DK0994863T3 - Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel - Google Patents

Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel

Info

Publication number
DK0994863T3
DK0994863T3 DK98934929T DK98934929T DK0994863T3 DK 0994863 T3 DK0994863 T3 DK 0994863T3 DK 98934929 T DK98934929 T DK 98934929T DK 98934929 T DK98934929 T DK 98934929T DK 0994863 T3 DK0994863 T3 DK 0994863T3
Authority
DK
Denmark
Prior art keywords
difluorobenzyl
carboxamide
triazole
crystal modification
antiepileptic agent
Prior art date
Application number
DK98934929T
Other languages
Danish (da)
English (en)
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0994863(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0994863T3 publication Critical patent/DK0994863T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98934929T 1997-06-10 1998-06-08 Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel DK0994863T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003427 WO1998056772A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic

Publications (1)

Publication Number Publication Date
DK0994863T3 true DK0994863T3 (da) 2003-05-26

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
DK98934929T DK0994863T3 (da) 1997-06-10 1998-06-08 Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel
DK98934930T DK0994864T3 (da) 1997-06-10 1998-06-08 Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98934930T DK0994864T3 (da) 1997-06-10 1998-06-08 Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum

Country Status (36)

Country Link
US (6) US6740669B1 (cg-RX-API-DMAC7.html)
EP (2) EP0994864B1 (cg-RX-API-DMAC7.html)
JP (2) JP3672574B2 (cg-RX-API-DMAC7.html)
KR (2) KR100425656B1 (cg-RX-API-DMAC7.html)
CN (3) CN1159300C (cg-RX-API-DMAC7.html)
AR (4) AR012946A1 (cg-RX-API-DMAC7.html)
AT (2) ATE237599T1 (cg-RX-API-DMAC7.html)
AU (2) AU725517B2 (cg-RX-API-DMAC7.html)
BR (2) BR9804946A (cg-RX-API-DMAC7.html)
CA (3) CA2256015C (cg-RX-API-DMAC7.html)
CO (2) CO4940448A1 (cg-RX-API-DMAC7.html)
CY (1) CY2007014I2 (cg-RX-API-DMAC7.html)
CZ (2) CZ292260B6 (cg-RX-API-DMAC7.html)
DE (3) DE69811500T2 (cg-RX-API-DMAC7.html)
DK (2) DK0994863T3 (cg-RX-API-DMAC7.html)
ES (2) ES2192779T3 (cg-RX-API-DMAC7.html)
FR (1) FR07C0037I2 (cg-RX-API-DMAC7.html)
HU (2) HU225153B1 (cg-RX-API-DMAC7.html)
ID (2) ID27660A (cg-RX-API-DMAC7.html)
IL (2) IL125733A (cg-RX-API-DMAC7.html)
LU (1) LU91345I2 (cg-RX-API-DMAC7.html)
MY (2) MY125854A (cg-RX-API-DMAC7.html)
NL (1) NL300284I2 (cg-RX-API-DMAC7.html)
NO (2) NO329315B1 (cg-RX-API-DMAC7.html)
NZ (2) NZ331370A (cg-RX-API-DMAC7.html)
PE (2) PE80999A1 (cg-RX-API-DMAC7.html)
PL (2) PL191943B1 (cg-RX-API-DMAC7.html)
PT (1) PT994864E (cg-RX-API-DMAC7.html)
RU (2) RU2198167C2 (cg-RX-API-DMAC7.html)
SI (2) SI0994864T1 (cg-RX-API-DMAC7.html)
SK (2) SK283685B6 (cg-RX-API-DMAC7.html)
TR (2) TR199801631T1 (cg-RX-API-DMAC7.html)
TW (2) TW526195B (cg-RX-API-DMAC7.html)
UY (1) UY25844A1 (cg-RX-API-DMAC7.html)
WO (2) WO1998056772A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA984966B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
AU2003249658A1 (en) * 2002-05-31 2003-12-19 Schering Corporation Xanthine phosphodiesterase v inhibitor polymorphs
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
NZ591725A (en) * 2008-10-13 2012-09-28 Cipla Ltd PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
EP2963023B1 (en) * 2009-09-04 2018-04-18 Tactical Therapeutics, Inc. Process for preparing 5-amino-1, 2, 3-triazole orotate derivatives
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
EP2563766B1 (en) 2010-04-30 2014-06-25 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
FI93544C (fi) * 1985-04-18 1995-04-25 Ciba Geigy Ag Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
JPH04506967A (ja) 1989-07-27 1992-12-03 ジー．ディー．サール　アンド　カンパニー 高血圧症治療用腎選択性生成物
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
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JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
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US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
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KR100419355B1 (ko) 1995-02-22 2004-06-04 훽스트파마슈티칼스앤드케미칼스가부시키가이샤 무정형피레타나이드,피레타나이드다형체,이들의제조방법및이를포함하는약제학적조성물
CA2260065C (en) * 1996-07-11 2006-10-17 Novartis Ag Process for preparing 1-substituted 4-cyano-1,2,3-triazoles
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
US20060116520A1 (en) 2006-06-01
KR100425656B1 (ko) 2004-05-17
AU725528B2 (en) 2000-10-12
AR061004A2 (es) 2008-07-30
DE122007000051I1 (de) 2007-11-08
PT994864E (pt) 2003-07-31
HUP0002113A2 (hu) 2001-02-28
HUP0000798A3 (en) 2000-10-30
EP0994864A1 (en) 2000-04-26
AU8437298A (en) 1998-12-30
HU225153B1 (en) 2006-07-28
JP3672575B2 (ja) 2005-07-20
HK1028031A1 (en) 2001-02-02
AR012946A1 (es) 2000-11-22
ID27660A (id) 2001-04-19
NL300284I2 (nl) 2007-11-01
CA2256013C (en) 2007-10-16
JP3672574B2 (ja) 2005-07-20
ZA984966B (en) 1999-01-11
HUP0002113A3 (en) 2002-09-30
CA2256015A1 (en) 1998-12-17
CN1217716A (zh) 1999-05-26
EP0994863A1 (en) 2000-04-26
CN1298708C (zh) 2007-02-07
RU2194041C2 (ru) 2002-12-10
US20030125568A1 (en) 2003-07-03
IL125732A0 (en) 1999-04-11
PE79799A1 (es) 1999-09-03
AU725517B2 (en) 2000-10-12
TR199801630T1 (xx) 1999-06-21
HK1028242A1 (en) 2001-02-09
US20010037029A1 (en) 2001-11-01
PL330798A1 (en) 1999-06-07
ID21014A (id) 1999-04-08
ATE237599T1 (de) 2003-05-15
SI0994864T1 (en) 2003-10-31
CZ253498A3 (cs) 1999-04-14
PL192114B1 (pl) 2006-08-31
DE69811500T2 (de) 2004-04-01
JP2000516259A (ja) 2000-12-05
BR9804946A (pt) 1999-08-24
DE69813560D1 (de) 2003-05-22
SK109398A3 (en) 1998-12-02
US7750028B2 (en) 2010-07-06
US6455556B2 (en) 2002-09-24
CO4940452A1 (es) 2000-07-24
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
LU91345I2 (fr) 2007-09-04
NO983666D0 (no) 1998-08-11
CN1259127A (zh) 2000-07-05
US20100310655A1 (en) 2010-12-09
NZ331371A (en) 2000-08-25
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
RU2198167C2 (ru) 2003-02-10
MY125854A (en) 2006-08-30
HUP0000798A2 (hu) 2000-10-30
ZA984967B (en) 1999-01-11
CY2007014I2 (el) 2009-11-04
IL125732A (en) 2002-12-01
LU91345I9 (cg-RX-API-DMAC7.html) 2018-12-31
CN1572789A (zh) 2005-02-02
US6740669B1 (en) 2004-05-25
CZ292481B6 (cs) 2003-09-17
ATE232852T1 (de) 2003-03-15
SK109498A3 (en) 1998-12-02
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
SI0994863T1 (en) 2003-08-31
PE80999A1 (es) 1999-09-06
US8076362B2 (en) 2011-12-13
NO329314B1 (no) 2010-09-27
WO1998056772A1 (en) 1998-12-17
TW403740B (en) 2000-09-01
US20040167186A1 (en) 2004-08-26
EP0994864B1 (en) 2003-04-16
TR199801631T1 (xx) 1999-06-21
IL125733A0 (en) 1999-04-11
BR9804947A (pt) 1999-08-24
CZ292260B6 (cs) 2003-08-13
KR19990087835A (ko) 1999-12-27
NO329315B1 (no) 2010-09-27
FR07C0037I1 (cg-RX-API-DMAC7.html) 2007-08-17
ES2197485T3 (es) 2004-01-01
EP0994863B1 (en) 2003-02-19
NO983666L (no) 1998-12-17
DE122007000051I2 (de) 2009-02-19
DE69813560T2 (de) 2004-02-05
CA2256015C (en) 2008-06-03
CA2614926A1 (en) 1998-12-17
NO983667L (no) 1998-12-17
KR100409168B1 (ko) 2004-01-31
ES2192779T3 (es) 2003-10-16
HU226107B1 (en) 2008-04-28
AR012945A1 (es) 2000-11-22
FR07C0037I2 (cg-RX-API-DMAC7.html) 2008-05-16
CZ253398A3 (cs) 1999-04-14
NZ331370A (en) 2000-08-25
SK283685B6 (sk) 2003-12-02
TW526195B (en) 2003-04-01
HK1028241A1 (en) 2001-02-09
DK0994864T3 (da) 2003-07-21
CN1132820C (zh) 2003-12-31
CA2614926C (en) 2010-02-09
PL191943B1 (pl) 2006-07-31
CN1159300C (zh) 2004-07-28
CA2256013A1 (en) 1998-12-17
JP2000516258A (ja) 2000-12-05
UY25844A1 (es) 2001-08-27
IL125733A (en) 2002-12-01
DE69811500D1 (de) 2003-03-27
AR061005A2 (es) 2008-07-30
MY120156A (en) 2005-09-30
CO4940448A1 (es) 2000-07-24
PL330764A1 (en) 1999-05-24
KR19990087836A (ko) 1999-12-27

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