ITMI982216A0 - Derivati benzazinici inibitori della fosfodiesterasi 4 - Google Patents

Derivati benzazinici inibitori della fosfodiesterasi 4

Info

Publication number
ITMI982216A0
ITMI982216A0 IT98MI002216A ITMI982216A ITMI982216A0 IT MI982216 A0 ITMI982216 A0 IT MI982216A0 IT 98MI002216 A IT98MI002216 A IT 98MI002216A IT MI982216 A ITMI982216 A IT MI982216A IT MI982216 A0 ITMI982216 A0 IT MI982216A0
Authority
IT
Italy
Prior art keywords
phosphodiesterase inhibitors
benzazine derivatives
benzazine
derivatives phosphodiesterase
inhibitors
Prior art date
Application number
IT98MI002216A
Other languages
English (en)
Inventor
Gabriele Norcini
Franco Pellacini
Gabriele Morazzoni
Mauro Napoletano
Lorenzo Pradella
Giancarlo Grancini
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ITMI982216A0 publication Critical patent/ITMI982216A0/it
Priority to IT1998MI002216A priority Critical patent/IT1302677B1/it
Priority to AU63322/99A priority patent/AU769338B2/en
Priority to PCT/EP1999/007302 priority patent/WO2000021947A1/en
Priority to CA002344694A priority patent/CA2344694A1/en
Priority to IL14144699A priority patent/IL141446A0/xx
Priority to EP99950597A priority patent/EP1121353A1/en
Priority to JP2000575853A priority patent/JP2002527430A/ja
Priority to US09/806,496 priority patent/US6358973B1/en
Publication of ITMI982216A1 publication Critical patent/ITMI982216A1/it
Application granted granted Critical
Publication of IT1302677B1 publication Critical patent/IT1302677B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT1998MI002216A 1998-10-15 1998-10-15 Derivati benzazinici inibitori della fosfodiesterasi 4 IT1302677B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT1998MI002216A IT1302677B1 (it) 1998-10-15 1998-10-15 Derivati benzazinici inibitori della fosfodiesterasi 4
IL14144699A IL141446A0 (en) 1998-10-15 1999-10-01 Benzazine derivatives as phosphodiesterase 4 inhibitors
PCT/EP1999/007302 WO2000021947A1 (en) 1998-10-15 1999-10-01 Benzazine derivatives as phosphodiesterase 4 inhibitors
CA002344694A CA2344694A1 (en) 1998-10-15 1999-10-01 Benzazine derivatives as phosphodiesterase 4 inhibitors
AU63322/99A AU769338B2 (en) 1998-10-15 1999-10-01 Benzazine derivatives as phosphodiesterase 4 inhibitors
EP99950597A EP1121353A1 (en) 1998-10-15 1999-10-01 Benzazine derivatives as phosphodiesterase 4 inhibitors
JP2000575853A JP2002527430A (ja) 1998-10-15 1999-10-01 ホスホジエステラーゼ４阻害剤としてのベンザジン誘導体
US09/806,496 US6358973B1 (en) 1998-10-15 1999-10-10 Benzazine derivatives as phosphodiesterase 4 inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002216A IT1302677B1 (it) 1998-10-15 1998-10-15 Derivati benzazinici inibitori della fosfodiesterasi 4

Publications (3)

Publication Number Publication Date
ITMI982216A0 true ITMI982216A0 (it) 1998-10-15
ITMI982216A1 ITMI982216A1 (it) 2000-04-15
IT1302677B1 IT1302677B1 (it) 2000-09-29

Family

ID=11380876

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998MI002216A IT1302677B1 (it) 1998-10-15 1998-10-15 Derivati benzazinici inibitori della fosfodiesterasi 4

Country Status (8)

Country Link
US (1) US6358973B1 (it)
EP (1) EP1121353A1 (it)
JP (1) JP2002527430A (it)
AU (1) AU769338B2 (it)
CA (1) CA2344694A1 (it)
IL (1) IL141446A0 (it)
IT (1) IT1302677B1 (it)
WO (1) WO2000021947A1 (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1816527A (zh) 2003-06-06 2006-08-09 菲布罗根有限公司 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途
CN101374815B (zh) * 2006-01-27 2013-07-17 菲布罗根有限公司 使低氧诱导因子（hif）稳定的氰基异喹啉化合物
BRPI0710527B8 (pt) * 2006-04-04 2021-05-25 Fibrogen Inc compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende
WO2008026704A1 (fr) * 2006-08-31 2008-03-06 Kyowa Hakko Kogyo Co., Ltd. Dérivé d'isoquinoline
TW200902025A (en) * 2007-04-11 2009-01-16 Alcon Res Ltd Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
JP5649584B2 (ja) 2008-11-14 2015-01-07 フィブロジェン インコーポレイテッド Ｈｉｆヒドロキシラーゼ阻害剤としてのチオクロメン誘導体
MX2012003693A (es) * 2009-10-01 2012-04-19 Alcon Res Ltd Composiciones de olopatadine y usos de las mismas.
AU2013229922B2 (en) 2012-03-09 2017-09-28 Fibrogen, Inc. 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
LT2872488T (lt) 2012-07-16 2018-10-25 Fibrogen, Inc. Kristalinės prolilhidroksilazės inhibitoriaus formos
US9340511B2 (en) 2012-07-16 2016-05-17 Fibrogen, Inc. Process for making isoquinoline compounds
RU2666144C2 (ru) 2013-01-24 2018-09-06 Фиброген, Инк. Кристаллические формы { [1-циано-5-(4-хлорофенокси)-4-гидроксиизохинолин-3-карбонил]-амино} -уксусной кислоты
CN108929228A (zh) * 2018-07-09 2018-12-04 上海华堇生物技术有限责任公司 一种3-甲氧基-β-硝基苯乙烯的新制备方法
CN113423435A (zh) 2018-12-28 2021-09-21 雷杰纳荣制药公司 使用花生四烯酸15-脂氧合酶(alox15)抑制剂治疗呼吸系统病症

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1199768A (en) * 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
WO1988007041A1 (en) * 1987-03-12 1988-09-22 Huhtamäki Oy Isoquinoline derivatives, their manufacture and use
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
JP3276762B2 (ja) * 1993-12-28 2002-04-22 日本臓器製薬株式会社 イソキノリン誘導体を含有する医薬組成物
HU219864B (hu) * 1994-08-09 2001-08-28 Eisai Co., Ltd. cGMP-PDE inhibitor kondenzált piridazinszármazékok és alkalmazásuk
EP0841929B1 (en) * 1995-08-02 2003-05-07 Darwin Discovery Limited Quinolones and their therapeutic use
AU706110B2 (en) * 1996-04-13 1999-06-10 Astrazeneca Ab Aminoisoquinolines and aminothienopyridine derivatives and their use as anti-inflammatory agents
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4

Also Published As

Publication number Publication date
EP1121353A1 (en) 2001-08-08
AU769338B2 (en) 2004-01-22
IT1302677B1 (it) 2000-09-29
IL141446A0 (en) 2002-03-10
JP2002527430A (ja) 2002-08-27
ITMI982216A1 (it) 2000-04-15
US6358973B1 (en) 2002-03-19
WO2000021947A1 (en) 2000-04-20
CA2344694A1 (en) 2000-04-20
AU6332299A (en) 2000-05-01

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