DK0817779T3 - Nye taxoider, deres fremstilling og farmaceutiske præparater deraf - Google Patents

Nye taxoider, deres fremstilling og farmaceutiske præparater deraf

Info

Publication number
DK0817779T3
DK0817779T3 DK96909192T DK96909192T DK0817779T3 DK 0817779 T3 DK0817779 T3 DK 0817779T3 DK 96909192 T DK96909192 T DK 96909192T DK 96909192 T DK96909192 T DK 96909192T DK 0817779 T3 DK0817779 T3 DK 0817779T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical compositions
new taxoids
taxoids
new
Prior art date
Application number
DK96909192T
Other languages
Danish (da)
English (en)
Inventor
Jean-Dominique Bourzat
Herve Bouchard
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9503545A external-priority patent/FR2732340B1/fr
Priority claimed from FR9515381A external-priority patent/FR2742754B1/fr
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0817779T3 publication Critical patent/DK0817779T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK96909192T 1995-03-27 1996-03-25 Nye taxoider, deres fremstilling og farmaceutiske præparater deraf DK0817779T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9503545A FR2732340B1 (fr) 1995-03-27 1995-03-27 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR9515381A FR2742754B1 (fr) 1995-12-22 1995-12-22 Procede de preparation de taxoides
PCT/FR1996/000440 WO1996030355A1 (fr) 1995-03-27 1996-03-25 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK0817779T3 true DK0817779T3 (da) 2000-06-19

Family

ID=26231838

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96909192T DK0817779T3 (da) 1995-03-27 1996-03-25 Nye taxoider, deres fremstilling og farmaceutiske præparater deraf
DK96909193T DK0817780T3 (da) 1995-03-27 1996-03-25 Taxoider, fremstilling af disse forbindelser og farmaceutiske præparater indeholdende disse forbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK96909193T DK0817780T3 (da) 1995-03-27 1996-03-25 Taxoider, fremstilling af disse forbindelser og farmaceutiske præparater indeholdende disse forbindelser

Country Status (41)

