DK0973512T3 - N-hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl-, aryl- eller heteroarylamider som matrixmetalloproteinaseinhibitorer - Google Patents
N-hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl-, aryl- eller heteroarylamider som matrixmetalloproteinaseinhibitorerInfo
- Publication number
- DK0973512T3 DK0973512T3 DK98906468T DK98906468T DK0973512T3 DK 0973512 T3 DK0973512 T3 DK 0973512T3 DK 98906468 T DK98906468 T DK 98906468T DK 98906468 T DK98906468 T DK 98906468T DK 0973512 T3 DK0973512 T3 DK 0973512T3
- Authority
- DK
- Denmark
- Prior art keywords
- aryl
- alkyl
- heteroarylamides
- heteroarylsulfanyl
- sulfinyl
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Diabetes (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US80672897A | 1997-02-27 | 1997-02-27 | |
PCT/US1998/002987 WO1998037877A1 (en) | 1997-02-27 | 1998-02-17 | N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
Publications (1)
Publication Number | Publication Date |
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DK0973512T3 true DK0973512T3 (da) | 2004-07-12 |
Family
ID=25194722
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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DK98910022T DK0970046T3 (da) | 1997-02-27 | 1998-02-17 | N-Hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl- eller heteroaryl-amider som matrixmetalloproteinaseinhibitorer |
DK98906468T DK0973512T3 (da) | 1997-02-27 | 1998-02-17 | N-hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl-, aryl- eller heteroarylamider som matrixmetalloproteinaseinhibitorer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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DK98910022T DK0970046T3 (da) | 1997-02-27 | 1998-02-17 | N-Hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl- eller heteroaryl-amider som matrixmetalloproteinaseinhibitorer |
Country Status (31)
Country | Link |
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EP (2) | EP0973512B1 (de) |
JP (2) | JP2001513771A (de) |
KR (2) | KR20000075809A (de) |
CN (2) | CN1210263C (de) |
AR (1) | AR011451A1 (de) |
AT (2) | ATE256107T1 (de) |
AU (2) | AU748998B2 (de) |
BG (2) | BG103757A (de) |
BR (2) | BR9807802A (de) |
CA (2) | CA2282655A1 (de) |
CY (1) | CY2477B1 (de) |
DE (2) | DE69820424T2 (de) |
DK (2) | DK0970046T3 (de) |
EA (2) | EA001742B1 (de) |
EE (2) | EE04295B1 (de) |
ES (2) | ES2212274T3 (de) |
GE (2) | GEP20022627B (de) |
HK (1) | HK1024875A1 (de) |
HU (2) | HUP0001463A3 (de) |
IL (2) | IL131257A0 (de) |
NO (2) | NO314258B1 (de) |
NZ (2) | NZ337336A (de) |
PL (2) | PL335401A1 (de) |
PT (2) | PT970046E (de) |
SK (2) | SK115799A3 (de) |
TR (2) | TR199901901T2 (de) |
TW (1) | TW568900B (de) |
UA (1) | UA58543C2 (de) |
WO (2) | WO1998037877A1 (de) |
YU (2) | YU41099A (de) |
ZA (2) | ZA981628B (de) |
Families Citing this family (54)
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WO1998039315A1 (en) * | 1997-03-04 | 1998-09-11 | Monsanto Company | Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds |
US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
ES2206903T3 (es) * | 1997-03-04 | 2004-05-16 | Monsanto Company | Compuestos sulfonilicos divalentes de acido aril o heteroaril-hidroxamco. |
US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
ES2281937T3 (es) * | 1997-10-15 | 2007-10-01 | Wyeth | Nuevas ariloxi-alquil-dialquilaminas. |
US6005102A (en) | 1997-10-15 | 1999-12-21 | American Home Products Corporation | Aryloxy-alkyl-dialkylamines |
US6750228B1 (en) * | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
NZ503485A (en) * | 1997-11-14 | 2002-10-25 | G | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
EP1054858A1 (de) * | 1998-02-19 | 2000-11-29 | American Cyanamid Company | N-hydroxy-2-(alkyl,aryl, oder heteroapyl, sulfanyl,sulfinyl oder sulfonyl)-3-substituierte-alkyl,aryl oder heteroarylamide, als inhibitoren der matrixmetalloproeinase |
ATE260255T1 (de) * | 1998-11-05 | 2004-03-15 | Pfizer Prod Inc | 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate |
AR035311A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento |
US6753337B2 (en) | 1999-01-27 | 2004-06-22 | Wyeth Holdings Corporation | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
EP1147085B1 (de) * | 1999-01-27 | 2005-11-16 | Wyeth Holdings Corporation | Alkynyl substituierte hydroxamsäure derivate, deren herstellung und deren verwendung als matrix metalloproteinase (mmp) inhibitoren / tnf-alpha converting enzyme (tace) inhibitoren |
AR035312A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Compuestos de acido hidroxamico que contienen alquinilo como inhibidores de metaloproteinasa de matriz/tace, composicion farmaceutica que los comprenden y el uso de los mismos para la manufactura de un medicamento |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
EE200100410A (et) | 1999-02-08 | 2002-12-16 | G.D. Searle & Co. | Sulfamaathüdroksaamhappe metalloproteaasi inhibiitor |
SE9901572D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
US6511993B1 (en) | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
WO2001055112A1 (en) * | 2000-01-27 | 2001-08-02 | American Cyanamid Company | Method for preparing alpha-sulfonyl hydroxamic acid derivatives |
US6683093B2 (en) | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
IL158454A0 (en) | 2001-05-11 | 2004-05-12 | Pharmacia Corp | Aromatic sulfone hydroxamates and their use as protease inhibitors |
US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
ATE529110T1 (de) | 2002-03-05 | 2011-11-15 | Transtech Pharma Inc | Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen |
WO2003091247A2 (en) | 2002-04-25 | 2003-11-06 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
JP2006502980A (ja) * | 2002-06-25 | 2006-01-26 | ファルマシア・コーポレーション | アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用 |
TW200418825A (en) | 2002-12-16 | 2004-10-01 | Hoffmann La Roche | Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives |
US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
JP2009519349A (ja) | 2005-12-15 | 2009-05-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を変調する化合物 |
WO2008014199A2 (en) | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 receptor |
CN101516839A (zh) | 2006-09-25 | 2009-08-26 | 贝林格尔.英格海姆国际有限公司 | 调节cb2受体的化合物 |
BRPI0720547A2 (pt) | 2006-10-05 | 2014-05-06 | Janssen Pharmaceutica Nv | Inibidores de metaloprotease derivada de heterocíclico |
US7879911B2 (en) | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
CA2704684A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
JP5749162B2 (ja) | 2008-07-10 | 2015-07-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節するスルホン化合物 |
EP2342200B1 (de) | 2008-09-25 | 2013-01-23 | Boehringer Ingelheim International GmbH | Selektiv den cb2-Rezeptor modulierende Verbindungen |
US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
EP2443107B1 (de) | 2009-06-16 | 2018-08-08 | Boehringer Ingelheim International GmbH | Azetidin 2 -carboxamidderivate als cb2-rezeptormodulatoren |
US8383651B2 (en) | 2009-09-22 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
US8580833B2 (en) | 2009-09-30 | 2013-11-12 | Transtech Pharma, Inc. | Substituted imidazole derivatives and methods of use thereof |
JP5671545B2 (ja) * | 2009-10-13 | 2015-02-18 | ファイザー・インク | 抗菌薬として有用なc結合ヒドロキサム酸誘導体 |
EP2523936A1 (de) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Cb2 rezeptor-modulierende verbindungen |
EP2542539B1 (de) | 2010-03-05 | 2014-02-26 | Boehringer Ingelheim International GmbH | Tetrazolverbindungen für selektive cb2-rezeptormodulation |
JP5746764B2 (ja) | 2010-07-22 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節する化合物 |
JP5876828B2 (ja) * | 2010-09-17 | 2016-03-02 | 国立大学法人 東京大学 | 血小板の機能を維持するための組成物 |
US9440989B2 (en) * | 2012-07-18 | 2016-09-13 | Proyecto De Biomedicina Cima, S.L. | Antifibrinolytic compounds |
EP2803668A1 (de) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole |
JP2017515906A (ja) | 2014-05-16 | 2017-06-15 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | 抗菌性キナゾロン−4(3h)−オン誘導体 |
CN107188837B (zh) * | 2017-06-06 | 2019-05-28 | 温州大学 | 一种α-酰基高烯丙基硫醚类化合物的合成方法 |
US20210393632A1 (en) | 2018-10-04 | 2021-12-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Egfr inhibitors for treating keratodermas |
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JPS50121218A (de) * | 1974-03-01 | 1975-09-23 | ||
DE2424742C3 (de) * | 1974-05-21 | 1982-04-22 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Thiophenderivate Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US3994997A (en) * | 1975-05-09 | 1976-11-30 | Gulf Oil Corporation | O,O-diethyl-O-carboxamidophosphate esters |
GB1520812A (en) * | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
GB1574822A (en) * | 1976-03-23 | 1980-09-10 | Lafon Labor | Acetohydroxamic acid derivatives and pharmaceutical compositions thereof |
FR2528041A1 (fr) * | 1982-06-04 | 1983-12-09 | Lafon Labor | Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique |
FR2561646B1 (fr) * | 1984-03-23 | 1987-10-09 | Lafon Labor | Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique |
IL92915A0 (en) * | 1989-01-05 | 1990-09-17 | Ciba Geigy Ag | Certain pyrrolylphenyl-substituted hydroxamic acid derivatives |
ATE150452T1 (de) * | 1992-04-07 | 1997-04-15 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
FR2708201B1 (fr) * | 1993-06-30 | 1995-10-20 | Lafon Labor | Utilisation de dérivés d'acétamide pour la fabrication de médicaments. |
GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
AU701279B2 (en) * | 1995-05-10 | 1999-01-21 | Darwin Discovery Limited | Peptide compounds which inhibit metalloproteinase and TNF liberation and their therapeutic uses |
US5665777A (en) * | 1995-11-14 | 1997-09-09 | Abbott Laboratories | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
PT871439E (pt) * | 1996-01-02 | 2004-08-31 | Aventis Pharma Inc | Compostos do acido hidroxamico substituidos (arilo heteroarilo arilmetilo ou heteroarilmetilo) |
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1998
- 1998-02-17 PT PT98910022T patent/PT970046E/pt unknown
- 1998-02-17 SK SK1157-99A patent/SK115799A3/sk unknown
- 1998-02-17 NZ NZ337336A patent/NZ337336A/en unknown
- 1998-02-17 HU HU0001463A patent/HUP0001463A3/hu unknown
- 1998-02-17 AT AT98910022T patent/ATE256107T1/de not_active IP Right Cessation
- 1998-02-17 DK DK98910022T patent/DK0970046T3/da active
- 1998-02-17 YU YU41099A patent/YU41099A/sh unknown
- 1998-02-17 BR BR9807802A patent/BR9807802A/pt not_active IP Right Cessation
- 1998-02-17 IL IL13125798A patent/IL131257A0/xx unknown
