EA199800837A1 - ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ, В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, КОТОРЫЕ ИХ СОДЕРЖАТ - Google Patents
ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ, В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, КОТОРЫЕ ИХ СОДЕРЖАТInfo
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- EA199800837A1 EA199800837A1 EA199800837A EA199800837A EA199800837A1 EA 199800837 A1 EA199800837 A1 EA 199800837A1 EA 199800837 A EA199800837 A EA 199800837A EA 199800837 A EA199800837 A EA 199800837A EA 199800837 A1 EA199800837 A1 EA 199800837A1
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/18—Nitrogen atoms not forming part of a nitro radical with hetero atoms attached to said nitrogen atoms, except nitro radicals, e.g. hydrazine radicals
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
- C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
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- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
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- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
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- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
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Abstract
Объектом изобретения являются продукты формулы (I), в которой R, R, R, R, Rи G такие, как определено в описании, пунктирные линии представляют собой возможную двойную связь, а также соли присоединения с кислотами и основаниями и сложные эфиры, их способ получения и промежуточные продукты этого способа, их применение в качестве медикаментов и содержащие их фармацевтические композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9603437A FR2746394B1 (fr) | 1996-03-20 | 1996-03-20 | Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
PCT/FR1997/000487 WO1997034865A1 (fr) | 1996-03-20 | 1997-03-20 | COMPOSES TRICYCLIQUES AYANT UNE ACTIVITE VIS-A-VIS DES INTEGRINES NOTAMMENT VIS-A-VIS DE L'INTEGRINE ALPHA vBETA3, LEUR PROCEDE DE PREPARATION ET LES INTERMEDIAIRES DE CE PROCEDE, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT |
Publications (2)
Publication Number | Publication Date |
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EA199800837A1 true EA199800837A1 (ru) | 1999-06-24 |
EA002271B1 EA002271B1 (ru) | 2002-02-28 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA199800837A EA002271B1 (ru) | 1996-03-20 | 1997-03-20 | ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ |
Country Status (21)
Country | Link |
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US (1) | US6221907B1 (ru) |
EP (1) | EP0888292B1 (ru) |
JP (1) | JP4091983B2 (ru) |
KR (1) | KR20000064710A (ru) |
AP (1) | AP806A (ru) |
AT (1) | ATE207889T1 (ru) |
AU (1) | AU728852B2 (ru) |
BG (1) | BG63569B1 (ru) |
BR (1) | BR9708231A (ru) |
CA (1) | CA2249471A1 (ru) |
DE (1) | DE69707843T2 (ru) |
DK (1) | DK0888292T3 (ru) |
EA (1) | EA002271B1 (ru) |
EE (1) | EE9800317A (ru) |
GE (1) | GEP20012516B (ru) |
LV (1) | LV12207B (ru) |
NO (1) | NO312459B1 (ru) |
NZ (1) | NZ331778A (ru) |
SI (1) | SI9720021A (ru) |
SK (1) | SK282894B6 (ru) |
WO (1) | WO1997034865A1 (ru) |
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FR2768734B1 (fr) * | 1997-09-24 | 2000-01-28 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
FR2768736B1 (fr) * | 1997-09-24 | 2000-05-26 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
TW538046B (en) | 1998-01-08 | 2003-06-21 | Hoechst Marion Roussel Inc | Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof |
FR2786181B1 (fr) | 1998-11-24 | 2001-10-26 | Hoechst Marion Roussel Inc | Nouveaux derives d'iminoguanidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
DE19916837A1 (de) * | 1999-04-14 | 2000-10-19 | Merck Patent Gmbh | Dibenzoazulenderivate |
AU1305201A (en) | 1999-11-18 | 2001-06-04 | Ajinomoto Co., Inc. | Novel intermediate for sweetener with high sweetness and process for producing the same |
BR0109235A (pt) * | 2000-03-16 | 2002-12-17 | Hoffmann La Roche | Derivados do ácido carboxìlico como antagonistas ip |
DK1381384T3 (da) | 2001-04-24 | 2011-07-25 | Merck Patent Gmbh | Kombinationsterapi under anvendelse af anti-angiogene midler og TNFalfa |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
US20090130098A1 (en) | 2006-01-18 | 2009-05-21 | Merck Patent Gmbh | Specific therapy using integrin ligands for treating cancer |
UY30838A1 (es) * | 2006-12-26 | 2008-07-31 | Centro Inmunologia Molecular | Composicion farmacéutica que comprende un anticuerpo monoclonal anti cd6 utilizado en el diagnostico y tratamiento de la artritis reumatoide |
CA2675813A1 (en) | 2007-01-18 | 2008-07-24 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Specific therapy and medicament using integrin ligands for treating cancer |
MX2010010085A (es) | 2008-03-14 | 2011-03-29 | Biocon Ltd | Un anticuerpo monoclonal y el metodo para su uso. |
AU2010252280A1 (en) | 2009-05-25 | 2012-01-19 | Merck Patent Gmbh | Continuous administration of cilengitide in cancer treatments |
CN102603743B (zh) * | 2012-02-24 | 2014-05-28 | 南京天易生物科技有限公司 | 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途 |
EP3024485B1 (en) | 2013-07-23 | 2020-11-18 | Biocon Limited | Use of a cd6 binding partner and method based thereon |
WO2015181676A1 (en) | 2014-05-30 | 2015-12-03 | Pfizer Inc. | Carbonitrile derivatives as selective androgen receptor modulators |
CA3039855A1 (en) | 2016-10-21 | 2018-04-26 | Biocon Limited | A monoclonal antibody and a method of use for the treatment of lupus |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
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---|---|---|---|---|
JPH10504825A (ja) * | 1994-08-22 | 1998-05-12 | スミスクライン・ビーチャム・コーポレイション | 二環式化合物 |
FR2731217B1 (fr) * | 1995-03-03 | 1997-06-13 | Roussel Uclaf | Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires |
-
1997
- 1997-03-20 US US09/155,063 patent/US6221907B1/en not_active Expired - Lifetime
- 1997-03-20 WO PCT/FR1997/000487 patent/WO1997034865A1/fr not_active Application Discontinuation
- 1997-03-20 KR KR1019980707434A patent/KR20000064710A/ko not_active Application Discontinuation
- 1997-03-20 EP EP97915519A patent/EP0888292B1/fr not_active Expired - Lifetime
- 1997-03-20 BR BR9708231A patent/BR9708231A/pt not_active Application Discontinuation
- 1997-03-20 NZ NZ331778A patent/NZ331778A/en unknown
- 1997-03-20 EA EA199800837A patent/EA002271B1/ru not_active IP Right Cessation
- 1997-03-20 SI SI9720021A patent/SI9720021A/sl not_active IP Right Cessation
- 1997-03-20 SK SK1249-98A patent/SK282894B6/sk unknown
- 1997-03-20 EE EE9800317A patent/EE9800317A/xx unknown
- 1997-03-20 DK DK97915519T patent/DK0888292T3/da active
- 1997-03-20 AU AU22966/97A patent/AU728852B2/en not_active Ceased
- 1997-03-20 JP JP53320897A patent/JP4091983B2/ja not_active Expired - Lifetime
- 1997-03-20 DE DE69707843T patent/DE69707843T2/de not_active Expired - Lifetime
- 1997-03-20 CA CA002249471A patent/CA2249471A1/fr not_active Abandoned
- 1997-03-20 GE GEAP19974530A patent/GEP20012516B/en unknown
- 1997-03-20 AT AT97915519T patent/ATE207889T1/de not_active IP Right Cessation
- 1997-03-20 AP APAP/P/1998/001342A patent/AP806A/en active
-
1998
- 1998-01-07 LV LVP-98-209A patent/LV12207B/lv unknown
- 1998-09-18 BG BG102778A patent/BG63569B1/bg unknown
- 1998-09-18 NO NO19984352A patent/NO312459B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO984352L (no) | 1998-11-19 |
EA002271B1 (ru) | 2002-02-28 |
LV12207B (lv) | 1999-03-20 |
AP9801342A0 (en) | 1998-09-30 |
EE9800317A (et) | 1999-04-15 |
NO312459B1 (no) | 2002-05-13 |
GEP20012516B (en) | 2001-08-27 |
AP806A (en) | 2000-01-28 |
BG102778A (en) | 1999-05-31 |
SK282894B6 (sk) | 2003-01-09 |
EP0888292B1 (fr) | 2001-10-31 |
NO984352D0 (no) | 1998-09-18 |
DK0888292T3 (da) | 2002-02-18 |
DE69707843D1 (de) | 2001-12-06 |
WO1997034865A1 (fr) | 1997-09-25 |
SK124998A3 (en) | 1999-08-06 |
AU2296697A (en) | 1997-10-10 |
LV12207A (lv) | 1999-01-20 |
AU728852B2 (en) | 2001-01-18 |
JP2000506879A (ja) | 2000-06-06 |
JP4091983B2 (ja) | 2008-05-28 |
EP0888292A1 (fr) | 1999-01-07 |
US6221907B1 (en) | 2001-04-24 |
BR9708231A (pt) | 1999-08-03 |
SI9720021A (sl) | 1999-04-30 |
ATE207889T1 (de) | 2001-11-15 |
NZ331778A (en) | 2000-02-28 |
DE69707843T2 (de) | 2002-05-16 |
CA2249471A1 (fr) | 1997-09-25 |
BG63569B1 (bg) | 2002-05-31 |
KR20000064710A (ko) | 2000-11-06 |
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