DK0708110T3 - Fremstilling af sucralose uden mellemliggende isolering af krystallinsk sucralose-6-ester - Google Patents

Fremstilling af sucralose uden mellemliggende isolering af krystallinsk sucralose-6-ester

Info

Publication number
DK0708110T3
DK0708110T3 DK95307329T DK95307329T DK0708110T3 DK 0708110 T3 DK0708110 T3 DK 0708110T3 DK 95307329 T DK95307329 T DK 95307329T DK 95307329 T DK95307329 T DK 95307329T DK 0708110 T3 DK0708110 T3 DK 0708110T3
Authority
DK
Denmark
Prior art keywords
iii
sucralose
contg
mixt
give
Prior art date
Application number
DK95307329T
Other languages
Danish (da)
English (en)
Inventor
Juan L Navia
Robert E Walkup
David S Neiditch
Nicholas M Vernon
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26984204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0708110(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Application granted granted Critical
Publication of DK0708110T3 publication Critical patent/DK0708110T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04Disaccharides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fish Paste Products (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95307329T 1994-10-17 1995-10-16 Fremstilling af sucralose uden mellemliggende isolering af krystallinsk sucralose-6-ester DK0708110T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32395494A 1994-10-17 1994-10-17
US08/448,710 US5498709A (en) 1994-10-17 1995-05-24 Production of sucralose without intermediate isolation of crystalline sucralose-6-ester

Publications (1)

Publication Number Publication Date
DK0708110T3 true DK0708110T3 (da) 2001-04-17

Family

ID=26984204

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95307329T DK0708110T3 (da) 1994-10-17 1995-10-16 Fremstilling af sucralose uden mellemliggende isolering af krystallinsk sucralose-6-ester

Country Status (21)