Country Link
US (3) US5889043A (ro)
EP (2) EP0817779B1 (ro)
JP (2) JP2941951B2 (ro)
KR (2) KR100485309B1 (ro)
CN (2) CN1213042C (ro)
AP (2) AP785A (ro)
AR (1) AR001440A1 (ro)
AT (2) ATE188471T1 (ro)
AU (2) AU703278B2 (ro)
BG (2) BG63121B1 (ro)
BR (2) BR9607929A (ro)
CA (2) CA2214321C (ro)
CO (1) CO4700576A1 (ro)
CZ (2) CZ287468B6 (ro)
DE (2) DE69604653T2 (ro)
DK (2) DK0817779T3 (ro)
DZ (1) DZ2009A1 (ro)
EA (2) EA000567B1 (ro)
EE (2) EE03608B1 (ro)
ES (2) ES2140075T3 (ro)
GE (2) GEP20002211B (ro)
GR (2) GR3031526T3 (ro)
HU (2) HU223732B1 (ro)
IL (1) IL117636A (ro)
IS (2) IS2058B (ro)
MA (1) MA23823A1 (ro)
MY (1) MY121225A (ro)
NO (2) NO316379B1 (ro)
NZ (2) NZ304901A (ro)
OA (2) OA10513A (ro)
PE (1) PE51097A1 (ro)
PL (2) PL188284B1 (ro)
PT (1) PT817779E (ro)
RO (2) RO115878B1 (ro)
SK (2) SK281927B6 (ro)
TN (1) TNSN96043A1 (ro)
TR (2) TR199701040T1 (ro)
TW (1) TW394765B (ro)
UY (2) UY24192A1 (ro)
WO (2) WO1996030356A1 (ro)
ZA (1) ZA962399B (ro)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
EP0982027A1 (en) * 1998-08-17 2000-03-01 Aventis Pharma S.A. Taxoid derivatives for treating abnormal cell proliferation of the brain
IL141231A0 (en) * 1998-08-20 2002-03-10 Aventis Pharma Sa New use of taxoid derivatives
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
EP1020188A1 (en) * 1999-01-13 2000-07-19 Aventis Pharma S.A. New use of taxoid derivatives
US6664275B2 (en) * 2000-02-02 2003-12-16 Fsu Research Foundation, Inc. C10 heterosubstituted acetate taxanes
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
US8147816B2 (en) * 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
CZ2003837A3 (cs) 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
AU2001290636A1 (en) * 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US6593334B1 (en) 2002-05-02 2003-07-15 The University Of North Carolina At Chapel Hill Camptothecin-taxoid conjugates as antimitotic and antitumor agents
CN102516417B (zh) 2002-09-06 2014-12-10 天蓝制药公司 用于传递治疗剂的以环糊精为基础的聚合物
US20040122081A1 (en) * 2002-11-08 2004-06-24 Gogate Uday Shankar Pharmaceutical compositions and methods of using taxane derivatives
CA2526278A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
SV2006002010A (es) * 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
GT200500025A (es) * 2004-02-13 2005-09-30 Taxanos sustituidos con esteres de ciclopentilo en c10
JP2008530122A (ja) * 2005-02-14 2008-08-07 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド C10シクロプロピルエステル置換タキサン組成物
RS52438B (en) * 2005-03-31 2013-02-28 Accord Healthcare Inc. PREPARATION OF 9-DIHYDRO-13-ACETYLBACCATINE TAXAN III
US8207358B2 (en) * 2005-11-04 2012-06-26 Accord Healthcare Ltd. Methods for the preparation of taxanes using chiral auxiliaries
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
EP2173732A4 (en) * 2007-07-04 2011-09-07 Reddys Lab Ltd Dr PROCESSES FOR THE PREPARATION OF DOCETAXEL AND POLYMORPHIC
FR2926551A1 (fr) * 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
EP2276755A4 (en) * 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
FR2945211A1 (fr) 2009-05-06 2010-11-12 Sanofi Aventis Combinaison antitumorale comprenant la cabazitaxel et la capecitabine
AU2010310986A1 (en) 2009-10-29 2012-06-14 Aventis Pharma S.A. Novel antitumoral use of cabazitaxel
CN104208716A (zh) * 2009-11-23 2014-12-17 天蓝制药公司 用于传递治疗剂的基于环糊精的聚合物
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088433A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
CN102060815B (zh) * 2010-12-24 2012-09-26 重庆泰濠制药有限公司 一种紫杉烷类化合物的制备方法
EP2620148A1 (en) 2012-01-27 2013-07-31 Aventis Pharma S.A. Antitumoral combination comprising cabazitaxel and cisplatin
EP2491925A1 (en) 2011-02-25 2012-08-29 Aventis Pharma S.A. Antitumoral combination comprising cabazitaxel and cisplatin
UY33923A (es) 2011-02-25 2012-09-28 Aventis Pharma Sa Combinación antitumoral que comprende cabazitaxel y cisplatino
JP2014514306A (ja) * 2011-04-12 2014-06-19 プラス・ケミカルス・エスアー 固体形態のカバジタキセル及びその製造方法
AU2012290979A1 (en) 2011-08-02 2014-02-13 Astellas Pharma Inc. Method for treating cancer by combined use of medicinal agents
TWI526437B (zh) * 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
WO2013069027A1 (en) * 2011-09-26 2013-05-16 Fresenius Kabi Oncology Ltd. Processes for the preparation of cabazitaxel involving c(7) -oh and c(13) -oh silylation or just c(7) -oh silylation
CN102336726B (zh) * 2011-09-30 2014-11-26 重庆泰濠制药有限公司 一种卡巴他赛的制备方法
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN102408397B (zh) 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN102516281B (zh) * 2011-10-20 2015-02-04 江苏红豆杉生物科技股份有限公司 一种10-脱乙酰基巴卡丁iii及其衍生物甲氧基化的方法
CN102603724B (zh) * 2011-10-20 2014-02-26 江苏红豆杉生物科技股份有限公司 二甲氧基紫杉烷类化合物纯化精制的方法
CN102424672A (zh) * 2011-10-20 2012-04-25 江苏红豆杉生物科技有限公司 脱保护基制备二甲氧基紫杉烷类化合物的方法
WO2013072766A2 (en) * 2011-10-31 2013-05-23 Scinopharm Taiwan, Ltd. Process for cabazitaxel and intermediates thereof
CN102417491B (zh) * 2011-10-31 2013-11-06 江苏红豆杉生物科技有限公司 以10-去乙酰基-巴卡丁iii为原料制备卡巴他赛的方法
DE112012004569T5 (de) * 2011-11-01 2014-08-14 Fresenius Kabi Oncology Ltd. Amorphe Form von Cabazitaxel und Verfahren zum Herstellen davon
CN103159705B (zh) * 2011-12-12 2015-05-27 福建南方制药股份有限公司 卡巴他赛中间体的制备方法
WO2013088335A1 (en) 2011-12-13 2013-06-20 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same
CN102532064B (zh) * 2011-12-13 2015-06-17 重庆泰濠制药有限公司 二甲氧基多西他赛的合成方法
CN104583189A (zh) * 2012-07-31 2015-04-29 永信药品工业股份有限公司 非晶型的卡巴利他索
CN102775435B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种用于制备7,10-甲氧基多西他赛的中间体的合成方法
CN102775434B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种7,10-二甲氧基紫杉烷化合物中间体的合成方法
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
CN103804323A (zh) * 2012-11-14 2014-05-21 上海希迈医药科技有限公司 一种卡巴他赛溶剂化物及其制备方法和应用
KR101407353B1 (ko) * 2012-12-04 2014-06-17 주식회사 삼양바이오팜 10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체
EP2743264A1 (en) 2012-12-13 2014-06-18 INDENA S.p.A. New crystalline form of cabazitaxel, process for the preparation and pharmaceutical compositions thereof
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
EP2865675A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物
CN104086514A (zh) * 2014-06-19 2014-10-08 上海应用技术学院 紫杉醇衍生物及其制备方法
PL3258931T3 (pl) 2015-02-17 2020-12-28 Erasmus University Medical Center Rotterdam Zastosowanie kabazitakselu w leczeniu nowotworu złośliwego prostaty
EP3093014A1 (en) 2015-05-13 2016-11-16 Aventis Pharma S.A. Cabazitaxel and its use for treating cancer
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it
US20210038578A1 (en) 2019-08-08 2021-02-11 Laekna Limited Method of treating cancer
EP3808345A1 (en) 2019-10-15 2021-04-21 Sanofi Mature IP Cabazitaxel in mcrpc patients previously treated with docetaxel and who failed a prior androgen signaling targeted inhibitor agent
EP3797834A1 (en) 2019-09-25 2021-03-31 Sanofi Mature IP Cabazitaxel in mcrpc patients previously treated with docetaxel and who failed a prior androgen signaling targeted inhibitor agent

