HUP9901801A2 - Kromatográfiai eljárás nagy tisztaságú ciklosporin A és hasonló ciklosporinok kinyerésére - Google Patents

Kromatográfiai eljárás nagy tisztaságú ciklosporin A és hasonló ciklosporinok kinyerésére

Info

Publication number
HUP9901801A2
HUP9901801A2 HU9901801A HUP9901801A HUP9901801A2 HU P9901801 A2 HUP9901801 A2 HU P9901801A2 HU 9901801 A HU9901801 A HU 9901801A HU P9901801 A HUP9901801 A HU P9901801A HU P9901801 A2 HUP9901801 A2 HU P9901801A2
Authority
HU
Hungary
Prior art keywords
extract
cyclamen
product fraction
obtaining
chromo
Prior art date
Application number
HU9901801A
Other languages
English (en)
Inventor
Roland Hempel
Joachim Kinkel
Roger-Marc Nicoud
Ullrich Voigt
Original Assignee
Arzneimittelwerk Dresden Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden Gmbh. filed Critical Arzneimittelwerk Dresden Gmbh.
Publication of HUP9901801A2 publication Critical patent/HUP9901801A2/hu
Publication of HUP9901801A3 publication Critical patent/HUP9901801A3/hu
Publication of HU222200B1 publication Critical patent/HU222200B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya új eljárás ciklőspőrin A (Cy A) és hasőnlóciklőspőrinők krőmatőgráfiai tisztítására ciklőspőrintartalmú, nyersextraktűmból kiindűlva krőmatőgráfiás eljárással, adszőrbenskéntkővasavgélt alkalmazva. Az eljárásra jellemző, hőgy a nyersextraktűmőt a) első krőmatőgráfiás lépésben preparatív HPLC- vagy SMB-technika (siműlated mőving bed) segítségével a kevésbé pőlárőskísérőanyagőkat tartalmazó 1. termékfrakcióra és az inkább pőlárőskísérőanyagőkat tartalmazó 2. termékfrakcióra szétválasztják, majd b)az 1. termékfrakciót (raffinátűmőt) és a 2. termékfrakciót(extraktűmőt) SMB-technikával végzett másődik krőmatőgrafálásnak vetikalá. ŕ
HU9901801A 1996-03-21 1997-03-14 Kromatográfiai eljárás nagy tisztaságú ciklosporin A és hasonló ciklosporinok kinyerésére HU222200B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996111094 DE19611094C2 (de) 1996-03-21 1996-03-21 Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
PCT/DE1997/000525 WO1997034918A1 (de) 1996-03-21 1997-03-14 Chromatographisches verfahren zur gewinnung von hochgereinigtem cyclosporin a und verwandten cyclosporinen

Publications (3)

Publication Number Publication Date
HUP9901801A2 true HUP9901801A2 (hu) 1999-09-28
HUP9901801A3 HUP9901801A3 (en) 2001-01-29
HU222200B1 HU222200B1 (hu) 2003-05-28

Family

ID=7788939

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901801A HU222200B1 (hu) 1996-03-21 1997-03-14 Kromatográfiai eljárás nagy tisztaságú ciklosporin A és hasonló ciklosporinok kinyerésére

Country Status (19)

Country Link
US (1) US6306306B1 (hu)
EP (1) EP0888382B1 (hu)
JP (1) JP3408818B2 (hu)
KR (1) KR100467127B1 (hu)
CN (1) CN1196711C (hu)
AT (1) ATE210146T1 (hu)
CZ (1) CZ293243B6 (hu)
DE (3) DE19611094C2 (hu)
DK (1) DK0888382T3 (hu)
ES (1) ES2169384T3 (hu)
HK (1) HK1015382A1 (hu)
HU (1) HU222200B1 (hu)
IL (1) IL125807A (hu)
NO (1) NO321570B1 (hu)
PL (1) PL187763B1 (hu)
PT (1) PT888382E (hu)
RU (1) RU2163607C2 (hu)
SK (1) SK282836B6 (hu)
WO (1) WO1997034918A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858892A1 (de) 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
DE69939335D1 (de) 1998-12-30 2008-09-25 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
PL210841B1 (pl) 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny izomerów (E) i (Z) ISATX247
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
CA2498725C (en) * 2002-09-13 2014-07-08 Biogen Idec Inc. Method of purifying polypeptides by simulated moving bed chromatography
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
CN102086226B (zh) * 2009-12-04 2012-10-10 山东新时代药业有限公司 一种制备环孢菌素a的方法
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP3118186B1 (fr) 2013-12-11 2022-02-09 Novasep Process Installation chromatographique de production d acides gras polyinsatures
BR112016015718B1 (pt) 2014-01-07 2021-12-07 Novasep Process Solutions Processo de purificação de aminoácidos aromáticos
HUP1500502A2 (en) * 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB568698A (en) 1943-05-26 1945-04-17 M O Valve Co Ltd Improvements in the capping of thermionic valves, electric lamps and like devices
US2985589A (en) * 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
US4117118A (en) 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4402832A (en) * 1982-08-12 1983-09-06 Uop Inc. High efficiency continuous separation process
US4923616A (en) * 1987-09-24 1990-05-08 Mitsubishi Petrochemical Company, Ltd. Method of separating chemical components in simulated moving bed
HU201577B (en) 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
WO1992013094A1 (fr) 1991-01-25 1992-08-06 Fujisawa Pharmaceutical Co., Ltd. Procede pour produire de la cyclosporine a et/ou c
HU213553B (en) 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins

Also Published As

Publication number Publication date
EP0888382A1 (de) 1999-01-07
DE19611094A1 (de) 1997-09-25
EP0888382B1 (de) 2001-12-05
ES2169384T3 (es) 2002-07-01
JP2000507237A (ja) 2000-06-13
IL125807A0 (en) 1999-04-11
CN1212703A (zh) 1999-03-31
NO984133L (no) 1998-09-08
DE19611094C2 (de) 1999-06-17
DE19716167C2 (de) 2000-06-29
KR100467127B1 (ko) 2005-05-27
ATE210146T1 (de) 2001-12-15
CZ293243B6 (cs) 2004-03-17
PT888382E (pt) 2002-05-31
JP3408818B2 (ja) 2003-05-19
US6306306B1 (en) 2001-10-23
HK1015382A1 (en) 1999-10-15
IL125807A (en) 2003-10-31
DE19716167A1 (de) 1998-10-22
WO1997034918A1 (de) 1997-09-25
RU2163607C2 (ru) 2001-02-27
DK0888382T3 (da) 2002-04-02
CN1196711C (zh) 2005-04-13
NO321570B1 (no) 2006-06-06
DE59705670D1 (de) 2002-01-17
HUP9901801A3 (en) 2001-01-29
CZ299998A3 (cs) 1999-10-13
HU222200B1 (hu) 2003-05-28
NO984133D0 (no) 1998-09-08
SK122298A3 (en) 1999-08-06
SK282836B6 (sk) 2002-12-03
PL187763B1 (pl) 2004-10-29
KR20000064784A (ko) 2000-11-06
PL329113A1 (en) 1999-03-15

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HFG4 Patent granted, date of granting

Effective date: 20030311