BG100954A - Нови производни на хидроксамови киселини, фармацевтични състави на тяхна основа и метод за получаването им - Google Patents

Нови производни на хидроксамови киселини, фармацевтични състави на тяхна основа и метод за получаването им

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Publication number
BG100954A
BG100954A BG100954A BG10095496A BG100954A BG 100954 A BG100954 A BG 100954A BG 100954 A BG100954 A BG 100954A BG 10095496 A BG10095496 A BG 10095496A BG 100954 A BG100954 A BG 100954A
Authority
BG
Bulgaria
Prior art keywords
group
formula
compounds
derivatives
preparation
Prior art date
Application number
BG100954A
Other languages
English (en)
Other versions
BG63336B1 (bg
Inventor
Mihaly Barabas
Ede Marvanyos
Laszlo Ueroegdi
Laszlo Vereczkey
Laszlo Jaszlits
Katalin Biro
Andrea Jednakovits
Erzsebet Radvanyi
Istvanne Udvardy-Nagy
Original Assignee
Biorex Kutato Es Fejlesztoe Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9401488A external-priority patent/HU219916B/hu
Application filed by Biorex Kutato Es Fejlesztoe Rt. filed Critical Biorex Kutato Es Fejlesztoe Rt.
Publication of BG100954A publication Critical patent/BG100954A/bg
Publication of BG63336B1 publication Critical patent/BG63336B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до нови съединения с формулав която Х означава халоген, Z е ароматна или пиридинилова група или подобни, иR - алкилова или фенилалкилова група, или групата -А-N(R1)R2, в коятоR1 и R2,независимо един от друг, означават водородили алкилова група или R1 и R2 заедно с азотния атом, с който са свързани, образуват 5- до 7-члененнаситен хетероциклен пръстен, в даден случай съдържащ допълнително азотен, кислороден или серен атом, като този хетероциклен пръстен в даден случай езаместен най-малко с една алкилова група и А означава алкиленова група с права или разклонена верига,и до техни фармацевтично приемливи, присъединителни с киселина соли. Изобретението се отнася и до нови междинни съединения с формулаСъединенията с формула I имат антиисхемичен ефект и намират приложение за третиране например на миокардна исхемия, индуцирана например чрез оклузия на коронарната артерия.
BG100954A 1994-05-06 1996-11-04 Нови производни на хидроксамови киселини, фармацевтични състави на тяхна основа и метод за получаването им BG63336B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9401488A HU219916B (hu) 1989-12-22 1994-05-06 Hidroximsav-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények, valamint egyes intermedierjeik
PCT/HU1995/000014 WO1995030649A1 (en) 1994-05-06 1995-05-04 Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (2)

Publication Number Publication Date
BG100954A true BG100954A (bg) 1997-08-29
BG63336B1 BG63336B1 (bg) 2001-10-31

Family

ID=10985174

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100954A BG63336B1 (bg) 1994-05-06 1996-11-04 Нови производни на хидроксамови киселини, фармацевтични състави на тяхна основа и метод за получаването им

Country Status (21)

Country Link
US (1) US5919796A (bg)
EP (1) EP0758315B1 (bg)
JP (1) JP3877762B2 (bg)
KR (1) KR100372312B1 (bg)
CN (1) CN1079789C (bg)
AT (1) ATE170170T1 (bg)
BG (1) BG63336B1 (bg)
BR (1) BR9507619A (bg)
CZ (1) CZ288824B6 (bg)
DE (1) DE69504329T2 (bg)
DK (1) DK0758315T3 (bg)
EE (1) EE03296B1 (bg)
ES (1) ES2123252T3 (bg)
FI (1) FI964436A (bg)
MX (1) MX9605376A (bg)
NO (1) NO307752B1 (bg)
NZ (1) NZ285151A (bg)
PL (1) PL179032B1 (bg)
RO (1) RO115873B1 (bg)
SK (1) SK281387B6 (bg)
WO (1) WO1995030649A1 (bg)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9502843D0 (en) * 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
HU222994B1 (hu) 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
WO2003057664A1 (en) 2002-01-11 2003-07-17 Biorex Kutató És Fejlesztö Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
BR0302750A (pt) * 2003-08-08 2005-03-29 Catarinense S A Lab Uso de produto compreendendo material vegetal das espécies trichilia sp. associada ou não para a reversão/combate da fibrilação ventricular; composição farmacêutica compreendendo o referido material vegetal para a reversão/combate da fibrilação ventricular; método para a reversão/combate da fibrilação ventricular usando o referido material vegetal; uso do referido material vegetal para a produção de uma composição farmacêutica para a reversão/combate da fibrilação ventricular
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
MX2009005798A (es) * 2006-12-01 2009-08-12 Cytrx Corp Recuperacion de apoplejia.
MX2023005954A (es) 2020-11-19 2023-09-04 Zevra Denmark As Procesos para preparar citrato de arimoclomol e intermediarios del mismo.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1110460B (it) * 1977-03-02 1985-12-23 Ciba Geigy Ag Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego
JPS608253A (ja) * 1983-06-28 1985-01-17 Showa Denko Kk ヒドロキシイミノブタノン誘導体及び殺虫剤
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
JPH068253A (ja) * 1992-06-29 1994-01-18 Kobe Steel Ltd プラスチック成形品用金型およびその製造方法

Also Published As

Publication number Publication date
KR100372312B1 (ko) 2003-05-09
ES2123252T3 (es) 1999-01-01
EP0758315B1 (en) 1998-08-26
MX9605376A (es) 1998-05-31
DE69504329D1 (de) 1998-10-01
NZ285151A (en) 1998-09-24
SK143096A3 (en) 1997-06-04
FI964436A (fi) 1996-11-27
US5919796A (en) 1999-07-06
NO964677L (no) 1996-11-05
EP0758315A1 (en) 1997-02-19
JPH09512815A (ja) 1997-12-22
DK0758315T3 (da) 1999-05-25
CZ325196A3 (en) 1997-06-11
DE69504329T2 (de) 1999-04-08
RO115873B1 (ro) 2000-07-28
NO307752B1 (no) 2000-05-22
AU2416195A (en) 1995-11-29
CN1151728A (zh) 1997-06-11
SK281387B6 (sk) 2001-03-12
ATE170170T1 (de) 1998-09-15
WO1995030649A1 (en) 1995-11-16
BR9507619A (pt) 1997-09-23
AU691284B2 (en) 1998-05-14
FI964436A0 (fi) 1996-11-05
CN1079789C (zh) 2002-02-27
BG63336B1 (bg) 2001-10-31
KR970702845A (ko) 1997-06-10
EE03296B1 (et) 2000-10-16
NO964677D0 (no) 1996-11-05
JP3877762B2 (ja) 2007-02-07
PL317154A1 (en) 1997-03-17
CZ288824B6 (cs) 2001-09-12
PL179032B1 (pl) 2000-07-31

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