DK0516410T3 - Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser - Google Patents

Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser

Info

Publication number
DK0516410T3
DK0516410T3 DK92304837T DK92304837T DK0516410T3 DK 0516410 T3 DK0516410 T3 DK 0516410T3 DK 92304837 T DK92304837 T DK 92304837T DK 92304837 T DK92304837 T DK 92304837T DK 0516410 T3 DK0516410 T3 DK 0516410T3
Authority
DK
Denmark
Prior art keywords
vitamin
compounds
synthesis
hitherto unknown
alpha
Prior art date
Application number
DK92304837T
Other languages
Danish (da)
English (en)
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Rolf E Swenson
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of DK0516410T3 publication Critical patent/DK0516410T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92304837T 1991-05-28 1992-05-28 Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser DK0516410T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70591791A 1991-05-28 1991-05-28

Publications (1)

Publication Number Publication Date
DK0516410T3 true DK0516410T3 (da) 1998-10-26

Family

ID=24835479

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92304837T DK0516410T3 (da) 1991-05-28 1992-05-28 Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser

Country Status (11)

Country Link
US (7) US5281731A (es)
EP (1) EP0516410B1 (es)
JP (4) JP2648845B2 (es)
KR (3) KR0160784B1 (es)
AT (1) ATE168996T1 (es)
AU (2) AU650751B2 (es)
CA (2) CA2191993C (es)
DE (1) DE69226402T2 (es)
DK (1) DK0516410T3 (es)
ES (1) ES2118794T3 (es)
IE (1) IE921700A1 (es)

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US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
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US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
KR970707089A (ko) * 1994-11-21 1997-12-01 리차드 에이취. 리이저 18, 19-디노르-비타민 D 화합물(18,19-Dinor-Vitamin D Compounds)
US5597815A (en) * 1995-07-13 1997-01-28 Wisconsin Alumni Research Foundation Prevention of hyperphosphatemia in kidney disorder patients
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6392071B1 (en) 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6306844B1 (en) 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US5945410A (en) * 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6316642B1 (en) 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
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AU762481C (en) * 1998-03-27 2004-08-19 Oregon Health Sciences University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
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US6114317A (en) 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
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IL152942A (en) 2000-05-31 2007-09-20 Wisconsin Alumni Res Found Compounds 2 - Ethyl and 2 - Ethylaidine - 19 - Nur - Vitamin D and pharmaceutical preparations containing them
JP4811547B2 (ja) * 2000-10-24 2011-11-09 史衛 佐藤 光学活性シクロヘキセン化合物の製造法及びこの製造に用いる光学活性シクロヘキセン誘導体
US6683219B2 (en) * 2001-07-30 2004-01-27 Wisconsin Alumni Research Foundation Synthesis of A-ring synthon of 19-nor-1α,25-dihydroxyvitamin D3 from (D)-glucose
US20040258801A1 (en) * 2001-09-27 2004-12-23 Alvin Ling Vitamin fortification of foodstuffs
US6846811B2 (en) * 2002-04-22 2005-01-25 Wisconsin Alumni Research Foundation (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
US7023347B2 (en) * 2002-08-02 2006-04-04 Symbol Technologies, Inc. Method and system for forming a die frame and for transferring dies therewith
ATE556999T1 (de) 2003-04-10 2012-05-15 Wisconsin Alumni Res Found 2-propyliden-19-nor-vitamin d verbindungen
US20040250417A1 (en) * 2003-06-12 2004-12-16 Arneson Michael R. Method, system, and apparatus for transfer of dies using a die plate
US6894037B2 (en) 2003-07-03 2005-05-17 Wisconsin Alumni Research Foundation 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en) 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
WO2006012358A2 (en) * 2004-06-29 2006-02-02 Symbol Technologies, Inc. Systems and methods for testing radio frequency identification tags
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US20060225273A1 (en) * 2005-03-29 2006-10-12 Symbol Technologies, Inc. Transferring die(s) from an intermediate surface to a substrate
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US20070131016A1 (en) * 2005-12-13 2007-06-14 Symbol Technologies, Inc. Transferring die(s) from an intermediate surface to a substrate
US20070139057A1 (en) * 2005-12-15 2007-06-21 Symbol Technologies, Inc. System and method for radio frequency identification tag direct connection test
US20090177002A1 (en) 2006-03-15 2009-07-09 Asako Toyoda Method For Preparing Indene Derivatives, And Intermediates For Preparation Of Derivatives
US8058265B2 (en) 2006-04-05 2011-11-15 Wisconsin Alumni Research Foundation 1a-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and treatment thereof
US20070244657A1 (en) * 2006-04-11 2007-10-18 Drago Randall A Methods and systems for testing radio frequency identification (RFID) tags having multiple antennas
AU2007314966A1 (en) 2006-11-02 2008-05-08 Mercian Corporation Process for production of 1-hydroxy-19-norcyclovitamin D derivative and intermediate for the production
JP5480131B2 (ja) 2007-05-30 2014-04-23 シトクロマ インコーポレイテッド ホスフィンオキシドビタミンｄ前駆物質の製造方法
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
US20090275768A1 (en) 2008-04-30 2009-11-05 Formosa Laboratories, Inc. Preparation of Paricalcitol
US8013176B2 (en) * 2008-09-11 2011-09-06 Alphora Research Inc. Paricalcitol purification
CA2639477C (en) * 2008-09-11 2016-03-22 Alphora Research Inc. Paricalcitol purification
EA026334B1 (ru) 2009-01-27 2017-03-31 БЕРГ ЭлЭлСи Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
CN101671288B (zh) * 2009-10-14 2013-10-30 兰州大学 帕立骨化醇的中间体的制备方法
CN112156097A (zh) 2013-05-29 2021-01-01 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
CN107501317B (zh) * 2017-09-13 2019-08-16 上海皓元医药股份有限公司 一种帕立骨化醇中间体的制备方法

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Also Published As

Publication number Publication date
JP3320025B2 (ja) 2002-09-03
US5563286A (en) 1996-10-08
KR0160784B1 (ko) 1999-01-15
DE69226402D1 (de) 1998-09-03
US5597932A (en) 1997-01-28
JPH09118641A (ja) 1997-05-06
KR0160936B1 (ko) 1999-01-15
JP2648845B2 (ja) 1997-09-03
DE69226402T2 (de) 1998-12-10
ATE168996T1 (de) 1998-08-15
KR920021505A (ko) 1992-12-18
CA2069374A1 (en) 1992-11-29
US5281731A (en) 1994-01-25
CA2069374C (en) 1999-08-31
EP0516410A3 (en) 1993-06-30
ES2118794T3 (es) 1998-10-01
EP0516410B1 (en) 1998-07-29
IE921700A1 (en) 1992-12-02
EP0516410A2 (en) 1992-12-02
US5391755A (en) 1995-02-21
AU659774B2 (en) 1995-05-25
JPH11240891A (ja) 1999-09-07
KR0160937B1 (ko) 1999-01-15
US5581006A (en) 1996-12-03
US5486636A (en) 1996-01-23
AU1712092A (en) 1992-12-03
AU5932594A (en) 1994-06-02
JP2926008B2 (ja) 1999-07-28
US5616759A (en) 1997-04-01
CA2191993A1 (en) 1992-11-29
AU650751B2 (en) 1994-06-30
CA2191993C (en) 2002-07-09
JP3494637B2 (ja) 2004-02-09
JPH05221960A (ja) 1993-08-31
JP2002201197A (ja) 2002-07-16

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