DK0795334T3 - Nye prodrugs til behandling af tumorer og betændelsessygdomme - Google Patents

Nye prodrugs til behandling af tumorer og betændelsessygdomme

Info

Publication number
DK0795334T3
DK0795334T3 DK97103162T DK97103162T DK0795334T3 DK 0795334 T3 DK0795334 T3 DK 0795334T3 DK 97103162 T DK97103162 T DK 97103162T DK 97103162 T DK97103162 T DK 97103162T DK 0795334 T3 DK0795334 T3 DK 0795334T3
Authority
DK
Denmark
Prior art keywords
alkyl
alkylamino
glycosyl
tumors
treatment
Prior art date
Application number
DK97103162T
Other languages
Danish (da)
English (en)
Inventor
Joerg Czech
Klaus Bosslet
Manfred Gerken
Rainer Straub
Claude Monneret
Jean-Claude Florent
Frederic Schmidt
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8222555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0795334(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of DK0795334T3 publication Critical patent/DK0795334T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK97103162T 1996-03-12 1997-02-27 Nye prodrugs til behandling af tumorer og betændelsessygdomme DK0795334T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96103866 1996-03-12

Publications (1)

Publication Number Publication Date
DK0795334T3 true DK0795334T3 (da) 2006-06-06

Family

ID=8222555

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97103162T DK0795334T3 (da) 1996-03-12 1997-02-27 Nye prodrugs til behandling af tumorer og betændelsessygdomme

Country Status (24)

Country Link
US (1) US5935995A (fr)
EP (1) EP0795334B1 (fr)
JP (1) JP4392065B2 (fr)
KR (1) KR100466467B1 (fr)
CN (1) CN1168733C (fr)
AT (1) ATE316799T1 (fr)
AU (1) AU708202B2 (fr)
BG (1) BG61900B1 (fr)
BR (1) BRPI9701248B1 (fr)
CA (1) CA2199664C (fr)
CZ (1) CZ297994B6 (fr)
DE (1) DE59712561D1 (fr)
DK (1) DK0795334T3 (fr)
ES (1) ES2257756T3 (fr)
HU (1) HU228764B1 (fr)
NO (1) NO320322B1 (fr)
NZ (1) NZ314368A (fr)
PL (1) PL189604B1 (fr)
RO (1) RO120951B1 (fr)
RU (1) RU2191021C2 (fr)
SG (1) SG50011A1 (fr)
SI (1) SI0795334T1 (fr)
TR (1) TR199700178A2 (fr)
UA (1) UA50719C2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
CA2328614C (fr) 1999-02-12 2012-06-26 Biostream, Inc. Matrices d'administration de medicaments et procedes de fabrication et d'utilisation de ces dernieres
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
HUP0200871A3 (en) 1999-05-04 2004-04-28 Strakan Int Ltd Androgen glycosides and androgenic activity thereof
US6191119B1 (en) * 1999-10-15 2001-02-20 Supergen, Inc. Combination therapy including 9-nitro-20(S)-camptothecin
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
DE10058596A1 (de) * 2000-11-25 2002-06-06 Aventis Pharma Gmbh Verfahren zum Screening von chemischen Verbindungen zur Modulierung der Wechselwirkung einer EVH1-Domäne oder eines Proteins mit einer EVH1-Domäne mit einer EVH1-Bindedomäne oder einem Protein mit einer EVH1-Bindedomäne sowie ein Verfahren zum Nachweis besagter Wechselwirkung
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
ES2330731T3 (es) 2001-08-30 2009-12-15 Chemocentryx, Inc. Compuestos biciclicos como inhibidores de la union de quimioquina a us28.
JPWO2004000863A1 (ja) * 2002-06-20 2005-10-20 日本水産株式会社 プロドラッグ、その医薬としての使用、およびその製法
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
US7160867B2 (en) 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
CA2561993A1 (fr) * 2004-03-30 2006-04-13 Painceptor Pharma Corporation Compositions et methodes de modulation des canaux ioniques commandes par porte
US7825096B2 (en) * 2004-09-08 2010-11-02 The United States Of America As Represented By The Department Of Health And Human Services O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs
PT2155682E (pt) * 2007-04-06 2015-10-15 Ziopharm Oncology Inc Sais de mostarda de isofosforamida e análogos da mesma
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
JP5925680B2 (ja) * 2009-09-02 2016-05-25 オークランド ユニサーヴィスィズ リミテッド キナーゼインヒビター、そのプロドラッグ型および治療におけるそれらの使用
KR101253399B1 (ko) 2010-10-26 2013-04-11 영남대학교 산학협력단 아포지단백질 ａ－ｉ 및 그 변이체를 포함한 재조합 고밀도지단백질을 이용한 라파마이신 제형
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
CN113599533A (zh) 2015-11-25 2021-11-05 乐高化学生物科学股份有限公司 包含分支接头的抗体-药物缀合物及其相关方法
KR20180079452A (ko) 2015-11-25 2018-07-10 주식회사 레고켐 바이오사이언스 자기-희생기를 포함하는 접합체 및 이의 제조방법
WO2017089894A1 (fr) 2015-11-25 2017-06-01 Legochem Biosciences, Inc. Conjugués comprenant des groupes peptidiques et procédés associés à ceux-ci
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
MX2018006218A (es) 2015-12-04 2018-09-05 Seattle Genetics Inc Conjugados de compuestos de tubulisina cuaternizada.
BR112019020136A2 (pt) 2017-03-29 2020-04-22 Legochem Biosciences Inc profármaco de dímero de pirrolobenzodiazepina e composto de conjugado ligando-ligante do mesmo
EP3746134A1 (fr) 2018-02-02 2020-12-09 Maverix Oncology, Inc. Conjugués de médicaments à petites molécules de monophosphate de gemcitabine
AU2019266406A1 (en) 2018-05-09 2020-11-26 Legochem Biosciences, Inc. Compositions and methods related to anti-CD19 antibody drug conjugates
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
DE3836676A1 (de) * 1988-10-28 1990-05-03 Hoechst Ag Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel
KR0185967B1 (ko) * 1989-01-23 1999-05-01 에프. 쥐. 엠. 헤르만스; 에이. 쥐. 제이. 베르미렌 치료용 약물의 부위 특이적 생체내 활성작용
DE4106389A1 (de) * 1991-02-28 1992-09-03 Behringwerke Ag Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung
BR9008022A (pt) * 1990-05-18 1993-04-06 Hoechst Ag Amida de acido isoxazol-4-carboxilico e amidas de acido hidroxialquilideno-cianoacetico,medicamentos contendo estes compostos e sua aplicacao
FR2676058B1 (fr) * 1991-04-30 1994-02-25 Hoechst Lab Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
ES2069955T3 (es) * 1991-10-25 1995-05-16 Tungsram Reszvenytarsasag Lampara de descarga de baja presion con un solo casquillo.
DE4233152A1 (de) * 1992-10-02 1994-04-07 Behringwerke Ag Antikörper-Enzym-Konjugate zur Prodrug-Aktivierung
CA2081281A1 (fr) * 1992-10-23 1994-04-24 Shing-Ming Wang Activation de promedicaments a base de glycuroconjugues au moyen de conjugues du ligand-beta-glucoronidase, utilises en chimiotherapie
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
DE4314556A1 (de) * 1993-05-04 1994-11-10 Behringwerke Ag Modifizierte Antikörperenzymkonjugate und Fusionsproteine sowie ihre Anwendung zur tumorselektiven Therapie
EP0647450A1 (fr) * 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Prodrogues améliorées pour activation médiée par enzyme
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie

Also Published As

Publication number Publication date
BG101290A (en) 1997-09-30
PL189604B1 (pl) 2005-08-31
ATE316799T1 (de) 2006-02-15
KR970065550A (ko) 1997-10-13
EP0795334A3 (fr) 1997-09-24
BG61900B1 (bg) 1998-09-30
UA50719C2 (uk) 2002-11-15
NO971116L (no) 1997-09-15
HU9700579D0 (en) 1997-04-28
CN1163895A (zh) 1997-11-05
JPH101495A (ja) 1998-01-06
TR199700178A2 (tr) 1997-09-21
NO320322B1 (no) 2005-11-21
NO971116D0 (no) 1997-03-11
BRPI9701248B1 (pt) 2022-01-18
JP4392065B2 (ja) 2009-12-24
CZ297994B6 (cs) 2007-05-16
PL318878A1 (en) 1997-09-15
ES2257756T3 (es) 2006-08-01
CN1168733C (zh) 2004-09-29
CA2199664A1 (fr) 1997-09-12
CA2199664C (fr) 2008-05-20
NZ314368A (en) 1998-10-28
SI0795334T1 (sl) 2006-06-30
MX9701832A (es) 1998-07-31
KR100466467B1 (ko) 2005-06-29
RO120951B1 (ro) 2006-10-30
HUP9700579A2 (en) 1997-12-29
EP0795334A2 (fr) 1997-09-17
BR9701248A (pt) 1999-10-13
BR9701248A8 (pt) 2013-06-18
RU2191021C2 (ru) 2002-10-20
DE59712561D1 (de) 2006-04-13
AU708202B2 (en) 1999-07-29
SG50011A1 (en) 1998-06-15
CZ74297A3 (en) 1997-09-17
HU228764B1 (en) 2013-05-28
AU1620597A (en) 1997-09-18
HUP9700579A3 (en) 1999-05-28
EP0795334B1 (fr) 2006-02-01
US5935995A (en) 1999-08-10

Similar Documents

Publication Publication Date Title
DK0795334T3 (da) Nye prodrugs til behandling af tumorer og betændelsessygdomme
ATE124405T1 (de) 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel.
FR2619111B1 (fr) Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
NO20015172L (no) 1-metyl-erytromycin-derivater
YU68792A (sh) Postupak za dobivanje derivata bakatina iii i 10-dezacetil-bakatina iii
SE9603283D0 (sv) New compounds
BR1100061A (pt) Composto, processo para a preparação do mesmo, composição e uso dos mesmos
IE892189L (en) Derivatives of (aza) naphthalenesultam, their preparation¹and compositions containing them
NO961000L (no) Piperidinderivater, fremgangsmåte for fremstilling derav og medikament og preparat inneholdende slike
ATE82969T1 (de) 6-phenyl-3-piperazinylalkyl-1h,3h-pyrimidindion 2,4-derivate, deren herstellung und verwendung als heilmittel.
ATE188217T1 (de) 1,2,3,4,10,14b-hexahydrodibenzo-c,f)pyrazino-1, - a)azepino-derivate
ATE213496T1 (de) Heterozyclische verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
ATE281452T1 (de) 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
KR970706280A (ko) 5-HT1A 길항제로서의 비사이클릭 카복스아미드(Bicyclic carboxamides as 5-HT1 antagonists)
DE69837628D1 (de) Aminderivate, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
TR199901484T2 (xx) 2-Amino-2-imidazolin, guanidin ve 2-amino-3,4,5,6-tetrahidropirimidin t�revleri haz�rlama i�lemi.
DE69711506T2 (de) Methylsulfomycin 1, Verfahren zu dessen Herstellung und Verwendung
DE59712054D1 (de) 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
ATE53839T1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
CO5150174A1 (es) Bi-pirrolidinilvinil (carba) cefalosporinas