- 1998-02-17 SK SK1158-99A patent/SK115899A3/sk unknown
- 1998-02-17 AT AT98906468T patent/ATE263554T1/de not_active IP Right Cessation
- 1998-02-17 YU YU40999A patent/YU40999A/sh unknown
- 1998-02-17 IL IL13125898A patent/IL131258A0/xx not_active IP Right Cessation
- 1998-02-17 EE EEP199900371A patent/EE04295B1/xx not_active IP Right Cessation
- 1998-02-17 TR TR1999/01901T patent/TR199901901T2/xx unknown
- 1998-02-17 ES ES98910022T patent/ES2212274T3/es not_active Expired - Lifetime
- 1998-02-17 DE DE69820424T patent/DE69820424T2/de not_active Expired - Fee Related
- 1998-02-17 AU AU64368/98A patent/AU748998B2/en not_active Ceased
- 1998-02-17 HU HU0002092A patent/HUP0002092A3/hu unknown
- 1998-02-17 CN CNB988043335A patent/CN1210263C/zh not_active Expired - Fee Related
- 1998-02-17 DK DK98906468T patent/DK0973512T3/da active
- 1998-02-17 AU AU61686/98A patent/AU726204B2/en not_active Ceased
- 1998-02-17 EP EP98906468A patent/EP0973512B1/de not_active Expired - Lifetime
- 1998-02-17 NZ NZ337298A patent/NZ337298A/xx unknown
- 1998-02-17 CN CN98804329A patent/CN1252790A/zh active Pending
- 1998-02-17 UA UA99095311A patent/UA58543C2/uk unknown
- 1998-02-17 PL PL98335401A patent/PL335401A1/xx unknown
- 1998-02-17 EA EA199900769A patent/EA001742B1/ru not_active IP Right Cessation
- 1998-02-17 PL PL98335286A patent/PL335286A1/xx unknown
- 1998-02-17 EP EP98910022A patent/EP0970046B1/de not_active Expired - Lifetime
- 1998-02-17 JP JP53772498A patent/JP2001513771A/ja not_active Withdrawn
- 1998-02-17 WO PCT/US1998/002987 patent/WO1998037877A1/en not_active Application Discontinuation
- 1998-02-17 CA CA002282655A patent/CA2282655A1/en not_active Abandoned
- 1998-02-17 EA EA199900768A patent/EA003836B1/ru not_active IP Right Cessation
- 1998-02-17 EE EEP199900369A patent/EE04150B1/xx not_active IP Right Cessation
- 1998-02-17 JP JP53770698A patent/JP2001519777A/ja not_active Withdrawn
- 1998-02-17 WO PCT/US1998/003291 patent/WO1998038163A1/en not_active Application Discontinuation
- 1998-02-17 TR TR1999/02095T patent/TR199902095T2/xx unknown
- 1998-02-17 CA CA002282656A patent/CA2282656A1/en not_active Abandoned
- 1998-02-17 PT PT98906468T patent/PT973512E/pt unknown
- 1998-02-17 DE DE69823019T patent/DE69823019T2/de not_active Expired - Fee Related
- 1998-02-17 ES ES98906468T patent/ES2217540T3/es not_active Expired - Lifetime
- 1998-02-17 KR KR1019997007882A patent/KR20000075809A/ko not_active Application Discontinuation
- 1998-02-17 BR BR9807803-8A patent/BR9807803A/pt not_active IP Right Cessation
- 1998-02-17 GE GEAP19985007A patent/GEP20022627B/en unknown
- 1998-02-17 KR KR1019997007881A patent/KR20000075808A/ko not_active Application Discontinuation
- 1998-02-17 GE GEAP19985008A patent/GEP20022626B/en unknown
- 1998-02-26 ZA ZA9801628A patent/ZA981628B/xx unknown
- 1998-02-26 ZA ZA9801625A patent/ZA981625B/xx unknown
- 1998-02-27 AR ARP980100909A patent/AR011451A1/es not_active Application Discontinuation
- 1998-03-17 TW TW087102853A patent/TW568900B/zh active
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1999
- 1999-08-26 NO NO19994124A patent/NO314258B1/no not_active IP Right Cessation
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- 1999-09-24 BG BG103757A patent/BG103757A/bg unknown
- 1999-09-27 BG BG103760A patent/BG103760A/bg unknown
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2000
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2004
- 2004-09-08 CY CY0400069A patent/CY2477B1/xx unknown
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