PA8478301A1 - Derivados ftalacinicos inhibidores de la fosfodiesterasa 4 - Google Patents

Derivados ftalacinicos inhibidores de la fosfodiesterasa 4

Info

Publication number
PA8478301A1
PA8478301A1 PA19998478301A PA8478301A PA8478301A1 PA 8478301 A1 PA8478301 A1 PA 8478301A1 PA 19998478301 A PA19998478301 A PA 19998478301A PA 8478301 A PA8478301 A PA 8478301A PA 8478301 A1 PA8478301 A1 PA 8478301A1
Authority
PA
Panama
Prior art keywords
alkyl
aryl
optionally
hydrogen
group
Prior art date
Application number
PA19998478301A
Other languages
English (en)
Inventor
Franco Pellacini
Mauro Napoletano
Gabriele Norcini
Giancarlo Grancini
Gian Marco Leali
Gabriele Morazzoni
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of PA8478301A1 publication Critical patent/PA8478301A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Pyridine Compounds (AREA)

Abstract

COMPUESTOS CON FORMULA I DONDE ----- ES UN ENLACE SIMPLE O DOBLE; Z ES NH, METILENO, UNA CADENA ALQUILENICA (C2-C6) OPCIONALMENTE RAMIFICADA Y/O INSATURADA Y/O INTERRUMPIDA POR UN RESIDUO (C5-C7)CICLOALQUILO; UN ES FENILO O HETEROCICLO OPCIONALMENTE SUSTITUIDO POR UNO O MÁS SUSTITUYENTES SELECCIONADOS ENTRE GRUPOS OXO, NITRO, CARBOXI Y ÁTOMOS DE HALÓGENO, O UN GRUPO COR4 DONDE R4 ES HIDROXI, (C1-C6)-ALCOXI, AMINO OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPOS (C1-C6)ALQUILO O POR HIDROXI; R ES UN GRUPO (C1-C6)ALQUILO O POLIFLUOR(C1-C6)ALQUILO; R1, ESTÁ AUSENTE CUANDO ----- ES UN ENLACE DOBLE O, CUANDO ----- ES UN ENLACE SIMPLE, ES (a) HIDROGENO; (b) (C1-C6)ALQUILO OPCIONALMENTE SUSTITUIDO POR ARILO, POR HETEROCICLO O POR UN GRUPO COR5 DONDE R5 ES HIDROXI, (C1-C4)ALCOXI O HIDROXAMINO; (c)- COR6 DONDE R6 ES HIDRÓGENO, ARILO, ARIL-(C1-C6)ALQUILO, AMINO OPCIONALMENTE ALQUILOADO O MONOHIDROXILATO, HIDROXI, (C1-C4)ALCOXI, CARBOXI, (C1-C4)ALCOXICARBONILO, HN=C-NH2, O (C1-C4)ALQUILO OPCIONALMENTE SUSTITUIDO POR HETEROCICLO; (d) (C1-C4)-ALQUILOSULFONIL; R2 REPRESENTA DOS ÁTOMOS DE HIDRÓGENO O UN GRUPO =O CUANDO ----- ES UN ENLACE SIMPLE, O, CUANDO ----- ES UN ENLACE DOBLE, R2 ES HIDRÓGENO, CIANO, (C1-C4)ALCOXICARBONILO, AMIDO, OPCIONALMENTE SUSTITUIDO POR ARILO O HETEROARILO, (C1-C8)ALQUILO, (C2-C8)ALQUENILO O (C2-C8)ALQUINILO OPCIONALMENTE RAMIFICADO Y/O SUSTITUIDO POR ARILO O HETEROCICLO; ARILOXI, HETEROCICLILOXI, ARIL-(C1-C4)ALCOXI, HETEROCICLIL-(C1-C4)ALCOXI, AMINO SUSTITUIDO POR UNO O DOS GRUPOS (C1-C4)-ALQUILO, ARILAMINO, HETEROCICLILAMINO, ARIL-(C1-C4)ALQUILOAMINO, HETEROCICLIL-(C1-C4)-ALQUILOAMINO; R3 ES HIDRÓGENO, O UN (C1-C8)ALQUILO, (C2-C8)ALQUENILO O (C2-C8) ALQUINILO GRUPO OPCIONALMENTE SUSTITUIDO POR HIDROXI, OXO, ARILO O HETEROCICLO, Y OPCIONALMENTE INTERRUMPIDO POR UNO O MÁS HETEROÁTOMOS O HETEROGRUPOS; LOS DERIVADOS N O DE LOS COMPUESTOS CON FÓRMULA I Y SUS SALES FARMACÉUTICAMENTE ACEPTABLES SON INHIBIDORES DE LA PDE 4.
PA19998478301A 1998-07-21 1999-07-19 Derivados ftalacinicos inhibidores de la fosfodiesterasa 4 PA8478301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI001670A ITMI981670A1 (it) 1998-07-21 1998-07-21 Derivati ftalazinici inibitori della fosfodiesterasi 4

Publications (1)

Publication Number Publication Date
PA8478301A1 true PA8478301A1 (es) 2000-09-29

Family

ID=11380474

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19998478301A PA8478301A1 (es) 1998-07-21 1999-07-19 Derivados ftalacinicos inhibidores de la fosfodiesterasa 4

Country Status (35)

