PT1115695E - (n+1) -alcanois 1-aminossubstituidos (r) -quirais halogenados uteis para inibir a actividade da proteina de transferencia de ester de colesterilo - Google Patents
(n+1) -alcanois 1-aminossubstituidos (r) -quirais halogenados uteis para inibir a actividade da proteina de transferencia de ester de colesteriloInfo
- Publication number
- PT1115695E PT1115695E PT99948429T PT99948429T PT1115695E PT 1115695 E PT1115695 E PT 1115695E PT 99948429 T PT99948429 T PT 99948429T PT 99948429 T PT99948429 T PT 99948429T PT 1115695 E PT1115695 E PT 1115695E
- Authority
- PT
- Portugal
- Prior art keywords
- transfer protein
- halogenated
- cholesteryl
- uiral
- aminosubstituidos
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
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- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10166398P | 1998-09-25 | 1998-09-25 |
Publications (1)
Publication Number | Publication Date |
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PT1115695E true PT1115695E (pt) | 2005-10-31 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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PT99969710T PT1115693E (pt) | 1998-09-25 | 1999-09-23 | Arial- e heteroaril - heteroalquilaminas terciárias policíclicas substituídas úteis para inibir a actividade da proteína de transferência de éster de colesterilo. |
PT99948429T PT1115695E (pt) | 1998-09-25 | 1999-09-23 | (n+1) -alcanois 1-aminossubstituidos (r) -quirais halogenados uteis para inibir a actividade da proteina de transferencia de ester de colesterilo |
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PT99969710T PT1115693E (pt) | 1998-09-25 | 1999-09-23 | Arial- e heteroaril - heteroalquilaminas terciárias policíclicas substituídas úteis para inibir a actividade da proteína de transferência de éster de colesterilo. |
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EP (3) | EP1589000A3 (pt) |
JP (4) | JP3924124B2 (pt) |
AT (2) | ATE296796T1 (pt) |
AU (2) | AU6059499A (pt) |
CA (2) | CA2345103C (pt) |
DE (3) | DE69935992D1 (pt) |
DK (2) | DK1115693T3 (pt) |
ES (2) | ES2286909T3 (pt) |
GE (1) | GEP20094661B (pt) |
PT (2) | PT1115693E (pt) |
WO (2) | WO2000018721A1 (pt) |
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ATE296796T1 (de) * | 1998-09-25 | 2005-06-15 | Monsanto Co | (r)-chirale halogenierte 1-substituierte amino- (n+1)-alkanolen für die hemmung der aktivität des cholesteryl-ester-transfer-proteins |
US7115279B2 (en) | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
AU2002302903B2 (en) | 2001-06-22 | 2007-05-17 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drug |
EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
JP2004534812A (ja) | 2001-06-22 | 2004-11-18 | ファイザー・プロダクツ・インク | 薬物および中性ポリマーの分散物の医薬組成物 |
DE10155064A1 (de) * | 2001-11-09 | 2003-05-28 | Covion Organic Semiconductors | Rhodium- und Iridium-Komplexe |
US7202247B2 (en) | 2001-12-19 | 2007-04-10 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
WO2003053368A2 (en) | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | Chalcone derivatives and their use to treat diseases |
AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
BR0307332A (pt) | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Formas de dosagem farmacêuticas de liberação controlada de um inibidor da proteìna de transferência do éster de colesterol |
EP1469832B2 (en) | 2002-02-01 | 2016-10-26 | Bend Research, Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
KR100634195B1 (ko) | 2002-08-30 | 2006-10-16 | 니뽄 다바코 산교 가부시키가이샤 | 디벤질아민 화합물 및 그 의약 용도 |
AU2003282976A1 (en) | 2002-10-21 | 2004-05-13 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
AU2003283769A1 (en) | 2002-12-20 | 2004-07-14 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
EP1603554A1 (en) | 2003-03-17 | 2005-12-14 | Japan Tobacco Inc. | Method for increasing the oral bioavailability of s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
ATE540671T1 (de) | 2003-08-04 | 2012-01-15 | Bend Res Inc | Pharmazeutische zusammensetzungen von adsorbaten von amorphen arzneimitteln und lipophilen mikrophasen-bildenden materialien |
JP4536061B2 (ja) | 2003-09-26 | 2010-09-01 | 日本たばこ産業株式会社 | レムナントリポ蛋白生成阻害方法 |
US7417040B2 (en) | 2004-03-01 | 2008-08-26 | Bristol-Myers Squibb Company | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
CA2560213A1 (en) * | 2004-03-22 | 2005-10-06 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
CN1942428A (zh) * | 2004-04-13 | 2007-04-04 | 默克公司 | Cetp抑制剂 |
AU2005268893B2 (en) * | 2004-08-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Indole, indazole or indoline derivatives |
