DK0994864T3 - Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum - Google Patents

Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum

Info

Publication number
DK0994864T3
DK0994864T3 DK98934930T DK98934930T DK0994864T3 DK 0994864 T3 DK0994864 T3 DK 0994864T3 DK 98934930 T DK98934930 T DK 98934930T DK 98934930 T DK98934930 T DK 98934930T DK 0994864 T3 DK0994864 T3 DK 0994864T3
Authority
DK
Denmark
Prior art keywords
antiepileptic
difluorobenzyl
carboxamide
triazole
crystal modification
Prior art date
Application number
DK98934930T
Other languages
Danish (da)
English (en)
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0994864(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0994864T3 publication Critical patent/DK0994864T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98934930T 1997-06-10 1998-06-08 Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum DK0994864T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (1)

Publication Number Publication Date
DK0994864T3 true DK0994864T3 (da) 2003-07-21

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
DK98934929T DK0994863T3 (da) 1997-06-10 1998-06-08 Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel
DK98934930T DK0994864T3 (da) 1997-06-10 1998-06-08 Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK98934929T DK0994863T3 (da) 1997-06-10 1998-06-08 Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel

Country Status (37)

Country Link
US (6) US6740669B1 (nl)
EP (2) EP0994863B1 (nl)
JP (2) JP3672575B2 (nl)
KR (2) KR100425656B1 (nl)
CN (3) CN1159300C (nl)
AR (4) AR012945A1 (nl)
AT (2) ATE237599T1 (nl)
AU (2) AU725528B2 (nl)
BR (2) BR9804947A (nl)
CA (3) CA2614926C (nl)
CO (2) CO4940448A1 (nl)
CY (1) CY2007014I1 (nl)
CZ (2) CZ292481B6 (nl)
DE (3) DE69813560T2 (nl)
DK (2) DK0994863T3 (nl)
ES (2) ES2197485T3 (nl)
FR (1) FR07C0037I2 (nl)
HK (3) HK1028242A1 (nl)
HU (2) HU226107B1 (nl)
ID (2) ID27660A (nl)
IL (2) IL125733A (nl)
LU (1) LU91345I2 (nl)
MY (2) MY120156A (nl)
NL (1) NL300284I2 (nl)
NO (2) NO329314B1 (nl)
NZ (2) NZ331370A (nl)
PE (2) PE79799A1 (nl)
PL (2) PL191943B1 (nl)
PT (1) PT994864E (nl)
RU (2) RU2198167C2 (nl)
SI (2) SI0994864T1 (nl)
SK (2) SK283685B6 (nl)
TR (2) TR199801631T1 (nl)
TW (2) TW526195B (nl)
UY (1) UY25844A1 (nl)
WO (2) WO1998056772A1 (nl)
ZA (2) ZA984967B (nl)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
US7192962B2 (en) * 2002-05-31 2007-03-20 Schering Corporation Xanthine phosphodiesterase V inhibitor polymorphs
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
CA2736703A1 (en) 2008-10-13 2010-04-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
JP2013503861A (ja) * 2009-09-04 2013-02-04 タクティカル セラピューティクス インコーポレイテッド 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法
ES2498267T3 (es) 2010-04-30 2014-09-24 Laboratorios Lesvi, S.L. Procedimiento mejorado para la preparación de un intermedio de rufinamida
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ITMI20110718A1 (it) * 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
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US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
FI93544C (fi) * 1985-04-18 1995-04-25 Ciba Geigy Ag Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
JPH04506967A (ja) 1989-07-27 1992-12-03 ジー．ディー．サール　アンド　カンパニー 高血圧症治療用腎選択性生成物
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
DE69132340T2 (de) 1990-11-06 2001-02-08 Yamanouchi Pharma Co Ltd Kondensiertes pyrazinderivat
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
ATE194607T1 (de) 1995-02-22 2000-07-15 Hoechst Japan Amorph piretanide, polymorphe davon, verfahren zur dessen herstellung und ihre verwendung
DE69712342T2 (de) * 1996-07-11 2002-11-14 Novartis Ag Verfahren zur herstellung von 1-substituierten 4-cyan-1,2,3-triazolen
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
DE69811500T2 (de) 2004-04-01
ZA984966B (en) 1999-01-11
FR07C0037I1 (nl) 2007-08-17
AR012945A1 (es) 2000-11-22
US20100310655A1 (en) 2010-12-09
PE79799A1 (es) 1999-09-03
CZ292260B6 (cs) 2003-08-13
HUP0000798A3 (en) 2000-10-30
CA2614926C (en) 2010-02-09
US20040167186A1 (en) 2004-08-26
EP0994864B1 (en) 2003-04-16
JP3672575B2 (ja) 2005-07-20
JP2000516258A (ja) 2000-12-05
MY125854A (en) 2006-08-30
ID21014A (id) 1999-04-08
PE80999A1 (es) 1999-09-06
HUP0000798A2 (hu) 2000-10-30
NO983666D0 (no) 1998-08-11
SK109498A3 (en) 1998-12-02
CN1217716A (zh) 1999-05-26
FR07C0037I2 (nl) 2008-05-16
AU725528B2 (en) 2000-10-12
NL300284I2 (nl) 2007-11-01
BR9804946A (pt) 1999-08-24
PL192114B1 (pl) 2006-08-31
CA2614926A1 (en) 1998-12-17
HK1028241A1 (en) 2001-02-09
CN1259127A (zh) 2000-07-05
PT994864E (pt) 2003-07-31
PL330798A1 (en) 1999-06-07
DE69811500D1 (de) 2003-03-27
KR19990087835A (ko) 1999-12-27
CN1132820C (zh) 2003-12-31
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
ZA984967B (en) 1999-01-11
CO4940452A1 (es) 2000-07-24
AU8437298A (en) 1998-12-30
DE122007000051I1 (de) 2007-11-08
NO329314B1 (no) 2010-09-27
DE122007000051I2 (de) 2009-02-19
CN1572789A (zh) 2005-02-02
US6455556B2 (en) 2002-09-24
ES2192779T3 (es) 2003-10-16
LU91345I2 (fr) 2007-09-04
MY120156A (en) 2005-09-30
CA2256013C (en) 2007-10-16
HK1028031A1 (en) 2001-02-02
US7750028B2 (en) 2010-07-06
ATE237599T1 (de) 2003-05-15
HK1028242A1 (en) 2001-02-09
US20010037029A1 (en) 2001-11-01
EP0994863B1 (en) 2003-02-19
AR061004A2 (es) 2008-07-30
US20060116520A1 (en) 2006-06-01
EP0994864A1 (en) 2000-04-26
KR19990087836A (ko) 1999-12-27
RU2194041C2 (ru) 2002-12-10
HUP0002113A2 (hu) 2001-02-28
ID27660A (id) 2001-04-19
CY2007014I2 (el) 2009-11-04
DE69813560D1 (de) 2003-05-22
US6740669B1 (en) 2004-05-25
WO1998056772A1 (en) 1998-12-17
DK0994863T3 (da) 2003-05-26
NZ331370A (en) 2000-08-25
SK109398A3 (en) 1998-12-02
PL330764A1 (en) 1999-05-24
CO4940448A1 (es) 2000-07-24
IL125732A (en) 2002-12-01
JP2000516259A (ja) 2000-12-05
HUP0002113A3 (en) 2002-09-30
CA2256015A1 (en) 1998-12-17
CA2256015C (en) 2008-06-03
CZ253398A3 (cs) 1999-04-14
HU225153B1 (en) 2006-07-28
AU725517B2 (en) 2000-10-12
CN1159300C (zh) 2004-07-28
EP0994863A1 (en) 2000-04-26
ES2197485T3 (es) 2004-01-01
US8076362B2 (en) 2011-12-13
UY25844A1 (es) 2001-08-27
NO329315B1 (no) 2010-09-27
CA2256013A1 (en) 1998-12-17
CN1298708C (zh) 2007-02-07
NZ331371A (en) 2000-08-25
US20030125568A1 (en) 2003-07-03
JP3672574B2 (ja) 2005-07-20
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
DE69813560T2 (de) 2004-02-05
TW403740B (en) 2000-09-01
CZ253498A3 (cs) 1999-04-14
TW526195B (en) 2003-04-01
TR199801630T1 (xx) 1999-06-21
CZ292481B6 (cs) 2003-09-17
SK283685B6 (sk) 2003-12-02
AR061005A2 (es) 2008-07-30
SI0994864T1 (en) 2003-10-31
LU91345I9 (nl) 2018-12-31
KR100425656B1 (ko) 2004-05-17
RU2198167C2 (ru) 2003-02-10
TR199801631T1 (xx) 1999-06-21
IL125733A (en) 2002-12-01
BR9804947A (pt) 1999-08-24
HU226107B1 (en) 2008-04-28
AR012946A1 (es) 2000-11-22
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
NO983666L (no) 1998-12-17
IL125733A0 (en) 1999-04-11
ATE232852T1 (de) 2003-03-15
SI0994863T1 (en) 2003-08-31
IL125732A0 (en) 1999-04-11
NO983667L (no) 1998-12-17
KR100409168B1 (ko) 2004-01-31
PL191943B1 (pl) 2006-07-31

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