DE69836439D1 - Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten - Google Patents
Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeitenInfo
- Publication number
- DE69836439D1 DE69836439D1 DE69836439T DE69836439T DE69836439D1 DE 69836439 D1 DE69836439 D1 DE 69836439D1 DE 69836439 T DE69836439 T DE 69836439T DE 69836439 T DE69836439 T DE 69836439T DE 69836439 D1 DE69836439 D1 DE 69836439D1
- Authority
- DE
- Germany
- Prior art keywords
- devices
- biocompatible
- polyhydroxyalkanoate
- patches
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 title abstract 5
- 229920000903 polyhydroxyalkanoate Polymers 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title 1
- 238000000855 fermentation Methods 0.000 abstract 3
- 230000004151 fermentation Effects 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 2
- 239000007943 implant Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000002639 bone cement Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000006260 foam Substances 0.000 abstract 1
- 238000010128 melt processing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 230000000399 orthopedic effect Effects 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G63/66—Polyesters containing oxygen in the form of ether groups
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
- C08G63/6852—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from hydroxy carboxylic acids
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0033—Additives activating the degradation of the macromolecular compound
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- C—CHEMISTRY; METALLURGY
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C12P7/625—Polyesters of hydroxy carboxylic acids
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- C08J2201/044—Elimination of an inorganic solid phase
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- C08J2201/048—Elimination of a frozen liquid phase
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6845597P | 1997-12-22 | 1997-12-22 | |
US68455P | 1997-12-22 | ||
PCT/US1998/027355 WO1999032536A1 (en) | 1997-12-22 | 1998-12-22 | Polyhydroxyalkanoate compositions having controlled degradation rates |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69836439D1 true DE69836439D1 (de) | 2006-12-28 |
DE69836439T2 DE69836439T2 (de) | 2007-05-24 |
Family
ID=22082684
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69836439T Expired - Lifetime DE69836439T2 (de) | 1997-12-22 | 1998-12-22 | Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten |
DE69841579T Expired - Lifetime DE69841579D1 (de) | 1997-12-22 | 1998-12-22 | Polyhydroxyalkanoatzusammensetzungen mit kontrollierten Abbaugeschwindigkeiten |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69841579T Expired - Lifetime DE69841579D1 (de) | 1997-12-22 | 1998-12-22 | Polyhydroxyalkanoatzusammensetzungen mit kontrollierten Abbaugeschwindigkeiten |
Country Status (11)
Country | Link |
---|---|
EP (4) | EP2258742A1 (de) |
JP (1) | JP4376455B2 (de) |
AT (2) | ATE345359T1 (de) |
AU (1) | AU751610B2 (de) |
CA (1) | CA2314151C (de) |
CY (1) | CY1106007T1 (de) |
DE (2) | DE69836439T2 (de) |
DK (1) | DK1042388T3 (de) |
ES (3) | ES2281147T3 (de) |
PT (1) | PT1042388E (de) |
WO (1) | WO1999032536A1 (de) |
Families Citing this family (69)
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- 1998-12-22 CA CA002314151A patent/CA2314151C/en not_active Expired - Lifetime
- 1998-12-22 DE DE69836439T patent/DE69836439T2/de not_active Expired - Lifetime
- 1998-12-22 EP EP10075367A patent/EP2258742A1/de not_active Withdrawn
- 1998-12-22 EP EP06075303A patent/EP1659142B1/de not_active Expired - Lifetime
- 1998-12-22 ES ES98964258T patent/ES2281147T3/es not_active Expired - Lifetime
- 1998-12-22 EP EP10075046A patent/EP2196484B1/de not_active Expired - Lifetime
- 1998-12-22 AU AU19429/99A patent/AU751610B2/en not_active Expired
- 1998-12-22 PT PT98964258T patent/PT1042388E/pt unknown
- 1998-12-22 AT AT98964258T patent/ATE345359T1/de active
- 1998-12-22 WO PCT/US1998/027355 patent/WO1999032536A1/en active IP Right Grant
- 1998-12-22 ES ES10075046T patent/ES2394953T3/es not_active Expired - Lifetime
- 1998-12-22 JP JP2000525470A patent/JP4376455B2/ja not_active Expired - Lifetime
- 1998-12-22 AT AT06075303T patent/ATE461957T1/de not_active IP Right Cessation
- 1998-12-22 ES ES06075303T patent/ES2356350T3/es not_active Expired - Lifetime
- 1998-12-22 EP EP98964258A patent/EP1042388B1/de not_active Expired - Lifetime
- 1998-12-22 DE DE69841579T patent/DE69841579D1/de not_active Expired - Lifetime
- 1998-12-22 DK DK98964258T patent/DK1042388T3/da active
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2007
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Publication number | Publication date |
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PT1042388E (pt) | 2007-01-31 |
ES2281147T3 (es) | 2007-09-16 |
ATE461957T1 (de) | 2010-04-15 |
EP2258742A1 (de) | 2010-12-08 |
JP4376455B2 (ja) | 2009-12-02 |
EP2196484B1 (de) | 2012-08-22 |
EP1659142B1 (de) | 2010-03-24 |
CA2314151A1 (en) | 1999-07-01 |
EP1659142A1 (de) | 2006-05-24 |
ES2394953T3 (es) | 2013-02-07 |
CY1106007T1 (el) | 2011-04-06 |
DE69841579D1 (de) | 2010-05-06 |
JP2001527101A (ja) | 2001-12-25 |
ES2356350T3 (es) | 2011-04-07 |
CA2314151C (en) | 2004-10-26 |
WO1999032536A1 (en) | 1999-07-01 |
AU751610B2 (en) | 2002-08-22 |
DE69836439T2 (de) | 2007-05-24 |
AU1942999A (en) | 1999-07-12 |
EP2196484A1 (de) | 2010-06-16 |
EP1042388B1 (de) | 2006-11-15 |
ATE345359T1 (de) | 2006-12-15 |
EP1042388A1 (de) | 2000-10-11 |
DK1042388T3 (da) | 2006-12-11 |
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