DE69226402T2 - Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen - Google Patents

Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen

Info

Publication number
DE69226402T2
DE69226402T2 DE69226402T DE69226402T DE69226402T2 DE 69226402 T2 DE69226402 T2 DE 69226402T2 DE 69226402 T DE69226402 T DE 69226402T DE 69226402 T DE69226402 T DE 69226402T DE 69226402 T2 DE69226402 T2 DE 69226402T2
Authority
DE
Germany
Prior art keywords
vitamin
compounds
synthesis
manufacturing process
new manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69226402T
Other languages
English (en)
Other versions
DE69226402D1 (de
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Rolf E Swenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of DE69226402D1 publication Critical patent/DE69226402D1/de
Application granted granted Critical
Publication of DE69226402T2 publication Critical patent/DE69226402T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69226402T 1991-05-28 1992-05-28 Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen Expired - Lifetime DE69226402T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70591791A 1991-05-28 1991-05-28

Publications (2)

Publication Number Publication Date
DE69226402D1 DE69226402D1 (de) 1998-09-03
DE69226402T2 true DE69226402T2 (de) 1998-12-10

Family

ID=24835479

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226402T Expired - Lifetime DE69226402T2 (de) 1991-05-28 1992-05-28 Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen

Country Status (11)

Country Link
US (7) US5281731A (de)
EP (1) EP0516410B1 (de)
JP (4) JP2648845B2 (de)
KR (3) KR0160784B1 (de)
AT (1) ATE168996T1 (de)
AU (2) AU650751B2 (de)
CA (2) CA2069374C (de)
DE (1) DE69226402T2 (de)
DK (1) DK0516410T3 (de)
ES (1) ES2118794T3 (de)
IE (1) IE921700A1 (de)

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RU2153491C2 (ru) * 1993-07-09 2000-07-27 Лаборатуар Терамекс С.А. Аналоги витамина d, соединения, способы их получения и фармацевтическая композиция
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
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BR9509739A (pt) * 1994-11-21 1997-10-21 Wisconsin Alumni Res Found Compostos 18,19-dinor-vitamina d
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US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
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US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6306844B1 (en) 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
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US6316642B1 (en) 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
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US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
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DK1286962T3 (da) 2000-05-31 2008-10-06 Wisconsin Alumni Res Found 2-Ethyl og 2-ethyliden-19-nor-vitamin D-forbindelser
JP4811547B2 (ja) * 2000-10-24 2011-11-09 史衛 佐藤 光学活性シクロヘキセン化合物の製造法及びこの製造に用いる光学活性シクロヘキセン誘導体
US6683219B2 (en) * 2001-07-30 2004-01-27 Wisconsin Alumni Research Foundation Synthesis of A-ring synthon of 19-nor-1α,25-dihydroxyvitamin D3 from (D)-glucose
JP2005504279A (ja) * 2001-09-27 2005-02-10 ザ・コカ−コーラ・カンパニー 食品のビタミン強化
US6846811B2 (en) * 2002-04-22 2005-01-25 Wisconsin Alumni Research Foundation (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
US7023347B2 (en) * 2002-08-02 2006-04-04 Symbol Technologies, Inc. Method and system for forming a die frame and for transferring dies therewith
KR20050120787A (ko) 2003-04-10 2005-12-23 위스콘신 얼럼나이 리서어치 화운데이션 2-프로필리덴-19-노르-비타민 ｄ 화합물
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EP1761790A2 (de) * 2004-06-29 2007-03-14 Symbol Technologies, Inc. Systeme und verfahren zum testen von rfid-etiketts
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
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US20070131016A1 (en) * 2005-12-13 2007-06-14 Symbol Technologies, Inc. Transferring die(s) from an intermediate surface to a substrate
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WO2007105773A1 (ja) 2006-03-15 2007-09-20 Mercian Corporation インデン誘導体の製造方法およびその製造中間体
NZ571896A (en) 2006-04-05 2011-09-30 Wisconsin Alumni Res Found 1-Alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and use thereof
US20070244657A1 (en) * 2006-04-11 2007-10-18 Drago Randall A Methods and systems for testing radio frequency identification (RFID) tags having multiple antennas
WO2008053961A1 (fr) 2006-11-02 2008-05-08 Mercian Corporation Procédé et intermédiaire pour la fabrication du dérivé 1-hydroxy-19-norcyclovitamine d
EP2167516B1 (de) * 2007-05-30 2015-07-22 Opko IP Holdings II, Inc. Verfahren zur herstellung von phosphinoxidvorstufen von vitamin d
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
US20090275768A1 (en) 2008-04-30 2009-11-05 Formosa Laboratories, Inc. Preparation of Paricalcitol
CA2639477C (en) * 2008-09-11 2016-03-22 Alphora Research Inc. Paricalcitol purification
US8013176B2 (en) * 2008-09-11 2011-09-06 Alphora Research Inc. Paricalcitol purification
SG173119A1 (en) * 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN105663146B (zh) 2009-08-14 2020-09-11 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
CN101671288B (zh) * 2009-10-14 2013-10-30 兰州大学 帕立骨化醇的中间体的制备方法
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN107501317B (zh) * 2017-09-13 2019-08-16 上海皓元医药股份有限公司 一种帕立骨化醇中间体的制备方法

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Also Published As

Publication number Publication date
US5597932A (en) 1997-01-28
JPH09118641A (ja) 1997-05-06
AU650751B2 (en) 1994-06-30
US5486636A (en) 1996-01-23
DK0516410T3 (da) 1998-10-26
JPH11240891A (ja) 1999-09-07
AU1712092A (en) 1992-12-03
KR0160937B1 (ko) 1999-01-15
JP3320025B2 (ja) 2002-09-03
CA2191993A1 (en) 1992-11-29
JP2648845B2 (ja) 1997-09-03
US5581006A (en) 1996-12-03
CA2191993C (en) 2002-07-09
AU659774B2 (en) 1995-05-25
ES2118794T3 (es) 1998-10-01
JP2002201197A (ja) 2002-07-16
EP0516410A2 (de) 1992-12-02
JP2926008B2 (ja) 1999-07-28
US5616759A (en) 1997-04-01
KR0160936B1 (ko) 1999-01-15
CA2069374A1 (en) 1992-11-29
US5563286A (en) 1996-10-08
EP0516410A3 (en) 1993-06-30
US5391755A (en) 1995-02-21
JP3494637B2 (ja) 2004-02-09
KR0160784B1 (ko) 1999-01-15
EP0516410B1 (de) 1998-07-29
DE69226402D1 (de) 1998-09-03
ATE168996T1 (de) 1998-08-15
AU5932594A (en) 1994-06-02
JPH05221960A (ja) 1993-08-31
CA2069374C (en) 1999-08-31
IE921700A1 (en) 1992-12-02
KR920021505A (ko) 1992-12-18
US5281731A (en) 1994-01-25

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