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696459B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
DE69427706T2 (de) 1993-12-21 2001-10-25 University Of Hawaii, Honolulu Cryptophycine
ATE171170T1 (de) 1994-06-28 1998-10-15 Upjohn Co 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US5481018A (en) 1995-03-31 1996-01-02 The Dow Chemical Company Amino nitrile intermediate for the preparation of alanine diacetic acid
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2771092B1 (fr) 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides

Also Published As

Publication number Publication date
RO115878B1 (ro) 2000-07-28
DE69604653T2 (de) 2000-05-31
TW394765B (en) 2000-06-21
US20020038038A1 (en) 2002-03-28
MA23823A1 (fr) 1996-10-01
NO316607B1 (no) 2004-03-08
AU711227B2 (en) 1999-10-07
DZ2009A1 (fr) 2002-10-23
CA2214321A1 (fr) 1996-10-03
AU5278196A (en) 1996-10-16
JP2941951B2 (ja) 1999-08-30
CZ303297A3 (cs) 1998-01-14
HUP9801204A3 (en) 2000-12-28
HU223666B1 (hu) 2004-11-29
UY24370A1 (es) 2001-10-25
NO973922D0 (no) 1997-08-26
HU223732B1 (hu) 2004-12-28
BG101918A (en) 1998-10-30
DE69606028T2 (de) 2000-08-10
PE51097A1 (es) 1997-12-22
HUP9801201A2 (hu) 2000-05-28
IS4567A (is) 1997-09-23
DE69606028D1 (de) 2000-02-10
HUP9801204A1 (hu) 2000-05-28
EA000567B1 (ru) 1999-12-29
EA199700269A1 (ru) 1998-04-30
EP0817779B1 (fr) 2000-01-05
HUP9801201A3 (en) 2000-12-28
EP0817780A1 (fr) 1998-01-14
KR100297196B1 (ko) 2001-11-22
AR001440A1 (es) 1997-10-22
CZ287468B6 (en) 2000-12-13
EE9700323A (et) 1998-06-15
RO115877B1 (ro) 2000-07-28
GEP20002188B (en) 2000-07-25
NZ304900A (en) 1998-09-24
EA199700270A1 (ru) 1998-02-26
ATE188471T1 (de) 2000-01-15
NO973923D0 (no) 1997-08-26
OA10513A (fr) 2002-04-22
PL188284B1 (pl) 2005-01-31
BG101917A (en) 1998-10-30
SK130197A3 (en) 1998-04-08
EE03609B1 (et) 2002-02-15
MY121225A (en) 2006-01-28
PL322465A1 (en) 1998-02-02
BR9607930A (pt) 1998-06-02
US6387946B1 (en) 2002-05-14
MX9706568A (es) 1997-11-29
AU5278096A (en) 1996-10-16
IL117636A0 (en) 1996-07-23
AU703278B2 (en) 1999-03-25
CZ287326B6 (en) 2000-10-11
SK130297A3 (en) 1998-03-04
US6331635B1 (en) 2001-12-18
PL188987B1 (pl) 2005-05-31
TR199701040T1 (xx) 1998-01-21
EE9700315A (et) 1998-06-15
ES2140075T3 (es) 2000-02-16
CZ303097A3 (cs) 1998-01-14
CN1179775A (zh) 1998-04-22
JPH11500141A (ja) 1999-01-06
CA2214319A1 (fr) 1996-10-03
ATE185562T1 (de) 1999-10-15
NO973923L (no) 1997-08-26
EE03608B1 (et) 2002-02-15
DK0817780T3 (da) 2000-03-27
NO316379B1 (no) 2004-01-19
GR3032316T3 (en) 2000-04-27
IS2056B (is) 2005-10-14
KR19980703287A (ko) 1998-10-15
CN1152870C (zh) 2004-06-09
WO1996030355A1 (fr) 1996-10-03
ZA962399B (en) 1996-10-01
AP753A (en) 1999-07-21
CN1179776A (zh) 1998-04-22
BG63121B1 (bg) 2001-04-30
TNSN96043A1 (fr) 2005-03-15
US5889043A (en) 1999-03-30
EP0817779A1 (fr) 1998-01-14
CA2214319C (fr) 2004-02-17
BG63009B1 (bg) 2001-01-31
IL117636A (en) 2004-08-31
KR19980703357A (ko) 1998-10-15
SK281927B6 (sk) 2001-09-11
IS2058B (is) 2005-10-14
AP9701090A0 (en) 1997-10-31
TR199701042T1 (xx) 1998-01-21
MX9706278A (es) 1997-10-31
AP9701093A0 (en) 1997-10-31
CO4700576A1 (es) 1998-12-29
NZ304901A (en) 1998-12-23
PL322499A1 (en) 1998-02-02
AP785A (en) 1999-11-26
GR3031526T3 (en) 2000-01-31
EA000709B1 (ru) 2000-02-28
EP0817780B1 (fr) 1999-10-13
WO1996030356A1 (fr) 1996-10-03
GEP20002211B (en) 2000-08-25
IS4536A (is) 1997-07-31
SK281928B6 (sk) 2001-09-11
UY24192A1 (es) 1996-06-14
PT817779E (pt) 2000-04-28
CN1213042C (zh) 2005-08-03
JPH11502531A (ja) 1999-03-02
JP3790826B2 (ja) 2006-06-28
ES2143187T3 (es) 2000-05-01
DE69604653D1 (de) 1999-11-18
NO973922L (no) 1997-08-26
BR9607929A (pt) 1998-06-02
OA10514A (fr) 2002-04-22
KR100485309B1 (ko) 2005-10-12
CA2214321C (fr) 2008-01-22

Similar Documents

Publication Publication Date Title
DK0817779T3 (da) Nye taxoider, deres fremstilling og farmaceutiske præparater deraf
DK0876362T3 (da) Nye taxoider, deres fremstilling og farmaceutiske præparater deraf
FI973039A0 (fi) Uusia farnesyylitransferaasin inhibiittoreita, niiden valmistus ja niitä sisältäviä farmaseuttisia koostumuksia
DK0820448T3 (da) Nye taxoider, deres fremstilling og farmaceutiske præparater deraf
NO996433D0 (no) Nye formuleringer av legemidler, fremgangsmåter for fremstilling derav og fremgangsmåter for anvendelse derav
NO20001409L (no) Karboksamidotiazolderivater, fremgangsmÕte for fremstilling derav og farmasøytiske blandinger
FI973279A (fi) Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset koostumukset
EE9500064A (et) Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
NO975711L (no) Nye Dolastatinderivater, deres fremstilling og anvendelse
NO961160D0 (no) Cykliske forbindelser, deres fremstilling og anvendelse
NO20024176L (no) Farmasöytiske preparater inneholder derivater av 3-amino- azetidin, de nye derivater og deres fremstilling
IS4706A (is) Lyfjasamsetningar
NO952677D0 (no) Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater
EE03680B1 (et) Asendatud püridiinid, nende kasutamine ja farmatseutilised kompositsioonid
IS1846B (is) Setin N-(indól-2-karbónýl)-b-alaninamíð, notkun þeirra og lyfjaefnablöndur
DK0836615T3 (da) Nye thrombininhibitorer, deres fremstilling og anvendelse
DE69300913D1 (de) Polymorph Terazosin und pharmazeutische Zusammenstellung.
DK1112266T3 (da) Substituerede 4-amino-2-arylpyrimidiner, fremstilling og anvendelse deraf og farmaceutiske præparater indeholdende dem
NO983472D0 (no) Taxoider, deres fremstilling og farmas°ytiske preparater inneholdende taxoidene
FI973229A (fi) Uusi farmaseuttinen koostumus
DK0821680T3 (da) Nye taxoider, fremstilling af disse forbindelser og farmaceutiske præparater indeholdende disse forbindelser
NO981195D0 (no) Nye aminoresin sammensetninger
NO974057D0 (no) Bisykliske takykinin-antagonister, fremstilling derav og deres anvendelse i farmasöytisk sammensetning
NO308842B1 (no) Nye retinoider, anvendelse derav, og farmasøytiske preparater inneholdende dem
NO973230D0 (no) Nye peptider, deres fremstilling og anvendelse