WO2006082518A1 (en) | 2005-02-03 | 2006-08-10 | Pfizer Products Inc. | Pharmaceutical compositions with enhanced performance |
EP1856060A1 (en) * | 2005-02-23 | 2007-11-21 | Pfizer Products Inc. | Substituted 1,1,1-trifluoro-3-[(benzyl)-(pyrimidin-2-yl)-amino]-prop an-2-ol compounds |
WO2006098394A1 (ja) * | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | 脂質吸収抑制方法および脂質吸収抑制剤 |
US7572823B2 (en) * | 2006-02-07 | 2009-08-11 | Hoffmann-La Roche Inc. | Heteroaryl carboxamide compounds |
CA2657258A1 (en) | 2006-07-20 | 2008-01-24 | Novartis Ag | Amino-piperidine derivatives as cetp inhibitors |
PL2463282T3 (pl) | 2007-11-05 | 2014-01-31 | Novartis Ag | Pochodne 4-benzyloamino-1-karboksyacylopiperydyny jako inhibitory CETP do leczenia chorób takich jak hiperlipidemia lub miażdżyca tętnic |
ATE528289T1 (de) | 2007-12-03 | 2011-10-15 | Novartis Ag | 1,2-disubstituierte 4- benzylaminopyrrolidinderivate als für die behandlung von krankheiten wie hyperlipidämie oder arteriosklerose geeignete cetp-inhibitoren |
CN102869667A (zh) | 2010-02-19 | 2013-01-09 | 贝林格尔.英格海姆国际有限公司 | 三环吡啶衍生物、包含此化合物的药物、其用途及其制备方法 |
EP2675811A1 (en) | 2011-02-17 | 2013-12-25 | Boehringer Ingelheim International GmbH | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
WO2013024130A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
WO2013080999A1 (ja) | 2011-11-29 | 2013-06-06 | 興和株式会社 | NPC1L1及び/又はLIPG mRNAの発現抑制剤並びに肥満症の予防及び/又は治療剤 |
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US2700686A (en) * | 1951-02-15 | 1955-01-25 | Eastman Kodak Co | Hydroxy substituted polyfluorinated compounds |
JPH0959155A (ja) * | 1995-08-23 | 1997-03-04 | Kaken Pharmaceut Co Ltd | コレステリルエステル転送反応阻害剤 |
JPH0978277A (ja) * | 1995-09-14 | 1997-03-25 | Kanegafuchi Chem Ind Co Ltd | 3−アミノ−2−ヒドロキシ−1,1,1−トリフルオロメチル化合物の製造法 |
GB2305665A (en) * | 1995-09-26 | 1997-04-16 | Merck & Co Inc | Selective ß3 agonists for the treatment of diabetes aand obesity |
DE19610932A1 (de) * | 1996-03-20 | 1997-09-25 | Bayer Ag | 2-Aryl-substituierte Pyridine |
EP0801060A1 (en) * | 1996-04-09 | 1997-10-15 | Pfizer Inc. | Heterocyclic Beta-3 Adrenergenic Agonists |
DE19627431A1 (de) * | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
JP3290962B2 (ja) * | 1997-02-12 | 2002-06-10 | 日本たばこ産業株式会社 | Cetp活性阻害剤 |
DE19709125A1 (de) * | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
DE19741399A1 (de) * | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
ATE296796T1 (de) * | 1998-09-25 | 2005-06-15 | Monsanto Co | (r)-chirale halogenierte 1-substituierte amino- (n+1)-alkanolen für die hemmung der aktivität des cholesteryl-ester-transfer-proteins |
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1999
- 1999-09-23 AT AT99948429T patent/ATE296796T1/de active
- 1999-09-23 DE DE69935992A patent/DE69935992D1/de not_active Expired - Lifetime
- 1999-09-23 JP JP2000572183A patent/JP3924124B2/ja not_active Expired - Lifetime
- 1999-09-23 CA CA2345103A patent/CA2345103C/en not_active Expired - Fee Related
- 1999-09-23 DK DK99969710T patent/DK1115693T3/da active
- 1999-09-23 AU AU60594/99A patent/AU6059499A/en not_active Abandoned
- 1999-09-23 EP EP05011025A patent/EP1589000A3/en not_active Withdrawn
- 1999-09-23 CA CA2345118A patent/CA2345118C/en not_active Expired - Fee Related
- 1999-09-23 JP JP2000572186A patent/JP3955180B2/ja not_active Expired - Fee Related
- 1999-09-23 AU AU61608/99A patent/AU6160899A/en not_active Abandoned
- 1999-09-23 EP EP99969710A patent/EP1115693B9/en not_active Expired - Lifetime
- 1999-09-23 DE DE69935992T patent/DE69935992T4/de not_active Expired - Lifetime
- 1999-09-23 ES ES99969710T patent/ES2286909T3/es not_active Expired - Lifetime
- 1999-09-23 GE GEAP199910720A patent/GEP20094661B/en unknown
- 1999-09-23 AT AT99969710T patent/ATE361273T1/de not_active IP Right Cessation
- 1999-09-23 ES ES99948429T patent/ES2244216T3/es not_active Expired - Lifetime
- 1999-09-23 PT PT99969710T patent/PT1115693E/pt unknown
- 1999-09-23 DE DE69925612T patent/DE69925612T2/de not_active Expired - Lifetime
- 1999-09-23 WO PCT/US1999/022119 patent/WO2000018721A1/en active IP Right Grant
- 1999-09-23 EP EP99948429A patent/EP1115695B1/en not_active Expired - Lifetime
- 1999-09-23 PT PT99948429T patent/PT1115695E/pt unknown
- 1999-09-23 WO PCT/US1999/022120 patent/WO2000018724A1/en active IP Right Grant
- 1999-09-23 DK DK99948429T patent/DK1115695T3/da active
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2006
- 2006-11-10 JP JP2006305973A patent/JP2007126460A/ja active Pending
- 2006-11-10 JP JP2006305077A patent/JP2007112804A/ja active Pending
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