DK1042388T3 - Polyhydroxyalkanoatsammensætninger med regulerede nedbrydningshastigheder - Google Patents

Polyhydroxyalkanoatsammensætninger med regulerede nedbrydningshastigheder

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Publication number
DK1042388T3
DK1042388T3 DK98964258T DK98964258T DK1042388T3 DK 1042388 T3 DK1042388 T3 DK 1042388T3 DK 98964258 T DK98964258 T DK 98964258T DK 98964258 T DK98964258 T DK 98964258T DK 1042388 T3 DK1042388 T3 DK 1042388T3
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DK
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Prior art keywords
devices
biocompatible
polyhydroxyalkanoate
patches
fermentation
Prior art date
Application number
DK98964258T
Other languages
English (en)
Inventor
David P Martin
Frank A Skraly
Simon F Williams
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
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Publication of DK1042388T3 publication Critical patent/DK1042388T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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DK98964258T 1997-12-22 1998-12-22 Polyhydroxyalkanoatsammensætninger med regulerede nedbrydningshastigheder DK1042388T3 (da)

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US6845597P 1997-12-22 1997-12-22

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DK1042388T3 true DK1042388T3 (da) 2006-12-11

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EP (4) EP1659142B1 (da)
JP (1) JP4376455B2 (da)
AT (2) ATE461957T1 (da)
AU (1) AU751610B2 (da)
CA (1) CA2314151C (da)
CY (1) CY1106007T1 (da)
DE (2) DE69836439T2 (da)
DK (1) DK1042388T3 (da)
ES (3) ES2281147T3 (da)
PT (1) PT1042388E (da)
WO (1) WO1999032536A1 (da)

Families Citing this family (70)

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WO1998051812A2 (en) 1997-05-12 1998-11-19 Metabolix, Inc. Polyhydroxyalkanoates for in vivo applications
ES2302386T3 (es) 1998-08-04 2008-07-01 Metabolix, Inc. Produccion de polihidroxialcanoatos a partir de polioles.
AU3722800A (en) 1999-03-04 2000-09-21 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
EP1867348B1 (en) 1999-03-25 2012-05-16 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
CA2382599C (en) * 1999-08-30 2005-11-08 Tepha, Inc. Flushable disposable polymeric products
US7025980B1 (en) 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
JP4723143B2 (ja) * 1999-09-14 2011-07-13 テファ， インコーポレイテッド γ−ヒドロキシブチレートを含むポリマーおよびオリゴマーの治療的用途
ES2261253T3 (es) * 1999-09-14 2006-11-16 Tepha, Inc. Composiciones de polihidroxialcanoato para la reparacion y aumentacion del rejido liso.
WO2002016284A2 (en) * 2000-08-23 2002-02-28 Metabolix, Inc. Low molecular weight polyhydroxyalkanoate molding compositions
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ATE345359T1 (de) 2006-12-15
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