NO20004696L - Kinoloner som serinproteaseinhibitorer - Google Patents
Kinoloner som serinproteaseinhibitorerInfo
- Publication number
- NO20004696L NO20004696L NO20004696A NO20004696A NO20004696L NO 20004696 L NO20004696 L NO 20004696L NO 20004696 A NO20004696 A NO 20004696A NO 20004696 A NO20004696 A NO 20004696A NO 20004696 L NO20004696 L NO 20004696L
- Authority
- NO
- Norway
- Prior art keywords
- quinolones
- protease inhibitors
- serine protease
- serine
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8009098P | 1998-03-31 | 1998-03-31 | |
| PCT/US1998/026709 WO1999050263A1 (en) | 1998-03-31 | 1998-12-15 | Quinolones as serine protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004696D0 NO20004696D0 (no) | 2000-09-20 |
| NO20004696L true NO20004696L (no) | 2000-09-20 |
Family
ID=22155200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004696A NO20004696L (no) | 1998-03-31 | 2000-09-20 | Kinoloner som serinproteaseinhibitorer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6855726B1 (no) |
| EP (1) | EP1091955A1 (no) |
| JP (1) | JP2002509928A (no) |
| KR (1) | KR20010042287A (no) |
| AU (1) | AU763110B2 (no) |
| BR (1) | BR9815786A (no) |
| CA (1) | CA2312953A1 (no) |
| HU (1) | HUP0101484A3 (no) |
| IL (1) | IL136605A0 (no) |
| IS (1) | IS5553A (no) |
| NO (1) | NO20004696L (no) |
| NZ (1) | NZ505921A (no) |
| PL (1) | PL343112A1 (no) |
| WO (1) | WO1999050263A1 (no) |
| ZA (1) | ZA992448B (no) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| PL351767A1 (en) * | 1999-02-09 | 2003-06-16 | Dimensional Pharmaceuticals 3 | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors |
| US7323496B2 (en) | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| KR20010069066A (ko) * | 2000-01-12 | 2001-07-23 | 이종원 | 저산소 농도하에서 생존이 가능하도록 하는 동물세포의배양방법 |
| IL150650A0 (en) | 2000-01-20 | 2003-02-12 | Eisai Co Ltd | Piperidine derivatives and pharmaceutical compositions containing the same |
| KR100784958B1 (ko) * | 2000-02-04 | 2007-12-11 | 테라코스, 인코포레이티드 | 신규한 디페닐에틸렌 화합물 |
| MXPA02007514A (es) * | 2000-02-04 | 2004-02-26 | Calyx Therapeutics Inc | Compuestos novedosos de difeniletileno. |
| MXPA03000289A (es) | 2000-08-04 | 2003-06-06 | Warner Lambert Co | Proceso para preparar 2-(4-piridil) amino-6-dialquiloxifenil-pirido (2,3-d) pirimidin-7-onas.. |
| AU2001293233A1 (en) | 2000-09-01 | 2002-03-13 | Chiron Corporation | Aza heterocyclic derivatives and their therapeutic use |
| EP1650203B1 (en) * | 2000-09-11 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Process of preparation of benzimidazol-2-yl quinolinone derivatives |
| FR2813791B1 (fr) * | 2000-09-14 | 2004-03-12 | Lafon Labor | Utilisation de 2- et 4-quinolones pour inhiber la neo-proliferation intimale |
| US7825132B2 (en) | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
| AU2003288899B2 (en) | 2002-08-23 | 2009-09-03 | Novartis Vaccines And Diagnostics, Inc. | Benzimidazole quinolinones and uses thereof |
| BR0316229A (pt) | 2002-11-13 | 2005-10-04 | Chiron Corp | Métodos de tratamento de câncer e métodos relacionados |
| US7479502B2 (en) | 2002-12-03 | 2009-01-20 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
| TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| AR047521A1 (es) * | 2004-02-06 | 2006-01-25 | Astrazeneca Ab | Compuestos piridin-2-ona utiles como inhibidores de trombina |
| JP5019884B2 (ja) | 2004-02-20 | 2012-09-05 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 炎症プロセスおよび転移プロセスの調節 |
| EP1799639B1 (en) | 2004-10-12 | 2013-09-04 | Glenmark Pharmaceuticals S.A. | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation |
| US7960548B2 (en) * | 2005-04-29 | 2011-06-14 | The Ohio State University Research Foundation | Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis |
| AU2006244072B2 (en) | 2005-05-10 | 2012-09-20 | Intermune, Inc. | Pyridone derivatives for modulating stress-activated protein kinase system |
| JP5545925B2 (ja) | 2005-05-17 | 2014-07-09 | ノバルティス アーゲー | ヘテロ環化合物の合成方法 |
