DE69532137D1 - Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen - Google Patents

Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen

Info

Publication number
DE69532137D1
DE69532137D1 DE69532137T DE69532137T DE69532137D1 DE 69532137 D1 DE69532137 D1 DE 69532137D1 DE 69532137 T DE69532137 T DE 69532137T DE 69532137 T DE69532137 T DE 69532137T DE 69532137 D1 DE69532137 D1 DE 69532137D1
Authority
DE
Germany
Prior art keywords
during drying
biological substances
substances during
improved method
subsequent storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69532137T
Other languages
English (en)
Other versions
DE69532137T2 (de
Inventor
Camilo Colaco
Joseph Roser
Shevanti Sen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Elan Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Drug Delivery Ltd filed Critical Elan Drug Delivery Ltd
Application granted granted Critical
Publication of DE69532137D1 publication Critical patent/DE69532137D1/de
Publication of DE69532137T2 publication Critical patent/DE69532137T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Drying Of Solid Materials (AREA)
DE69532137T 1994-08-19 1995-08-18 Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen Expired - Lifetime DE69532137T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US293157 1994-08-19
US08/293,157 US5955448A (en) 1994-08-19 1994-08-19 Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
PCT/GB1995/001967 WO1996005809A1 (en) 1994-08-19 1995-08-18 Improved method for stabilization of biological substances during drying and subsequent storage and compositions thereof

Publications (2)

Publication Number Publication Date
DE69532137D1 true DE69532137D1 (de) 2003-12-18
DE69532137T2 DE69532137T2 (de) 2004-04-22

Family

ID=23127893

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532137T Expired - Lifetime DE69532137T2 (de) 1994-08-19 1995-08-18 Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen

Country Status (11)

Country Link
US (2) US5955448A (de)
EP (1) EP0804163B1 (de)
JP (1) JP3815793B2 (de)
CN (1) CN1160345A (de)
AT (1) ATE253898T1 (de)
AU (1) AU3349695A (de)
DE (1) DE69532137T2 (de)
DK (1) DK0804163T3 (de)
ES (1) ES2208693T3 (de)
PT (1) PT804163E (de)
WO (1) WO1996005809A1 (de)

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JPH10505591A (ja) 1998-06-02
PT804163E (pt) 2004-04-30
CN1160345A (zh) 1997-09-24
ES2208693T3 (es) 2004-06-16
WO1996005809A1 (en) 1996-02-29
EP0804163B1 (de) 2003-11-12
DE69532137T2 (de) 2004-04-22
ATE253898T1 (de) 2003-11-15
EP0804163A1 (de) 1997-11-05
US6313102B1 (en) 2001-11-06
DK0804163T3 (da) 2004-03-29
AU3349695A (en) 1996-03-14
US5955448A (en) 1999-09-21

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