ES2123252T3 - Nuevos derivados de acido hidroximico, composiciones farmaceuticas que los contienen y procedimiento para su preparacion. - Google Patents

Nuevos derivados de acido hidroximico, composiciones farmaceuticas que los contienen y procedimiento para su preparacion.

Info

Publication number
ES2123252T3
ES2123252T3 ES95918106T ES95918106T ES2123252T3 ES 2123252 T3 ES2123252 T3 ES 2123252T3 ES 95918106 T ES95918106 T ES 95918106T ES 95918106 T ES95918106 T ES 95918106T ES 2123252 T3 ES2123252 T3 ES 2123252T3
Authority
ES
Spain
Prior art keywords
group
sub
pharmaceutical compositions
preparation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95918106T
Other languages
English (en)
Inventor
Mihaly Barabas
Ede Marvanyos
Laszlo Urogdi
Laszlo Vereczkey
Laszlo Jaszlits
Katalin Biro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biorex Kutato Fejleszto Kft
Original Assignee
Biorex Kutato Fejleszto Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9401488A external-priority patent/HU219916B/hu
Application filed by Biorex Kutato Fejleszto Kft filed Critical Biorex Kutato Fejleszto Kft
Application granted granted Critical
Publication of ES2123252T3 publication Critical patent/ES2123252T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE FORMULA (I), EN DONDE X SIGNIFICA HALOGENO; Z REPRESENTA UN GRUPO AROMATICO, GRUPO PIRINIDILO O SIMILAR; Y R REPRESENTA UN GRUPO ALQUILO O FENILALQUILO, O UN GRUPO -A-N(R{SUB,1}R{SUB,2}, Y, EN ESTE ULTIMO, R{SUB,1} Y R{SUB,2} REPRESENTAN, INDEPENDIENTEMENTE UNO DEL OTRO, HIDROGENO O UN GRUPO ALQUILO; O R{SUB,1} Y R{SUB,2}, JUNTO CON EL ATOMO DE NITROGENO ADYACENTE, FORMAN UN GRUPO HETEROCICLICO SATURADO DE 5 A 7 MIEMBROS, QUE CONTIENE OPCIONALMENTE UN ATOMO ADICIONAL DE AZUFRE, OXIGENO, O NITROGENO, ESTANDO SUSTITUIDO OPCIONALMENTE DICHO GRUPO HETEROCICLICO POR AL MENOS UN GRUPO ALQUILO; Y A REPRESENTA UN GRUPO ALQUILENO DE CADENA RECTA O RAMIFICADO. LA INVENCION SE REFIERE TAMBIEN A LAS SALES DE ADICION FARMACOLOGICAMENTE ACEPTABLES DE DICHOS COMPUESTOS; ASI COMO A PROCESOS PARA LA PREPARACION DE DICHOS COMPUESTOS , Y DE COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS MISMOS, O SUS SALES DE ADICION FARMACOLOGICAMENTE ACPTABLES COMO INGREDIENTESACTIVOS. ADEMAS, LA INVENCION SE REFIERE A CIERTOS INTERMEDIARIOS NUEVOS DE FORMULA (II). LOS COMPUESTOS DE FORMULA (I) TIENEN EFECTO ANTIISQUEMICO Y, POR TANTO, SON UTILES PARA EL TRATAMIENTO DE ESTADOS Y ALTERACIONES ISQUEMICOS, P.EJ. ISQUEMIA MIOCARDIAL (INDUCIDA P.EJ. POR OCLUSION DE LAS ARTERIAS CORONARIAS.
ES95918106T 1994-05-06 1995-05-04 Nuevos derivados de acido hidroximico, composiciones farmaceuticas que los contienen y procedimiento para su preparacion. Expired - Lifetime ES2123252T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9401488A HU219916B (hu) 1989-12-22 1994-05-06 Hidroximsav-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények, valamint egyes intermedierjeik

Publications (1)

Publication Number Publication Date
ES2123252T3 true ES2123252T3 (es) 1999-01-01

Family

ID=10985174

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95918106T Expired - Lifetime ES2123252T3 (es) 1994-05-06 1995-05-04 Nuevos derivados de acido hidroximico, composiciones farmaceuticas que los contienen y procedimiento para su preparacion.

Country Status (21)

Country Link
US (1) US5919796A (es)
EP (1) EP0758315B1 (es)
JP (1) JP3877762B2 (es)
KR (1) KR100372312B1 (es)
CN (1) CN1079789C (es)
AT (1) ATE170170T1 (es)
BG (1) BG63336B1 (es)
BR (1) BR9507619A (es)
CZ (1) CZ288824B6 (es)
DE (1) DE69504329T2 (es)
DK (1) DK0758315T3 (es)
EE (1) EE03296B1 (es)
ES (1) ES2123252T3 (es)
FI (1) FI964436A (es)
MX (1) MX9605376A (es)
NO (1) NO307752B1 (es)
NZ (1) NZ285151A (es)
PL (1) PL179032B1 (es)
RO (1) RO115873B1 (es)
SK (1) SK281387B6 (es)
WO (1) WO1995030649A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9502843D0 (en) * 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
AU2003202104B8 (en) * 2002-01-11 2008-10-02 Cytrx Corporation Carboxamidine derivatives and their use in the treatment of vascular diseases
BR0302750A (pt) * 2003-08-08 2005-03-29 Catarinense S A Lab Uso de produto compreendendo material vegetal das espécies trichilia sp. associada ou não para a reversão/combate da fibrilação ventricular; composição farmacêutica compreendendo o referido material vegetal para a reversão/combate da fibrilação ventricular; método para a reversão/combate da fibrilação ventricular usando o referido material vegetal; uso do referido material vegetal para a produção de uma composição farmacêutica para a reversão/combate da fibrilação ventricular
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
US20080227813A1 (en) * 2006-09-26 2008-09-18 Jack Raymond Barber Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
AU2007328280A1 (en) * 2006-12-01 2008-06-12 Cytrx Corporation Hydroxylamine derivatives for the treatment of stroke
US20230416224A1 (en) 2020-11-19 2023-12-28 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1110460B (it) * 1977-03-02 1985-12-23 Ciba Geigy Ag Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego
JPS608253A (ja) * 1983-06-28 1985-01-17 Showa Denko Kk ヒドロキシイミノブタノン誘導体及び殺虫剤
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
JPH068253A (ja) * 1992-06-29 1994-01-18 Kobe Steel Ltd プラスチック成形品用金型およびその製造方法

Also Published As

Publication number Publication date
CN1079789C (zh) 2002-02-27
DE69504329T2 (de) 1999-04-08
CN1151728A (zh) 1997-06-11
AU2416195A (en) 1995-11-29
BG100954A (en) 1997-08-29
AU691284B2 (en) 1998-05-14
NZ285151A (en) 1998-09-24
DK0758315T3 (da) 1999-05-25
WO1995030649A1 (en) 1995-11-16
JPH09512815A (ja) 1997-12-22
PL179032B1 (pl) 2000-07-31
SK281387B6 (sk) 2001-03-12
CZ288824B6 (cs) 2001-09-12
CZ325196A3 (en) 1997-06-11
MX9605376A (es) 1998-05-31
FI964436A (fi) 1996-11-27
US5919796A (en) 1999-07-06
BR9507619A (pt) 1997-09-23
RO115873B1 (ro) 2000-07-28
KR100372312B1 (ko) 2003-05-09
ATE170170T1 (de) 1998-09-15
NO964677L (no) 1996-11-05
PL317154A1 (en) 1997-03-17
DE69504329D1 (de) 1998-10-01
SK143096A3 (en) 1997-06-04
KR970702845A (ko) 1997-06-10
JP3877762B2 (ja) 2007-02-07
EP0758315A1 (en) 1997-02-19
NO307752B1 (no) 2000-05-22
EE03296B1 (et) 2000-10-16
BG63336B1 (bg) 2001-10-31
FI964436A0 (fi) 1996-11-05
NO964677D0 (no) 1996-11-05
EP0758315B1 (en) 1998-08-26

Similar Documents

Publication Publication Date Title
CU23132A3 (es) Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
ES2185665T3 (es) Derivados de benzofurano como antagonistas de taquicininas.
UY26143A1 (es) Derivados heterocíclicos útiles como agentes anticancerosos
DOP2005000046A (es) Compuestos de acido alfa arilo o heteroaril metil beta piperidino propanoico como antagonistas del receptor orl1
UY27322A1 (es) Nuevos derivados de indol con afinidad por el receptor 5-ht6
ES2178038T3 (es) Nuevos derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.
ES2190396T3 (es) Nuevos compuestos amino-triazoles, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
UY26872A1 (es) Derivados de la 4- fenil piridina
ECSP014097A (es) Derivados de tiofeno utiles como agentes anticancerosos
CO5560573A2 (es) Derivados activos de amino-ftalazinona como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que los contienen
AR008377A1 (es) Un compuesto derivado de la 3-aroilbencilpiridazinona, una composicion farmaceutica particularmente para el tratamiento de enfermedades inflamatorias o autoinmunes que contiene dicho compuesto
PA8480101A1 (es) Derivados de quinolin-2-ona alquinilsustituidos utiles como agentes anticancerosos
NO305209B1 (no) N-alkyl-2-substituerte ATP-analoger, slike forbindelser til fremstilling av terapeutikum, farmas°ytisk preparat inneholdende slike forbindelser, og deres anvendelse
AR001999A1 (es) Derivados de acido carboxilico y composiciones conteniendolos, utiles como inhibidores de metaloproteasa de matriz, y procesos para su preparacion.
ES2174579T3 (es) Nuevos derivados benzotiofenicos, benzofuranicos e indolicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2123252T3 (es) Nuevos derivados de acido hidroximico, composiciones farmaceuticas que los contienen y procedimiento para su preparacion.
ES2059804T3 (es) Procedimiento de preparacion de eteres de oxima de propenona.
ES2102994T3 (es) Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa.
MX9204094A (es) Derivados de fenilalquilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
UY27685A1 (es) Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso
ES2106185T3 (es) 3-carboxiesteroides 17-beta-sustituidos no saturados.
ES2045189T3 (es) Nuevos agentes anti-arritmicos i.
ES2029879T3 (es) Procedimiento para producir derivados de aminas sustituidas.
ES2172294T3 (es) Nuevos derivados del 1-indanol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AR007690A1 (es) Sales de complejos anionicos de ru (iii) como agentes antimetastasicos y antineoplasicos, procedimiento para la preparacion y usos de dichas sales, y composiciones farmaceuticas que las contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 758315

Country of ref document: ES