EP1455822A4 - Lyophilisierte monoklonale antikörper-zusammensetzungen - Google Patents

Lyophilisierte monoklonale antikörper-zusammensetzungen

Info

Publication number
EP1455822A4
EP1455822A4 EP02773798A EP02773798A EP1455822A4 EP 1455822 A4 EP1455822 A4 EP 1455822A4 EP 02773798 A EP02773798 A EP 02773798A EP 02773798 A EP02773798 A EP 02773798A EP 1455822 A4 EP1455822 A4 EP 1455822A4
Authority
EP
European Patent Office
Prior art keywords
monoclonal antibody
antibody compositions
lyophilized monoclonal
lyophilized
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02773798A
Other languages
English (en)
French (fr)
Other versions
EP1455822A2 (de
Inventor
Tracy Chen
Glen Tolman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of EP1455822A2 publication Critical patent/EP1455822A2/de
Publication of EP1455822A4 publication Critical patent/EP1455822A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
EP02773798A 2001-11-09 2002-10-18 Lyophilisierte monoklonale antikörper-zusammensetzungen Withdrawn EP1455822A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34206301P 2001-11-09 2001-11-09
US342063P 2001-11-09
PCT/US2002/033272 WO2003041637A2 (en) 2001-11-09 2002-10-18 Lyophilized monoclonal antibody compositions

Publications (2)

Publication Number Publication Date
EP1455822A2 EP1455822A2 (de) 2004-09-15
EP1455822A4 true EP1455822A4 (de) 2004-12-29

Family

ID=23340162

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02773798A Withdrawn EP1455822A4 (de) 2001-11-09 2002-10-18 Lyophilisierte monoklonale antikörper-zusammensetzungen

Country Status (7)

Country Link
EP (1) EP1455822A4 (de)
JP (1) JP2005508992A (de)
AR (1) AR037304A1 (de)
CA (1) CA2466641A1 (de)
MX (1) MXPA04004459A (de)
TW (1) TW200303213A (de)
WO (1) WO2003041637A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982080B2 (en) * 2002-03-15 2006-01-03 Wyeth Hydroxyethyl starch—containing polypeptide compositions
CA2744510A1 (en) * 2008-12-09 2010-06-17 F.Hoffmann-La Roche Ag Method for obtaining an excipient-free antibody solution
WO2012028683A1 (en) 2010-09-02 2012-03-08 Novartis Ag Antibody gel system for sustained drug delivery
KR20180019247A (ko) 2010-11-05 2018-02-23 노파르티스 아게 Ｉｌ-１７ 길항제를 사용한 류마티스성 관절염의 치료 방법
JP2020534255A (ja) * 2017-09-15 2020-11-26 アムジエン・インコーポレーテツド 治療用タンパク質の凍結乾燥医薬配合物のためのプロセス

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000807A1 (en) * 1991-07-03 1993-01-21 Cryolife, Inc. Method for stabilization of biomaterials
WO1993014191A1 (en) * 1992-01-21 1993-07-22 Cryopharm Corporation Method of freezing cells and cell-like materials

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4891319A (en) * 1985-07-09 1990-01-02 Quadrant Bioresources Limited Protection of proteins and the like
US5656272A (en) * 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
ES2194992T3 (es) * 1995-06-07 2003-12-01 Elan Drug Delivery Ltd Procedimientos para la incorporacion estable de sustancias en matrices vitreas secas esponjosas, y composiciones asi obtenidas.
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
KR100923514B1 (ko) * 2000-12-28 2009-10-27 알투스 파마슈티컬스 인코포레이티드 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000807A1 (en) * 1991-07-03 1993-01-21 Cryolife, Inc. Method for stabilization of biomaterials
WO1993014191A1 (en) * 1992-01-21 1993-07-22 Cryopharm Corporation Method of freezing cells and cell-like materials

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CARPENTER JOHN F ET AL: "Rational design of stable lyophilized protein formulations: Some practical advice", PHARMACEUTICAL RESEARCH (NEW YORK), vol. 14, no. 8, 1997, pages 969 - 975, XP002303280, ISSN: 0724-8741 *
GARZON-RODRIGUEZ W ET AL: "Use of polymer/sugar mixtures to optimize storage stability of freeze-dried recombinant human interleukin-11", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 221, no. 1-2, April 2001 (2001-04-01), & 221ST NATIONAL MEETING OF THE AMERICAN CHEMICAL SOCIETY; SAN DIEGO, CALIFORNIA, USA; APRIL 01-05, 2001, pages BIOT 14, XP009039111, ISSN: 0065-7727 *
SEARLES JAMES A ET AL: "Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine Tg' in pharmaceutical lyophilization", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 90, no. 7, July 2001 (2001-07-01), pages 872 - 887, XP002303281, ISSN: 0022-3549 *

Also Published As

Publication number Publication date
AR037304A1 (es) 2004-11-03
EP1455822A2 (de) 2004-09-15
WO2003041637A2 (en) 2003-05-22
WO2003041637A3 (en) 2004-01-22
TW200303213A (en) 2003-09-01
MXPA04004459A (es) 2005-05-16
CA2466641A1 (en) 2003-05-22
JP2005508992A (ja) 2005-04-07

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Legal Events

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Effective date: 20041116

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