EA199700314A1 - Способ очистки эритропоэтиноподобьных гликопротеинов - Google Patents

Способ очистки эритропоэтиноподобьных гликопротеинов

Info

Publication number
EA199700314A1
EA199700314A1 EA199700314A EA199700314A EA199700314A1 EA 199700314 A1 EA199700314 A1 EA 199700314A1 EA 199700314 A EA199700314 A EA 199700314A EA 199700314 A EA199700314 A EA 199700314A EA 199700314 A1 EA199700314 A1 EA 199700314A1
Authority
EA
Eurasian Patent Office
Prior art keywords
erythropoythene
glycoproteins
cleaning
phenylboronic
erythropoietin
Prior art date
Application number
EA199700314A
Other languages
English (en)
Other versions
EA000694B1 (ru
Inventor
Дино Цанетте
Эдоардо Джакомо Сарубби
Адольфо Соффьентини
Эрменеджильдо Рестелли
Армандо Григолетто
Original Assignee
Группо Лепетит С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Группо Лепетит С.П.А. filed Critical Группо Лепетит С.П.А.
Publication of EA199700314A1 publication Critical patent/EA199700314A1/ru
Publication of EA000694B1 publication Critical patent/EA000694B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящее изобретение относится к простому и эффективному способу выделения биологически активного гликопротеина из содержащей его биологической жидкости. Он включает стадию фенил-борнатной хроматографии и является особенно применимым в случае очистки эритропоэтина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700314A 1995-04-14 1996-04-09 Способ очистки эритропоэтина EA000694B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95200945 1995-04-14
US47526095A 1995-06-07 1995-06-07
PCT/EP1996/001509 WO1996032413A1 (en) 1995-04-14 1996-04-09 Process for the purification of glycoproteins like erythropoietin

Publications (2)

Publication Number Publication Date
EA199700314A1 true EA199700314A1 (ru) 1998-04-30
EA000694B1 EA000694B1 (ru) 2000-02-28

Family

ID=26139217

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700314A EA000694B1 (ru) 1995-04-14 1996-04-09 Способ очистки эритропоэтина

Country Status (22)

Country Link
EP (1) EP0820468B1 (ru)
JP (1) JP3998156B2 (ru)
KR (1) KR100442076B1 (ru)
CN (1) CN1154658C (ru)
AR (1) AR001622A1 (ru)
AT (1) ATE194144T1 (ru)
AU (1) AU693693B2 (ru)
CA (1) CA2216130C (ru)
CZ (1) CZ291770B6 (ru)
DE (1) DE69609061T2 (ru)
DK (1) DK0820468T3 (ru)
EA (1) EA000694B1 (ru)
ES (1) ES2147647T3 (ru)
GR (1) GR3034294T3 (ru)
HU (1) HU225591B1 (ru)
IL (1) IL117849A (ru)
NO (1) NO317188B1 (ru)
NZ (1) NZ307173A (ru)
PT (1) PT820468E (ru)
SI (1) SI0820468T1 (ru)
TW (1) TW421652B (ru)
WO (1) WO1996032413A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1428878E (pt) * 2002-12-13 2008-11-18 Bioceuticals Arzneimittel Ag Processo para a produção e purificação de eritropoietina
KR100900033B1 (ko) 2007-11-21 2009-06-01 한국생명공학연구원 인간 에리스로포이에틴의 정제방법
WO2010034442A1 (en) 2008-09-23 2010-04-01 F. Hoffmann-La Roche Ag Purification of erythropoietin
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
EP2528933A1 (en) * 2010-01-28 2012-12-05 Glycotope GmbH Process for the purification of glycoproteins
IL267489B (en) 2016-12-30 2022-09-01 Dow Global Technologies Llc Resin beads and their use in the process of aqueous solutions
KR20190099442A (ko) * 2016-12-30 2019-08-27 다우 글로벌 테크놀로지스 엘엘씨 수지 비드 및 수용액의 가공에서의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2024829B (en) * 1978-06-28 1982-08-04 Amicon Corp Method and product for separation of glycoproteins
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
AU4104889A (en) * 1988-09-07 1990-03-15 Bioclones (Pty) Ltd Purification of erythropoietin

Also Published As

Publication number Publication date
CN1181759A (zh) 1998-05-13
HUP9802038A3 (en) 2001-01-29
KR19980703851A (ko) 1998-12-05
JPH11503726A (ja) 1999-03-30
CZ325697A3 (cs) 1998-06-17
HUP9802038A2 (hu) 1998-12-28
NO974524D0 (no) 1997-09-30
GR3034294T3 (en) 2000-12-29
NO974524L (no) 1997-09-30
CZ291770B6 (cs) 2003-05-14
MX9707527A (es) 1997-11-29
DE69609061D1 (de) 2000-08-03
CN1154658C (zh) 2004-06-23
CA2216130A1 (en) 1996-10-17
CA2216130C (en) 2012-03-13
DE69609061T2 (de) 2000-11-09
JP3998156B2 (ja) 2007-10-24
ES2147647T3 (es) 2000-09-16
IL117849A0 (en) 1996-08-04
TW421652B (en) 2001-02-11
HU225591B1 (en) 2007-05-02
AR001622A1 (es) 1997-11-26
NO317188B1 (no) 2004-09-13
KR100442076B1 (ko) 2004-10-06
NZ307173A (en) 1998-08-26
AU5645796A (en) 1996-10-30
AU693693B2 (en) 1998-07-02
PT820468E (pt) 2000-11-30
EP0820468B1 (en) 2000-06-28
SI0820468T1 (en) 2000-10-31
IL117849A (en) 2002-07-25
EP0820468A1 (en) 1998-01-28
WO1996032413A1 (en) 1996-10-17
DK0820468T3 (da) 2000-08-28
EA000694B1 (ru) 2000-02-28
ATE194144T1 (de) 2000-07-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU