DK1098957T3 - Indføring af materialer i celler under anvendelse af porøst eller polykrystallinsk silicum - Google Patents
Indføring af materialer i celler under anvendelse af porøst eller polykrystallinsk silicumInfo
- Publication number
- DK1098957T3 DK1098957T3 DK99934933T DK99934933T DK1098957T3 DK 1098957 T3 DK1098957 T3 DK 1098957T3 DK 99934933 T DK99934933 T DK 99934933T DK 99934933 T DK99934933 T DK 99934933T DK 1098957 T3 DK1098957 T3 DK 1098957T3
- Authority
- DK
- Denmark
- Prior art keywords
- polycrystalline silicon
- porous
- cells
- materials
- cell
- Prior art date
Links
- 239000000463 material Substances 0.000 title abstract 4
- 229910021420 polycrystalline silicon Inorganic materials 0.000 title abstract 2
- 229910021426 porous silicon Inorganic materials 0.000 title abstract 2
- 230000037431 insertion Effects 0.000 title 1
- 238000003780 insertion Methods 0.000 title 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 239000011856 silicon-based particle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Silicon Compounds (AREA)
- Electrotherapy Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Battery Electrode And Active Subsutance (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9815819.9A GB9815819D0 (en) | 1998-07-22 | 1998-07-22 | Transferring materials into cells and a microneedle array |
| PCT/GB1999/002383 WO2000005339A1 (en) | 1998-07-22 | 1999-07-22 | Transferring materials into cells using porous silicon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1098957T3 true DK1098957T3 (da) | 2003-01-06 |
Family
ID=10835869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99934933T DK1098957T3 (da) | 1998-07-22 | 1999-07-22 | Indføring af materialer i celler under anvendelse af porøst eller polykrystallinsk silicum |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6770480B1 (ja) |
| EP (3) | EP1231259A3 (ja) |
| JP (1) | JP4585119B2 (ja) |
| KR (1) | KR100633273B1 (ja) |
| CN (1) | CN1252275C (ja) |
| AT (1) | ATE223479T1 (ja) |
| AU (1) | AU753542B2 (ja) |
| CA (1) | CA2337331C (ja) |
| DE (1) | DE69902794T2 (ja) |
| DK (1) | DK1098957T3 (ja) |
| ES (2) | ES2400472T3 (ja) |
| GB (1) | GB9815819D0 (ja) |
| HK (1) | HK1039146B (ja) |
| NZ (1) | NZ509142A (ja) |
| WO (1) | WO2000005339A1 (ja) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9808052D0 (en) | 1998-04-17 | 1998-06-17 | Secr Defence | Implants for administering substances and methods of producing implants |
| GB9815819D0 (en) * | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
| GB0008494D0 (en) * | 2000-04-07 | 2000-05-24 | Secr Defence | Microprojectile delivery system |
| GB2363115A (en) * | 2000-06-10 | 2001-12-12 | Secr Defence | Porous or polycrystalline silicon orthopaedic implants |
| US6533949B1 (en) * | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
| US6897067B2 (en) | 2000-11-03 | 2005-05-24 | Regents Of The University Of Michigan | Surface transfection and expression procedure |
| WO2002042447A2 (en) * | 2000-11-03 | 2002-05-30 | Regents Of The University Of Michigan | Surface transfection and expression procedure |
| US6902933B2 (en) | 2000-11-03 | 2005-06-07 | Regents Of The University Of Michigan | Surface transfection and expression procedure |
| EP1373894B1 (en) * | 2001-02-21 | 2006-12-13 | The University Of Rochester | Microcavity biosensor, methods of making, and uses thereof |
| GB0104383D0 (en) | 2001-02-22 | 2001-04-11 | Psimedica Ltd | Cancer Treatment |
| US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| WO2002088165A1 (en) * | 2001-04-30 | 2002-11-07 | Doranz Benjamin J | Elucidation of gene function |
| US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
| JP2004121064A (ja) * | 2002-10-01 | 2004-04-22 | Jfe Steel Kk | 遺伝子制御用のセラミック被覆針 |
| AU2003222691A1 (en) * | 2002-04-30 | 2003-11-17 | Morteza Shirkhanzadeh | Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents |
