 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
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EA025649B1 (ru) 2010-11-04 2017-01-30 Ф.Хоффманн-Ля Рош Аг Таблетка, содержащая s-[2-([[1-(2-этилбутил)циклогексил]карбонил]амино)фенил]-2-метилпропантиоат и кроскарамеллозу натрия
RU2707533C2 (ru) 2013-03-27 2019-11-27 Ф. Хоффманн-Ля Рош Аг Генетические маркеры для прогнозирования восприимчивости к терапии
CN106559998B (zh) 2014-07-30 2022-01-25 豪夫迈·罗氏有限公司 预测对hdl升高剂或hdl模拟剂疗法的应答性的遗传标记

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Also Published As

Publication number Publication date
BRPI0408442A (pt) 2006-04-04
AU2004222436A1 (en) 2004-09-30
WO2004082675A8 (en) 2005-11-03
WO2004082675A1 (en) 2004-09-30
US20080045599A1 (en) 2008-02-21
US7276536B2 (en) 2007-10-02
US20040242683A1 (en) 2004-12-02
NO20054739L (no) 2005-12-14
CA2519458A1 (en) 2004-09-30
CO5700729A2 (es) 2006-11-30
KR20050110017A (ko) 2005-11-22
NO20054739D0 (no) 2005-10-14
EP1603554A1 (en) 2005-12-14
JP2006520810A (ja) 2006-09-14

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