ES2118794T3 - Nueva sintesis de compuestos de 19-nor-vitamina d. - Google Patents

Nueva sintesis de compuestos de 19-nor-vitamina d.

Info

Publication number
ES2118794T3
ES2118794T3 ES92304837T ES92304837T ES2118794T3 ES 2118794 T3 ES2118794 T3 ES 2118794T3 ES 92304837 T ES92304837 T ES 92304837T ES 92304837 T ES92304837 T ES 92304837T ES 2118794 T3 ES2118794 T3 ES 2118794T3
Authority
ES
Spain
Prior art keywords
vitamin
compounds
synthesis
new synthesis
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92304837T
Other languages
English (en)
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Rolf E Swenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of ES2118794T3 publication Critical patent/ES2118794T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

SE DESCRIBE UNA SINTESIS CONVERGENTE DE COMPUESTOS DE 19-NOR VITAMINA D, ESPECIFICAMENTE 19-NOR-1O,25-DIHIDROXIVITAMINA D3. TAMBIEN SE PUEDE UTILIZAR LA SINTESIS FACILMENTE PARA PREPARAR OTROS COMPUESTOS DE 19-NOR EL PASO CLAVE EN LA SINTESIS ES UNA APLICACION ADECUADA DEL PROCEDIMIENTO DE LYTHGOE, ES DECIR UNA REACCION HORNER-WITTIG DEL ANION DE LITIO DE UN OXIDO DE FOSFINA CON UNA CETONA WINDAUS GRUNDMANN PARA FACILITAR, TRAS CUALQUIER DESPROTECCION NECESARIA, EL COMPUESTO DESEADO DE 19-NOR
ES92304837T 1991-05-28 1992-05-28 Nueva sintesis de compuestos de 19-nor-vitamina d. Expired - Lifetime ES2118794T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70591791A 1991-05-28 1991-05-28

Publications (1)

Publication Number Publication Date
ES2118794T3 true ES2118794T3 (es) 1998-10-01

Family

ID=24835479

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92304837T Expired - Lifetime ES2118794T3 (es) 1991-05-28 1992-05-28 Nueva sintesis de compuestos de 19-nor-vitamina d.

Country Status (11)

Country Link
US (7) US5281731A (es)
EP (1) EP0516410B1 (es)
JP (4) JP2648845B2 (es)
KR (3) KR0160784B1 (es)
AT (1) ATE168996T1 (es)
AU (2) AU650751B2 (es)
CA (2) CA2069374C (es)
DE (1) DE69226402T2 (es)
DK (1) DK0516410T3 (es)
ES (1) ES2118794T3 (es)
IE (1) IE921700A1 (es)

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Also Published As

Publication number Publication date
JPH05221960A (ja) 1993-08-31
KR0160784B1 (ko) 1999-01-15
EP0516410B1 (en) 1998-07-29
AU659774B2 (en) 1995-05-25
CA2191993C (en) 2002-07-09
DE69226402D1 (de) 1998-09-03
US5281731A (en) 1994-01-25
JPH09118641A (ja) 1997-05-06
IE921700A1 (en) 1992-12-02
EP0516410A3 (en) 1993-06-30
ATE168996T1 (de) 1998-08-15
US5486636A (en) 1996-01-23
US5597932A (en) 1997-01-28
AU1712092A (en) 1992-12-03
EP0516410A2 (en) 1992-12-02
KR920021505A (ko) 1992-12-18
JP3320025B2 (ja) 2002-09-03
US5581006A (en) 1996-12-03
US5616759A (en) 1997-04-01
JP3494637B2 (ja) 2004-02-09
KR0160937B1 (ko) 1999-01-15
CA2191993A1 (en) 1992-11-29
US5563286A (en) 1996-10-08
CA2069374C (en) 1999-08-31
KR0160936B1 (ko) 1999-01-15
JP2648845B2 (ja) 1997-09-03
JP2002201197A (ja) 2002-07-16
AU5932594A (en) 1994-06-02
JPH11240891A (ja) 1999-09-07
DE69226402T2 (de) 1998-12-10
CA2069374A1 (en) 1992-11-29
JP2926008B2 (ja) 1999-07-28
DK0516410T3 (da) 1998-10-26
AU650751B2 (en) 1994-06-30
US5391755A (en) 1995-02-21

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