| US6864692B1 (en) * | 2002-06-20 | 2005-03-08 | Xsilogy, Inc. | Sensor having improved selectivity |
| EP1523367A1 (en) | 2002-07-19 | 2005-04-20 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
| US7244513B2 (en) * | 2003-02-21 | 2007-07-17 | Nano-Proprietary, Inc. | Stain-etched silicon powder |
| US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| US20070087436A1 (en) * | 2003-04-11 | 2007-04-19 | Atsushi Miyawaki | Microinjection method and device |
| CA2536249A1 (en) | 2003-08-25 | 2005-03-10 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| EP1718452A1 (en) * | 2004-02-23 | 2006-11-08 | 3M Innovative Properties Company | Method of molding for microneedle arrays |
| CA2560840C (en) | 2004-03-24 | 2014-05-06 | Corium International, Inc. | Transdermal delivery device |
| US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US20090208556A1 (en) * | 2004-10-29 | 2009-08-20 | Regents Of The University Of California, The | Porous photonic crystals for drug delivery to the eye |
| EP1824655B1 (en) | 2004-12-07 | 2010-05-26 | 3M Innovative Properties Company | Method of molding a microneedle |
| US20060276047A1 (en) * | 2005-03-14 | 2006-12-07 | University Of Rochester | Macroporous silicon microcavity with tunable pore size |
| WO2007037787A1 (en) * | 2005-05-09 | 2007-04-05 | Vesta Research, Ltd. | Porous silicon particles |
| US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US8043250B2 (en) * | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| EP1893130A4 (en) * | 2005-06-17 | 2015-08-26 | Georgia Tech Res Inst | COATED MICROSTRUCTURES AND METHOD FOR THE PRODUCTION THEREOF |
| CN101208129B (zh) | 2005-06-27 | 2011-03-30 | 3M创新有限公司 | 微针药筒组件及其施放方法 |
| WO2007012114A1 (en) * | 2005-07-25 | 2007-02-01 | Nanotechnology Victoria Pty Ltd | Microarray device |
| US20070185432A1 (en) * | 2005-09-19 | 2007-08-09 | Transport Pharmaceuticals, Inc. | Electrokinetic system and method for delivering methotrexate |
| US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
| WO2007061964A1 (en) * | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Methods for coating microneedles |
| US20080262416A1 (en) * | 2005-11-18 | 2008-10-23 | Duan Daniel C | Microneedle Arrays and Methods of Preparing Same |
| US20080319404A1 (en) * | 2005-12-21 | 2008-12-25 | Pekurovsky Mikhail L | Microneedle Devices |
| US20070142781A1 (en) * | 2005-12-21 | 2007-06-21 | Sayre Chauncey B | Microinjector chip |
| US9610459B2 (en) | 2009-07-24 | 2017-04-04 | Emkinetics, Inc. | Cooling systems and methods for conductive coils |
| WO2011053607A1 (en) | 2009-10-26 | 2011-05-05 | Emkinetics, Inc. | Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues |
| US9339641B2 (en) | 2006-01-17 | 2016-05-17 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
| US20100168501A1 (en) * | 2006-10-02 | 2010-07-01 | Daniel Rogers Burnett | Method and apparatus for magnetic induction therapy |
| DE102006028781A1 (de) * | 2006-06-23 | 2007-12-27 | Robert Bosch Gmbh | Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung |
| US10786669B2 (en) | 2006-10-02 | 2020-09-29 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
| JP2010505471A (ja) | 2006-10-02 | 2010-02-25 | エムキネティクス， インコーポレイテッド | 磁気誘導療法のための方法および装置 |
| US9005102B2 (en) | 2006-10-02 | 2015-04-14 | Emkinetics, Inc. | Method and apparatus for electrical stimulation therapy |
| US11224742B2 (en) | 2006-10-02 | 2022-01-18 | Emkinetics, Inc. | Methods and devices for performing electrical stimulation to treat various conditions |
| WO2008076465A1 (en) * | 2006-12-21 | 2008-06-26 | Primegen Biotech, Llc | Microinjector chip |
| US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
| US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
| CN100998901B (zh) * | 2007-01-12 | 2012-10-10 | 中国科学院上海微系统与信息技术研究所 | 多孔硅无痛注射微针阵列及其制备方法 |
| DE102007002832A1 (de) * | 2007-01-19 | 2008-07-24 | Robert Bosch Gmbh | Verfahren zur Herstellung einer Vorrichtung umfassend eine Anordnung von Mikronadeln auf einem Träger und nach diesem Verfahren herstellbare Vorrichtung |
| US8821446B2 (en) | 2007-01-22 | 2014-09-02 | Corium International, Inc. | Applicators for microneedles |
| CN101678166B (zh) * | 2007-03-02 | 2012-08-22 | 特克法马许可公司 | 模块化的给药系统 |
| US20090017562A1 (en) * | 2007-03-13 | 2009-01-15 | Iowa State University Research Foundation, Inc. | Raman-active reagents |
| AU2014200648B2 (en) * | 2007-04-16 | 2015-09-24 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
| US9114238B2 (en) * | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
| AU2008245496A1 (en) * | 2007-04-27 | 2008-11-06 | Board Of Regents Of The University Of Texas System | Porous particles and methods of making thereof |
| CN101815504B (zh) | 2007-07-10 | 2013-11-20 | 加利福尼亚大学董事会 | 用于向所选择组织递送组合物的材料和方法 |
| US8349554B2 (en) * | 2007-08-14 | 2013-01-08 | Fred Hutchinson Cancer Research Center | Needle array assembly and method for delivering therapeutic agents |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| JP5178132B2 (ja) * | 2007-10-11 | 2013-04-10 | キヤノン株式会社 | 画像処理システム並びに画像処理方法 |
| CA2745339C (en) | 2007-12-24 | 2016-06-28 | The University Of Queensland | Coating method |
| AU2009212106B9 (en) | 2008-02-07 | 2014-05-22 | Vaxxas Pty Limited | Patch production |
| EP2100850A1 (en) * | 2008-03-11 | 2009-09-16 | Stichting Voor De Technische Wetenschappen | Microneedle array and a method for manufacturing microneedles |
| CA2760680A1 (en) | 2008-05-23 | 2009-11-26 | The University Of Queensland | Analyte detection by microneedle patch with analyte selective reagents |
| WO2010124255A2 (en) * | 2009-04-24 | 2010-10-28 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| CN102405042A (zh) | 2009-05-04 | 2012-04-04 | 普西维达公司 | 多孔硅药物洗脱颗粒 |
| PT2563453T (pt) | 2010-04-28 | 2017-03-15 | Kimberly Clark Co | Dispositivo medicinal possuindo uma nanoforma com melhor interacção celular e um método para a sua formação |
| WO2012046149A1 (en) | 2010-04-28 | 2012-04-12 | Kimberly-Clark Worldwide, Inc. | Method for increasing permeability of an epithelial barrier |
| WO2011135531A2 (en) | 2010-04-28 | 2011-11-03 | Kimberly-Clark Worldwide, Inc. | MEDICAL DEVICES FOR DELIVERY OF siRNA |
| JP5860032B2 (ja) | 2010-04-28 | 2016-02-16 | キンバリー クラーク ワールドワイド インコーポレイテッド | 関節リウマチ薬の送達のためのデバイス |
| JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル， インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
| US8588884B2 (en) | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
| US9943673B2 (en) | 2010-07-14 | 2018-04-17 | Vaxxas Pty Limited | Patch applying apparatus |
| EP2635255B1 (en) | 2010-11-01 | 2019-08-21 | EyePoint Pharmaceuticals US, Inc. | Bioerodible silicon-based devices for delivery of therapeutic agents |
| US9394369B2 (en) | 2011-01-03 | 2016-07-19 | The Regents Of The University Of California | Luminescent porous silicon nanoparticles for targeted delivery and immunization |
| WO2012159058A2 (en) * | 2011-05-18 | 2012-11-22 | Brigham Young University | Apparatuses and related methods for delivering biological material into a cell |
| GB2492167C (en) | 2011-06-24 | 2018-12-05 | Nexeon Ltd | Structured particles |
| EP4233839A3 (en) | 2011-10-12 | 2023-09-27 | Vaxxas Pty Limited | Delivery device |
| US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
| HUE058275T2 (hu) * | 2011-10-27 | 2022-07-28 | Sorrento Therapeutics Inc | Beültethetõ eszközök biológiailag hatásos szerek tobábbítására |
| KR102265775B1 (ko) | 2011-10-27 | 2021-06-16 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 고점도 생체활성 제제의 경피 전달 방법 |
| CA2851828A1 (en) | 2011-10-28 | 2013-05-02 | Presage Biosciences, Inc. | Methods for drug delivery |
| CN102553066B (zh) * | 2011-12-28 | 2013-07-17 | 上海交通大学 | 基于多孔微针结构的经皮给药系统 |
| EP2810322A1 (en) | 2012-01-30 | 2014-12-10 | Nexeon Limited | Composition of si/c electro active material |
| GB2499984B (en) | 2012-02-28 | 2014-08-06 | Nexeon Ltd | Composite particles comprising a removable filler |
| GB2502625B (en) | 2012-06-06 | 2015-07-29 | Nexeon Ltd | Method of forming silicon |
| US10548854B2 (en) | 2012-10-01 | 2020-02-04 | The Hong Kong University Of Science And Technology | Manufacture of nonelectronic, active-infusion patch and device for transdermal delivery across skin |
| GB2507535B (en) | 2012-11-02 | 2015-07-15 | Nexeon Ltd | Multilayer electrode |
| CA2896188C (en) | 2012-12-21 | 2021-02-23 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| MX2015012155A (es) | 2013-03-12 | 2015-11-30 | Corium Int Inc | Aplicadores de microproyeccion. |
| US20140309610A1 (en) * | 2013-03-12 | 2014-10-16 | Psivida Corp. | Drug Delivery Device Comprising Silicon-Based Carrier Particles |
| CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| EP2968119B1 (en) | 2013-03-15 | 2019-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| RU2711567C2 (ru) | 2013-03-15 | 2020-01-17 | Кориум, ИНК. | Микрочип для доставки лекарственного средства и способы его использования |
| EP2968571A4 (en) | 2013-03-15 | 2016-09-07 | Psivida Inc | BIODEGRADABLE SILICONE BASED COMPOSITIONS FOR THE DELIVERY OF THERAPEUTIC AGENTS |
| JP2016514133A (ja) | 2013-03-15 | 2016-05-19 | コリウム インターナショナル， インコーポレイテッド | ポリマーを含まない微細構造物を含むマイクロアレイ、製造方法および使用方法 |
| KR101567203B1 (ko) | 2014-04-09 | 2015-11-09 | (주)오렌지파워 | 이차 전지용 음극 활물질 및 이의 방법 |
| KR101604352B1 (ko) | 2014-04-22 | 2016-03-18 | (주)오렌지파워 | 음극 활물질 및 이를 포함하는 리튬 이차 전지 |
| WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| KR101549086B1 (ko) * | 2014-11-10 | 2015-09-02 | 주식회사 스몰랩 | 마이크로 니들 및 마이크로 니들 패치 |
| GB2533161C (en) | 2014-12-12 | 2019-07-24 | Nexeon Ltd | Electrodes for metal-ion batteries |
| EP3253440B1 (en) | 2015-02-02 | 2022-12-21 | Vaxxas Pty Limited | Microprojection array applicator |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| CN107920964B (zh) | 2015-07-09 | 2022-02-25 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| WO2017054040A1 (en) | 2015-09-28 | 2017-04-06 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| JP2017176652A (ja) | 2016-03-31 | 2017-10-05 | 花王株式会社 | 微細中空突起具 |
| EP4167312B1 (en) | 2016-06-14 | 2024-09-18 | Nexeon Limited | Electrodes for metal-ion batteries |
| KR101746024B1 (ko) * | 2016-07-14 | 2017-06-12 | 경북대학교 산학협력단 | 다공성 코팅층이 코팅된 마이크로니들과 이것의 제조 방법 그리고 마이크로니들이 구비된 마이크로니들패치 |
| EP3606760B1 (en) | 2017-03-31 | 2023-09-27 | Vaxxas Pty Limited | Device and method for coating surfaces |
| EP3639010A4 (en) | 2017-06-13 | 2021-03-17 | Vaxxas Pty Limited | QUALITY CONTROL OF SUBSTRATE COATINGS |
| US11464957B2 (en) | 2017-08-04 | 2022-10-11 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP) |
| CN109529186B (zh) * | 2018-12-17 | 2021-05-11 | 广东工业大学 | 一种药物涂层非晶合金微针及其制作方法 |
| CN110251824B (zh) * | 2019-04-30 | 2021-03-16 | 山东大学 | 一种用于透皮给药的柔性微针贴片及其制作方法 |
| JP7466181B2 (ja) * | 2020-03-24 | 2024-04-12 | 国立研究開発法人産業技術総合研究所 | マイクロニードルアレイ及びそれを用いた植物細胞への物質導入方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4784737A (en) * | 1986-04-18 | 1988-11-15 | The United States Department Of Energy | Electromicroinjection of particles into living cells |
| US5262128A (en) | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
| GB8927709D0 (en) * | 1989-12-07 | 1990-02-07 | Secretary Of The State For Def | Silicon quantum wires |
| AU8418091A (en) * | 1990-07-19 | 1992-02-18 | Chris Brinegar | Methods and apparatus for ice-medicated introduction of substances into biological material in a non-lethal manner |
| JPH0634361A (ja) * | 1992-07-15 | 1994-02-08 | Canon Inc | マイクロティップ及びこれを用いた原子間力顕微鏡装置 |
