CY2007014I2 - Μετατροπη σε κρυσταλλικη μορφη του 1-(2,6-διφθοροβενζυλο)-1η-1,2,3-τριαζολο-4-καρβοχαμιδιου και η χρηση τους ως αντιεπιληπτικο - Google Patents

Μετατροπη σε κρυσταλλικη μορφη του 1-(2,6-διφθοροβενζυλο)-1η-1,2,3-τριαζολο-4-καρβοχαμιδιου και η χρηση τους ως αντιεπιληπτικο

Info

Publication number
CY2007014I2
CY2007014I2 CY200700014C CY2007014C CY2007014I2 CY 2007014 I2 CY2007014 I2 CY 2007014I2 CY 200700014 C CY200700014 C CY 200700014C CY 2007014 C CY2007014 C CY 2007014C CY 2007014 I2 CY2007014 I2 CY 2007014I2
Authority
CY
Cyprus
Prior art keywords
sepillant
difluorobenzyl
carboxamide
triazole
conversion
Prior art date
Application number
CY200700014C
Other languages
Greek (el)
English (en)
Other versions
CY2007014I1 (el
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2007014(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2007014I1 publication Critical patent/CY2007014I1/el
Publication of CY2007014I2 publication Critical patent/CY2007014I2/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CY200700014C 1997-06-10 2007-07-13 Μετατροπη σε κρυσταλλικη μορφη του 1-(2,6-διφθοροβενζυλο)-1η-1,2,3-τριαζολο-4-καρβοχαμιδιου και η χρηση τους ως αντιεπιληπτικο CY2007014I2 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003427 WO1998056772A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic

Publications (2)

Publication Number Publication Date
CY2007014I1 CY2007014I1 (el) 2009-11-04
CY2007014I2 true CY2007014I2 (el) 2009-11-04

Family

ID=4209650

Family Applications (1)

Application Number Title Priority Date Filing Date
CY200700014C CY2007014I2 (el) 1997-06-10 2007-07-13 Μετατροπη σε κρυσταλλικη μορφη του 1-(2,6-διφθοροβενζυλο)-1η-1,2,3-τριαζολο-4-καρβοχαμιδιου και η χρηση τους ως αντιεπιληπτικο

Country Status (36)

