DK0758315T3 - Hidtil ukendte hydroximsyrederivater, farmaceutiske sammensætninger indeholdende dem og fremgangsmåde til fremstilling af d - Google Patents

Hidtil ukendte hydroximsyrederivater, farmaceutiske sammensætninger indeholdende dem og fremgangsmåde til fremstilling af d

Info

Publication number
DK0758315T3
DK0758315T3 DK95918106T DK95918106T DK0758315T3 DK 0758315 T3 DK0758315 T3 DK 0758315T3 DK 95918106 T DK95918106 T DK 95918106T DK 95918106 T DK95918106 T DK 95918106T DK 0758315 T3 DK0758315 T3 DK 0758315T3
Authority
DK
Denmark
Prior art keywords
group
formula
compounds
pct
date nov
Prior art date
Application number
DK95918106T
Other languages
Danish (da)
English (en)
Inventor
Mihsly Barabas
Ede Marvanyos
Lsszl Rigdi
Lsszl Vereczkey
Lsszl Jaszlits
Katalin Biro
Erzsebet Radvanyi
Istvsnne Udvardy-Nagy
Andrea Jednakovits
Original Assignee
Biorex Kutato Es Fejleszti Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9401488A external-priority patent/HU219916B/hu
Application filed by Biorex Kutato Es Fejleszti Rt filed Critical Biorex Kutato Es Fejleszti Rt
Application granted granted Critical
Publication of DK0758315T3 publication Critical patent/DK0758315T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK95918106T 1994-05-06 1995-05-04 Hidtil ukendte hydroximsyrederivater, farmaceutiske sammensætninger indeholdende dem og fremgangsmåde til fremstilling af d DK0758315T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9401488A HU219916B (hu) 1989-12-22 1994-05-06 Hidroximsav-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények, valamint egyes intermedierjeik
PCT/HU1995/000014 WO1995030649A1 (en) 1994-05-06 1995-05-04 Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (1)

Publication Number Publication Date
DK0758315T3 true DK0758315T3 (da) 1999-05-25

Family

ID=10985174

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95918106T DK0758315T3 (da) 1994-05-06 1995-05-04 Hidtil ukendte hydroximsyrederivater, farmaceutiske sammensætninger indeholdende dem og fremgangsmåde til fremstilling af d

Country Status (21)

Country Link
US (1) US5919796A (cs)
EP (1) EP0758315B1 (cs)
JP (1) JP3877762B2 (cs)
KR (1) KR100372312B1 (cs)
CN (1) CN1079789C (cs)
AT (1) ATE170170T1 (cs)
BG (1) BG63336B1 (cs)
BR (1) BR9507619A (cs)
CZ (1) CZ288824B6 (cs)
DE (1) DE69504329T2 (cs)
DK (1) DK0758315T3 (cs)
EE (1) EE03296B1 (cs)
ES (1) ES2123252T3 (cs)
FI (1) FI964436A7 (cs)
MX (1) MX9605376A (cs)
NO (1) NO307752B1 (cs)
NZ (1) NZ285151A (cs)
PL (1) PL179032B1 (cs)
RO (1) RO115873B1 (cs)
SK (1) SK281387B6 (cs)
WO (1) WO1995030649A1 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9502843D0 (en) * 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
HUP9602204D0 (en) * 1996-08-09 1996-10-28 Biorex Rt Pharmaceutical compositions for treating diseases connected with the disfunction of the vascular endothelial cells
IL162941A0 (en) 2002-01-11 2005-11-20 Biorex Kutato Fejlesztoe Kft Carboxamidine derivatives and their use in the treatment of vascular diseases
BR0302750A (pt) * 2003-08-08 2005-03-29 Catarinense S A Lab Uso de produto compreendendo material vegetal das espécies trichilia sp. associada ou não para a reversão/combate da fibrilação ventricular; composição farmacêutica compreendendo o referido material vegetal para a reversão/combate da fibrilação ventricular; método para a reversão/combate da fibrilação ventricular usando o referido material vegetal; uso do referido material vegetal para a produção de uma composição farmacêutica para a reversão/combate da fibrilação ventricular
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
WO2008039514A1 (en) * 2006-09-26 2008-04-03 Cytrx Corporation Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
CA2671049A1 (en) * 2006-12-01 2008-06-12 Cytrx Corporation Stroke recovery
CA3202568A1 (en) 2020-11-19 2022-05-27 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1110460B (it) * 1977-03-02 1985-12-23 Ciba Geigy Ag Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego
JPS608253A (ja) * 1983-06-28 1985-01-17 Showa Denko Kk ヒドロキシイミノブタノン誘導体及び殺虫剤
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
JPH068253A (ja) * 1992-06-29 1994-01-18 Kobe Steel Ltd プラスチック成形品用金型およびその製造方法

Also Published As

Publication number Publication date
BG63336B1 (bg) 2001-10-31
DE69504329T2 (de) 1999-04-08
EP0758315B1 (en) 1998-08-26
FI964436A0 (fi) 1996-11-05
CZ325196A3 (en) 1997-06-11
BG100954A (bg) 1997-08-29
CZ288824B6 (cs) 2001-09-12
FI964436A7 (fi) 1996-11-27
SK281387B6 (sk) 2001-03-12
CN1079789C (zh) 2002-02-27
AU691284B2 (en) 1998-05-14
EP0758315A1 (en) 1997-02-19
NZ285151A (en) 1998-09-24
ES2123252T3 (es) 1999-01-01
KR100372312B1 (ko) 2003-05-09
ATE170170T1 (de) 1998-09-15
DE69504329D1 (de) 1998-10-01
US5919796A (en) 1999-07-06
AU2416195A (en) 1995-11-29
BR9507619A (pt) 1997-09-23
WO1995030649A1 (en) 1995-11-16
PL317154A1 (en) 1997-03-17
NO964677D0 (no) 1996-11-05
NO964677L (no) 1996-11-05
NO307752B1 (no) 2000-05-22
MX9605376A (es) 1998-05-31
EE03296B1 (et) 2000-10-16
PL179032B1 (pl) 2000-07-31
KR970702845A (ko) 1997-06-10
SK143096A3 (en) 1997-06-04
CN1151728A (zh) 1997-06-11
JP3877762B2 (ja) 2007-02-07
JPH09512815A (ja) 1997-12-22
RO115873B1 (ro) 2000-07-28

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