| US5635216A (en) * | 1993-12-16 | 1997-06-03 | Eli Lilly And Company | Microparticle compositions containing peptides, and methods for the preparation thereof |
| DE69433727T2 (de) * | 1993-11-02 | 2004-09-30 | Matsushita Electric Industrial Co., Ltd., Kadoma | Halbleiterbauelement mit einem Aggregat von Mikro-Nadeln aus Halbleitermaterial |
| US5457041A (en) * | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
| US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
| US5484720A (en) * | 1994-09-08 | 1996-01-16 | Genentech, Inc. | Methods for calcium phosphate transfection |
| WO1996010630A1 (en) | 1994-09-30 | 1996-04-11 | Rutgers, The State University | Direct introduction of foreign materials into cells |
| JP2697645B2 (ja) * | 1994-10-31 | 1998-01-14 | 日本電気株式会社 | 半導体装置の製造方法 |
| DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| GB9611437D0 (en) * | 1995-08-03 | 1996-08-07 | Secr Defence | Biomaterial |
| US6284345B1 (en) * | 1997-12-08 | 2001-09-04 | Washington University | Designer particles of micron and submicron dimension |
| US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| GB9815819D0 (en) * | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
| GB0008494D0 (en) * | 2000-04-07 | 2000-05-24 | Secr Defence | Microprojectile delivery system |
-
1998
- 1998-07-22 GB GBGB9815819.9A patent/GB9815819D0/en not_active Ceased
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1999
- 1999-07-22 DK DK99934933T patent/DK1098957T3/da active
- 1999-07-22 EP EP02004895A patent/EP1231259A3/en not_active Withdrawn
- 1999-07-22 AT AT99934933T patent/ATE223479T1/de active
- 1999-07-22 WO PCT/GB1999/002383 patent/WO2000005339A1/en active IP Right Grant
- 1999-07-22 CA CA2337331A patent/CA2337331C/en not_active Expired - Lifetime
- 1999-07-22 EP EP99934933A patent/EP1098957B1/en not_active Expired - Lifetime
- 1999-07-22 KR KR1020017001028A patent/KR100633273B1/ko not_active IP Right Cessation
- 1999-07-22 EP EP04030257A patent/EP1522578B1/en not_active Expired - Lifetime
- 1999-07-22 DE DE69902794T patent/DE69902794T2/de not_active Expired - Lifetime
- 1999-07-22 AU AU50554/99A patent/AU753542B2/en not_active Expired
- 1999-07-22 JP JP2000561286A patent/JP4585119B2/ja not_active Expired - Lifetime
- 1999-07-22 NZ NZ509142A patent/NZ509142A/en not_active IP Right Cessation
- 1999-07-22 ES ES04030257T patent/ES2400472T3/es not_active Expired - Lifetime
- 1999-07-22 US US09/743,447 patent/US6770480B1/en not_active Expired - Lifetime
- 1999-07-22 ES ES99934933T patent/ES2179666T3/es not_active Expired - Lifetime
- 1999-07-22 CN CNB99809028XA patent/CN1252275C/zh not_active Expired - Lifetime
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2002
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2004
- 2004-05-27 US US10/854,255 patent/US7332339B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1522578B1 (en) | 2013-01-09 |
| ES2179666T3 (es) | 2003-01-16 |
| ATE223479T1 (de) | 2002-09-15 |
| JP4585119B2 (ja) | 2010-11-24 |
| AU5055499A (en) | 2000-02-14 |
| EP1098957B1 (en) | 2002-09-04 |
| ES2400472T3 (es) | 2013-04-10 |
| WO2000005339A1 (en) | 2000-02-03 |
| CN1310755A (zh) | 2001-08-29 |
| EP1231259A3 (en) | 2003-11-19 |
| DE69902794T2 (de) | 2003-08-07 |
| KR100633273B1 (ko) | 2006-10-16 |
| HK1039146B (zh) | 2006-10-27 |
| EP1098957A1 (en) | 2001-05-16 |
| NZ509142A (en) | 2004-01-30 |
| EP1522578A1 (en) | 2005-04-13 |
| US7332339B2 (en) | 2008-02-19 |
| AU753542B2 (en) | 2002-10-24 |
| CA2337331A1 (en) | 2000-02-03 |
| EP1231259A2 (en) | 2002-08-14 |
| US6770480B1 (en) | 2004-08-03 |
| JP2002521024A (ja) | 2002-07-16 |
| US20040220535A1 (en) | 2004-11-04 |
| DE69902794D1 (de) | 2002-10-10 |
| HK1039146A1 (en) | 2002-04-12 |
| CN1252275C (zh) | 2006-04-19 |
| CA2337331C (en) | 2012-08-28 |
| KR20010072050A (ko) | 2001-07-31 |
| GB9815819D0 (en) | 1998-09-16 |
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