ITMI981670A0 - Derivati ftalazinici inibitori della fosfodiesterasi 4 - Google Patents
Derivati ftalazinici inibitori della fosfodiesterasi 4Info
- Publication number
- ITMI981670A0 ITMI981670A0 IT98MI001670A ITMI981670A ITMI981670A0 IT MI981670 A0 ITMI981670 A0 IT MI981670A0 IT 98MI001670 A IT98MI001670 A IT 98MI001670A IT MI981670 A ITMI981670 A IT MI981670A IT MI981670 A0 ITMI981670 A0 IT MI981670A0
- Authority
- IT
- Italy
- Prior art keywords
- phosphodiesterase inhibitors
- phthalazine derivatives
- derivatives phosphodiesterase
- phthalazine
- inhibitors
- Prior art date
Links
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Priority Applications (37)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT98MI001670A ITMI981670A1 (it) | 1998-07-21 | 1998-07-21 | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
PE1999000670A PE20000755A1 (es) | 1998-07-21 | 1999-07-08 | Derivados ftalacinicos inhibidores de la fosfodiesterasa 4 |
CA002338044A CA2338044A1 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
BR9911175-6A BR9911175A (pt) | 1998-07-21 | 1999-07-13 | Derivados de ftalazina, composições farmacêuticas contendo os mesmos e uso como inibidores de fosfodiesterase 4 |
US09/743,813 US6329370B1 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
UA2001010439A UA68383C2 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives and pharmaceutical compositions |
KR1020017000971A KR20010087161A (ko) | 1998-07-21 | 1999-07-13 | 프탈라진 유도체 포스포디에스테라아제 4 억제제 |
EP99938229A EP1097142B1 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
IL13949099A IL139490A0 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives as phosphodiesterase 4 inhibitors |
DE69921139T DE69921139T2 (de) | 1998-07-21 | 1999-07-13 | Phtalazine derivate phosphodiesterase 4 inhibitoren |
SK100-2001A SK1002001A3 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
AT99938229T ATE279397T1 (de) | 1998-07-21 | 1999-07-13 | Phtalazine derivate phosphodiesterase 4 inhibitoren |
IDW20010132A ID28874A (id) | 1998-07-21 | 1999-07-13 | Inhibitor fosfodiesterase 4 turunan ftalazina. |
CN99807294A CN1127486C (zh) | 1998-07-21 | 1999-07-13 | 二氮杂萘衍生物磷酸二酯酶4抑制剂 |
MXPA01000670A MXPA01000670A (es) | 1998-07-21 | 1999-07-13 | Derivados ftalacinicos inhibidores de la fosfodiesterasa 4. |
YU77500A YU77500A (sh) | 1998-07-21 | 1999-07-13 | Ftalazin derivati fosfodiestarazni 4 inhibitori |
APAP/P/2000/001993A AP2000001993A0 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors. |
OA1200100019A OA11582A (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors. |
PCT/EP1999/004904 WO2000005218A1 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
AU52810/99A AU765457B2 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
PL99345187A PL345187A1 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
JP2000561174A JP2002521370A (ja) | 1998-07-21 | 1999-07-13 | フタラジン誘導体ホスホジエステラーゼ4阻害剤 |
HU0102646A HUP0102646A3 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors and pharmaceutical compositions containing the same |
NZ507926A NZ507926A (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
EP03102377A EP1371648A1 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
EEP200100039A EE200100039A (et) | 1998-07-21 | 1999-07-13 | Ftalasiinderivaadid kui fosfodiesteraas-4 inhibiitorid |
EA200100062A EA200100062A1 (ru) | 1998-07-21 | 1999-07-13 | Фталазиновые производные ингибиторов производных фосфодиэстеразы 4 |
ARP990103501A AR019409A1 (es) | 1998-07-21 | 1999-07-16 | Derivados de ftalacina utiles como inhibidores de la fosfodiestearasa 4 y composiciones farmaceuticas que incluyen dichos derivados |
TW088112218A TW509682B (en) | 1998-07-21 | 1999-07-19 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
PA19998478301A PA8478301A1 (es) | 1998-07-21 | 1999-07-19 | Derivados ftalacinicos inhibidores de la fosfodiesterasa 4 |
CO99045518A CO5090842A1 (es) | 1998-07-21 | 1999-07-19 | Derivados ftalacinicos inhibidores de la fosfodiesterasa 4 |
IS5772A IS5772A (is) | 1998-07-21 | 2000-12-15 | Þalazín (phthalazine) afleiður af fosfódíesterasa4 lötum |
BG105063A BG105063A (en) | 1998-07-21 | 2000-12-18 | Phthalazine derivatives phosphodiestrase 4 inhibitors |
NO20010331A NO318988B1 (no) | 1998-07-21 | 2001-01-19 | Ftalazinderivater som fosfodiesterase 4-inhibitorer |
HR20010057A HRP20010057A2 (en) | 1998-07-21 | 2001-01-22 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
US09/976,436 US6492360B1 (en) | 1998-07-21 | 2001-10-15 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
