PL2463282T3 - Pochodne 4-benzyloamino-1-karboksyacylopiperydyny jako inhibitory CETP do leczenia chorób takich jak hiperlipidemia lub miażdżyca tętnic - Google Patents
Pochodne 4-benzyloamino-1-karboksyacylopiperydyny jako inhibitory CETP do leczenia chorób takich jak hiperlipidemia lub miażdżyca tętnicInfo
- Publication number
- PL2463282T3 PL2463282T3 PL11188373T PL11188373T PL2463282T3 PL 2463282 T3 PL2463282 T3 PL 2463282T3 PL 11188373 T PL11188373 T PL 11188373T PL 11188373 T PL11188373 T PL 11188373T PL 2463282 T3 PL2463282 T3 PL 2463282T3
- Authority
- PL
- Poland
- Prior art keywords
- carboxyacyl
- benzylamino
- hyperlipidemia
- arteriosclerosis
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98545607P | 2007-11-05 | 2007-11-05 | |
EP08848438A EP2207775B1 (en) | 2007-11-05 | 2008-11-03 | 4-benzylamino-1-carboxyacyl-piperidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
EP11188373.2A EP2463282B1 (en) | 2007-11-05 | 2008-11-03 | 4-Benzylamino-1-carboxyacyl-piperidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2463282T3 true PL2463282T3 (pl) | 2014-01-31 |
Family
ID=40343337
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL08848438T PL2207775T3 (pl) | 2007-11-05 | 2008-11-03 | Pochodne 4-benzyloamino-1-karboksyacylo-piperydyny jako inhibitory CETP użyteczne do leczenia chorób, takich jak hiperlipidemia lub stwardnienie tętnic |
PL11188373T PL2463282T3 (pl) | 2007-11-05 | 2008-11-03 | Pochodne 4-benzyloamino-1-karboksyacylopiperydyny jako inhibitory CETP do leczenia chorób takich jak hiperlipidemia lub miażdżyca tętnic |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL08848438T PL2207775T3 (pl) | 2007-11-05 | 2008-11-03 | Pochodne 4-benzyloamino-1-karboksyacylo-piperydyny jako inhibitory CETP użyteczne do leczenia chorób, takich jak hiperlipidemia lub stwardnienie tętnic |
Country Status (25)
Country | Link |
---|---|
US (3) | US8193349B2 (pl) |
EP (2) | EP2463282B1 (pl) |
JP (1) | JP5555635B2 (pl) |
KR (1) | KR101564793B1 (pl) |
CN (1) | CN101910150B (pl) |
AR (1) | AR069165A1 (pl) |
AT (1) | ATE550333T1 (pl) |
AU (1) | AU2008324243B2 (pl) |
BR (1) | BRPI0819223A2 (pl) |
CA (1) | CA2704633C (pl) |
CL (1) | CL2008003284A1 (pl) |
CY (1) | CY1112706T1 (pl) |
DK (1) | DK2207775T3 (pl) |
EA (1) | EA022912B1 (pl) |
ES (2) | ES2381518T3 (pl) |
HK (1) | HK1168096A1 (pl) |
HR (1) | HRP20120476T1 (pl) |
JO (1) | JO2732B1 (pl) |
MX (1) | MX2010004929A (pl) |
PE (1) | PE20090982A1 (pl) |
PL (2) | PL2207775T3 (pl) |
PT (2) | PT2207775E (pl) |
SI (1) | SI2207775T1 (pl) |
TW (1) | TWI426910B (pl) |
WO (1) | WO2009059943A1 (pl) |
Families Citing this family (25)
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PT2404901E (pt) | 2007-12-03 | 2013-08-29 | Novartis Ag | Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como a hiperlipidemia ou a arteriosclerose |
TWI574963B (zh) | 2009-06-17 | 2017-03-21 | 維泰克斯製藥公司 | 流感病毒複製之抑制劑 |
JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
JP5931905B2 (ja) | 2010-12-03 | 2016-06-08 | エピザイム,インコーポレイティド | 置換プリン及び7‐デアザプリン化合物 |
US9052326B2 (en) | 2011-01-26 | 2015-06-09 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Method for assessing a subject's risk of having a cardiovascular disease |
CA2839937C (en) * | 2011-07-05 | 2020-11-03 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for producing azaindoles |
PT2729142T (pt) * | 2011-07-08 | 2018-10-01 | Novartis Ag | Método de tratamento de aterosclerose em sujeitos com nível elevado de triglicéridos |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
DK2780368T3 (en) | 2011-11-14 | 2018-02-05 | Regeneron Pharma | COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A |
NZ702154A (en) | 2012-05-25 | 2016-12-23 | Nutech Ventures | Amphiphilic cyclobutenes and cyclobutanes |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
TW201518323A (zh) | 2013-07-25 | 2015-05-16 | Novartis Ag | 合成apelin多肽之生物結合物 |
MX2016001020A (es) | 2013-07-25 | 2016-08-03 | Novartis Ag | Polipeptidos ciclicos para el tratamiento de insuficiencia cardiaca. |
TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素a之抗體及其用途 |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
SI3421468T1 (sl) | 2013-11-13 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Postopki za pripravo inhibitorjev replikacije virusov influence |
EP3247405B1 (en) | 2015-01-23 | 2019-07-17 | Novartis AG | Synthetic apelin fatty acid conjugates with improved half-life |
CN104788482B (zh) * | 2015-01-23 | 2016-09-14 | 沧州普瑞东方科技有限公司 | 一种制备2-氨基嘧啶-5-硼酸频那醇酯的方法 |
WO2016168613A1 (en) | 2015-04-15 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
MA42422A (fr) | 2015-05-13 | 2018-05-23 | Vertex Pharma | Inhibiteurs de la réplication des virus de la grippe |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
EA202092064A1 (ru) | 2018-03-01 | 2020-12-21 | Ридженерон Фармасьютикалз, Инк. | Способы изменения состава тела |
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PE20071025A1 (es) | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
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UY30244A1 (es) * | 2006-03-30 | 2007-11-30 | Tanabe Seiyaku Co | Un proceso para preparar derivados de tetrahidroquinolina |
PL2049517T3 (pl) | 2006-07-20 | 2014-06-30 | Novartis Ag | Pochodne amino-piperydyny jako inhibitory CETP |
JP4846769B2 (ja) | 2007-07-30 | 2011-12-28 | 田辺三菱製薬株式会社 | 医薬組成物 |
JP4834699B2 (ja) | 2007-07-30 | 2011-12-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
PT2404901E (pt) | 2007-12-03 | 2013-08-29 | Novartis Ag | Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como a hiperlipidemia ou a arteriosclerose |
PT2231636E (pt) | 2007-12-07 | 2012-01-02 | Novartis Ag | Derivados de pirazole e a sua utilização a título de inibidores de quinases dependentes de ciclina |
-
2008
- 2008-11-03 CA CA2704633A patent/CA2704633C/en not_active Expired - Fee Related
- 2008-11-03 WO PCT/EP2008/064859 patent/WO2009059943A1/en active Application Filing
- 2008-11-03 EA EA201000750A patent/EA022912B1/ru not_active IP Right Cessation
- 2008-11-03 PL PL08848438T patent/PL2207775T3/pl unknown
- 2008-11-03 EP EP11188373.2A patent/EP2463282B1/en not_active Not-in-force
- 2008-11-03 EP EP08848438A patent/EP2207775B1/en active Active
- 2008-11-03 ES ES08848438T patent/ES2381518T3/es active Active
- 2008-11-03 PT PT08848438T patent/PT2207775E/pt unknown
- 2008-11-03 AR ARP080104803A patent/AR069165A1/es active IP Right Grant
- 2008-11-03 CN CN2008801240151A patent/CN101910150B/zh not_active Expired - Fee Related
- 2008-11-03 DK DK08848438.1T patent/DK2207775T3/da active
- 2008-11-03 AU AU2008324243A patent/AU2008324243B2/en not_active Ceased
- 2008-11-03 SI SI200830588T patent/SI2207775T1/sl unknown
- 2008-11-03 KR KR1020107012318A patent/KR101564793B1/ko active IP Right Grant
- 2008-11-03 ES ES11188373T patent/ES2434417T3/es active Active
- 2008-11-03 AT AT08848438T patent/ATE550333T1/de active
- 2008-11-03 PE PE2008001884A patent/PE20090982A1/es active IP Right Grant
- 2008-11-03 PT PT111883732T patent/PT2463282E/pt unknown
- 2008-11-03 BR BRPI0819223-5A patent/BRPI0819223A2/pt not_active Application Discontinuation
- 2008-11-03 MX MX2010004929A patent/MX2010004929A/es active IP Right Grant
- 2008-11-03 PL PL11188373T patent/PL2463282T3/pl unknown
- 2008-11-03 JP JP2010532558A patent/JP5555635B2/ja not_active Expired - Fee Related
- 2008-11-04 JO JO2008500A patent/JO2732B1/en active
- 2008-11-04 CL CL2008003284A patent/CL2008003284A1/es unknown
- 2008-11-04 TW TW097142524A patent/TWI426910B/zh not_active IP Right Cessation
- 2008-11-05 US US12/265,369 patent/US8193349B2/en active Active
-
2012
- 2012-04-18 US US13/449,347 patent/US8420641B2/en active Active
- 2012-04-26 CY CY20121100398T patent/CY1112706T1/el unknown
- 2012-06-05 HR HRP20120476AT patent/HRP20120476T1/hr unknown
- 2012-06-07 US US13/490,579 patent/US8440682B2/en active Active
- 2012-09-10 HK HK12108840.1A patent/HK1168096A1/xx not_active IP Right Cessation
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