GR3035878T3 - Production of sucralose without intermediate isolation of crystalline sucralose-6-ester - Google Patents

Production of sucralose without intermediate isolation of crystalline sucralose-6-ester

Info

Publication number
GR3035878T3
GR3035878T3 GR20010400731T GR20010400731T GR3035878T3 GR 3035878 T3 GR3035878 T3 GR 3035878T3 GR 20010400731 T GR20010400731 T GR 20010400731T GR 20010400731 T GR20010400731 T GR 20010400731T GR 3035878 T3 GR3035878 T3 GR 3035878T3
Authority
GR
Greece
Prior art keywords
iii
sucralose
contg
mixt
give
Prior art date
Application number
GR20010400731T
Other languages
English (en)
Inventor
Juan L Navia
Robert E Walkup
David S Neiditch
Nicholas M Vernon
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26984204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3035878(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Publication of GR3035878T3 publication Critical patent/GR3035878T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fish Paste Products (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR20010400731T 1994-10-17 2001-05-15 Production of sucralose without intermediate isolation of crystalline sucralose-6-ester GR3035878T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32395494A 1994-10-17 1994-10-17
US08/448,710 US5498709A (en) 1994-10-17 1995-05-24 Production of sucralose without intermediate isolation of crystalline sucralose-6-ester

Publications (1)

Publication Number Publication Date
GR3035878T3 true GR3035878T3 (en) 2001-08-31

Family

ID=26984204

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010400731T GR3035878T3 (en) 1994-10-17 2001-05-15 Production of sucralose without intermediate isolation of crystalline sucralose-6-ester

Country Status (21)

