HUP9903745A2 - Polikarboxil-polimer-alapú térhálós kopolimerek - Google Patents

Polikarboxil-polimer-alapú térhálós kopolimerek

Info

Publication number
HUP9903745A2
HUP9903745A2 HU9903745A HUP9903745A HUP9903745A2 HU P9903745 A2 HUP9903745 A2 HU P9903745A2 HU 9903745 A HU9903745 A HU 9903745A HU P9903745 A HUP9903745 A HU P9903745A HU P9903745 A2 HUP9903745 A2 HU P9903745A2
Authority
HU
Hungary
Prior art keywords
polycarboxyl
polymers
cross
polysaccharide
stone
Prior art date
Application number
HU9903745A
Other languages
English (en)
Inventor
Nada El Matni
Hatem Fessim
Denis Labarre
Original Assignee
Societe De Conseils De Recherches Et D'applications Scientifiques S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe De Conseils De Recherches Et D'applications Scientifiques S.A. filed Critical Societe De Conseils De Recherches Et D'applications Scientifiques S.A.
Publication of HUP9903745A2 publication Critical patent/HUP9903745A2/hu
Publication of HUP9903745A3 publication Critical patent/HUP9903745A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

A találmány tárgya nem térhálós pőlikarbőxil-pőlimereken és legalábbkét amin-fűnkcióscsőpőrtőt tartalmazó térhálósító szeren alapűlótérhálósítőtt kőpőlimerek, amelyek legalább egyféle pőlikarbőxil-pőliszacharidőt és legalább egy másik pőlikarbőxil-pőliszacharidtóleltérő nem térhálós pőlikarbőxil-pőlimert tartalmaznak. A találmánykiterjed a fenti kőpőlimerek előállítására, melynek sőrán atérhálósítőtt pőlikarbőxil-pőlimert vizes közegben reagáltatjákaktivátőr és térhálósító szer jelenlétében. A találmány kiterjedtővábbá legalább egy hatóanyagőt és hőrdőzóként vagy adalékanyagkéntlegalább egy fenti kőpőlimert tartalmazó gyógyszerkészítményekre,tővábbá ezek vastagbélbetegségek kezelésére történő alkalmazására is. ŕ
HU9903745A 1996-08-30 1997-08-29 Polycarboxylic based cross-linked copolymers HUP9903745A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9610601A FR2752843B1 (fr) 1996-08-30 1996-08-30 Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique
PCT/FR1997/001534 WO1998008897A1 (fr) 1996-08-30 1997-08-29 Copolymeres reticules a base de polymeres polycarboxyliques

Publications (2)

Publication Number Publication Date
HUP9903745A2 true HUP9903745A2 (hu) 2000-03-28
HUP9903745A3 HUP9903745A3 (en) 2001-03-28

Family

ID=9495309

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903745A HUP9903745A3 (en) 1996-08-30 1997-08-29 Polycarboxylic based cross-linked copolymers

Country Status (20)

