HK1168096A1 - 4-benzylamino-1-carboxyacyl-piperidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis - Google Patents
4-benzylamino-1-carboxyacyl-piperidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosisInfo
- Publication number
- HK1168096A1 HK1168096A1 HK12108840.1A HK12108840A HK1168096A1 HK 1168096 A1 HK1168096 A1 HK 1168096A1 HK 12108840 A HK12108840 A HK 12108840A HK 1168096 A1 HK1168096 A1 HK 1168096A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- carboxyacyl
- benzylamino
- hyperlipidemia
- arteriosclerosis
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98545607P | 2007-11-05 | 2007-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1168096A1 true HK1168096A1 (en) | 2012-12-21 |
Family
ID=40343337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12108840.1A HK1168096A1 (en) | 2007-11-05 | 2012-09-10 | 4-benzylamino-1-carboxyacyl-piperidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
Country Status (25)
Country | Link |
---|---|
US (3) | US8193349B2 (xx) |
EP (2) | EP2463282B1 (xx) |
JP (1) | JP5555635B2 (xx) |
KR (1) | KR101564793B1 (xx) |
CN (1) | CN101910150B (xx) |
AR (1) | AR069165A1 (xx) |
AT (1) | ATE550333T1 (xx) |
AU (1) | AU2008324243B2 (xx) |
BR (1) | BRPI0819223A2 (xx) |
CA (1) | CA2704633C (xx) |
CL (1) | CL2008003284A1 (xx) |
CY (1) | CY1112706T1 (xx) |
DK (1) | DK2207775T3 (xx) |
EA (1) | EA022912B1 (xx) |
ES (2) | ES2381518T3 (xx) |
HK (1) | HK1168096A1 (xx) |
HR (1) | HRP20120476T1 (xx) |
JO (1) | JO2732B1 (xx) |
MX (1) | MX2010004929A (xx) |
PE (1) | PE20090982A1 (xx) |
PL (2) | PL2207775T3 (xx) |
PT (2) | PT2463282E (xx) |
SI (1) | SI2207775T1 (xx) |
TW (1) | TWI426910B (xx) |
WO (1) | WO2009059943A1 (xx) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101878199B (zh) | 2007-12-03 | 2013-09-18 | 诺瓦提斯公司 | 用于治疗例如高血脂或动脉硬化疾病的作为cetp抑制剂的1,2-二取代的-4-苄基氨基-吡咯烷衍生物 |
DK3141252T3 (en) | 2009-06-17 | 2018-11-19 | Vertex Pharma | INHIBITORS OF INFLUENZA VIRUS REPLICATION |
JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
RU2606514C2 (ru) | 2010-12-03 | 2017-01-10 | Эпизайм, Инк. | Замещенные пуриновые и 7-деазапуриновые соединения |
US9052326B2 (en) | 2011-01-26 | 2015-06-09 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Method for assessing a subject's risk of having a cardiovascular disease |
JP2014520815A (ja) * | 2011-07-05 | 2014-08-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | アザインドールを作製するための方法および中間体 |
JP2014520795A (ja) * | 2011-07-08 | 2014-08-25 | ノバルティス アーゲー | 高トリグリセリド対象においてアテローム性動脈硬化症を治療する方法 |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
SI2780368T1 (en) | 2011-11-14 | 2018-04-30 | Regeneron Pharmaceuticals, Inc. | INGREDIENTS AND PROCEDURES FOR INCREASING PURE MASS AND MICROWAVE WITH SPECIFIC ANTAGONISING OF GDF8 AND / OR ACTIVITY A |
AU2013267594A1 (en) * | 2012-05-25 | 2014-12-18 | Nutech Ventures | Amphiphilic cyclobutenes and cyclobutanes |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
MX2016001021A (es) | 2013-07-25 | 2016-08-03 | Novartis Ag | Bioconjugados de polipeptidos de apelina sinteticos. |
TW201536814A (zh) | 2013-07-25 | 2015-10-01 | Novartis Ag | 用於治療心臟衰竭之合成環狀多肽 |
TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素a之抗體及其用途 |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