Country Link
US (1) US5498709A (ja)
EP (1) EP0708110B1 (ja)
JP (1) JP4450436B2 (ja)
KR (1) KR100390629B1 (ja)
AT (1) ATE199723T1 (ja)
AU (1) AU707557B2 (ja)
BR (1) BR9504423A (ja)
CA (1) CA2160641C (ja)
DE (1) DE69520321T2 (ja)
DK (1) DK0708110T3 (ja)
ES (1) ES2157304T3 (ja)
FI (1) FI954908A (ja)
GR (1) GR3035878T3 (ja)
IL (1) IL115562A (ja)
MY (1) MY113405A (ja)
NO (1) NO304950B1 (ja)
NZ (1) NZ280208A (ja)
PE (1) PE37196A1 (ja)
PT (1) PT708110E (ja)
TR (1) TR199501279A2 (ja)
TW (1) TW331561B (ja)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9517281D0 (en) * 1995-08-23 1995-10-25 Tate & Lyle Plc Solid sucralose
US6075139A (en) * 1996-07-24 2000-06-13 Iowa State University Research Foundation, Inc. Linear and cyclic sucrose reaction products, their preparation and their use
EP0970096B1 (en) * 1997-02-13 2004-11-10 Tate & Lyle Public Limited Company Chromatographic purification of chlorinated sucrose
US5900478A (en) * 1997-06-20 1999-05-04 Iowa State University Research Foundation, Inc. Activated mono-, di-, and polysaccharides reaction products thereof, their preparation and uses
GB0008392D0 (en) * 2000-04-05 2000-05-24 Unilever Plc Process for the production of a deodorant or antiperspirant product
US6646121B2 (en) * 2000-11-17 2003-11-11 Mcneil-Ppc, Inc. Sucralose composition and process for its preparation
WO2002041705A2 (en) 2000-11-17 2002-05-30 Mcneil-Ppc, Inc. Meltable form of sucralose
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US7049435B2 (en) 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6998480B2 (en) * 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US6890581B2 (en) * 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
US20040030124A1 (en) * 2002-08-06 2004-02-12 Catani Steven J. Process for recovering chlorosucrose compounds
US6984732B2 (en) * 2003-03-31 2006-01-10 Mcneil-Ppc, Inc. High-intensity sweetener composition and delivery of same
US6943248B2 (en) * 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
WO2005090376A1 (en) * 2004-03-19 2005-09-29 Pharmed Medicare Private Limited An improved process for producing chlorinated sucrose
KR20080043194A (ko) * 2004-03-19 2008-05-16 팜드 메디케어 프리베이트 리미티드 향상된 염소화 수크로스의 제조 방법
US20050214425A1 (en) * 2004-03-23 2005-09-29 Roma Vazirani Sugar substitute prepared with nutritive and high-intensity sweeteners
US20060062811A1 (en) * 2004-09-21 2006-03-23 Szymczak Christopher E Medicinal cooling emulsions
US20080125584A1 (en) * 2004-12-10 2008-05-29 Rakesh Ratnam Salts Assisted Selective Extraction Of 6-Acetyl- 4,1' , 6' Trichlorogalactosucrose And 4,1', 6' Trichlorogalactosucrosse From Aqueous Reaction Mixture
US20080051574A1 (en) * 2004-12-10 2008-02-28 Rakesh Ratnam Control of Ph By Direct Addition of Carbonates and Bicarbonates During Concentration of Organics Solvent Extracts of 6-Acetyl-4,1',6' Trichlorogalactosucrose and 4,1',6' trichlorogalactosucrose
WO2006072965A2 (en) * 2005-01-03 2006-07-13 Pharmed Medicare Private Limited Sucrose-6-ester chlorination by co-addition of chlorination reagent.
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
US7750146B2 (en) * 2005-03-18 2010-07-06 Tate & Lyle Plc Granular sucralose
US20060247180A1 (en) * 2005-04-29 2006-11-02 Bergey James L Purgative composition and uses thereof
CN102124017A (zh) * 2005-06-01 2011-07-13 V.B.医疗保险私人有限公司 利用溶剂萃取法纯化氯化蔗糖衍生物的方法
US20060276639A1 (en) * 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
CA2620902A1 (en) * 2005-08-30 2007-05-10 Pharmed Medicare Pvt. Ltd. Novel method of extraction of 6-o-protected trichlorogalactose from the chlorinated mass
US7951937B2 (en) * 2005-08-30 2011-05-31 V.B. Medicare Private Limited Process for purification of trichlorogalactosucrose based on direct extraction in organic solvent from reaction mixture followed by evaporative removal of solvent
WO2007069269A1 (en) * 2005-10-20 2007-06-21 Pharmed Medicare Pvt. Ltd. Acid mediated deacylation of 6-0-trichlorogalactosucrose to trich-lorogalactosucrose.
US20070100139A1 (en) * 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
US20100184969A1 (en) * 2005-11-08 2010-07-22 Mangesh Rajadhyaksha Process to Prepare Sucralose
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN1814609B (zh) * 2006-03-06 2010-11-10 盐城捷康三氯蔗糖制造有限公司 一种提高三氯蔗糖合成收率的方法
GB2452870A (en) * 2006-04-27 2009-03-18 Vb Medicare Pvt Ltd Continuous neutralizer mixer reactor and a continuous process for quenching chlorination reaction mixture in production of chlorinated sucrose
BRPI0621844A2 (pt) * 2006-07-06 2013-03-19 Alembic Ltd processo aperfeiÇoado para a preparaÇço de sucralose de alta pureza
US20080031927A1 (en) * 2006-07-11 2008-02-07 Catani Steven J Solid oral dosage vitamin and mineral compositions
US8575333B2 (en) * 2006-09-14 2013-11-05 Bahram Memarzadeh Halogenated alkyl di- and trisaccharides, pharmaceutical formulations, diagnostic kits and methods of treatment
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
CN100591684C (zh) * 2006-12-27 2010-02-24 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖结晶方法
US20080227971A1 (en) * 2007-01-19 2008-09-18 Leinhos Duane A Deacylation of sucralose-6-acylates
