ES2147238T3 - Nuevos analogos estructurales de la vitamina d. - Google Patents

Nuevos analogos estructurales de la vitamina d.

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Publication number
ES2147238T3
ES2147238T3 ES94924749T ES94924749T ES2147238T3 ES 2147238 T3 ES2147238 T3 ES 2147238T3 ES 94924749 T ES94924749 T ES 94924749T ES 94924749 T ES94924749 T ES 94924749T ES 2147238 T3 ES2147238 T3 ES 2147238T3
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ES
Spain
Prior art keywords
vitamin
ring
analogue
membered
structural analogs
Prior art date
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Expired - Lifetime
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ES94924749T
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English (en)
Inventor
Roger Bouillon
Maurits Vandewalle
Clercq Pierre Jean De
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Laboratoire Theramex SAM
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Laboratoire Theramex SAM
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    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/198—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing ether groups, groups, groups, or groups
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
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    • C07C47/19—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C47/37—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
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    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
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    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
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    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
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  • Neurology (AREA)
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  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A ANALOGOS DE VITAMINA D, QUE CARECEN DE LA PRESENCIA COMBINADA DEL ANILLO-C DE SEIS ELEMENTOS TRANSFUNDIDO Y DEL ANILLO-D DE CINCO ELEMENTOS, PERO TODAVIA POSEE UNA PARTE CENTRAL QUE CONSISTE EN UNA CADENA SUSTITUIDA DE CINCO ATOMOS, ATOMOS QUE CORRESPONDEN A LAS POSICIONES 8,14,13,17 Y 20 DE VITAMINA D, Y A CUYOS EXTREMOS ESTAN CONECTADOS, EN POSICION 20 UNA UNIDAD ESTRUCTURAL QUE REPRESENTA PARTE DE LA CADENA LATERAL DE VITAMINA D O DE UN ANALOGO DE VITAMINA D, Y EN POSICION 8 LA UNIDAD DELTA/5,7)-DIENO CONECTADA AL ANILLO-A DEL METABOLITO 1-ALFA-HIDROXI O DE UN ANALOGO ESTABLECIDO DE VITAMINA D, A SU PROCESO DE PREPARACION, A INTERMEDIO DE PREPARACION, O PREPARACIONES FARMACEUTICAS QUE COMPRENDEN ESTOS COMPUESTOS Y A SU USO EN MEDICINA.
ES94924749T 1993-07-09 1994-07-07 Nuevos analogos estructurales de la vitamina d. Expired - Lifetime ES2147238T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93202037 1993-07-09

Publications (1)

Publication Number Publication Date
ES2147238T3 true ES2147238T3 (es) 2000-09-01

Family

ID=8213977

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94924749T Expired - Lifetime ES2147238T3 (es) 1993-07-09 1994-07-07 Nuevos analogos estructurales de la vitamina d.
ES99203513T Expired - Lifetime ES2209327T3 (es) 1993-07-09 1994-07-07 Nuevos analogos estructurales de la vitamina d.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99203513T Expired - Lifetime ES2209327T3 (es) 1993-07-09 1994-07-07 Nuevos analogos estructurales de la vitamina d.

Country Status (16)

Country Link
US (2) US6017907A (es)
EP (2) EP0707566B1 (es)
JP (2) JP4235256B2 (es)
CN (1) CN1103755C (es)
AT (2) ATE191712T1 (es)
AU (1) AU699200B2 (es)
CA (1) CA2166898C (es)
DE (2) DE69423966T2 (es)
DK (2) DK0972762T3 (es)
ES (2) ES2147238T3 (es)
GR (1) GR3033856T3 (es)
NO (1) NO314142B1 (es)
NZ (1) NZ271332A (es)
PT (2) PT972762E (es)
RU (1) RU2153491C2 (es)
WO (1) WO1995001960A1 (es)

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DE69423966D1 (de) 2000-05-18
US6017907A (en) 2000-01-25
EP0972762A2 (en) 2000-01-19
AU7492794A (en) 1995-02-06
CN1103755C (zh) 2003-03-26
ES2209327T3 (es) 2004-06-16
ATE251133T1 (de) 2003-10-15
WO1995001960A1 (en) 1995-01-19
NO960099D0 (no) 1996-01-09
PT972762E (pt) 2004-02-27
DE69433220D1 (de) 2003-11-06
DK0707566T3 (da) 2000-09-04
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JP4235256B2 (ja) 2009-03-11
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ATE191712T1 (de) 2000-04-15
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