DK1020427T3 - Middel til at potensere nervevækstfaktoraktivitet indeholdende 1,2-ethandiolderivater eller salte deraf - Google Patents

Middel til at potensere nervevækstfaktoraktivitet indeholdende 1,2-ethandiolderivater eller salte deraf

Info

Publication number
DK1020427T3
DK1020427T3 DK00100580T DK00100580T DK1020427T3 DK 1020427 T3 DK1020427 T3 DK 1020427T3 DK 00100580 T DK00100580 T DK 00100580T DK 00100580 T DK00100580 T DK 00100580T DK 1020427 T3 DK1020427 T3 DK 1020427T3
Authority
DK
Denmark
Prior art keywords
salts
agent
growth factor
nerve growth
factor activity
Prior art date
Application number
DK00100580T
Other languages
English (en)
Inventor
Satoshi Ono
Mutsuko Maekawa
Hirokazu Narita
Kazunari Hirata
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6284273A external-priority patent/JPH08268883A/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of DK1020427T3 publication Critical patent/DK1020427T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C07C217/10—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK00100580T 1994-10-25 1995-10-20 Middel til at potensere nervevækstfaktoraktivitet indeholdende 1,2-ethandiolderivater eller salte deraf DK1020427T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6284273A JPH08268883A (ja) 1994-10-25 1994-10-25 １−フェニル−１，２−エタンジオール誘導体またはそ の塩を含有する神経成長因子の作用増強剤
JP28427294 1994-10-25

Publications (1)

Publication Number Publication Date
DK1020427T3 true DK1020427T3 (da) 2004-02-09

Family

ID=26555404

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95934859T DK0790246T3 (da) 1994-10-25 1995-10-20 Middel til potensering af nervevækstfaktoraktivitet indeholdende 1,2-ethandiolderivat eller salt deraf
DK00100580T DK1020427T3 (da) 1994-10-25 1995-10-20 Middel til at potensere nervevækstfaktoraktivitet indeholdende 1,2-ethandiolderivater eller salte deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK95934859T DK0790246T3 (da) 1994-10-25 1995-10-20 Middel til potensering af nervevækstfaktoraktivitet indeholdende 1,2-ethandiolderivat eller salt deraf

Country Status (16)

Country Link
US (6) US5807887A (da)
EP (3) EP1223169A1 (da)
JP (1) JP3218247B2 (da)
KR (1) KR100447738B1 (da)
AU (1) AU700561B2 (da)
CA (1) CA2202032C (da)
CZ (1) CZ293528B6 (da)
DE (2) DE69525063T2 (da)
DK (2) DK0790246T3 (da)
ES (2) ES2208156T3 (da)
HU (1) HU226980B1 (da)
NZ (1) NZ294328A (da)
PL (2) PL187004B1 (da)
RO (1) RO119196B1 (da)
TW (1) TW341570B (da)
WO (1) WO1996012717A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69525063T2 (de) * 1994-10-25 2002-08-14 Toyama Chemical Co Ltd 1,2-ethandiolderivat oder dessen salz enthaltender potentiator der aktivität des nervenwachstumsfaktors
AU2576797A (en) * 1996-04-22 1997-11-12 Toyama Chemical Co. Ltd. Patch containing 1,2-ethanediol derivatives or salts thereof
AU1506499A (en) * 1997-12-12 1999-07-05 Toyama Chemical Co. Ltd. Alkyl ether derivatives or salts thereof and calcium antagonists containing the same
JP4549452B2 (ja) * 1997-12-12 2010-09-22 富山化学工業株式会社 アルキルエーテル誘導体またはその塩並びにそれらを含有するカルシウム拮抗剤
JP4782961B2 (ja) 1999-06-11 2011-09-28 富山化学工業株式会社 Ｎ−アルコキシアルキル−ｎ，ｎ−ジアルキルアミン誘導体またはその塩、それらを含有する神経変性疾患の治療剤
EP1325744A4 (en) * 2000-10-10 2005-08-17 Toyama Chemical Co Ltd REMEDIES FOR OPTICAL NERVE DISEASES CONTAINING 1,2-ETHANEDIOL DERIVATIVES OR CORRESPONDING SALTS
IL161308A0 (en) 2001-10-19 2004-09-27 Toyama Chemical Co Ltd Alkyl ether derivatives or their salts
JP4675103B2 (ja) 2002-06-14 2011-04-20 富山化学工業株式会社 脳機能を改善する医薬組成物および脳機能を改善するための方法
EP2248899B8 (en) 2003-03-19 2015-07-15 Biogen MA Inc. NOGO receptor binding protein
WO2006002437A2 (en) 2004-06-24 2006-01-05 Biogen Idec Ma Inc. Treatment of conditions involving demyelination
AU2006269458B2 (en) 2005-07-08 2012-11-08 Biogen Ma Inc. Sp35 antibodies and uses thereof
US8642040B2 (en) 2006-07-24 2014-02-04 Biogen Idec Ma Inc. Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of Sp35 or TrkA antagonists
WO2009048605A1 (en) * 2007-10-11 2009-04-16 Biogen Idec Ma Inc. Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell, survival via administration of lingo-1 antagonists and trkb agonists
EP2217697B1 (en) * 2007-11-08 2015-06-10 Biogen MA Inc. Use of lingo-4 antagonists in the treatment of conditions involving demyelination
JP2011527572A (ja) 2008-07-09 2011-11-04 バイオジェン・アイデック・エムエイ・インコーポレイテッド Ｌｉｎｇｏ抗体または断片を含む組成物
US9796780B2 (en) 2012-05-14 2017-10-24 Biogen Ma Inc. LINGO-2 antagonists for treatment of conditions involving motor neurons
EP3242893A1 (en) 2015-01-08 2017-11-15 Biogen MA Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894058A (en) * 1974-05-17 1975-07-08 Hoechst Co American Tetrahydrobenzofuranylphenoxypropylamines
US5254595A (en) * 1988-12-23 1993-10-19 Elf Sanofi Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them
US5280032A (en) * 1989-02-14 1994-01-18 Toyama Chemical Co., Ltd. 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same
NZ232493A (en) * 1989-02-14 1992-06-25 Toyama Chemical Co Ltd Aryl- or heterocyclyl-substituted 1,2-ethanediol derivatives and pharmaceutical compositions
JP3044055B2 (ja) * 1990-08-09 2000-05-22 富山化学工業株式会社 １，２―エタンジオール誘導体およびその塩
JPH05230103A (ja) * 1992-02-18 1993-09-07 Taisho Pharmaceut Co Ltd ガングリオシド化合物
DE69525063T2 (de) * 1994-10-25 2002-08-14 Toyama Chemical Co Ltd 1,2-ethandiolderivat oder dessen salz enthaltender potentiator der aktivität des nervenwachstumsfaktors