Country Link
US (1) US5498709A (el)
EP (1) EP0708110B1 (el)
JP (1) JP4450436B2 (el)
KR (1) KR100390629B1 (el)
AT (1) ATE199723T1 (el)
AU (1) AU707557B2 (el)
BR (1) BR9504423A (el)
CA (1) CA2160641C (el)
DE (1) DE69520321T2 (el)
DK (1) DK0708110T3 (el)
ES (1) ES2157304T3 (el)
FI (1) FI954908A (el)
GR (1) GR3035878T3 (el)
IL (1) IL115562A (el)
MY (1) MY113405A (el)
NO (1) NO304950B1 (el)
NZ (1) NZ280208A (el)
PE (1) PE37196A1 (el)
PT (1) PT708110E (el)
TR (1) TR199501279A2 (el)
TW (1) TW331561B (el)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9517281D0 (en) * 1995-08-23 1995-10-25 Tate & Lyle Plc Solid sucralose
US6075139A (en) 1996-07-24 2000-06-13 Iowa State University Research Foundation, Inc. Linear and cyclic sucrose reaction products, their preparation and their use
BR9807377B1 (pt) * 1997-02-13 2009-12-01 processo para separação de fase lìquida de uma sacarose clorada a partir de uma mistura de reação de sacarose clorada.
US5900478A (en) * 1997-06-20 1999-05-04 Iowa State University Research Foundation, Inc. Activated mono-, di-, and polysaccharides reaction products thereof, their preparation and uses
GB0008392D0 (en) * 2000-04-05 2000-05-24 Unilever Plc Process for the production of a deodorant or antiperspirant product
RU2265375C2 (ru) 2000-11-17 2005-12-10 Тейт Энд Лайл Паблик Лимитед Компани Плавкий, содержащий сукралозу подсластитель
EP1339728B1 (en) * 2000-11-17 2013-02-27 Tate & Lyle Technology Limited Improved sucralose composition and process for the crystallization thereof
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US7049435B2 (en) 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6998480B2 (en) * 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US6890581B2 (en) * 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
US20040030124A1 (en) * 2002-08-06 2004-02-12 Catani Steven J. Process for recovering chlorosucrose compounds
US6984732B2 (en) * 2003-03-31 2006-01-10 Mcneil-Ppc, Inc. High-intensity sweetener composition and delivery of same
US6943248B2 (en) * 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
WO2005090376A1 (en) * 2004-03-19 2005-09-29 Pharmed Medicare Private Limited An improved process for producing chlorinated sucrose
NZ550064A (en) * 2004-03-19 2010-06-25 V B Medicare Private Ltd An improved process for producing chlorinated sucrose (sucralose)
US20050214425A1 (en) * 2004-03-23 2005-09-29 Roma Vazirani Sugar substitute prepared with nutritive and high-intensity sweeteners
US20060062811A1 (en) * 2004-09-21 2006-03-23 Szymczak Christopher E Medicinal cooling emulsions
CN101098970B (zh) * 2004-12-10 2010-05-12 V.B.医疗保险私人有限公司 通过在6-乙酰基-4,1',6'三氯半乳蔗糖和4,1',6'三氯半乳蔗糖的有机溶剂提取物的浓缩过程中直接加入碳酸盐和碳酸氢盐来调节pH的方法
CN101098971B (zh) * 2004-12-10 2010-04-21 V.B.医疗保险私人有限公司 有助于从含水反应混合物中选择性萃取4,1',6'三氯半乳蔗糖的盐
US20080004439A1 (en) * 2005-01-03 2008-01-03 Rakesh Ratnam Sucrose-6-Ester Chlorination by Co-Addition of Chlorination Reagent
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
US7750146B2 (en) 2005-03-18 2010-07-06 Tate & Lyle Plc Granular sucralose
US20060247180A1 (en) * 2005-04-29 2006-11-02 Bergey James L Purgative composition and uses thereof
KR20080016826A (ko) * 2005-06-01 2008-02-22 팜드 메디케어 프리베이트 리미티드 용매 추출에 의한 염소화 수크로스 유도체의 정제 방법
US20060276639A1 (en) * 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
CN101253188A (zh) * 2005-08-30 2008-08-27 法马德医疗保险私人有限公司 从氯化物中提取6-o-保护的三氯半乳糖的新方法
CN101263153A (zh) * 2005-08-30 2008-09-10 法马德医疗保险私人有限公司 基于疏水亲和色谱层析生产氯化蔗糖的方法
CA2626602A1 (en) * 2005-10-20 2007-06-21 Pharmed Medicare Pvt. Ltd. Acid mediated deacylation of 6-0-trichlorogalactosucrose to trich-lorogalactosucrose
US20070100139A1 (en) * 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
EP1948673A4 (en) * 2005-11-08 2009-09-23 Camlin Fine Chemicals Ltd PROCESS FOR THE PRODUCTION OF SUCRALOSE
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN1814609B (zh) * 2006-03-06 2010-11-10 盐城捷康三氯蔗糖制造有限公司 一种提高三氯蔗糖合成收率的方法
WO2007125543A1 (en) * 2006-04-27 2007-11-08 V. B. Medicare Pvt. Ltd. Continuous neutralizer mixer reactor and a continuous process for quenching chlorination reaction mixture in production of chlorinated sucrose
US20090312538A1 (en) * 2006-07-06 2009-12-17 Alembic Limited process for the preparation of sucralose of high purity
WO2008008801A2 (en) * 2006-07-11 2008-01-17 Mcneil Nutritionals, Llc Solid oral dosage vitamin and mineral compositions
WO2008033543A2 (en) * 2006-09-14 2008-03-20 Bahram Memarzadeh Halogenated alkyl di- and trisaccharides, pharmaceutical formulations, diagnostic kits and methods of treatment
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
CN100591684C (zh) * 2006-12-27 2010-02-24 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖结晶方法
US20080227971A1 (en) * 2007-01-19 2008-09-18 Leinhos Duane A Deacylation of sucralose-6-acylates
GB0702857D0 (en) * 2007-01-19 2007-03-28 Tate & Lyle Plc Improved sucralose production method
CN101260126B (zh) * 2007-03-06 2010-12-22 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖的结晶方法
CN101386632B (zh) * 2007-09-12 2011-03-09 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖生产过程中回收叔酰胺溶剂的方法
CN101245085B (zh) * 2007-12-19 2012-02-01 上海同辰生物科技有限公司 一种三氯蔗糖的合成及纯化工艺
CA2710628A1 (en) * 2007-12-27 2009-07-09 Mcneil Nutritionals, Llc Low calorie syrups
CA2710629C (en) * 2007-12-27 2016-06-21 Mcneil Nutritionals, Llc Synergistic sweetening compositions
US8436156B2 (en) * 2008-01-04 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
US8557976B2 (en) * 2008-03-13 2013-10-15 Tate & Lyle Technology Limited Microbial consortia and methods for their use
KR20100130219A (ko) 2008-03-20 2010-12-10 테이트 앤드 라일 테크놀러지 리미티드 ３급 아미드 용매로부터 산을 제거하는 방법
US8436157B2 (en) * 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
EP2260049B1 (en) * 2008-04-03 2013-02-27 Tate & Lyle Technology Limited Effect of carbohydrate concentration on sucralose extraction efficiency
US20090299055A1 (en) * 2008-04-03 2009-12-03 Tate & Lyle Technology Limited Purification of Sucralose Containing Feed Streams for Sucralose Crystallization
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
WO2009124113A1 (en) * 2008-04-03 2009-10-08 Tate & Lyle Technology Ltd. Extraction of less polar impurities from sucralose containing aqueous feed streams
US7862744B2 (en) * 2008-07-23 2011-01-04 Mamtek International Limited Methods and systems for preparing materials for sucralose production
CA2732105A1 (en) * 2008-08-08 2010-02-11 Mcneil-Ppc, Inc. Use of sucralose as a granulating agent
GB2468936B (en) * 2009-03-27 2011-09-07 Mohamad Rami Radwan Jaber Chlorination of sucrose-6-esters
GB2469157B (en) 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
GB2469158B (en) 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
GB2471348B (en) * 2009-06-22 2011-12-14 Tate & Lyle Technology Ltd A method for producing sucralose-6-acylate
GB2474310B (en) 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
GB2474311B (en) * 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
WO2012071385A1 (en) 2010-11-23 2012-05-31 Lexington Pharmaceutical Laboratories, Llc Low temperature chlorination of carbohydrates
GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
WO2012175582A1 (en) 2011-06-24 2012-12-27 Construction Research & Technology Gmbh Cementitious composition and admixture
EP2723695B1 (en) 2011-06-24 2017-01-04 Construction Research & Technology GmbH Cement additive
US8884004B2 (en) 2011-09-02 2014-11-11 Divi's Laboratories, Ltd. Process for the preparation of sucralose
MX342969B (es) 2011-10-14 2016-10-20 Lexington Pharmaceuticals Laboratories Llc Cloracion de carbohidratos y derivados de carbohidratos.
CN103087116A (zh) * 2011-11-07 2013-05-08 常茂生物化学工程股份有限公司 三氯蔗糖的制备方法
US9151747B1 (en) 2013-03-14 2015-10-06 Mercyhurst University Sucralose antibody and immunoassay
CN105829332B (zh) 2013-12-16 2018-10-02 塔特和莱利技术有限公司 蔗糖-6-酯的氯化
GB2544217B (en) 2014-08-08 2020-03-25 Tate & Lyle Tech Ltd Chlorination of sucrose-6-esters
CN104387427A (zh) * 2014-10-30 2015-03-04 安徽金禾实业股份有限公司 一种三氯蔗糖的生产方法
GB2536480B (en) 2015-03-17 2019-09-04 Tate & Lyle Tech Ltd DMF Distillation
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
CN108191926A (zh) * 2018-01-10 2018-06-22 福建科宏生物工程股份有限公司 一种气相氯化剂制备三氯蔗糖-6-乙酸酯的方法
CN109180748B (zh) * 2018-10-12 2022-04-08 安徽金禾实业股份有限公司 一种三氯蔗糖氯化中和反应后溶剂的分离方法
CN111574394B (zh) * 2020-05-22 2022-08-19 安徽金禾实业股份有限公司 一种三氯蔗糖生产中含羧酸dmf的处理方法
WO2022067621A1 (zh) 2020-09-30 2022-04-07 安徽金禾实业股份有限公司 三氯蔗糖的纯化方法
CN112585151A (zh) * 2020-11-13 2021-03-30 安徽金禾实业股份有限公司 三氯蔗糖的提纯方法
CN112933635B (zh) * 2021-03-04 2022-04-12 安徽金禾实业股份有限公司 一种环绕离心式蔗糖-6-酯连续生产设备及生产方法
WO2023010323A1 (zh) * 2021-08-04 2023-02-09 安徽金禾实业股份有限公司 三氯蔗糖的制备方法
WO2024082177A1 (zh) * 2022-10-19 2024-04-25 安徽金禾实业股份有限公司 一种利用水解体系制备三氯蔗糖粗品的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043649B1 (en) * 1980-07-08 1984-09-12 TATE & LYLE PUBLIC LIMITED COMPANY Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs)
GB8617222D0 (en) * 1986-07-15 1986-08-20 Tate & Lyle Plc Sweetener
US4950746A (en) * 1988-07-18 1990-08-21 Noramco, Inc. Process for synthesizing sucrose derivatives by regioselective reaction
GB8822673D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Selective acylation of sugars
US4980463A (en) * 1989-07-18 1990-12-25 Noramco, Inc. Sucrose-6-ester chlorination
US5089608A (en) * 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
US5034551A (en) * 1990-04-23 1991-07-23 Noramco, Inc. Process for recovery of organotin esters from reaction mixtures containing the same and re-use of the recovered organotin compounds
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5136031A (en) * 1990-07-09 1992-08-04 Tate & Lyle Public Limited Company Chlorination of sugars
US5298611A (en) * 1993-03-12 1994-03-29 Mcneil-Ppc, Inc. Sucralose pentaester production

Also Published As

Publication number Publication date
TR199501279A2 (tr) 1996-06-21
KR100390629B1 (ko) 2003-12-06
KR960014150A (ko) 1996-05-22
DE69520321T2 (de) 2001-08-09
DK0708110T3 (da) 2001-04-17
FI954908A (fi) 1996-04-18
CA2160641A1 (en) 1996-04-18
US5498709A (en) 1996-03-12
EP0708110A2 (en) 1996-04-24
EP0708110B1 (en) 2001-03-14
EP0708110A3 (en) 1996-08-07
FI954908A0 (fi) 1995-10-16
MY113405A (en) 2002-02-28
JPH08208679A (ja) 1996-08-13
NO304950B1 (no) 1999-03-08
IL115562A0 (en) 1996-01-19
CA2160641C (en) 2007-03-20
ATE199723T1 (de) 2001-03-15
AU707557B2 (en) 1999-07-15
PT708110E (pt) 2001-06-29
BR9504423A (pt) 1997-05-27
PE37196A1 (es) 1996-09-24
ES2157304T3 (es) 2001-08-16
JP4450436B2 (ja) 2010-04-14
NZ280208A (en) 1996-07-26
IL115562A (en) 2000-11-21
DE69520321D1 (de) 2001-04-19
TW331561B (en) 1998-05-11
AU3420195A (en) 1996-05-02
NO954111D0 (no) 1995-10-16
NO954111L (no) 1996-04-18

Similar Documents

Publication Publication Date Title
GR3035878T3 (en) Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
CA2114180A1 (en) Sucralose Pentaester Production
FI95802C (fi) Sakkaroosi-6-esterin parannettu klooraus
JPH08208681A (ja) スクロース誘導体の製造法
IL164404A0 (en) A process for producing sucralose and sucralose compositions prepared thereby
NO983867L (no) FremgangsmÕte og apparat for fremstilling av vandig klordioksid
CA2404969A1 (en) Removal of chloride from phosphonomethyliminodiacetic acid process
AU8173987A (en) Process for producing effervescent granulates, effervescent granulates thus produced and their use
US20080300391A1 (en) Acid Mediated Deacylation of 6-0-Trichlorogalactosurcrose to Trich-Lorogalactosucrose
CA2187210A1 (en) Method for purifying diacetylrhein
EP0572521B1 (en) Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose.
CA2027514A1 (en) Process for the recovery of rhodium from distillation residues of products of the oxo synthesis
Guest et al. 6α-fluoroalkyl penicillins
AU2003243925A8 (en) Mpg added to fermentation
US5811540A (en) 5-O-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, and production method and use thereof
EP0148146A3 (en) Hydrolysis of nitrilotriacetonitrile
CA2205535A1 (en) Sucralose pentaester production
JPS631955B2 (el)
JPH06336489A (ja) ラクツロースの製造方法
JPS6155912B2 (el)
JPH06321979A (ja) ラクツロースの製造方法

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees