CO5150174A1 - Bi-pirrolidinilvinil (carba) cefalosporinas - Google Patents

Bi-pirrolidinilvinil (carba) cefalosporinas

Info

Publication number
CO5150174A1
CO5150174A1 CO99075208A CO99075208A CO5150174A1 CO 5150174 A1 CO5150174 A1 CO 5150174A1 CO 99075208 A CO99075208 A CO 99075208A CO 99075208 A CO99075208 A CO 99075208A CO 5150174 A1 CO5150174 A1 CO 5150174A1
Authority
CO
Colombia
Prior art keywords
alkyl
hydrogen
halogen
jpeg
heterocyclyl
Prior art date
Application number
CO99075208A
Other languages
English (en)
Inventor
Ingrid Heinze-Kraus
Hans Richter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5150174A1 publication Critical patent/CO5150174A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Derivados de cefalosporina de fórmula general:<EMI FILE="99075208_1" ID="1" IMF=JPEG >en los queR es R4-Ys-(CR5R6)m- o <EMI FILE="99075208_2" ID="2" IMF=JPEG >R1, R2 son cada uno independientemente hidrógeno o alquilo C1-C8;R3 es hidrógeno, hidroxi-alquilo C1-C8 o carbamoil-metilo;Z es fenileno, heterociclileno o naftileno;R4 es halógeno, fenilo, bencilo, naftilo o heterociclilo, estando opcionalmente sustituidos el fenilo, bencilo, naftilo, o heterociclilo por la menos uno de halógeno, hidroxi, alquilo C1-C8 opcionalmente sustituido, alcoxi C1-C8, amino, alquilamino C1-C8, di-alquilo C1-C8 -amino, carboxi, alcoxi- C1-C8 -carbonilo o carbamoílo;Q es S o CH2;y es S, O, NH o CH2;m es 0 ó 1;s es 0 ó 1;R5, R6 son cada uno independientemente hidrógeno oalquilo C1-C8;X es CR8 o N;R7 es hidrógeno, alquilo C1-C8, cicloalquilo C3-C7, formilo, acetilo o pivaloílo;R8 es hidrógeno o halógeno;y ésteres directamente hidrolizables de los mismos,sales farmacéuticamente aceptables de dichos compuestose hidratos de los compuestos de fórmula I y de sus ésteres y sales.
CO99075208A 1998-12-03 1999-11-30 Bi-pirrolidinilvinil (carba) cefalosporinas CO5150174A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98122965 1998-12-03
EP99119895 1999-10-07

Publications (1)

Publication Number Publication Date
CO5150174A1 true CO5150174A1 (es) 2002-04-29

Family

ID=26149851

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99075208A CO5150174A1 (es) 1998-12-03 1999-11-30 Bi-pirrolidinilvinil (carba) cefalosporinas

Country Status (5)

Country Link
AR (1) AR023065A1 (es)
AU (1) AU1654900A (es)
CO (1) CO5150174A1 (es)
PE (1) PE20001402A1 (es)
WO (1) WO2000032605A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1067131B1 (en) * 1999-07-05 2007-08-15 Basilea Pharmaceutica AG New process for the manufacture of cephalosporin derivatives
AU6267100A (en) * 1999-07-07 2001-01-30 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883247A (en) * 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
EP0831093A1 (en) * 1996-09-23 1998-03-25 F. Hoffmann-La Roche Ag 1-Carba-(dethia)-Cephalosporin Derivatives
EP0838465A1 (en) * 1996-10-22 1998-04-29 F. Hoffmann-La Roche Ag Pyridinium-substituted (lactamylvinyl)cephalosporin derivatives, their preparation and their use as antibiotics
DK0841339T3 (da) * 1996-11-06 2007-07-02 Basilea Pharmaceutica Ag Vinylpyrrolidinon-cephalosporinderivater
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
US6150350A (en) * 1997-09-15 2000-11-21 Hoffman-La Roche Inc. Antimicrobial compositions

Also Published As

Publication number Publication date
PE20001402A1 (es) 2000-12-15
WO2000032605A1 (en) 2000-06-08
AR023065A1 (es) 2002-09-04
AU1654900A (en) 2000-06-19

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