HK02100584.0A HK1039124B (zh) | 1998-07-21 | 2002-01-25 | 二氮雜萘衍生物磷酸二酯酶4抑制劑 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT98MI001670A ITMI981670A1 (it) | 1998-07-21 | 1998-07-21 | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI981670A0 true ITMI981670A0 (it) | 1998-07-21 |
ITMI981670A1 ITMI981670A1 (it) | 2000-01-21 |
Family
ID=11380474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT98MI001670A ITMI981670A1 (it) | 1998-07-21 | 1998-07-21 | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
Country Status (35)
Country | Link |
---|---|
US (2) | US6329370B1 (it) |
EP (2) | EP1371648A1 (it) |
JP (1) | JP2002521370A (it) |
KR (1) | KR20010087161A (it) |
CN (1) | CN1127486C (it) |
AP (1) | AP2000001993A0 (it) |
AR (1) | AR019409A1 (it) |
AT (1) | ATE279397T1 (it) |
AU (1) | AU765457B2 (it) |
BG (1) | BG105063A (it) |
BR (1) | BR9911175A (it) |
CA (1) | CA2338044A1 (it) |
CO (1) | CO5090842A1 (it) |
DE (1) | DE69921139T2 (it) |
EA (1) | EA200100062A1 (it) |
EE (1) | EE200100039A (it) |
HK (1) | HK1039124B (it) |
HR (1) | HRP20010057A2 (it) |
HU (1) | HUP0102646A3 (it) |
ID (1) | ID28874A (it) |
IL (1) | IL139490A0 (it) |
IS (1) | IS5772A (it) |
IT (1) | ITMI981670A1 (it) |
MX (1) | MXPA01000670A (it) |
NO (1) | NO318988B1 (it) |
NZ (1) | NZ507926A (it) |
OA (1) | OA11582A (it) |
PA (1) | PA8478301A1 (it) |
PE (1) | PE20000755A1 (it) |
PL (1) | PL345187A1 (it) |
SK (1) | SK1002001A3 (it) |
TW (1) | TW509682B (it) |
UA (1) | UA68383C2 (it) |
WO (1) | WO2000005218A1 (it) |
YU (1) | YU77500A (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
DE19921567A1 (de) * | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
DE19963607B4 (de) * | 1999-12-23 | 2005-12-15 | Schering Ag | Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen |
ITMI20000261A1 (it) * | 2000-02-16 | 2001-08-16 | Zambon Group | Processo per la preparazione di piridiniliden-ftalidi |
EP1274689A2 (en) * | 2000-04-13 | 2003-01-15 | Annovis, Inc. | Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors |
US6525049B2 (en) * | 2000-07-05 | 2003-02-25 | Pharmacia & Upjohn Company | Pyrroloquinolones as antiviral agents |
WO2002044157A2 (en) * | 2000-12-01 | 2002-06-06 | Iconix Pharmaceuticals, Inc. | Parb inhibitors |
ITMI20022738A1 (it) * | 2002-12-23 | 2004-06-24 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4. |
ITMI20022739A1 (it) * | 2002-12-23 | 2004-06-24 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4. |
JP4790594B2 (ja) | 2003-02-25 | 2011-10-12 | トポターゲット ユーケー リミテッド | Hdacインヒビターとしての、二環式ヘテロアリール基を含むヒドロキサム酸化合物 |
ITMI20031451A1 (it) * | 2003-07-16 | 2005-01-17 | Zambon Spa | Derivati diidro-ftalazinici inibitori della fosfodiesterasi 4 |
AU2005260102A1 (en) * | 2004-05-08 | 2006-01-12 | Novartis International Pharmaceutical Ltd. | 3-aryl-5,6-disubstituted pyridazines |
CA2593005A1 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof |
JP2009512676A (ja) | 2005-10-19 | 2009-03-26 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性受容体アンタゴニストの医薬組成物 |
WO2008061108A2 (en) | 2006-11-15 | 2008-05-22 | Forest Laboratories Holdings Limited | Phthalazine derivatives |
JP5529131B2 (ja) * | 2008-08-13 | 2014-06-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キマーゼ阻害薬 |
CN102108078B (zh) * | 2009-12-24 | 2013-10-30 | 沈阳药科大学 | 1,4-取代酞嗪类化合物及其制备方法和用途 |
MX2014005705A (es) * | 2011-11-09 | 2014-09-04 | Abbvie Deutschland | Carboxamidas heterociclicas utiles como inhibidores de fosfodiesterasa del tipo 10a. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2063249A (en) * | 1979-10-09 | 1981-06-03 | Mitsubishi Yuka Pharma | 4-Phenylphthalazine derivatives |
JPH03106873A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1―ピリジルフタラジン誘導体及びそれらを含有する血小板凝集抑制剤 |
EP0449203B1 (en) * | 1990-03-30 | 1994-12-07 | Mitsubishi Chemical Corporation | 4-Phenylphthalazine derivatives |
EP0634404A1 (en) | 1993-07-13 | 1995-01-18 | Rhone Poulenc Agriculture Ltd. | Phtalazin derivatives and their use as pesticides |
US5849741A (en) * | 1994-08-09 | 1998-12-15 | Eisai Co., Ltd. | Fused pyridazine compounds |
IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
-
1998
- 1998-07-21 IT IT98MI001670A patent/ITMI981670A1/it unknown
-
1999
- 1999-07-08 PE PE1999000670A patent/PE20000755A1/es not_active Application Discontinuation
- 1999-07-13 ID IDW20010132A patent/ID28874A/id unknown
- 1999-07-13 AT AT99938229T patent/ATE279397T1/de not_active IP Right Cessation
- 1999-07-13 EP EP03102377A patent/EP1371648A1/en not_active Withdrawn
- 1999-07-13 AP APAP/P/2000/001993A patent/AP2000001993A0/en unknown
- 1999-07-13 UA UA2001010439A patent/UA68383C2/uk unknown
- 1999-07-13 BR BR9911175-6A patent/BR9911175A/pt not_active IP Right Cessation
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