DE69226402T2 - Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen - Google Patents

Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen

Info

Publication number
DE69226402T2
DE69226402T2 DE69226402T DE69226402T DE69226402T2 DE 69226402 T2 DE69226402 T2 DE 69226402T2 DE 69226402 T DE69226402 T DE 69226402T DE 69226402 T DE69226402 T DE 69226402T DE 69226402 T2 DE69226402 T2 DE 69226402T2
Authority
DE
Germany
Prior art keywords
vitamin
compounds
synthesis
manufacturing process
new manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69226402T
Other languages
English (en)
Other versions
DE69226402D1 (de
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Rolf E Swenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE69226402D1 publication Critical patent/DE69226402D1/de
Publication of DE69226402T2 publication Critical patent/DE69226402T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69226402T 1991-05-28 1992-05-28 Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen Expired - Lifetime DE69226402T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70591791A 1991-05-28 1991-05-28

Publications (2)

Publication Number Publication Date
DE69226402D1 DE69226402D1 (de) 1998-09-03
DE69226402T2 true DE69226402T2 (de) 1998-12-10

Family

ID=24835479

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226402T Expired - Lifetime DE69226402T2 (de) 1991-05-28 1992-05-28 Neues Herstellungsverfahren zur 19-nor Vitamin-D-Verbindungen

Country Status (11)

Country Link
US (7) US5281731A (de)
EP (1) EP0516410B1 (de)
JP (4) JP2648845B2 (de)
KR (3) KR0160784B1 (de)
AT (1) ATE168996T1 (de)
AU (2) AU650751B2 (de)
CA (2) CA2191993C (de)
DE (1) DE69226402T2 (de)
DK (1) DK0516410T3 (de)
ES (1) ES2118794T3 (de)
IE (1) IE921700A1 (de)

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US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
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US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
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US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
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US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
US6114317A (en) 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
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DE10019861A1 (de) * 2000-04-18 2001-10-31 Schering Ag Neues Synthesezwischenprodukt, seine mikrobiologische Herstellung und Verwendung zur Synthese von Vitamin D-Derivaten
ATE399151T1 (de) 2000-05-31 2008-07-15 Wisconsin Alumni Res Found 2-ethyl und 2-ethyliden-19-nor-vitamin d- verbindungen
JP4811547B2 (ja) * 2000-10-24 2011-11-09 史衛 佐藤 光学活性シクロヘキセン化合物の製造法及びこの製造に用いる光学活性シクロヘキセン誘導体
US6683219B2 (en) * 2001-07-30 2004-01-27 Wisconsin Alumni Research Foundation Synthesis of A-ring synthon of 19-nor-1α,25-dihydroxyvitamin D3 from (D)-glucose
WO2003026445A1 (en) * 2001-09-27 2003-04-03 The Coca-Cola Company Vitamin fortification of foodstuffs
US6846811B2 (en) * 2002-04-22 2005-01-25 Wisconsin Alumni Research Foundation (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
US7023347B2 (en) * 2002-08-02 2006-04-04 Symbol Technologies, Inc. Method and system for forming a die frame and for transferring dies therewith
MXPA05009336A (es) 2003-04-10 2005-11-04 Wisconsin Alumni Res Found Compuestos de 2-propiliden-19-nor-vitamina d.
US20050005434A1 (en) * 2003-06-12 2005-01-13 Matrics, Inc. Method, system, and apparatus for high volume transfer of dies
US6894037B2 (en) 2003-07-03 2005-05-17 Wisconsin Alumni Research Foundation 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en) 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
WO2006012358A2 (en) * 2004-06-29 2006-02-02 Symbol Technologies, Inc. Systems and methods for testing radio frequency identification tags
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
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US20070107186A1 (en) * 2005-11-04 2007-05-17 Symbol Technologies, Inc. Method and system for high volume transfer of dies to substrates
US20070131016A1 (en) * 2005-12-13 2007-06-14 Symbol Technologies, Inc. Transferring die(s) from an intermediate surface to a substrate
US20070139057A1 (en) * 2005-12-15 2007-06-21 Symbol Technologies, Inc. System and method for radio frequency identification tag direct connection test
WO2007105773A1 (ja) 2006-03-15 2007-09-20 Mercian Corporation インデン誘導体の製造方法およびその製造中間体
NZ571896A (en) 2006-04-05 2011-09-30 Wisconsin Alumni Res Found 1-Alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and use thereof
US20070244657A1 (en) * 2006-04-11 2007-10-18 Drago Randall A Methods and systems for testing radio frequency identification (RFID) tags having multiple antennas
US20110319644A1 (en) 2006-11-02 2011-12-29 Asako Toyoda Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
EP2167516B1 (de) 2007-05-30 2015-07-22 Opko IP Holdings II, Inc. Verfahren zur herstellung von phosphinoxidvorstufen von vitamin d
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
US20090275768A1 (en) 2008-04-30 2009-11-05 Formosa Laboratories, Inc. Preparation of Paricalcitol
CA2639477C (en) * 2008-09-11 2016-03-22 Alphora Research Inc. Paricalcitol purification
US8013176B2 (en) * 2008-09-11 2011-09-06 Alphora Research Inc. Paricalcitol purification
JP5932339B2 (ja) * 2009-01-27 2016-06-08 バーグ エルエルシー 化学療法に付随する副作用を軽減するためのビタミンｄ３およびその類似体
IN2012DN02137A (de) 2009-08-14 2015-08-07 Berg Biosystems Llc
CN101671288B (zh) * 2009-10-14 2013-10-30 兰州大学 帕立骨化醇的中间体的制备方法
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CN107501317B (zh) * 2017-09-13 2019-08-16 上海皓元医药股份有限公司 一种帕立骨化醇中间体的制备方法

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Also Published As

Publication number Publication date
JP2926008B2 (ja) 1999-07-28
EP0516410A3 (en) 1993-06-30
JPH05221960A (ja) 1993-08-31
EP0516410A2 (de) 1992-12-02
AU1712092A (en) 1992-12-03
CA2191993A1 (en) 1992-11-29
KR0160936B1 (ko) 1999-01-15
KR0160937B1 (ko) 1999-01-15
US5486636A (en) 1996-01-23
JPH11240891A (ja) 1999-09-07
JP2002201197A (ja) 2002-07-16
AU650751B2 (en) 1994-06-30
CA2069374A1 (en) 1992-11-29
JP3320025B2 (ja) 2002-09-03
ATE168996T1 (de) 1998-08-15
JP3494637B2 (ja) 2004-02-09
AU659774B2 (en) 1995-05-25
US5563286A (en) 1996-10-08
JPH09118641A (ja) 1997-05-06
DK0516410T3 (da) 1998-10-26
KR920021505A (ko) 1992-12-18
EP0516410B1 (de) 1998-07-29
US5616759A (en) 1997-04-01
DE69226402D1 (de) 1998-09-03
JP2648845B2 (ja) 1997-09-03
US5581006A (en) 1996-12-03
US5597932A (en) 1997-01-28
CA2069374C (en) 1999-08-31
ES2118794T3 (es) 1998-10-01
IE921700A1 (en) 1992-12-02
AU5932594A (en) 1994-06-02
US5281731A (en) 1994-01-25
US5391755A (en) 1995-02-21
KR0160784B1 (ko) 1999-01-15
CA2191993C (en) 2002-07-09

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