HUP9802038A2 - Eljárás eritropoietin-szerű glikoproteinek tisztítására - Google Patents

Eljárás eritropoietin-szerű glikoproteinek tisztítására

Info

Publication number
HUP9802038A2
HUP9802038A2 HU9802038A HUP9802038A HUP9802038A2 HU P9802038 A2 HUP9802038 A2 HU P9802038A2 HU 9802038 A HU9802038 A HU 9802038A HU P9802038 A HUP9802038 A HU P9802038A HU P9802038 A2 HUP9802038 A2 HU P9802038A2
Authority
HU
Hungary
Prior art keywords
erythropoietin
purification
biologically active
glycoproteins
active substance
Prior art date
Application number
HU9802038A
Other languages
English (en)
Inventor
Armando Grigoletto
Ermenegildo Restelli
Edoardo Giacomo Sarubbi
Adolfo Soffientini
Dino Zanette
Original Assignee
Gruppo Lepetit S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit S.P.A. filed Critical Gruppo Lepetit S.P.A.
Publication of HUP9802038A2 publication Critical patent/HUP9802038A2/hu
Publication of HUP9802038A3 publication Critical patent/HUP9802038A3/hu
Publication of HU225591B1 publication Critical patent/HU225591B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány tárgya egyszerű és hatékőny eljárás egy biőlógiailag aktívanyagnak egy, a biőlógiailag aktív anyagőt tartalmazó biőlógiaifőlyadékból történő kinyerésére. A találmány szerinti eljárás egyiklényeges jellemzője, hőgy az eljárás magában főglal egy fenil-bőrőnát-krőmatőgráfiás lépést. Az eljárás különösen alkalmas az eritrőpőietintisztítására. ŕ
HU9802038A 1995-04-14 1996-04-09 Process for the purification of erythropoietin HU225591B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95200945 1995-04-14
US47526095A 1995-06-07 1995-06-07
PCT/EP1996/001509 WO1996032413A1 (en) 1995-04-14 1996-04-09 Process for the purification of glycoproteins like erythropoietin

Publications (3)

Publication Number Publication Date
HUP9802038A2 true HUP9802038A2 (hu) 1998-12-28
HUP9802038A3 HUP9802038A3 (en) 2001-01-29
HU225591B1 HU225591B1 (en) 2007-05-02

Family

ID=26139217

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802038A HU225591B1 (en) 1995-04-14 1996-04-09 Process for the purification of erythropoietin

Country Status (22)

Country Link
EP (1) EP0820468B1 (hu)
JP (1) JP3998156B2 (hu)
KR (1) KR100442076B1 (hu)
CN (1) CN1154658C (hu)
AR (1) AR001622A1 (hu)
AT (1) ATE194144T1 (hu)
AU (1) AU693693B2 (hu)
CA (1) CA2216130C (hu)
CZ (1) CZ291770B6 (hu)
DE (1) DE69609061T2 (hu)
DK (1) DK0820468T3 (hu)
EA (1) EA000694B1 (hu)
ES (1) ES2147647T3 (hu)
GR (1) GR3034294T3 (hu)
HU (1) HU225591B1 (hu)
IL (1) IL117849A (hu)
NO (1) NO317188B1 (hu)
NZ (1) NZ307173A (hu)
PT (1) PT820468E (hu)
SI (1) SI0820468T1 (hu)
TW (1) TW421652B (hu)
WO (1) WO1996032413A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1428878E (pt) * 2002-12-13 2008-11-18 Bioceuticals Arzneimittel Ag Processo para a produção e purificação de eritropoietina
KR100900033B1 (ko) 2007-11-21 2009-06-01 한국생명공학연구원 인간 에리스로포이에틴의 정제방법
CA2736141C (en) 2008-09-23 2018-03-20 F. Hoffmann-La Roche Ag Purification of erythropoietin
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
EP2528933A1 (en) * 2010-01-28 2012-12-05 Glycotope GmbH Process for the purification of glycoproteins
EP3562867B1 (en) 2016-12-30 2023-04-05 Dow Global Technologies LLC Resin beads and use in processing of aqueous solutions
CN110088146B (zh) 2016-12-30 2023-06-27 陶氏环球技术有限责任公司 树脂珠以及在水性溶液的处理中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2024829B (en) * 1978-06-28 1982-08-04 Amicon Corp Method and product for separation of glycoproteins
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
AU4104889A (en) * 1988-09-07 1990-03-15 Bioclones (Pty) Ltd Purification of erythropoietin

Also Published As

Publication number Publication date
MX9707527A (es) 1997-11-29
CZ291770B6 (cs) 2003-05-14
CA2216130A1 (en) 1996-10-17
AR001622A1 (es) 1997-11-26
AU693693B2 (en) 1998-07-02
CA2216130C (en) 2012-03-13
KR19980703851A (ko) 1998-12-05
SI0820468T1 (en) 2000-10-31
NO317188B1 (no) 2004-09-13
CN1154658C (zh) 2004-06-23
PT820468E (pt) 2000-11-30
ATE194144T1 (de) 2000-07-15
IL117849A0 (en) 1996-08-04
AU5645796A (en) 1996-10-30
EA199700314A1 (ru) 1998-04-30
IL117849A (en) 2002-07-25
EP0820468A1 (en) 1998-01-28
NZ307173A (en) 1998-08-26
HU225591B1 (en) 2007-05-02
JP3998156B2 (ja) 2007-10-24
CN1181759A (zh) 1998-05-13
GR3034294T3 (en) 2000-12-29
KR100442076B1 (ko) 2004-10-06
ES2147647T3 (es) 2000-09-16
WO1996032413A1 (en) 1996-10-17
NO974524D0 (no) 1997-09-30
EP0820468B1 (en) 2000-06-28
NO974524L (no) 1997-09-30
DE69609061D1 (de) 2000-08-03
DE69609061T2 (de) 2000-11-09
TW421652B (en) 2001-02-11
DK0820468T3 (da) 2000-08-28
EA000694B1 (ru) 2000-02-28
HUP9802038A3 (en) 2001-01-29
CZ325697A3 (cs) 1998-06-17
JPH11503726A (ja) 1999-03-30

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: SANOFI AVENTIS SPA, IT

Free format text: FORMER OWNER(S): AVENTIS BULK S.P.A., IT; GRUPPO LEPETIT S.P.A., IT

FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): S.B.G. & K. BUDAPESTI NEMZETKOEZI SZABADALMI IRODA, HU

Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU

FH92 Termination of representative

Representative=s name: S.B.G. & K. BUDAPESTI NEMZETKOEZI SZABADALMI I, HU

MM4A Lapse of definitive patent protection due to non-payment of fees