ATE170170T1 - Hydroximsäurederivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu deren herstellung - Google Patents
Hydroximsäurederivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu deren herstellungInfo
- Publication number
- ATE170170T1 ATE170170T1 AT95918106T AT95918106T ATE170170T1 AT E170170 T1 ATE170170 T1 AT E170170T1 AT 95918106 T AT95918106 T AT 95918106T AT 95918106 T AT95918106 T AT 95918106T AT E170170 T1 ATE170170 T1 AT E170170T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- formula
- compounds
- pct
- date nov
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000002253 anti-ischaemic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004351 coronary vessel Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9401488A HU219916B (hu) | 1989-12-22 | 1994-05-06 | Hidroximsav-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények, valamint egyes intermedierjeik |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE170170T1 true ATE170170T1 (de) | 1998-09-15 |
Family
ID=10985174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95918106T ATE170170T1 (de) | 1994-05-06 | 1995-05-04 | Hydroximsäurederivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu deren herstellung |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5919796A (de) |
| EP (1) | EP0758315B1 (de) |
| JP (1) | JP3877762B2 (de) |
| KR (1) | KR100372312B1 (de) |
| CN (1) | CN1079789C (de) |
| AT (1) | ATE170170T1 (de) |
| BG (1) | BG63336B1 (de) |
| BR (1) | BR9507619A (de) |
| CZ (1) | CZ288824B6 (de) |
| DE (1) | DE69504329T2 (de) |
| DK (1) | DK0758315T3 (de) |
| EE (1) | EE03296B1 (de) |
| ES (1) | ES2123252T3 (de) |
| FI (1) | FI964436A (de) |
| MX (1) | MX9605376A (de) |
| NO (1) | NO307752B1 (de) |
| NZ (1) | NZ285151A (de) |
| PL (1) | PL179032B1 (de) |
| RO (1) | RO115873B1 (de) |
| SK (1) | SK281387B6 (de) |
| WO (1) | WO1995030649A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU9502843D0 (en) * | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| KR20040089102A (ko) * | 2002-01-11 | 2004-10-20 | 비오렉스 쿠타토 에쉬 훼레스테 에르테 | 카르복사미딘 유도체 및 혈관 질환의 치료에서의 이들 용도 |
| BR0302750A (pt) * | 2003-08-08 | 2005-03-29 | Catarinense S A Lab | Uso de produto compreendendo material vegetal das espécies trichilia sp. associada ou não para a reversão/combate da fibrilação ventricular; composição farmacêutica compreendendo o referido material vegetal para a reversão/combate da fibrilação ventricular; método para a reversão/combate da fibrilação ventricular usando o referido material vegetal; uso do referido material vegetal para a produção de uma composição farmacêutica para a reversão/combate da fibrilação ventricular |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| US20080227813A1 (en) * | 2006-09-26 | 2008-09-18 | Jack Raymond Barber | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
| WO2008070010A2 (en) * | 2006-12-01 | 2008-06-12 | Cytrx Corporation | Hydroxylamine derivatives for the treatment of stroke |
| IL303026A (en) | 2020-11-19 | 2023-07-01 | Zevra Denmark As | Processes for preparing arimoclomol citrate and its intermediates |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1110460B (it) * | 1977-03-02 | 1985-12-23 | Ciba Geigy Ag | Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego |
| JPS608253A (ja) * | 1983-06-28 | 1985-01-17 | Showa Denko Kk | ヒドロキシイミノブタノン誘導体及び殺虫剤 |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| JPH068253A (ja) * | 1992-06-29 | 1994-01-18 | Kobe Steel Ltd | プラスチック成形品用金型およびその製造方法 |
-
1995
- 1995-05-04 ES ES95918106T patent/ES2123252T3/es not_active Expired - Lifetime
- 1995-05-04 WO PCT/HU1995/000014 patent/WO1995030649A1/en active IP Right Grant
- 1995-05-04 CZ CZ19963251A patent/CZ288824B6/cs not_active IP Right Cessation
- 1995-05-04 RO RO96-02093A patent/RO115873B1/ro unknown
- 1995-05-04 BR BR9507619A patent/BR9507619A/pt not_active IP Right Cessation
- 1995-05-04 US US08/737,168 patent/US5919796A/en not_active Expired - Fee Related
- 1995-05-04 SK SK1430-96A patent/SK281387B6/sk not_active IP Right Cessation
- 1995-05-04 CN CN95193977A patent/CN1079789C/zh not_active Expired - Fee Related
- 1995-05-04 DE DE69504329T patent/DE69504329T2/de not_active Expired - Fee Related
- 1995-05-04 PL PL95317154A patent/PL179032B1/pl not_active IP Right Cessation
- 1995-05-04 MX MX9605376A patent/MX9605376A/es not_active IP Right Cessation
- 1995-05-04 JP JP52879995A patent/JP3877762B2/ja not_active Expired - Fee Related
- 1995-05-04 EP EP95918106A patent/EP0758315B1/de not_active Expired - Lifetime
- 1995-05-04 EE EE9600137A patent/EE03296B1/xx not_active IP Right Cessation
- 1995-05-04 AT AT95918106T patent/ATE170170T1/de not_active IP Right Cessation
- 1995-05-04 DK DK95918106T patent/DK0758315T3/da active
- 1995-05-04 NZ NZ285151A patent/NZ285151A/en not_active IP Right Cessation
- 1995-05-04 KR KR1019960706277A patent/KR100372312B1/ko not_active IP Right Cessation
-
1996
- 1996-11-04 BG BG100954A patent/BG63336B1/bg unknown
- 1996-11-05 NO NO964677A patent/NO307752B1/no unknown
- 1996-11-05 FI FI964436A patent/FI964436A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK281387B6 (sk) | 2001-03-12 |
| AU2416195A (en) | 1995-11-29 |
| PL179032B1 (pl) | 2000-07-31 |
| SK143096A3 (en) | 1997-06-04 |
| DE69504329T2 (de) | 1999-04-08 |
| JPH09512815A (ja) | 1997-12-22 |
| EP0758315A1 (de) | 1997-02-19 |
| CZ288824B6 (cs) | 2001-09-12 |
| PL317154A1 (en) | 1997-03-17 |
| KR970702845A (ko) | 1997-06-10 |
| CZ325196A3 (en) | 1997-06-11 |
| FI964436A0 (fi) | 1996-11-05 |
| BG100954A (en) | 1997-08-29 |
| ES2123252T3 (es) | 1999-01-01 |
| RO115873B1 (ro) | 2000-07-28 |
| CN1079789C (zh) | 2002-02-27 |
| WO1995030649A1 (en) | 1995-11-16 |
| KR100372312B1 (ko) | 2003-05-09 |
| NZ285151A (en) | 1998-09-24 |
| NO964677D0 (no) | 1996-11-05 |
| BR9507619A (pt) | 1997-09-23 |
| NO307752B1 (no) | 2000-05-22 |
| AU691284B2 (en) | 1998-05-14 |
| EE03296B1 (et) | 2000-10-16 |
| EP0758315B1 (de) | 1998-08-26 |
| CN1151728A (zh) | 1997-06-11 |
| NO964677L (no) | 1996-11-05 |
| MX9605376A (es) | 1998-05-31 |
| US5919796A (en) | 1999-07-06 |
| DE69504329D1 (de) | 1998-10-01 |
| BG63336B1 (bg) | 2001-10-31 |
| DK0758315T3 (da) | 1999-05-25 |
| JP3877762B2 (ja) | 2007-02-07 |
| FI964436A (fi) | 1996-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |