DK1051398T3 - Termodynamisk stabil form af (R)-3-[[(4-fluorphenyl)sulfonyl]-amino]-1,2,3,4-tetrahydro-9H-carbazol-9-propansyre (ramatroban) - Google Patents
Termodynamisk stabil form af (R)-3-[[(4-fluorphenyl)sulfonyl]-amino]-1,2,3,4-tetrahydro-9H-carbazol-9-propansyre (ramatroban)Info
- Publication number
- DK1051398T3 DK1051398T3 DK98961506T DK98961506T DK1051398T3 DK 1051398 T3 DK1051398 T3 DK 1051398T3 DK 98961506 T DK98961506 T DK 98961506T DK 98961506 T DK98961506 T DK 98961506T DK 1051398 T3 DK1051398 T3 DK 1051398T3
- Authority
- DK
- Denmark
- Prior art keywords
- ramatroban
- carbazole
- fluorophenyl
- tetrahydro
- sulfonyl
- Prior art date
Links
- LDXDSHIEDAPSSA-OAHLLOKOSA-N Ramatroban Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CCC(=O)O)S(=O)(=O)C1=CC=C(F)C=C1 LDXDSHIEDAPSSA-OAHLLOKOSA-N 0.000 title 2
- 229950004496 ramatroban Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19757983A DE19757983A1 (de) | 1997-12-24 | 1997-12-24 | Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban) |
| PCT/JP1998/005844 WO1999033803A1 (en) | 1997-12-24 | 1998-12-24 | Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1051398T3 true DK1051398T3 (da) | 2004-07-19 |
Family
ID=7853457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98961506T DK1051398T3 (da) | 1997-12-24 | 1998-12-24 | Termodynamisk stabil form af (R)-3-[[(4-fluorphenyl)sulfonyl]-amino]-1,2,3,4-tetrahydro-9H-carbazol-9-propansyre (ramatroban) |
Country Status (36)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008075028A1 (en) * | 2006-12-20 | 2008-06-26 | Cardoz Ab | New combination for use in the treatment of inflammatory disorders |
| WO2008087371A1 (en) * | 2007-01-16 | 2008-07-24 | Cardoz Ab | New combination for use in the treatment of inflammatory disorders |
| WO2009007674A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast |
| WO2011115069A1 (ja) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 結晶の網羅的探索 |
| CN103054857A (zh) * | 2012-12-30 | 2013-04-24 | 北京阜康仁生物制药科技有限公司 | 一种以雷马曲班为活性成分的固体制剂 |
| ES2991300T3 (es) | 2015-02-13 | 2024-12-03 | Inserm Institut Nat De La Sante Et De Larecherche Medicale | Antagonistas de PTGDR-1 y/o PTGDR-2 para prevenir y/o tratar lupus eritematoso sistémico |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1557665A (en) * | 1975-12-10 | 1979-12-12 | Ici Ltd | Process for the manufacture of a carboxyalkylamino anthraquinone compounds |
| US4616028A (en) * | 1985-04-22 | 1986-10-07 | American Home Products Corporation | Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, compositions and use |
| CN1015711B (zh) | 1986-02-21 | 1992-03-04 | 拜尔公司 | 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法 |
| DE3631824A1 (de) | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
| GB8924392D0 (en) * | 1989-10-30 | 1989-12-20 | Bayer Ag | Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides |
| DE19506739A1 (de) | 1995-02-27 | 1996-08-29 | Bayer Ag | [3-Amino]-tetrahydrocarbazol-propansäureester |
-
1997
- 1997-12-24 DE DE19757983A patent/DE19757983A1/de not_active Withdrawn
-
1998
- 1998-12-09 HN HN1998000186A patent/HN1998000186A/es unknown
- 1998-12-11 AR ARP980106318A patent/AR013803A1/es unknown
- 1998-12-15 GT GT199800198A patent/GT199800198A/es unknown
- 1998-12-22 MY MYPI98005837A patent/MY116312A/en unknown
- 1998-12-22 PE PE1998001272A patent/PE20000115A1/es not_active Application Discontinuation
- 1998-12-23 CO CO98076459A patent/CO4970800A1/es unknown
- 1998-12-23 ZA ZA9811817A patent/ZA9811817B/xx unknown
- 1998-12-23 UY UY25324A patent/UY25324A1/es not_active IP Right Cessation
- 1998-12-23 TW TW087121479A patent/TW552258B/zh not_active IP Right Cessation
- 1998-12-24 IN IN43MU2000 patent/IN192932B/en unknown
- 1998-12-24 AU AU16874/99A patent/AU744242B2/en not_active Ceased
- 1998-12-24 DE DE69822882T patent/DE69822882T2/de not_active Expired - Fee Related
- 1998-12-24 IL IL13627898A patent/IL136278A/xx not_active IP Right Cessation
- 1998-12-24 CN CNB98812405XA patent/CN1140510C/zh not_active Expired - Fee Related
- 1998-12-24 CA CA002313230A patent/CA2313230A1/en not_active Abandoned
- 1998-12-24 ID IDW20001226A patent/ID25446A/id unknown
- 1998-12-24 HU HU0004432A patent/HUP0004432A3/hu unknown
- 1998-12-24 WO PCT/JP1998/005844 patent/WO1999033803A1/en not_active Ceased
- 1998-12-24 BR BR9814496-0A patent/BR9814496A/pt not_active Application Discontinuation
- 1998-12-24 PT PT98961506T patent/PT1051398E/pt unknown
- 1998-12-24 DK DK98961506T patent/DK1051398T3/da active
- 1998-12-24 PL PL98341359A patent/PL341359A1/xx not_active Application Discontinuation
- 1998-12-24 US US09/582,250 patent/US6362214B1/en not_active Expired - Fee Related
- 1998-12-24 NZ NZ504741A patent/NZ504741A/xx unknown
- 1998-12-24 SI SI9830656T patent/SI1051398T1/xx unknown
- 1998-12-24 TR TR2000/01936T patent/TR200001936T2/xx unknown
- 1998-12-24 AT AT98961506T patent/ATE263152T1/de not_active IP Right Cessation
- 1998-12-24 RU RU2000119741/04A patent/RU2220137C2/ru not_active IP Right Cessation
- 1998-12-24 JP JP2000526487A patent/JP3817668B2/ja not_active Expired - Lifetime
- 1998-12-24 ES ES98961506T patent/ES2218874T3/es not_active Expired - Lifetime
- 1998-12-24 KR KR1020007007031A patent/KR100586350B1/ko not_active Expired - Fee Related
- 1998-12-24 EP EP98961506A patent/EP1051398B1/en not_active Expired - Lifetime
- 1998-12-24 SK SK975-2000A patent/SK285109B6/sk unknown
- 1998-12-24 UA UA2000074335A patent/UA66832C2/uk unknown
-
1999
- 1999-06-18 UY UY25575A patent/UY25575A1/es unknown
-
2000
- 2000-06-21 NO NO20003217A patent/NO316618B1/no unknown
- 2000-06-23 BG BG104554A patent/BG65024B1/bg unknown
-
2005
- 2005-11-25 JP JP2005340586A patent/JP4411269B2/ja not_active Expired - Lifetime
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