Country Link
US (6) US6740669B1 (cg-RX-API-DMAC7.html)
EP (2) EP0994864B1 (cg-RX-API-DMAC7.html)
JP (2) JP3672574B2 (cg-RX-API-DMAC7.html)
KR (2) KR100425656B1 (cg-RX-API-DMAC7.html)
CN (3) CN1159300C (cg-RX-API-DMAC7.html)
AR (4) AR012946A1 (cg-RX-API-DMAC7.html)
AT (2) ATE237599T1 (cg-RX-API-DMAC7.html)
AU (2) AU725517B2 (cg-RX-API-DMAC7.html)
BR (2) BR9804946A (cg-RX-API-DMAC7.html)
CA (3) CA2256015C (cg-RX-API-DMAC7.html)
CO (2) CO4940448A1 (cg-RX-API-DMAC7.html)
CY (1) CY2007014I2 (cg-RX-API-DMAC7.html)
CZ (2) CZ292260B6 (cg-RX-API-DMAC7.html)
DE (3) DE69811500T2 (cg-RX-API-DMAC7.html)
DK (2) DK0994863T3 (cg-RX-API-DMAC7.html)
ES (2) ES2192779T3 (cg-RX-API-DMAC7.html)
FR (1) FR07C0037I2 (cg-RX-API-DMAC7.html)
HU (2) HU225153B1 (cg-RX-API-DMAC7.html)
ID (2) ID27660A (cg-RX-API-DMAC7.html)
IL (2) IL125733A (cg-RX-API-DMAC7.html)
LU (1) LU91345I2 (cg-RX-API-DMAC7.html)
MY (2) MY125854A (cg-RX-API-DMAC7.html)
NL (1) NL300284I2 (cg-RX-API-DMAC7.html)
NO (2) NO329315B1 (cg-RX-API-DMAC7.html)
NZ (2) NZ331370A (cg-RX-API-DMAC7.html)
PE (2) PE80999A1 (cg-RX-API-DMAC7.html)
PL (2) PL191943B1 (cg-RX-API-DMAC7.html)
PT (1) PT994864E (cg-RX-API-DMAC7.html)
RU (2) RU2198167C2 (cg-RX-API-DMAC7.html)
SI (2) SI0994864T1 (cg-RX-API-DMAC7.html)
SK (2) SK283685B6 (cg-RX-API-DMAC7.html)
TR (2) TR199801631T1 (cg-RX-API-DMAC7.html)
TW (2) TW526195B (cg-RX-API-DMAC7.html)
UY (1) UY25844A1 (cg-RX-API-DMAC7.html)
WO (2) WO1998056772A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA984966B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
AU2003249658A1 (en) * 2002-05-31 2003-12-19 Schering Corporation Xanthine phosphodiesterase v inhibitor polymorphs
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
NZ591725A (en) * 2008-10-13 2012-09-28 Cipla Ltd PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
EP2963023B1 (en) * 2009-09-04 2018-04-18 Tactical Therapeutics, Inc. Process for preparing 5-amino-1, 2, 3-triazole orotate derivatives
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
EP2563766B1 (en) 2010-04-30 2014-06-25 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
FI93544C (fi) * 1985-04-18 1995-04-25 Ciba Geigy Ag Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
JPH04506967A (ja) 1989-07-27 1992-12-03 ジー．ディー．サール　アンド　カンパニー 高血圧症治療用腎選択性生成物
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
CA2095444C (en) 1990-11-06 2001-06-19 Shuichi Sakamoto Fused pyrazine derivatives
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
KR100419355B1 (ko) 1995-02-22 2004-06-04 훽스트파마슈티칼스앤드케미칼스가부시키가이샤 무정형피레타나이드,피레타나이드다형체,이들의제조방법및이를포함하는약제학적조성물
CA2260065C (en) * 1996-07-11 2006-10-17 Novartis Ag Process for preparing 1-substituted 4-cyano-1,2,3-triazoles
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
US20060116520A1 (en) 2006-06-01
KR100425656B1 (ko) 2004-05-17
AU725528B2 (en) 2000-10-12
AR061004A2 (es) 2008-07-30
DE122007000051I1 (de) 2007-11-08
PT994864E (pt) 2003-07-31
HUP0002113A2 (hu) 2001-02-28
HUP0000798A3 (en) 2000-10-30
EP0994864A1 (en) 2000-04-26
AU8437298A (en) 1998-12-30
HU225153B1 (en) 2006-07-28
JP3672575B2 (ja) 2005-07-20
HK1028031A1 (en) 2001-02-02
AR012946A1 (es) 2000-11-22
ID27660A (id) 2001-04-19
NL300284I2 (nl) 2007-11-01
CA2256013C (en) 2007-10-16
JP3672574B2 (ja) 2005-07-20
ZA984966B (en) 1999-01-11
HUP0002113A3 (en) 2002-09-30
CA2256015A1 (en) 1998-12-17
CN1217716A (zh) 1999-05-26
EP0994863A1 (en) 2000-04-26
CN1298708C (zh) 2007-02-07
RU2194041C2 (ru) 2002-12-10
US20030125568A1 (en) 2003-07-03
IL125732A0 (en) 1999-04-11
PE79799A1 (es) 1999-09-03
AU725517B2 (en) 2000-10-12
TR199801630T1 (xx) 1999-06-21
HK1028242A1 (en) 2001-02-09
US20010037029A1 (en) 2001-11-01
PL330798A1 (en) 1999-06-07
ID21014A (id) 1999-04-08
ATE237599T1 (de) 2003-05-15
SI0994864T1 (en) 2003-10-31
CZ253498A3 (cs) 1999-04-14
PL192114B1 (pl) 2006-08-31
DE69811500T2 (de) 2004-04-01
JP2000516259A (ja) 2000-12-05
BR9804946A (pt) 1999-08-24
DE69813560D1 (de) 2003-05-22
SK109398A3 (en) 1998-12-02
US7750028B2 (en) 2010-07-06
US6455556B2 (en) 2002-09-24
CO4940452A1 (es) 2000-07-24
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
LU91345I2 (fr) 2007-09-04
NO983666D0 (no) 1998-08-11
CN1259127A (zh) 2000-07-05
US20100310655A1 (en) 2010-12-09
NZ331371A (en) 2000-08-25
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
RU2198167C2 (ru) 2003-02-10
MY125854A (en) 2006-08-30
HUP0000798A2 (hu) 2000-10-30
ZA984967B (en) 1999-01-11
IL125732A (en) 2002-12-01
LU91345I9 (cg-RX-API-DMAC7.html) 2018-12-31
DK0994863T3 (da) 2003-05-26
CN1572789A (zh) 2005-02-02
US6740669B1 (en) 2004-05-25
CZ292481B6 (cs) 2003-09-17
ATE232852T1 (de) 2003-03-15
SK109498A3 (en) 1998-12-02
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
SI0994863T1 (en) 2003-08-31
PE80999A1 (es) 1999-09-06
US8076362B2 (en) 2011-12-13
NO329314B1 (no) 2010-09-27
WO1998056772A1 (en) 1998-12-17
TW403740B (en) 2000-09-01
US20040167186A1 (en) 2004-08-26
EP0994864B1 (en) 2003-04-16
TR199801631T1 (xx) 1999-06-21
IL125733A0 (en) 1999-04-11
BR9804947A (pt) 1999-08-24
CZ292260B6 (cs) 2003-08-13
KR19990087835A (ko) 1999-12-27
NO329315B1 (no) 2010-09-27
FR07C0037I1 (cg-RX-API-DMAC7.html) 2007-08-17
ES2197485T3 (es) 2004-01-01
EP0994863B1 (en) 2003-02-19
NO983666L (no) 1998-12-17
DE122007000051I2 (de) 2009-02-19
DE69813560T2 (de) 2004-02-05
CA2256015C (en) 2008-06-03
CA2614926A1 (en) 1998-12-17
NO983667L (no) 1998-12-17
KR100409168B1 (ko) 2004-01-31
ES2192779T3 (es) 2003-10-16
HU226107B1 (en) 2008-04-28
AR012945A1 (es) 2000-11-22
FR07C0037I2 (cg-RX-API-DMAC7.html) 2008-05-16
CZ253398A3 (cs) 1999-04-14
NZ331370A (en) 2000-08-25
SK283685B6 (sk) 2003-12-02
TW526195B (en) 2003-04-01
HK1028241A1 (en) 2001-02-09
DK0994864T3 (da) 2003-07-21
CN1132820C (zh) 2003-12-31
CA2614926C (en) 2010-02-09
PL191943B1 (pl) 2006-07-31
CN1159300C (zh) 2004-07-28
CA2256013A1 (en) 1998-12-17
JP2000516258A (ja) 2000-12-05
UY25844A1 (es) 2001-08-27
IL125733A (en) 2002-12-01
DE69811500D1 (de) 2003-03-27
AR061005A2 (es) 2008-07-30
MY120156A (en) 2005-09-30
CO4940448A1 (es) 2000-07-24
PL330764A1 (en) 1999-05-24
KR19990087836A (ko) 1999-12-27

Similar Documents

Publication Publication Date Title
CY2007014I2 (el) Μετατροπη σε κρυσταλλικη μορφη του 1-(2,6-διφθοροβενζυλο)-1η-1,2,3-τριαζολο-4-καρβοχαμιδιου και η χρηση τους ως αντιεπιληπτικο
DE69024556D1 (de) Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten
NL350031I2 (nl) Combinaties van fungicide werkzame stoffen.
DE69825271D1 (de) Aminoalkyl-glucosamin-phosphat-verbindungen und ihrer verwendung als adjuvanten und immunoeffektoren
CY2007005I2 (el) Υποκατεστημενες 3,5-διφαινυλ-1,2,4-τριαζολες και η χρηση τους ως φαρμακευτικων χηλικων σκευασματων για μεταλλα
EP0745843A3 (en) Electrochemical immunobiosensor
ATE214057T1 (de) Triazolverbindungen und deren verwendung als dopamin-d 3-liganden
FR2748857B1 (fr) Solution d'electrolyte et accumulateurs au plomb utilisant cette solution
DE69303864D1 (de) Neue 3,5-Diphenyl-substituierte 1,2,4-Triazole und ihre Verwendung als Insektizide und Akarizide
ATE246186T1 (de) Triazol enthaltende antifungale mittel
ATE232207T1 (de) N-triazolyl-2-indolcarbonsäureamide und ihre verwendung als cck-a agonisten
DE69811018D1 (de) Triazol-Derivate und ihre Verwendung als antimykotische Mittel
DE69615831D1 (de) Speicherverwaltung
FI923723L (fi) 4-(4-(4-(-hydroxifenyl)-1-piperazinyl)fenyl)-5-metyl-3h-1,2,4-triazol-3-on derivat
DE69600766D1 (de) Cyclohexyloxycarbonylacetohydrazide, und ihre Verwendung für die Herstellung von 1H-1,2,4-Triazolen
TR199800273T1 (xx) Herbisitetil alfa-2-dikloro-5-$4-(Difluorometil)-4,
TH9801002100B (th) รูปแบบโครงสร้างผลึกดัดแปลงของ 1-(2,6-ไดฟลูออโรเบนซิล)-1h-1,2,3-ไตรอาโซล-4-คาร์บอกซาไมด์
KR970004295U (ko) 치솔갑을 겸한 개인용 치솔살균소독기
KR950032579U (ko) 다용도 사무용품 수납케이스
DE69609172D1 (de) 3-phenyl-1,4-dialkyl-1,2,4-triazolium salze und ihre verwendung als antidepressiva
ITFO970009V0 (it) Accorgimenti per la scomponibilita' di poltrone e divani al fine di ri ordinare l'ingombro durante il trasporto e lo stoccaggio.
KR960019835U (ko) 일회용 사물보관함(disposable storage box for personal thing property)
KR960019834U (ko) 일회용 사물보관함(disposable storage box for personal thing property)
FI973845L (fi) Imidatsoli-, triatsoli- ja tetratsolijohdannaisia
KR960030367U (ko) 다용도 보관대