| WO2006127926A2 (en) | 2005-05-23 | 2006-11-30 | Novartis Ag | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts |
| GB0515323D0 (en) * | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP3126362B1 (en) | 2014-04-02 | 2022-01-12 | Intermune, Inc. | Anti-fibrotic pyridinones |
| JP2020524717A (ja) * | 2017-06-22 | 2020-08-20 | キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ | ヒトｓｔｉｎｇの小分子調節因子 |
| BR112019027127A2 (pt) | 2017-06-22 | 2020-07-07 | Curadev Pharma Limited | moduladores de sting humano de molécula pequena |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3330823A (en) | 1964-12-16 | 1967-07-11 | Squibb & Sons Inc | N-amino-loweralkylene-benzo-lactams |
| US3551413A (en) | 1969-03-12 | 1970-12-29 | Squibb & Sons Inc | Benzo-lactams |
| GB1305278A (no) | 1970-03-12 | 1973-01-31 | ||
| JPS5310989B2 (no) | 1974-04-25 | 1978-04-18 | ||
| FI59246C (fi) | 1974-06-24 | 1981-07-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin |
| US4329347A (en) | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
| FR2439196A1 (fr) | 1978-10-17 | 1980-05-16 | Yoshitomi Pharmaceutical | Nouveaux derives de la pyridazinone utilisables en therapeutique comme agents anti-thrombotiques et anti-hypertenseurs |
| EP0024638A1 (en) | 1979-08-30 | 1981-03-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituted quinolinone-alkanecarboxylic acids, their preparation, and medicaments containing them |
| JPS5649359A (en) | 1979-09-28 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| JPS56125388A (en) | 1980-03-08 | 1981-10-01 | Yuichi Kaneoka | Dihydrobenzofuran derivative |
| DE3810080A1 (de) | 1988-03-25 | 1989-10-05 | Bayer Ag | Trisubstituierte 1,3,5-triazin-2,4,6-trione |
| HUT76640A (en) | 1995-08-17 | 1997-10-28 | Chinoin Gyogyszer Es Vegyeszet | Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| TW338037B (en) * | 1995-10-05 | 1998-08-11 | Otsuka Pharma Co Ltd | Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition |
| DE19610723A1 (de) | 1996-03-19 | 1997-09-25 | Bayer Ag | Elektrolumineszierende Anordnungen unter Verwendung von Blendsystemen |
| DE19718181A1 (de) | 1997-04-30 | 1998-11-05 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
1998
- 1998-12-15 US US09/601,479 patent/US6855726B1/en not_active Expired - Fee Related
- 1998-12-15 PL PL98343112A patent/PL343112A1/xx unknown
- 1998-12-15 EP EP98963966A patent/EP1091955A1/en not_active Withdrawn
- 1998-12-15 KR KR1020007010830A patent/KR20010042287A/ko not_active Application Discontinuation
- 1998-12-15 AU AU19184/99A patent/AU763110B2/en not_active Ceased
- 1998-12-15 JP JP2000541167A patent/JP2002509928A/ja active Pending
- 1998-12-15 CA CA002312953A patent/CA2312953A1/en not_active Abandoned
- 1998-12-15 IL IL13660598A patent/IL136605A0/xx unknown
- 1998-12-15 WO PCT/US1998/026709 patent/WO1999050263A1/en not_active Application Discontinuation
- 1998-12-15 HU HU0101484A patent/HUP0101484A3/hu unknown
- 1998-12-15 NZ NZ505921A patent/NZ505921A/en unknown
- 1998-12-15 BR BR9815786-8A patent/BR9815786A/pt not_active Application Discontinuation
-
1999
- 1999-03-30 ZA ZA9902448A patent/ZA992448B/xx unknown
-
2000
- 2000-06-28 IS IS5553A patent/IS5553A/is unknown
- 2000-09-20 NO NO20004696A patent/NO20004696L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA992448B (en) | 2000-10-11 |
| BR9815786A (pt) | 2000-11-21 |
| AU1918499A (en) | 1999-10-18 |
| IS5553A (is) | 2000-06-28 |
| HUP0101484A3 (en) | 2003-02-28 |
| KR20010042287A (ko) | 2001-05-25 |
| NO20004696D0 (no) | 2000-09-20 |
| AU763110B2 (en) | 2003-07-10 |
| NZ505921A (en) | 2003-08-29 |
| US6855726B1 (en) | 2005-02-15 |
| EP1091955A1 (en) | 2001-04-18 |
| WO1999050263A1 (en) | 1999-10-07 |
| HUP0101484A2 (hu) | 2001-10-28 |
| JP2002509928A (ja) | 2002-04-02 |
| PL343112A1 (en) | 2001-07-30 |
| IL136605A0 (en) | 2001-06-14 |
| CA2312953A1 (en) | 1999-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |