DK0516410T3 - Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser - Google Patents

Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser

Info

Publication number
DK0516410T3
DK0516410T3 DK92304837T DK92304837T DK0516410T3 DK 0516410 T3 DK0516410 T3 DK 0516410T3 DK 92304837 T DK92304837 T DK 92304837T DK 92304837 T DK92304837 T DK 92304837T DK 0516410 T3 DK0516410 T3 DK 0516410T3
Authority
DK
Denmark
Prior art keywords
vitamin
compounds
synthesis
hitherto unknown
alpha
Prior art date
Application number
DK92304837T
Other languages
English (en)
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Rolf E Swenson
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of DK0516410T3 publication Critical patent/DK0516410T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92304837T 1991-05-28 1992-05-28 Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser DK0516410T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70591791A 1991-05-28 1991-05-28

Publications (1)

Publication Number Publication Date
DK0516410T3 true DK0516410T3 (da) 1998-10-26

Family

ID=24835479

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92304837T DK0516410T3 (da) 1991-05-28 1992-05-28 Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser

Country Status (11)

Country Link
US (7) US5281731A (da)
EP (1) EP0516410B1 (da)
JP (4) JP2648845B2 (da)
KR (3) KR0160784B1 (da)
AT (1) ATE168996T1 (da)
AU (2) AU650751B2 (da)
CA (2) CA2069374C (da)
DE (1) DE69226402T2 (da)
DK (1) DK0516410T3 (da)
ES (1) ES2118794T3 (da)
IE (1) IE921700A1 (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
US5464866A (en) * 1992-08-17 1995-11-07 Alcon Laboratories, Inc. Substituted hydrindanes for the treatment of angiogenesis-dependent diseases
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
DE69400495T2 (de) * 1993-04-05 1997-04-30 Wisconsin Alumni Res Found 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
ATE251133T1 (de) * 1993-07-09 2003-10-15 Theramex Neue strukturelle vitamin d derivate
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
EP0793649B1 (en) * 1994-11-21 1999-02-03 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin d compounds
US5597815A (en) * 1995-07-13 1997-01-28 Wisconsin Alumni Research Foundation Prevention of hyperphosphatemia in kidney disorder patients
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6316642B1 (en) 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US6392071B1 (en) 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6306844B1 (en) 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
DE69804606T2 (de) * 1997-05-23 2002-11-07 Basilea Pharmaceutica Ag Binni Cyclohexandiolderivate
US5936105A (en) * 1997-06-13 1999-08-10 Tetrionics, Inc. 14-EPI-19-nor-vitamin D compounds and methods
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
EP1064000B1 (en) * 1998-03-27 2011-07-06 Oregon Health & Science University Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
US6114317A (en) * 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
US6603030B1 (en) * 1999-04-22 2003-08-05 Hoffman-La Roche Inc. Process for producing phosphineoxide vitamin D precursors
US6310262B1 (en) 1999-10-18 2001-10-30 Basilea Pharmaceutica Ag Process for preparing retiferol derivatives
DE10019861A1 (de) * 2000-04-18 2001-10-31 Schering Ag Neues Synthesezwischenprodukt, seine mikrobiologische Herstellung und Verwendung zur Synthese von Vitamin D-Derivaten
US6806262B2 (en) 2000-05-31 2004-10-19 Wisconsin Alumni Research Foundation 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds
JP4811547B2 (ja) * 2000-10-24 2011-11-09 史衛 佐藤 光学活性シクロヘキセン化合物の製造法及びこの製造に用いる光学活性シクロヘキセン誘導体
US6683219B2 (en) * 2001-07-30 2004-01-27 Wisconsin Alumni Research Foundation Synthesis of A-ring synthon of 19-nor-1α,25-dihydroxyvitamin D3 from (D)-glucose
CA2461295A1 (en) * 2001-09-27 2003-04-03 The Coca-Cola Company Vitamin fortification of foodstuffs
US6846811B2 (en) * 2002-04-22 2005-01-25 Wisconsin Alumni Research Foundation (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
US7023347B2 (en) * 2002-08-02 2006-04-04 Symbol Technologies, Inc. Method and system for forming a die frame and for transferring dies therewith
US20060293291A1 (en) 2003-04-10 2006-12-28 Deluca Hector F 2-Propylidene-19-nor-vitamin d compounds
US7404199B2 (en) * 2003-06-12 2008-07-22 Symbol Technologies, Inc. Method, system, and apparatus for high volume assembly of compact discs and digital video discs incorporating radio frequency identification tag technology
US6894037B2 (en) 2003-07-03 2005-05-17 Wisconsin Alumni Research Foundation 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en) 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
US20060012387A1 (en) * 2004-06-29 2006-01-19 Symbol Technologies, Inc. Systems and methods for testing radio frequency identification tags
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US20060225273A1 (en) * 2005-03-29 2006-10-12 Symbol Technologies, Inc. Transferring die(s) from an intermediate surface to a substrate
WO2007011951A2 (en) * 2005-07-18 2007-01-25 Teva Pharmaceutical Industries Ltd. Purification of paricalcitol
US20070107186A1 (en) * 2005-11-04 2007-05-17 Symbol Technologies, Inc. Method and system for high volume transfer of dies to substrates
US20070131016A1 (en) * 2005-12-13 2007-06-14 Symbol Technologies, Inc. Transferring die(s) from an intermediate surface to a substrate
US20070139057A1 (en) * 2005-12-15 2007-06-21 Symbol Technologies, Inc. System and method for radio frequency identification tag direct connection test
EP2011781B1 (en) 2006-03-15 2014-03-05 MicroBiopharm Japan Co., Ltd. Process for production of indene derivative, and intermediate for production of the derivative
NZ571896A (en) 2006-04-05 2011-09-30 Wisconsin Alumni Res Found 1-Alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and use thereof
US20070244657A1 (en) * 2006-04-11 2007-10-18 Drago Randall A Methods and systems for testing radio frequency identification (RFID) tags having multiple antennas
US20110319644A1 (en) 2006-11-02 2011-12-29 Asako Toyoda Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
JP5480131B2 (ja) 2007-05-30 2014-04-23 シトクロマ インコーポレイテッド ホスフィンオキシドビタミンｄ前駆物質の製造方法
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
US20090275768A1 (en) 2008-04-30 2009-11-05 Formosa Laboratories, Inc. Preparation of Paricalcitol
CA2639477C (en) * 2008-09-11 2016-03-22 Alphora Research Inc. Paricalcitol purification
US8013176B2 (en) * 2008-09-11 2011-09-06 Alphora Research Inc. Paricalcitol purification
CN107019795A (zh) * 2009-01-27 2017-08-08 博格有限责任公司 用于减轻与化疗有关的副作用的维生素d3化合物
MX366076B (es) 2009-08-14 2019-06-27 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
CN101671288B (zh) * 2009-10-14 2013-10-30 兰州大学 帕立骨化醇的中间体的制备方法
NZ714801A (en) 2013-05-29 2021-07-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN107501317B (zh) * 2017-09-13 2019-08-16 上海皓元医药股份有限公司 一种帕立骨化醇中间体的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607118A (en) * 1981-04-30 1986-08-19 Philip Morris Incorporated Flavor-release β-hydroxy-ester compositions
EP0115314B1 (de) * 1983-01-28 1988-06-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Cholecalciferolderivaten
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
ATE40106T1 (de) * 1983-05-18 1989-02-15 Ciba Geigy Ag Cyclohexandion-carbonsaeurederivate mit herbizider und das pflanzenwachstum regulierender wirkung.
US4668817A (en) * 1983-12-21 1987-05-26 International Flavors & Fragrances Inc. Alkyl substituted para-carboalkoxy cyclohexanones
US4681976A (en) * 1983-12-21 1987-07-21 International Flavors & Fragrances Inc. Process for preparing alkyl substituted and unsubstituted para-carboalkoxy cyclohexanones
AU575373B2 (en) * 1984-02-08 1988-07-28 F. Hoffmann-La Roche Ag Calciferol derivatives
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
US4755329A (en) * 1985-06-10 1988-07-05 Wisconsin Alumni Research Foundation Process and intermediates for preparing 1α-hydroxyvitamin D compounds
EP0227826B1 (en) * 1985-08-02 1989-10-25 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
IL77668A (en) * 1986-01-21 1989-03-31 Teva Pharma Production of cholecalciferol derivatives and novel intermediates used therefor
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4847012A (en) * 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US5232836A (en) * 1988-05-04 1993-08-03 Ire-Medgenix S.A. Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D
FR2631025B1 (fr) * 1988-05-04 1991-04-12 Ire Medgenix Sa Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3
GB8904153D0 (en) * 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5086191A (en) * 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds

Also Published As

Publication number Publication date
AU5932594A (en) 1994-06-02
JPH11240891A (ja) 1999-09-07
ATE168996T1 (de) 1998-08-15
JPH05221960A (ja) 1993-08-31
AU650751B2 (en) 1994-06-30
DE69226402D1 (de) 1998-09-03
US5281731A (en) 1994-01-25
CA2191993A1 (en) 1992-11-29
JP3320025B2 (ja) 2002-09-03
EP0516410B1 (en) 1998-07-29
DE69226402T2 (de) 1998-12-10
KR0160936B1 (ko) 1999-01-15
KR0160937B1 (ko) 1999-01-15
US5563286A (en) 1996-10-08
US5597932A (en) 1997-01-28
EP0516410A3 (en) 1993-06-30
US5486636A (en) 1996-01-23
US5391755A (en) 1995-02-21
KR0160784B1 (ko) 1999-01-15
AU1712092A (en) 1992-12-03
AU659774B2 (en) 1995-05-25
JPH09118641A (ja) 1997-05-06
KR920021505A (ko) 1992-12-18
EP0516410A2 (en) 1992-12-02
CA2069374A1 (en) 1992-11-29
US5581006A (en) 1996-12-03
JP2648845B2 (ja) 1997-09-03
CA2191993C (en) 2002-07-09
CA2069374C (en) 1999-08-31
JP2926008B2 (ja) 1999-07-28
JP2002201197A (ja) 2002-07-16
JP3494637B2 (ja) 2004-02-09
ES2118794T3 (es) 1998-10-01
US5616759A (en) 1997-04-01
IE921700A1 (en) 1992-12-02

Similar Documents

Publication Publication Date Title
DK0516410T3 (da) Hidtil ukendt syntese af 19-nor-vitamin D-forbindelser
DK188590A (da) Forbedring af reproduktionsevne
DK0474517T3 (da) Hidtil ukendt anvendelse af 1alfa-hydroxyleret-19-nor-vitamin D-
ES2085898T3 (es) Tratamiento de la enfermedad hepatobiliar con compuestos 15-cetoprostaglandina.
EP0126651A3 (en) 2,4-dihydro-5-((substituted)phenyl)-4,4-disubstituted-3h-pyrazol-3-ones, 2,4-dihydro-5-((substituted)phenyl)-4, 4-disubstituted-3h-pyrazol-3-thiones, and a process for producing the same
JPS57122038A (en) Pure enanthiomer of bicyclo(2,2,2)oct-5- ene-2-one, manufacture and use
DE3061398D1 (en) Substituted alkylammonium salts, their preparation and use in plant growth regulation
IT8109380A0 (it) Procedimento ed attrezzatura per la realizzazione di calzature aperte con fondo stampato in resina, e calzature cosi' realizzate
JPS51124197A (en) A resin composition
ATE117693T1 (de) P-substituierte propanphosphinsäureverbindungen.
DE3683158D1 (de) Faerbende zusammensetzung.
DK96379A (da) Fremgangsmaade til fremstilling af disubstituerede 2,3-dihydroimidazo (1,2-c)-pyrimidiner
JPS559465A (en) Light polymerizable resin composition for hybrid ic coating
DE69128763T2 (de) Zusammensetzung, die Polyetherverbindungen enthält, Prozess zu ihrer Herstellung sowie Licht härtbare Harzzusammensetzungen
JPS5325655A (en) Composition used for the formation of film
IT8420577A1 (it) "procedimento per la fabbricazione di suole di scarpe stampo per l'esecuzione di questo procedimento"
ATE32063T1 (de) Iminosulfonamide und verfahren zu ihrer herstellung, die pharmazeutische praeparate solche verbindungen enthalten, sowie die verbindungen zur verwendung.
JPS5340746A (en) Organophosphorous compound and chlorine-containing resin composition
DK391482A (da) Fremgangsmaade til fremstilling af ren 6,6-diiodpenicillansyre ved diazotering af 6beta-aminopenicillansyre i naervaer af iod
JPS5432071A (en) Manufacture of semiconductor element
JPS5298100A (en) Curing of epoxy resins
NL7608865A (en) Emergency tooth filling - comprising clove oil, oil of cajeput, oil of cinnamon, turpentine oil, almond oil and yellow wax
IT7850577A0 (it) Procedimento di fabbricazione di una calzatura per una diretta traspirazione del piede e calzatura co si' prodotta
JPS5436492A (en) Pressure type reactor
JPS52148612A (en) Fva and its preparation