GB0702857D0 (en) * 2007-01-19 2007-03-28 Tate & Lyle Plc Improved sucralose production method
CN101260126B (zh) * 2007-03-06 2010-12-22 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖的结晶方法
CN101386632B (zh) * 2007-09-12 2011-03-09 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖生产过程中回收叔酰胺溶剂的方法
CN101245085B (zh) * 2007-12-19 2012-02-01 上海同辰生物科技有限公司 一种三氯蔗糖的合成及纯化工艺
WO2009086049A2 (en) * 2007-12-27 2009-07-09 Mc Neil Nutritionals, Llc Synergistic sweetening compositions
CA2710628A1 (en) * 2007-12-27 2009-07-09 Mcneil Nutritionals, Llc Low calorie syrups
AR070082A1 (es) * 2008-01-04 2010-03-10 Tate & Lyle Technology Ltd Metodo para la produccion de sucralosa
US8557976B2 (en) * 2008-03-13 2013-10-15 Tate & Lyle Technology Limited Microbial consortia and methods for their use
KR20100130219A (ko) 2008-03-20 2010-12-10 테이트 앤드 라일 테크놀러지 리미티드 3급 아미드 용매로부터 산을 제거하는 방법
US8436157B2 (en) * 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
US20090259036A1 (en) * 2008-04-03 2009-10-15 Tate & Lyle Technology Limited Extraction of less polar impurities from sucralose containing aqueous feed streams
US8212022B2 (en) * 2008-04-03 2012-07-03 Tate & Lyle Technology Limited Effect of carbohydrate concentration on sucralose extraction efficiency
US20090299055A1 (en) * 2008-04-03 2009-12-03 Tate & Lyle Technology Limited Purification of Sucralose Containing Feed Streams for Sucralose Crystallization
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
US7862744B2 (en) * 2008-07-23 2011-01-04 Mamtek International Limited Methods and systems for preparing materials for sucralose production
AU2009279521A1 (en) * 2008-08-08 2010-02-11 Mcneil-Ppc, Inc. Use of sucralose as a granulating agent
GB2468936B (en) * 2009-03-27 2011-09-07 Mohamad Rami Radwan Jaber Chlorination of sucrose-6-esters
GB2469157B (en) * 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
GB2469158B (en) 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
GB2471348B (en) * 2009-06-22 2011-12-14 Tate & Lyle Technology Ltd A method for producing sucralose-6-acylate
GB2474311B (en) 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
GB2474310B (en) 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
WO2012071385A1 (en) 2010-11-23 2012-05-31 Lexington Pharmaceutical Laboratories, Llc Low temperature chlorination of carbohydrates
GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
RU2014102107A (ru) 2011-06-24 2015-08-10 Констракшн Рисёрч Энд Текнолоджи Гмбх Цементирующая композиция и присадка
EP2723695B1 (en) 2011-06-24 2017-01-04 Construction Research & Technology GmbH Cement additive
US8884004B2 (en) 2011-09-02 2014-11-11 Divi's Laboratories, Ltd. Process for the preparation of sucralose
ES2574261T3 (es) 2011-10-14 2016-06-16 Lexington Pharmaceuticals Laboratories, Llc Cloración de carbohidratos y derivados de carbohidratos
CN103087116A (zh) * 2011-11-07 2013-05-08 常茂生物化学工程股份有限公司 三氯蔗糖的制备方法
US9151747B1 (en) 2013-03-14 2015-10-06 Mercyhurst University Sucralose antibody and immunoassay
US10227367B2 (en) 2013-12-16 2019-03-12 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
GB2544217B (en) 2014-08-08 2020-03-25 Tate & Lyle Tech Ltd Chlorination of sucrose-6-esters
CN104387427A (zh) * 2014-10-30 2015-03-04 安徽金禾实业股份有限公司 一种三氯蔗糖的生产方法
GB2536480B (en) 2015-03-17 2019-09-04 Tate & Lyle Tech Ltd DMF Distillation
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
CN108191926A (zh) * 2018-01-10 2018-06-22 福建科宏生物工程股份有限公司 一种气相氯化剂制备三氯蔗糖-6-乙酸酯的方法
CN109180748B (zh) * 2018-10-12 2022-04-08 安徽金禾实业股份有限公司 一种三氯蔗糖氯化中和反应后溶剂的分离方法
CN111574394B (zh) * 2020-05-22 2022-08-19 安徽金禾实业股份有限公司 一种三氯蔗糖生产中含羧酸dmf的处理方法
MX2023003704A (es) 2020-09-30 2023-05-09 Anhui Jinhe Ind Co Ltd Método de purificación de sucralosa.
WO2022099606A1 (zh) * 2020-11-13 2022-05-19 安徽金禾实业股份有限公司 三氯蔗糖的提纯方法
CN112933635B (zh) * 2021-03-04 2022-04-12 安徽金禾实业股份有限公司 一种环绕离心式蔗糖-6-酯连续生产设备及生产方法
CN113767109A (zh) * 2021-08-04 2021-12-07 安徽金禾实业股份有限公司 三氯蔗糖的制备方法
CN115956082A (zh) * 2022-10-19 2023-04-11 安徽金禾实业股份有限公司 一种利用水解体系制备三氯蔗糖粗品的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3165986D1 (en) * 1980-07-08 1984-10-18 Tate & Lyle Plc Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs)
GB8617222D0 (en) * 1986-07-15 1986-08-20 Tate & Lyle Plc Sweetener
US4950746A (en) * 1988-07-18 1990-08-21 Noramco, Inc. Process for synthesizing sucrose derivatives by regioselective reaction
GB8822673D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Selective acylation of sugars
US4980463A (en) * 1989-07-18 1990-12-25 Noramco, Inc. Sucrose-6-ester chlorination
US5089608A (en) * 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
US5034551A (en) * 1990-04-23 1991-07-23 Noramco, Inc. Process for recovery of organotin esters from reaction mixtures containing the same and re-use of the recovered organotin compounds
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5136031A (en) * 1990-07-09 1992-08-04 Tate & Lyle Public Limited Company Chlorination of sugars
US5298611A (en) * 1993-03-12 1994-03-29 Mcneil-Ppc, Inc. Sucralose pentaester production

