MX9605376A - Derivados novedosos de acido hidroximico, composiciones farmaceuticas que los contienen y procesos para preparar los mismos. - Google Patents

Derivados novedosos de acido hidroximico, composiciones farmaceuticas que los contienen y procesos para preparar los mismos.

Info

Publication number
MX9605376A
MX9605376A MX9605376A MX9605376A MX9605376A MX 9605376 A MX9605376 A MX 9605376A MX 9605376 A MX9605376 A MX 9605376A MX 9605376 A MX9605376 A MX 9605376A MX 9605376 A MX9605376 A MX 9605376A
Authority
MX
Mexico
Prior art keywords
group
formula
compounds
pharmaceutical compositions
compositions containing
Prior art date
Application number
MX9605376A
Other languages
English (en)
Inventor
Mihaly Barabas
Ede Marvanyos
Laszlo Urogdi
Laszlo Vereczkey
Laszlo Jaszlits
Katalin Biro
Andrea Jednakovits
Erzsebet Radvanyi
Istvanne Udvardy-Nagy
Original Assignee
Biorex Kutato Fejlesztoe Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9401488A external-priority patent/HU219916B/hu
Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft
Publication of MX9605376A publication Critical patent/MX9605376A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se refiere a derivados de ácido hidroxímicos biologicamente activos de la formula (I): en donde X significa halogeno; Z se refiere a un grupo aromático, grupo piridinilo o similares; y R representa un grupo alquilo o fenilalquilo o un grupo -A-N(R1 y R2), y en la ultima, R1 y R2 se refieren, independientemente uno del otro, a hidrogeno o grupo alquilo; o R1 y R2, junto con el átomo de nitrogeno adyacente, forman un grupo heterocíclico saturado de 5 o 7 miembros, que contienen opcionalmente un átomo de nitrogeno, oxígeno o azufre adicional, dicho grupo heterocíclico siendo substituido opcionalmente por lo menos de un grupo alquilo; y A se refiere aun grupo alquileno de cadena recta o ramificada, así como a sus sales ácidas de adicion farmacéuticamente aceptables; además, la invencion se refiere a un proceso para la preparacion de los compuestos novedosos anteriores y a composiciones farmacéuticas que contienen estos compuestos o sus sales ácidas de adicion farmacéuticamente aceptables como ingredientes activos.
MX9605376A 1994-05-06 1995-05-04 Derivados novedosos de acido hidroximico, composiciones farmaceuticas que los contienen y procesos para preparar los mismos. MX9605376A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9401488A HU219916B (hu) 1989-12-22 1994-05-06 Hidroximsav-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények, valamint egyes intermedierjeik
PCT/HU1995/000014 WO1995030649A1 (en) 1994-05-06 1995-05-04 Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (1)

Publication Number Publication Date
MX9605376A true MX9605376A (es) 1998-05-31

Family

ID=10985174

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605376A MX9605376A (es) 1994-05-06 1995-05-04 Derivados novedosos de acido hidroximico, composiciones farmaceuticas que los contienen y procesos para preparar los mismos.

Country Status (21)

Country Link
US (1) US5919796A (es)
EP (1) EP0758315B1 (es)
JP (1) JP3877762B2 (es)
KR (1) KR100372312B1 (es)
CN (1) CN1079789C (es)
AT (1) ATE170170T1 (es)
BG (1) BG63336B1 (es)
BR (1) BR9507619A (es)
CZ (1) CZ288824B6 (es)
DE (1) DE69504329T2 (es)
DK (1) DK0758315T3 (es)
EE (1) EE03296B1 (es)
ES (1) ES2123252T3 (es)
FI (1) FI964436A (es)
MX (1) MX9605376A (es)
NO (1) NO307752B1 (es)
NZ (1) NZ285151A (es)
PL (1) PL179032B1 (es)
RO (1) RO115873B1 (es)
SK (1) SK281387B6 (es)
WO (1) WO1995030649A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9502843D0 (en) * 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
IL162941A0 (en) 2002-01-11 2005-11-20 Biorex Kutato Fejlesztoe Kft Carboxamidine derivatives and their use in the treatment of vascular diseases
BR0302750A (pt) * 2003-08-08 2005-03-29 Catarinense S A Lab Uso de produto compreendendo material vegetal das espécies trichilia sp. associada ou não para a reversão/combate da fibrilação ventricular; composição farmacêutica compreendendo o referido material vegetal para a reversão/combate da fibrilação ventricular; método para a reversão/combate da fibrilação ventricular usando o referido material vegetal; uso do referido material vegetal para a produção de uma composição farmacêutica para a reversão/combate da fibrilação ventricular
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
WO2008039514A1 (en) * 2006-09-26 2008-04-03 Cytrx Corporation Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
JP2010511622A (ja) * 2006-12-01 2010-04-15 シトルックス コーポレイション 発作の回復
CA3202568A1 (en) 2020-11-19 2022-05-27 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1110460B (it) * 1977-03-02 1985-12-23 Ciba Geigy Ag Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego
JPS608253A (ja) * 1983-06-28 1985-01-17 Showa Denko Kk ヒドロキシイミノブタノン誘導体及び殺虫剤
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
JPH068253A (ja) * 1992-06-29 1994-01-18 Kobe Steel Ltd プラスチック成形品用金型およびその製造方法

Also Published As

Publication number Publication date
CZ288824B6 (cs) 2001-09-12
NO307752B1 (no) 2000-05-22
EE03296B1 (et) 2000-10-16
RO115873B1 (ro) 2000-07-28
CN1151728A (zh) 1997-06-11
FI964436A0 (fi) 1996-11-05
JPH09512815A (ja) 1997-12-22
WO1995030649A1 (en) 1995-11-16
NZ285151A (en) 1998-09-24
ATE170170T1 (de) 1998-09-15
CZ325196A3 (en) 1997-06-11
EP0758315B1 (en) 1998-08-26
KR970702845A (ko) 1997-06-10
US5919796A (en) 1999-07-06
FI964436A (fi) 1996-11-27
AU691284B2 (en) 1998-05-14
BR9507619A (pt) 1997-09-23
PL317154A1 (en) 1997-03-17
KR100372312B1 (ko) 2003-05-09
NO964677D0 (no) 1996-11-05
CN1079789C (zh) 2002-02-27
DE69504329D1 (de) 1998-10-01
PL179032B1 (pl) 2000-07-31
SK281387B6 (sk) 2001-03-12
SK143096A3 (en) 1997-06-04
JP3877762B2 (ja) 2007-02-07
ES2123252T3 (es) 1999-01-01
BG100954A (en) 1997-08-29
EP0758315A1 (en) 1997-02-19
NO964677L (no) 1996-11-05
DE69504329T2 (de) 1999-04-08
AU2416195A (en) 1995-11-29
BG63336B1 (bg) 2001-10-31
DK0758315T3 (da) 1999-05-25

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees