AR023065A1 - Bi-pirrolidinilvinil(carba)cefalosporinas - Google Patents

Bi-pirrolidinilvinil(carba)cefalosporinas

Info

Publication number
AR023065A1
AR023065A1 ARP990106105A ARP990106105A AR023065A1 AR 023065 A1 AR023065 A1 AR 023065A1 AR P990106105 A ARP990106105 A AR P990106105A AR P990106105 A ARP990106105 A AR P990106105A AR 023065 A1 AR023065 A1 AR 023065A1
Authority
AR
Argentina
Prior art keywords
formula
lower alkyl
hydrogen
halogen
compounds
Prior art date
Application number
ARP990106105A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR023065A1 publication Critical patent/AR023065A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Derivados de(carba) cefalosporina de formula (1) en las que R es R4 -Ys-(CR5R6)m- o formula a; R1 y R2 son cada uno independientemente hidrogeno o alquiloinferior; R3 es hidrogeno, hidroxi-alquilo inferior o carbamoilmetilo; Z es fenileno, heterociclileno no naftileno; R4 es halogeno, fenilo, bencilo, naftilo oheterociclilo estando opcionalmente sustituidos el fenilo, bencilo, naftilo o heterociclilo por al menos uno de halogeno, hidroxi, alquilo inferioropcionalmente sustituido, alcoxi inferior, amino, alquilamino inferior, di-alquilo-inferior-amino, carboxi, alcoxi-inferior-carbonilo o carbamoilo; Q es S oCH2; Y es S, O, NH o CH2; m es 0 o 1; s es 0 o 1; R5 y R6 son cada uno independientemente hidrogeno o alquilo inferior; X es CR8 o N; R7 es hidrogeno, alquiloinferior, cicloalquilo inferior, formilo, acetilo o pivaloílo; R8 es hidrogeno o halogeno; y ésteres directamente hidrolizables de los mismos, salesfarmacéuticamente aceptables de dichos compuestos e hidratos de los compuestosde formula 1 y de sus ésteres y sales. La invencion se refiere adicionalmente ala fabricacion de compuestos de formula 1, a su uos como sustancias farmacéuticamente activas, en particular para el tratamiento y profilaxis de enfermedadesinfecciosas, ya preparacines farmacéuticas que contienen un compuesto de formula 1 para el tratamiento y profilaxis de enfermedades infecciosas.
ARP990106105A 1998-12-03 1999-12-01 Bi-pirrolidinilvinil(carba)cefalosporinas AR023065A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98122965 1998-12-03
EP99119895 1999-10-07

Publications (1)

Publication Number Publication Date
AR023065A1 true AR023065A1 (es) 2002-09-04

Family

ID=26149851

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990106105A AR023065A1 (es) 1998-12-03 1999-12-01 Bi-pirrolidinilvinil(carba)cefalosporinas

Country Status (5)

Country Link
AR (1) AR023065A1 (es)
AU (1) AU1654900A (es)
CO (1) CO5150174A1 (es)
PE (1) PE20001402A1 (es)
WO (1) WO2000032605A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE370146T1 (de) * 1999-07-05 2007-09-15 Basilea Pharmaceutica Ag Verfahren zur herstellung von cephalosporin- derivaten
WO2001004127A1 (en) * 1999-07-07 2001-01-18 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883247A (en) * 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
EP0831093A1 (en) * 1996-09-23 1998-03-25 F. Hoffmann-La Roche Ag 1-Carba-(dethia)-Cephalosporin Derivatives
EP0838465A1 (en) * 1996-10-22 1998-04-29 F. Hoffmann-La Roche Ag Pyridinium-substituted (lactamylvinyl)cephalosporin derivatives, their preparation and their use as antibiotics
DE69737382T2 (de) * 1996-11-06 2007-10-31 Basilea Pharmaceutica Ag Vinylpyrrolidinon-Cephalosporin-Derivate
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
US6150350A (en) * 1997-09-15 2000-11-21 Hoffman-La Roche Inc. Antimicrobial compositions

Also Published As

Publication number Publication date
CO5150174A1 (es) 2002-04-29
AU1654900A (en) 2000-06-19
PE20001402A1 (es) 2000-12-15
WO2000032605A1 (en) 2000-06-08

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