EP3421468B1 (en) | 2013-11-13 | 2020-11-04 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
BR112017014194A2 (pt) | 2015-01-23 | 2018-01-09 | Novartis Ag | conjugados de ácido graxo de apelina sintéticos com meia-vida melhorada |
CN104788482B (zh) * | 2015-01-23 | 2016-09-14 | 沧州普瑞东方科技有限公司 | 一种制备2-氨基嘧啶-5-硼酸频那醇酯的方法 |
JP6877357B2 (ja) | 2015-04-15 | 2021-05-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Gdf8阻害剤を用いて、強度及び機能を増加させる方法 |
JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
MA42422A (fr) | 2015-05-13 | 2018-05-23 | Vertex Pharma | Inhibiteurs de la réplication des virus de la grippe |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
EP3758800A1 (en) | 2018-03-01 | 2021-01-06 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition |
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CN101878199B (zh) | 2007-12-03 | 2013-09-18 | 诺瓦提斯公司 | 用于治疗例如高血脂或动脉硬化疾病的作为cetp抑制剂的1,2-二取代的-4-苄基氨基-吡咯烷衍生物 |
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-
2008
- 2008-11-03 WO PCT/EP2008/064859 patent/WO2009059943A1/en active Application Filing
- 2008-11-03 SI SI200830588T patent/SI2207775T1/sl unknown
- 2008-11-03 KR KR1020107012318A patent/KR101564793B1/ko active IP Right Grant
- 2008-11-03 PT PT111883732T patent/PT2463282E/pt unknown
- 2008-11-03 EP EP11188373.2A patent/EP2463282B1/en not_active Not-in-force
- 2008-11-03 CA CA2704633A patent/CA2704633C/en not_active Expired - Fee Related
- 2008-11-03 PL PL08848438T patent/PL2207775T3/pl unknown
- 2008-11-03 PL PL11188373T patent/PL2463282T3/pl unknown
- 2008-11-03 JP JP2010532558A patent/JP5555635B2/ja not_active Expired - Fee Related
- 2008-11-03 ES ES08848438T patent/ES2381518T3/es active Active
- 2008-11-03 DK DK08848438.1T patent/DK2207775T3/da active
- 2008-11-03 MX MX2010004929A patent/MX2010004929A/es active IP Right Grant
- 2008-11-03 PE PE2008001884A patent/PE20090982A1/es active IP Right Grant
- 2008-11-03 AR ARP080104803A patent/AR069165A1/es active IP Right Grant
- 2008-11-03 AU AU2008324243A patent/AU2008324243B2/en not_active Ceased
- 2008-11-03 ES ES11188373T patent/ES2434417T3/es active Active
- 2008-11-03 CN CN2008801240151A patent/CN101910150B/zh not_active Expired - Fee Related
- 2008-11-03 BR BRPI0819223-5A patent/BRPI0819223A2/pt not_active Application Discontinuation
- 2008-11-03 AT AT08848438T patent/ATE550333T1/de active
- 2008-11-03 EP EP08848438A patent/EP2207775B1/en active Active
- 2008-11-03 EA EA201000750A patent/EA022912B1/ru not_active IP Right Cessation
- 2008-11-03 PT PT08848438T patent/PT2207775E/pt unknown
- 2008-11-04 CL CL2008003284A patent/CL2008003284A1/es unknown
- 2008-11-04 TW TW097142524A patent/TWI426910B/zh not_active IP Right Cessation
- 2008-11-04 JO JO2008500A patent/JO2732B1/en active
- 2008-11-05 US US12/265,369 patent/US8193349B2/en active Active
-
2012
- 2012-04-18 US US13/449,347 patent/US8420641B2/en active Active
- 2012-04-26 CY CY20121100398T patent/CY1112706T1/el unknown
- 2012-06-05 HR HRP20120476AT patent/HRP20120476T1/hr unknown
- 2012-06-07 US US13/490,579 patent/US8440682B2/en active Active
- 2012-09-10 HK HK12108840.1A patent/HK1168096A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20171103 |