CY1106007T1 - Πολυυδροξυαλκανοϊκα σκευασματα με ελεγχομενες ταχυτητες αποικοδομησης - Google Patents

Πολυυδροξυαλκανοϊκα σκευασματα με ελεγχομενες ταχυτητες αποικοδομησης

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Publication number
CY1106007T1
CY1106007T1 CY20071100182T CY071100182T CY1106007T1 CY 1106007 T1 CY1106007 T1 CY 1106007T1 CY 20071100182 T CY20071100182 T CY 20071100182T CY 071100182 T CY071100182 T CY 071100182T CY 1106007 T1 CY1106007 T1 CY 1106007T1
Authority
CY
Cyprus
Prior art keywords
polyhydroxyalkanoate
degradation rates
formulations
alter
biocompatible
Prior art date
Application number
CY20071100182T
Other languages
English (en)
Inventor
David P. Martin
Frank A. Skraly
Simon F. Williams
Original Assignee
Metabolix, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix, Inc. filed Critical Metabolix, Inc.
Publication of CY1106007T1 publication Critical patent/CY1106007T1/el

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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract

Βιοσυμβατά πολυυδροξυαλκανοϊκά σκευάσματα, που βασίζονται ιδιαίτερα σε βιοτεχνολογικώς παραγόμενα ομο- και συμπολυμερή 4-υδροξυβουτυρικού οξέος, με ελεγχόμενες ταχύτητες αποικοδόμησης αναπτύχθηκαν. Σε μια εφαρμογή, τα πολυυδροξυαλκανοϊκά πολυμερή περιέχουν πρόσθετες ουσίες όπως για παράδειγμα μέσα σχηματισμού πόρων που μεταβάλλουν τις ταχύτητες αποικοδόμησης. Σε μια άλλη εφαρμογή, τα πολυυδροξυαλκανοϊκά πολυμερή σχηματίζονται από μίγματα μονομερών ή περιέχουν ελεύθερες ομάδες στο σκελετό τους που μεταβάλλουν τις ταχύτητες αποικοδόμησης. Σε μια ακόμα εφαρμογή, οι πολυυδροξυαλκανοϊκοί εστέρες είναι χημικός τροποποιημένοι. Μέθοδοι παρασκευής των διατάξεων που αυξάνουν το πορώδες ή την εκτεθειμένη επιφανειακή περιοχή μπορούν να χρησιμοποιηθούν για να μεταβάλλουν την ικανότητα αποικοδόμησης. Όπως φαίνεται στα παραδείγματα, αυτά τα πολυυδροξυαλκανοϊκά σκευάσματα έχουν εξαιρετικά προτιμούμενες μηχανικές ιδιότητες, κι επίσης είναι βιοσυμβατά και αποικοδομούνται σε επιθυμητά χρονικά πλαίσια κάτω από φυσιολογικές συνθήκες. Αυτά τα πολυυδροξυαλκανοϊκά υλικά προσφέρουν μεγαλύτερο εύρος ταχυτήτων αποικοδόμησης πολυυδροξυαλκανοϊκών πολυμερών από αυτές που είναι διαθέσιμες αυτή τη στιγμή. Μέθοδοι επεξεργασίας αυτόν των υλικών, και ιδιαίτερα για θεραπευτικές, προληπτικές ή διαγνωστικές εφαρμογές, ή σε διατάξεις που μπορούν να εμφυτευτούν ή να ενεθούν, επίσης περιγράφονται.
CY20071100182T 1997-12-22 2007-02-12 Πολυυδροξυαλκανοϊκα σκευασματα με ελεγχομενες ταχυτητες αποικοδομησης CY1106007T1 (el)

Applications Claiming Priority (2)

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US6845597P 1997-12-22 1997-12-22
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EP1042388A1 (en) 2000-10-11
AU1942999A (en) 1999-07-12
JP2001527101A (ja) 2001-12-25
WO1999032536A1 (en) 1999-07-01
DE69836439D1 (de) 2006-12-28
JP4376455B2 (ja) 2009-12-02
EP1659142A1 (en) 2006-05-24
DE69841579D1 (de) 2010-05-06
ATE345359T1 (de) 2006-12-15
CA2314151A1 (en) 1999-07-01
ES2281147T3 (es) 2007-09-16
EP2196484A1 (en) 2010-06-16
EP2196484B1 (en) 2012-08-22
ES2394953T3 (es) 2013-02-07
EP1042388B1 (en) 2006-11-15
EP1659142B1 (en) 2010-03-24
PT1042388E (pt) 2007-01-31
DE69836439T2 (de) 2007-05-24
DK1042388T3 (da) 2006-12-11
ES2356350T3 (es) 2011-04-07
AU751610B2 (en) 2002-08-22
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ATE461957T1 (de) 2010-04-15
CA2314151C (en) 2004-10-26

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