Also Published As

Publication number Publication date
PE37196A1 (es) 1996-09-24
ES2157304T3 (es) 2001-08-16
KR100390629B1 (ko) 2003-12-06
NO304950B1 (no) 1999-03-08
GR3035878T3 (en) 2001-08-31
AU3420195A (en) 1996-05-02
EP0708110A3 (en) 1996-08-07
MY113405A (en) 2002-02-28
FI954908A (fi) 1996-04-18
TW331561B (en) 1998-05-11
IL115562A0 (en) 1996-01-19
BR9504423A (pt) 1997-05-27
KR960014150A (ko) 1996-05-22
IL115562A (en) 2000-11-21
CA2160641A1 (en) 1996-04-18
NO954111L (no) 1996-04-18
EP0708110B1 (en) 2001-03-14
ATE199723T1 (de) 2001-03-15
DE69520321D1 (de) 2001-04-19
JP4450436B2 (ja) 2010-04-14
TR199501279A2 (tr) 1996-06-21
FI954908A0 (fi) 1995-10-16
NZ280208A (en) 1996-07-26
JPH08208679A (ja) 1996-08-13
DE69520321T2 (de) 2001-08-09
AU707557B2 (en) 1999-07-15
CA2160641C (en) 2007-03-20
US5498709A (en) 1996-03-12
NO954111D0 (no) 1995-10-16
PT708110E (pt) 2001-06-29
EP0708110A2 (en) 1996-04-24

Similar Documents

Publication Publication Date Title
DK0708110T3 (da) Fremstilling af sucralose uden mellemliggende isolering af krystallinsk sucralose-6-ester
JP2505817B2 (ja) スクロ―ス誘導体の製造法
US4980463A (en) Sucrose-6-ester chlorination
CA2114180A1 (en) Sucralose Pentaester Production
IL164404A0 (en) A process for producing sucralose and sucralose compositions prepared thereby
CA2404969A1 (en) Removal of chloride from phosphonomethyliminodiacetic acid process
AU8173987A (en) Process for producing effervescent granulates, effervescent granulates thus produced and their use
US5013828A (en) Preparation of diacyl derivatives of 2'-deoxy-5-fluorouridine via novel intermediate compound
WO2007069269A1 (en) Acid mediated deacylation of 6-0-trichlorogalactosucrose to trich-lorogalactosucrose.
EP0572521B1 (en) Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose.
AU2003243925A8 (en) Mpg added to fermentation
RU95118102A (ru) Получение сукралозы без промежуточного выделения кристаллического сукралоза-6-эфира
EP0842942A1 (en) D-pentofuranose derivatives and process for the preparation thereof
KR960037666A (ko) 1-(2-클로로페닐)-5(4h)-테트라졸리논의 제조방법
JP2579678B2 (ja) アントラサイクリン誘導体及びその製法
ITMI961595A1 (it) Procedimento per la preparazione di penicilline
JPH05202087A (ja) デスアラニンベナノマイシンa誘導体およびそれらの製造法
JPS6155912B2 (ja)
JPH06336489A (ja) ラクツロースの製造方法