Country Link
EP (1) EP0922071B1 (hu)
JP (1) JP4162265B2 (hu)
AT (1) ATE208803T1 (hu)
AU (1) AU730566B2 (hu)
CA (1) CA2266645C (hu)
CZ (1) CZ296041B6 (hu)
DE (1) DE69708304T2 (hu)
DK (1) DK0922071T3 (hu)
ES (1) ES2167784T3 (hu)
FR (1) FR2752843B1 (hu)
HU (1) HUP9903745A3 (hu)
IL (1) IL128619A (hu)
MY (1) MY116595A (hu)
NO (1) NO311621B1 (hu)
NZ (1) NZ334301A (hu)
PL (1) PL193227B1 (hu)
PT (1) PT922071E (hu)
RU (1) RU2194055C2 (hu)
WO (1) WO1998008897A1 (hu)
ZA (1) ZA977671B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
IT1303735B1 (it) * 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
US6288043B1 (en) * 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
FR2799196B1 (fr) * 1999-10-04 2002-02-08 Sod Conseils Rech Applic Copolymeres reticules a base de copolymeres polycarboxyliques non reticules
KR100378109B1 (ko) * 2000-10-24 2003-03-29 주식회사 메디프렉스 소수성 다중복합 헤파린 결합체, 그의 제조방법 및 용도
US20060153903A1 (en) * 2003-07-18 2006-07-13 Masao Ieno Polymer sustainedly -release polymer amino acid derivative, cosmetic and fiber construct containing the polymer of producing the same and method for regenerating the same
FR2873379B1 (fr) * 2004-07-23 2008-05-16 Jerome Asius Procede de preparation d'acide hyaluronique reticule, acide hyaluronique reticule susceptible d'etre obtenu par ledit procede, implant contenant ledit acide hyaluronique reticule, et son utilisation
GB2423252B (en) * 2005-02-18 2007-10-17 Engelhard Lyon Cross-linked polymer of carbohydrate, notably based on polysaccharides, and/or on oligosaccharides and/or on polyols
WO2007101243A1 (en) * 2006-02-28 2007-09-07 Novozymes Biopolymer A/S Derivatives of hyaluronic acids
EP1942117A1 (en) * 2006-12-29 2008-07-09 Sigea S.R.L. Derivatives of acid polysaccharides
JP2011500553A (ja) * 2007-10-10 2011-01-06 ルピン・リミテッド ５−アミノサリチル酸またはその塩もしくは代謝産物の新規な結腸を標的とする調節放出性生体接着性製剤
JP5722217B2 (ja) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｈｏｌｄｉｎｇｓ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． ヒアルロン酸および／またはその誘導体の糸、その作製方法、ならびにその使用
CZ302789B6 (cs) * 2009-11-25 2011-11-09 Zentiva, K. S. Zpusob zvýšení rozpustnosti farmaceuticky aktivních látek a cílený (kontrolovaný) transport do streva
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
EP3520827B1 (en) 2010-03-22 2022-05-25 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
KR102015676B1 (ko) 2011-06-03 2019-10-21 알러간, 인코포레이티드 항산화제를 포함하는 피부 충전제 조성물
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
FR2997014B1 (fr) * 2012-10-24 2015-03-20 Teoxane Composition sterile dermo-injectable
ITUD20130119A1 (it) * 2013-09-12 2015-03-13 Limacorporate Spa Idrogel biocompatibile per uso biomedico o farmaceutico, polimero intermedio per realizzare detto idrogel biocompatibile e relativo metodo di realizzazione
EP3101064B1 (en) 2014-01-31 2020-07-15 Seikagaku Corporation Diamine crosslinking agent, acidic polysaccharide crosslinked body, and medical material
EP3620184A1 (en) 2014-09-30 2020-03-11 Allergan Industrie, SAS Stable hydrogel compositions including additives
WO2017100697A1 (en) * 2015-12-11 2017-06-15 The General Hospital Corporation Dextran nanoparticles for macrophage specific imaging and therapy

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US4026851A (en) * 1975-08-13 1977-05-31 E. I. Du Pont De Nemours And Company Acrylate polymers cured with diamines in the presence of an acid catalyst
US4663050A (en) * 1982-01-18 1987-05-05 Standard Oil Company Semipermeable membranes prepared from polymers containing adjacent, pendent carboxy groups
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
DE3809764A1 (de) * 1988-03-23 1989-10-05 Knoll Ag Mischung aus alginaten und polyacrylaten und deren verwendung
ATE185267T1 (de) * 1990-05-04 1999-10-15 Perio Prod Ltd System zur arzneistoffabgabe im colon

Also Published As

Publication number Publication date
EP0922071A1 (fr) 1999-06-16
CA2266645A1 (fr) 1998-03-05
DK0922071T3 (da) 2002-03-11
FR2752843B1 (fr) 1998-10-16
HUP9903745A3 (en) 2001-03-28
RU2194055C2 (ru) 2002-12-10
NO990935L (no) 1999-04-15
WO1998008897A1 (fr) 1998-03-05
NZ334301A (en) 2000-06-23
DE69708304D1 (de) 2001-12-20
ZA977671B (en) 1998-02-23
IL128619A0 (en) 2000-01-31
DE69708304T2 (de) 2002-07-25
ATE208803T1 (de) 2001-11-15
AU4121597A (en) 1998-03-19
ES2167784T3 (es) 2002-05-16
PL193227B1 (pl) 2007-01-31
JP4162265B2 (ja) 2008-10-08
PT922071E (pt) 2002-05-31
CZ296041B6 (cs) 2005-12-14
MY116595A (en) 2004-02-28
EP0922071B1 (fr) 2001-11-14
JP2001501228A (ja) 2001-01-30
NO311621B1 (no) 2001-12-17
AU730566B2 (en) 2001-03-08
PL331848A1 (en) 1999-08-16
FR2752843A1 (fr) 1998-03-06
IL128619A (en) 2004-02-19
CZ60699A3 (cs) 2000-06-14
NO990935D0 (no) 1999-02-26
CA2266645C (fr) 2008-03-18

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Legal Events

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HC9A Change of name, address

Owner name: IPSEN PHARMA S.A.S., FR

Free format text: FORMER OWNER(S): SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A., FR

FD9A Lapse of provisional protection due to non-payment of fees