DK0888382T3 - Chromatografisk fremgangsmåde til udvinding af højrent cyclosporin A og beslægtede cyclosporiner - Google Patents

Chromatografisk fremgangsmåde til udvinding af højrent cyclosporin A og beslægtede cyclosporiner

Info

Publication number
DK0888382T3
DK0888382T3 DK97920517T DK97920517T DK0888382T3 DK 0888382 T3 DK0888382 T3 DK 0888382T3 DK 97920517 T DK97920517 T DK 97920517T DK 97920517 T DK97920517 T DK 97920517T DK 0888382 T3 DK0888382 T3 DK 0888382T3
Authority
DK
Denmark
Prior art keywords
cyclosporin
recovering high
chromatographic procedure
purity
cyclosporins
Prior art date
Application number
DK97920517T
Other languages
Danish (da)
English (en)
Inventor
Ullrich Voigt
Roland Hempel
Joachim Kinkel
Roger-Marc Nicoud
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Application granted granted Critical
Publication of DK0888382T3 publication Critical patent/DK0888382T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97920517T 1996-03-21 1997-03-14 Chromatografisk fremgangsmåde til udvinding af højrent cyclosporin A og beslægtede cyclosporiner DK0888382T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996111094 DE19611094C2 (de) 1996-03-21 1996-03-21 Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
PCT/DE1997/000525 WO1997034918A1 (de) 1996-03-21 1997-03-14 Chromatographisches verfahren zur gewinnung von hochgereinigtem cyclosporin a und verwandten cyclosporinen

Publications (1)

Publication Number Publication Date
DK0888382T3 true DK0888382T3 (da) 2002-04-02

Family

ID=7788939

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97920517T DK0888382T3 (da) 1996-03-21 1997-03-14 Chromatografisk fremgangsmåde til udvinding af højrent cyclosporin A og beslægtede cyclosporiner

Country Status (19)

Country Link
US (1) US6306306B1 (xx)
EP (1) EP0888382B1 (xx)
JP (1) JP3408818B2 (xx)
KR (1) KR100467127B1 (xx)
CN (1) CN1196711C (xx)
AT (1) ATE210146T1 (xx)
CZ (1) CZ293243B6 (xx)
DE (3) DE19611094C2 (xx)
DK (1) DK0888382T3 (xx)
ES (1) ES2169384T3 (xx)
HK (1) HK1015382A1 (xx)
HU (1) HU222200B1 (xx)
IL (1) IL125807A (xx)
NO (1) NO321570B1 (xx)
PL (1) PL187763B1 (xx)
PT (1) PT888382E (xx)
RU (1) RU2163607C2 (xx)
SK (1) SK282836B6 (xx)
WO (1) WO1997034918A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858892A1 (de) 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
SI1436321T1 (sl) 2001-10-19 2006-12-31 Isotechnika Inc Sinteza analogov ciklosporina
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
SI1545574T1 (sl) 2002-09-13 2014-10-30 Biogen Idec Inc. Postopek za čiščenje polipeptidov s simulirano "moving bed" kromatografijo
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
CN102086226B (zh) * 2009-12-04 2012-10-10 山东新时代药业有限公司 一种制备环孢菌素a的方法
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
US10975031B2 (en) 2014-01-07 2021-04-13 Novasep Process Method for purifying aromatic amino acids
HUP1500502A2 (en) * 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB568698A (en) 1943-05-26 1945-04-17 M O Valve Co Ltd Improvements in the capping of thermionic valves, electric lamps and like devices
US2985589A (en) * 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
US4117118A (en) 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4402832A (en) * 1982-08-12 1983-09-06 Uop Inc. High efficiency continuous separation process
US4923616A (en) * 1987-09-24 1990-05-08 Mitsubishi Petrochemical Company, Ltd. Method of separating chemical components in simulated moving bed
HU201577B (en) 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
ATE158022T1 (de) * 1991-01-25 1997-09-15 Fujisawa Pharmaceutical Co Prozess zur produktion von cyclosporin-a und/oder c
HU213553B (en) 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins

Also Published As

Publication number Publication date
EP0888382B1 (de) 2001-12-05
SK282836B6 (sk) 2002-12-03
US6306306B1 (en) 2001-10-23
JP2000507237A (ja) 2000-06-13
CN1212703A (zh) 1999-03-31
NO321570B1 (no) 2006-06-06
PL187763B1 (pl) 2004-10-29
DE59705670D1 (de) 2002-01-17
IL125807A0 (en) 1999-04-11
IL125807A (en) 2003-10-31
CZ299998A3 (cs) 1999-10-13
ES2169384T3 (es) 2002-07-01
HU222200B1 (hu) 2003-05-28
ATE210146T1 (de) 2001-12-15
NO984133L (no) 1998-09-08
KR20000064784A (ko) 2000-11-06
HUP9901801A3 (en) 2001-01-29
KR100467127B1 (ko) 2005-05-27
CN1196711C (zh) 2005-04-13
DE19716167C2 (de) 2000-06-29
EP0888382A1 (de) 1999-01-07
RU2163607C2 (ru) 2001-02-27
DE19611094A1 (de) 1997-09-25
DE19716167A1 (de) 1998-10-22
WO1997034918A1 (de) 1997-09-25
DE19611094C2 (de) 1999-06-17
PL329113A1 (en) 1999-03-15
HK1015382A1 (en) 1999-10-15
HUP9901801A2 (hu) 1999-09-28
CZ293243B6 (cs) 2004-03-17
PT888382E (pt) 2002-05-31
NO984133D0 (no) 1998-09-08
SK122298A3 (en) 1999-08-06
JP3408818B2 (ja) 2003-05-19

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