ATE265453T1 - Diketopiperazinderivate als thrombininhibitoren - Google Patents
Diketopiperazinderivate als thrombininhibitorenInfo
- Publication number
- ATE265453T1 ATE265453T1 AT00981112T AT00981112T ATE265453T1 AT E265453 T1 ATE265453 T1 AT E265453T1 AT 00981112 T AT00981112 T AT 00981112T AT 00981112 T AT00981112 T AT 00981112T AT E265453 T1 ATE265453 T1 AT E265453T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- moiety
- aryl
- hydrogen
- hydroheteroaryl
- Prior art date
Links
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical class O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title abstract 2
- 229940122388 Thrombin inhibitor Drugs 0.000 title 1
- 239000003868 thrombin inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 206010062506 Heparin-induced thrombocytopenia Diseases 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 208000015294 blood coagulation disease Diseases 0.000 abstract 1
- 230000009852 coagulant defect Effects 0.000 abstract 1
- -1 hydroheteroaryl Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004963 sulfonylalkyl group Chemical group 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16790199P | 1999-11-30 | 1999-11-30 | |
| US19436600P | 2000-04-04 | 2000-04-04 | |
| PCT/CA2000/001414 WO2001040224A1 (en) | 1999-11-30 | 2000-11-29 | Diketopiperazine derivatives to inhibit thrombin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE265453T1 true ATE265453T1 (de) | 2004-05-15 |
Family
ID=26863579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00981112T ATE265453T1 (de) | 1999-11-30 | 2000-11-29 | Diketopiperazinderivate als thrombininhibitoren |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1261608B1 (de) |
| CN (1) | CN1174982C (de) |
| AT (1) | ATE265453T1 (de) |
| AU (1) | AU1847401A (de) |
| CA (1) | CA2392936A1 (de) |
| DE (1) | DE60010344T2 (de) |
| WO (1) | WO2001040224A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112010930B (zh) * | 2019-05-28 | 2022-08-02 | 首都医科大学 | Rgd修饰的五环哌嗪二酮及其制备和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
-
2000
- 2000-11-29 CA CA002392936A patent/CA2392936A1/en not_active Abandoned
- 2000-11-29 WO PCT/CA2000/001414 patent/WO2001040224A1/en not_active Ceased
- 2000-11-29 AU AU18474/01A patent/AU1847401A/en not_active Abandoned
- 2000-11-29 DE DE60010344T patent/DE60010344T2/de not_active Expired - Fee Related
- 2000-11-29 CN CNB008163170A patent/CN1174982C/zh not_active Expired - Fee Related
- 2000-11-29 AT AT00981112T patent/ATE265453T1/de not_active IP Right Cessation
- 2000-11-29 EP EP00981112A patent/EP1261608B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU1847401A (en) | 2001-06-12 |
| CN1402725A (zh) | 2003-03-12 |
| EP1261608B1 (de) | 2004-04-28 |
| CN1174982C (zh) | 2004-11-10 |
| DE60010344T2 (de) | 2005-02-17 |
| EP1261608A1 (de) | 2002-12-04 |
| WO2001040224A1 (en) | 2001-06-07 |
| DE60010344D1 (de) | 2004-06-03 |
| CA2392936A1 (en) | 2001-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |