DK1076558T3 - 2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener - Google Patents

2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener

Info

Publication number
DK1076558T3
DK1076558T3 DK99921834T DK99921834T DK1076558T3 DK 1076558 T3 DK1076558 T3 DK 1076558T3 DK 99921834 T DK99921834 T DK 99921834T DK 99921834 T DK99921834 T DK 99921834T DK 1076558 T3 DK1076558 T3 DK 1076558T3
Authority
DK
Denmark
Prior art keywords
aminoethoxy
estrogens
indole
benzyl
phenyl
Prior art date
Application number
DK99921834T
Other languages
Danish (da)
English (en)
Inventor
James Harrison Pickar
Barry Samuel Komm
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1076558(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1076558T3 publication Critical patent/DK1076558T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK99921834T 1998-05-15 1999-05-11 2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener DK1076558T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (1)

Publication Number Publication Date
DK1076558T3 true DK1076558T3 (da) 2003-11-03

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99921834T DK1076558T3 (da) 1998-05-15 1999-05-11 2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener

Country Status (41)

Country Link
EP (1) EP1076558B1 (cs)
JP (3) JP2002515431A (cs)
KR (1) KR100620772B1 (cs)
CN (1) CN1230163C (cs)
AP (1) AP1424A (cs)
AR (1) AR020074A1 (cs)
AT (1) ATE245026T1 (cs)
AU (1) AU760378B2 (cs)
BE (1) BE2015C026I2 (cs)
BG (1) BG64783B1 (cs)
BR (1) BR9911040A (cs)
CA (1) CA2329530A1 (cs)
CU (1) CU23241B7 (cs)
CY (1) CY2015020I1 (cs)
CZ (1) CZ299334B6 (cs)
DE (1) DE69909616T2 (cs)
DK (1) DK1076558T3 (cs)
EA (1) EA005932B1 (cs)
EE (1) EE04262B1 (cs)
ES (1) ES2203131T3 (cs)
FR (1) FR15C0035I2 (cs)
GE (1) GEP20033079B (cs)
HR (1) HRP20000778B1 (cs)
HU (2) HU226587B1 (cs)
ID (1) ID26890A (cs)
IL (1) IL139130A (cs)
IN (1) IN192220B (cs)
LT (1) LTC1076558I2 (cs)
LU (1) LU92699I2 (cs)
NO (2) NO328129B1 (cs)
NZ (1) NZ508200A (cs)
OA (1) OA11552A (cs)
PL (1) PL194750B1 (cs)
PT (1) PT1076558E (cs)
SI (1) SI1076558T1 (cs)
SK (1) SK284666B6 (cs)
TR (1) TR200003377T2 (cs)
TW (1) TW565554B (cs)
UA (1) UA66861C2 (cs)
WO (1) WO1999059581A1 (cs)
ZA (1) ZA200006959B (cs)

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UA66861C2 (uk) * 1998-05-15 2004-06-15 Уайт 2-феніл-1-[4-(2-аміноетокси)бензил]індол в комбінації з естрогенами, способи лікування та продукт для лікування
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
BR0012354A (pt) 1999-07-06 2002-04-02 Endorech Inc Compostos e composição farmacêutica e métodos para tratar e/ou suprimir ganho de peso
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
AU2001271784A1 (en) * 2000-07-06 2002-01-21 Wyeth Therapy for prosthesis-related bone degeneration
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
EP1299093A2 (en) * 2000-07-06 2003-04-09 Wyeth Combinations of bisphosphonates, estrogenic agents and optionally estrogens
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
CN1468110A (zh) * 2000-07-06 2004-01-14 惠氏公司 他汀类、雌激素药物以及任选雌激素的联合应用
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
IL158871A0 (en) 2001-07-31 2004-05-12 Pfizer Prod Inc Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
RU2492164C2 (ru) 2008-04-16 2013-09-10 Каро Био Аб Новые лиганды эстрогеновых рецепторов
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
KR102781141B1 (ko) * 2017-12-15 2025-03-13 브리스톨-마이어스 스큅 컴퍼니 치환된 인돌 에테르 화합물
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
US20230158152A1 (en) * 2020-03-17 2023-05-25 Medshine Discovery Inc. Proteolysis regulator and method for using same

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US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
WO1993023374A1 (en) * 1992-05-08 1993-11-25 Otsuka Pharmaceutical Factory, Inc. Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
ES2162198T3 (es) * 1996-04-19 2001-12-16 American Home Prod Agentes estrogenos.
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
PL330994A1 (en) * 1996-07-09 1999-06-21 Smithkline Beecham Spa Indolic derivatives for use in treating osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
BR9813069A (pt) * 1997-10-15 2000-08-22 American Home Prod Arilóxi-alquil-dialquilaminas
WO1999021557A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
UA66861C2 (uk) * 1998-05-15 2004-06-15 Уайт 2-феніл-1-[4-(2-аміноетокси)бензил]індол в комбінації з естрогенами, способи лікування та продукт для лікування

Also Published As

Publication number Publication date
ES2203131T3 (es) 2004-04-01
EE200000652A (et) 2002-04-15
LU92699I2 (fr) 2015-06-24
WO1999059581A1 (en) 1999-11-25
NO328129B1 (no) 2009-12-14
JP5872624B2 (ja) 2016-03-01
KR100620772B1 (ko) 2006-09-13
SI1076558T1 (en) 2003-10-31
JP2002515431A (ja) 2002-05-28
OA11552A (en) 2004-06-07
PL345268A1 (en) 2001-12-03
CA2329530A1 (en) 1999-11-25
NO20005770L (no) 2001-01-12
KR20010043641A (ko) 2001-05-25
TR200003377T2 (tr) 2001-03-21
AR020074A1 (es) 2002-04-10
EA005932B1 (ru) 2005-08-25
HUS1500023I1 (hu) 2017-03-28
HK1031691A1 (en) 2001-06-22
IL139130A (en) 2005-11-20
HRP20000778A2 (en) 2001-06-30
CY2015020I1 (el) 2020-05-29
AU3894499A (en) 1999-12-06
NZ508200A (en) 2003-09-26
EP1076558B1 (en) 2003-07-16
NO2015015I2 (no) 2015-06-02
TW565554B (en) 2003-12-11
EE04262B1 (et) 2004-04-15
JP5607871B2 (ja) 2014-10-15
EA200001193A1 (ru) 2001-12-24
BR9911040A (pt) 2001-02-13
BE2015C026I2 (en) 2018-08-24
AP1424A (en) 2005-06-06
IL139130A0 (en) 2001-11-25
FR15C0035I1 (cs) 2015-06-26
CZ20004254A3 (cs) 2001-12-12
IN192220B (cs) 2004-03-20
NO2015015I1 (no) 2015-06-02
JP2014159472A (ja) 2014-09-04
EP1076558A1 (en) 2001-02-21
CN1326347A (zh) 2001-12-12
BG64783B1 (bg) 2006-04-28
PL194750B1 (pl) 2007-06-29
ID26890A (id) 2001-02-15
UA66861C2 (uk) 2004-06-15
HUP0103096A2 (hu) 2002-05-29
SK284666B6 (sk) 2005-08-04
ATE245026T1 (de) 2003-08-15
DE69909616D1 (de) 2003-08-21
NO20005770D0 (no) 2000-11-14
ZA200006959B (en) 2001-11-27
BG104930A (en) 2001-07-31
FR15C0035I2 (fr) 2015-08-28
AP2000001970A0 (en) 2000-12-31
JP2009019042A (ja) 2009-01-29
GEP20033079B (en) 2003-10-27
CZ299334B6 (cs) 2008-06-25
CN1230163C (zh) 2005-12-07
LTC1076558I2 (lt) 2016-11-10
AU760378B2 (en) 2003-05-15
SK17202000A3 (sk) 2001-07-10
DE69909616T2 (de) 2004-06-17
HU226587B1 (en) 2009-04-28
CU23241B7 (es) 2007-10-17
HUP0103096A3 (en) 2002-11-28
PT1076558E (pt) 2003-11-28
HRP20000778B1 (en) 2004-10-31

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