Country Link
US (2) US6329370B1 (es)
EP (2) EP1097142B1 (es)
JP (1) JP2002521370A (es)
KR (1) KR20010087161A (es)
CN (1) CN1127486C (es)
AP (1) AP2000001993A0 (es)
AR (1) AR019409A1 (es)
AT (1) ATE279397T1 (es)
AU (1) AU765457B2 (es)
BG (1) BG105063A (es)
BR (1) BR9911175A (es)
CA (1) CA2338044A1 (es)
CO (1) CO5090842A1 (es)
DE (1) DE69921139T2 (es)
EA (1) EA200100062A1 (es)
EE (1) EE200100039A (es)
HK (1) HK1039124B (es)
HR (1) HRP20010057A2 (es)
HU (1) HUP0102646A3 (es)
ID (1) ID28874A (es)
IL (1) IL139490A0 (es)
IS (1) IS5772A (es)
IT (1) ITMI981670A1 (es)
MX (1) MXPA01000670A (es)
NO (1) NO318988B1 (es)
NZ (1) NZ507926A (es)
OA (1) OA11582A (es)
PA (1) PA8478301A1 (es)
PE (1) PE20000755A1 (es)
PL (1) PL345187A1 (es)
SK (1) SK1002001A3 (es)
TW (1) TW509682B (es)
UA (1) UA68383C2 (es)
WO (1) WO2000005218A1 (es)
YU (1) YU77500A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
DE19921567A1 (de) * 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
ITMI20000261A1 (it) * 2000-02-16 2001-08-16 Zambon Group Processo per la preparazione di piridiniliden-ftalidi
WO2001079181A2 (en) * 2000-04-13 2001-10-25 Annovis, Inc. Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors
US6525049B2 (en) * 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
WO2002044157A2 (en) * 2000-12-01 2002-06-06 Iconix Pharmaceuticals, Inc. Parb inhibitors
ITMI20022739A1 (it) * 2002-12-23 2004-06-24 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4.
ITMI20022738A1 (it) * 2002-12-23 2004-06-24 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4.
WO2004076386A2 (en) 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
ITMI20031451A1 (it) * 2003-07-16 2005-01-17 Zambon Spa Derivati diidro-ftalazinici inibitori della fosfodiesterasi 4
EP1745039A4 (en) * 2004-05-08 2009-07-22 Neurogen Corp 3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES
WO2006074223A2 (en) * 2005-01-03 2006-07-13 Myriad Genetics, Inc. Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
US20090221664A1 (en) 2005-10-19 2009-09-03 Abhijit Ray Pharmaceutical compositions of muscarinic receptor antagonists
CA2669687C (en) 2006-11-15 2013-09-10 Forest Laboratories Holdings Limited Phthalazine derivatives
US8969348B2 (en) 2008-08-13 2015-03-03 Boehringer Ingelheim International Gmbh Chymase inhibitors
CN102108078B (zh) * 2009-12-24 2013-10-30 沈阳药科大学 1,4-取代酞嗪类化合物及其制备方法和用途
SG11201402134VA (en) * 2011-11-09 2014-06-27 Abbvie Deutschland Heterocyclic carboxamides useful as inhibitors of phosphodiesterase type 10a

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2063249A (en) * 1979-10-09 1981-06-03 Mitsubishi Yuka Pharma 4-Phenylphthalazine derivatives
JPH03106873A (ja) * 1989-09-20 1991-05-07 Morishita Pharmaceut Co Ltd １―ピリジルフタラジン誘導体及びそれらを含有する血小板凝集抑制剤
ATE115136T1 (de) * 1990-03-30 1994-12-15 Mitsubishi Chem Ind 4-phenylphthalazin-derivate.
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
HU219864B (hu) * 1994-08-09 2001-08-28 Eisai Co., Ltd. cGMP-PDE inhibitor kondenzált piridazinszármazékok és alkalmazásuk
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4

Also Published As

Publication number Publication date
BR9911175A (pt) 2001-03-20
ID28874A (id) 2001-07-12
IS5772A (is) 2000-12-15
NO318988B1 (no) 2005-05-30
AP2000001993A0 (en) 2000-12-31
AR019409A1 (es) 2002-02-20
NZ507926A (en) 2002-10-25
US6492360B1 (en) 2002-12-10
HUP0102646A2 (hu) 2001-12-28
ITMI981670A0 (it) 1998-07-21
HK1039124A1 (en) 2002-04-12
ITMI981670A1 (it) 2000-01-21
HRP20010057A2 (en) 2002-04-30
EA200100062A1 (ru) 2001-08-27
PE20000755A1 (es) 2000-09-01
EP1097142B1 (en) 2004-10-13
HK1039124B (zh) 2005-04-01
OA11582A (en) 2004-07-26
AU765457B2 (en) 2003-09-18
EP1371648A1 (en) 2003-12-17
MXPA01000670A (es) 2002-05-14
EE200100039A (et) 2002-06-17
NO20010331L (no) 2001-03-20
AU5281099A (en) 2000-02-14
WO2000005218A1 (en) 2000-02-03
TW509682B (en) 2002-11-11
EP1097142A1 (en) 2001-05-09
PL345187A1 (en) 2001-12-03
DE69921139T2 (de) 2005-10-13
CN1305467A (zh) 2001-07-25
NO20010331D0 (no) 2001-01-19
YU77500A (sh) 2002-11-15
BG105063A (en) 2001-07-31
SK1002001A3 (en) 2001-12-03
CN1127486C (zh) 2003-11-12
UA68383C2 (en) 2004-08-16
DE69921139D1 (de) 2004-11-18
CA2338044A1 (en) 2000-02-03
ATE279397T1 (de) 2004-10-15
KR20010087161A (ko) 2001-09-15
US6329370B1 (en) 2001-12-11
JP2002521370A (ja) 2002-07-16
HUP0102646A3 (en) 2003-01-28
IL139490A0 (en) 2001-11-25
CO5090842A1 (es) 2001-10-30

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