Also Published As

Publication number Publication date
DE69525063T2 (de) 2002-08-14
US5968935A (en) 1999-10-19
EP0790246A4 (en) 1998-03-11
PL187004B1 (pl) 2004-04-30
KR100447738B1 (ko) 2005-09-20
AU3709795A (en) 1996-05-15
EP0790246B1 (en) 2002-01-16
DK0790246T3 (da) 2002-03-18
US5922721A (en) 1999-07-13
US5807887A (en) 1998-09-15
PL319940A1 (en) 1997-09-01
CZ293528B6 (cs) 2004-05-12
WO1996012717A1 (fr) 1996-05-02
CZ124997A3 (en) 1997-10-15
TW341570B (en) 1998-10-01
EP0790246A1 (en) 1997-08-20
US6103754A (en) 2000-08-15
PL187490B1 (pl) 2004-07-30
AU700561B2 (en) 1999-01-07
US6034119A (en) 2000-03-07
ES2208156T3 (es) 2004-06-16
DE69531877T2 (de) 2004-07-29
KR970707114A (ko) 1997-12-01
HUT77361A (hu) 1998-03-30
NZ294328A (en) 1998-06-26
EP1223169A1 (en) 2002-07-17
JP3218247B2 (ja) 2001-10-15
DE69525063D1 (de) 2002-02-21
RO119196B1 (ro) 2004-05-28
ES2171559T3 (es) 2002-09-16
US5932620A (en) 1999-08-03
DE69531877D1 (de) 2003-11-06
EP1020427A1 (en) 2000-07-19
CA2202032C (en) 2009-06-16
EP1020427B1 (en) 2003-10-01
HU226980B1 (en) 2010-04-28
CA2202032A1 (en) 1996-05-02

Similar Documents

Publication Publication Date Title
DK1020427T3 (da) Middel til at potensere nervevækstfaktoraktivitet indeholdende 1,2-ethandiolderivater eller salte deraf
NO161366C (no) Nye 1,3-cyklheksandion-derivater og anvendelse derav som herbicid middel.
BR8904519A (pt) Composicao fungicida,processos para preparar compostos fungicidas e para preparar compostos de benzoilacetonitrila
DE68911266T2 (de) Korrosionsbeständige Nickelbasislegierung.
DE3679920D1 (de) Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.
DK146786A (da) 4'-demethyl-4-epipodophyllotoxinderivater, deres fremstilling og anvendelse i laegemidler, isaer som antitumormidler
DK164187A (da) Plaquemodvirkende oralt middel
ES295930Y (es) Cornisa perfeccionada para obras de arte.
DK51689A (da) Synergistisk arthropodicidt middel
NO874691D0 (no) Middel for appetittregulering eller sovemiddel.
DE68903964T2 (de) Stranggiessmaschine vom typ raupenkette.
DE68907933T2 (de) Therapeutisches Mittel für Thrombocytopenia.
ES556082A0 (es) Procedimiento para preparar derivados de 1,4-dihidropiridina con actividad cardiovascular
DK260884D0 (da) 7-oxo-4-thia-1-azabicyclo(3.2.0)-hept-2-en-derivater,fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
NO873628L (no) 2,3-dihydro-1h-fenalen-2-amino-forbindelser som antipsykotiske legemidler.
DK256689D0 (da) 1,2-dithiol-3-thion-s-oxid-forbindelser til anven delse som laegemidler
IL81044A0 (en) Pyridine derivatives,processes for the preparation thereof,agents containing same,and the use thereof as pesticides
FI905765A0 (fi) Diorganotina-yhdisteitä ja näitä sisältäviä aineita, joilla on bakteerimyrkky- ja sienimyrkkyvaikutus
DK165789C (da) 4-oxo-4h-pyrimidooe2,1,aaaisoquinolinderivater, analogifremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse samt derivaterne til anvendelse som antiallergisk middel
IT8720271A0 (it) Nuovi derivati dell'ergolene, composizioni farmaceutiche che licontengono e procedimento per lapreparazione dei medesimi.
DK537587A (da) Halogencyklopropylforbindelser, deres fremstilling og anvendelse som herbicidt middel
ZA958991B (en) Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof
IT8421627A1 (it) Composizione farmaceutica contenente come ingrediente attivo 24,25-diidrossicolecalciferolo
ITMI922071A0 (it) Derivati xantonici, loro preparazione ed attivita'
DK514686A (da) 5-naphthyl-2,4-dialkyl-3h-1,2,4-triazol-3-thioner og tautomer deraf, deres fremstilling og anvendelse som antidepressive midler