ATE43833T1 - Verfahren zur herstellung des 1'ethoxycarbonyloxyethylestersvon benzylpenicillin. - Google Patents
Verfahren zur herstellung des 1'ethoxycarbonyloxyethylestersvon benzylpenicillin.Info
- Publication number
- ATE43833T1 ATE43833T1 AT83306482T AT83306482T ATE43833T1 AT E43833 T1 ATE43833 T1 AT E43833T1 AT 83306482 T AT83306482 T AT 83306482T AT 83306482 T AT83306482 T AT 83306482T AT E43833 T1 ATE43833 T1 AT E43833T1
- Authority
- AT
- Austria
- Prior art keywords
- ethoxycarbonyloxyethylester
- benzylpenicillin
- preparing
- compounds
- penicillins
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 title 2
- 235000019371 penicillin G benzathine Nutrition 0.000 title 1
- 229940056360 penicillin g Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229930182555 Penicillin Natural products 0.000 abstract 2
- 150000002960 penicillins Chemical class 0.000 abstract 2
- RKRZYVQFKUXDEZ-UHFFFAOYSA-N 1-bromoethyl ethyl carbonate Chemical compound CCOC(=O)OC(C)Br RKRZYVQFKUXDEZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012374 esterification agent Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL67177A IL67177A (en) | 1982-11-04 | 1982-11-04 | 1-bromoethyl ethyl carbonate,methods for its preparation and 1-bromoethylchloroformate and 1-bromoethylbromoformate obtained as intermediates |
| IL67637A IL67637A0 (en) | 1983-01-07 | 1983-01-07 | Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins and novel intermediates |
| EP83306482A EP0108547B1 (de) | 1982-11-04 | 1983-10-25 | Verfahren zur Herstellung des 1'-Ethoxycarbonyloxyethylesters von Benzylpenicillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE43833T1 true ATE43833T1 (de) | 1989-06-15 |
Family
ID=26321084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83306482T ATE43833T1 (de) | 1982-11-04 | 1983-10-25 | Verfahren zur herstellung des 1'ethoxycarbonyloxyethylestersvon benzylpenicillin. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0108547B1 (de) |
| AT (1) | ATE43833T1 (de) |
| DE (1) | DE3380024D1 (de) |
| MY (1) | MY130320A (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2177698B (en) * | 1982-06-29 | 1987-08-19 | Astra Laekemedel Ab | Improvements in the preparation of antibiotics |
| FR2532933B1 (fr) * | 1982-06-29 | 1987-11-13 | Astra Laekemedel Ab | Perfectionnements apportes a la preparation d'antibiotiques |
| SE454879B (sv) * | 1982-06-29 | 1988-06-06 | Astra Laekemedel Ab | Alfa-bromodietylkarbonat samt dess anvendning som mellanprodukt vid framstellning av penicillin g |
| DE3348300C2 (de) * | 1982-06-29 | 1994-04-21 | Astra Laekemedel Ab | Verwendung von alpha-Bromdiethylcarbonat |
| FR2573756B1 (fr) * | 1984-11-23 | 1987-01-16 | Poudres & Explosifs Ste Nale | Procede de preparation des carbonates de bromo-1 ethyle et d'hydrocarbyle et nouveaux carbonates de bromo-1 ethyle et d'hydrocarbyle |
| FR2601361B1 (fr) * | 1986-07-11 | 1988-09-30 | Poudres & Explosifs Ste Nale | Procede de fabrication de carbonates de bromo-1 alkyle et d'hydrocarbyle. |
| US5202454A (en) * | 1986-07-11 | 1993-04-13 | Societe Nationale Des Poudres Et Explosifs | Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1003479A (en) * | 1963-05-30 | 1965-09-02 | Wyeth John & Brother Ltd | Acetoxymethyl benzylpenicillinate |
| US3697507A (en) * | 1968-09-26 | 1972-10-10 | Leo Pharm Prod Ltd | Esters of {60 -aminobenzylpenicillin |
| IT1190897B (it) * | 1982-06-29 | 1988-02-24 | Opos Biochimica Srl | Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico |
-
1983
- 1983-10-25 EP EP83306482A patent/EP0108547B1/de not_active Expired
- 1983-10-25 AT AT83306482T patent/ATE43833T1/de not_active IP Right Cessation
- 1983-10-25 DE DE8383306482T patent/DE3380024D1/de not_active Expired
-
1987
- 1987-09-26 MY MYPI87001981A patent/MY130320A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY130320A (en) | 2007-06-29 |
| EP0108547A3 (en) | 1984-06-27 |
| EP0108547A2 (de) | 1984-05-16 |
| DE3380024D1 (en) | 1989-07-13 |
| EP0108547B1 (de) | 1989-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |