DE69423966D1 - Neue strukturelle vitamin d derivate - Google Patents

Neue strukturelle vitamin d derivate

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Publication number
DE69423966D1
DE69423966D1 DE69423966T DE69423966T DE69423966D1 DE 69423966 D1 DE69423966 D1 DE 69423966D1 DE 69423966 T DE69423966 T DE 69423966T DE 69423966 T DE69423966 T DE 69423966T DE 69423966 D1 DE69423966 D1 DE 69423966D1
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DE
Germany
Prior art keywords
vitamin
ring
derivatives
analogue
membered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69423966T
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English (en)
Other versions
DE69423966T2 (de
Inventor
Roger Bouillon
Maurits Vandewalle
Clercq Jean De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roger Bouillon Herent Be
Universiteit Gent
KU Leuven Research and Development
Original Assignee
Laboratoire Theramex SAM
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Application filed by Laboratoire Theramex SAM filed Critical Laboratoire Theramex SAM
Publication of DE69423966D1 publication Critical patent/DE69423966D1/de
Application granted granted Critical
Publication of DE69423966T2 publication Critical patent/DE69423966T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
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    • C07C47/19—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups
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    • C07C49/385—Saturated compounds containing a keto group being part of a ring
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    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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DE69423966T 1993-07-09 1994-07-07 Neue strukturelle vitamin d derivate Expired - Lifetime DE69423966T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93202037 1993-07-09
PCT/EP1994/002294 WO1995001960A1 (en) 1993-07-09 1994-07-07 Novel structural analogues of vitamin d

Publications (2)

Publication Number Publication Date
DE69423966D1 true DE69423966D1 (de) 2000-05-18
DE69423966T2 DE69423966T2 (de) 2000-11-16

Family

ID=8213977

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69423966T Expired - Lifetime DE69423966T2 (de) 1993-07-09 1994-07-07 Neue strukturelle vitamin d derivate
DE69433220T Expired - Lifetime DE69433220T2 (de) 1993-07-09 1994-07-07 Neue strukturelle Vitamin D Derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69433220T Expired - Lifetime DE69433220T2 (de) 1993-07-09 1994-07-07 Neue strukturelle Vitamin D Derivate

Country Status (16)

Country Link
US (2) US6017907A (de)
EP (2) EP0707566B1 (de)
JP (2) JP4235256B2 (de)
CN (1) CN1103755C (de)
AT (2) ATE191712T1 (de)
AU (1) AU699200B2 (de)
CA (1) CA2166898C (de)
DE (2) DE69423966T2 (de)
DK (2) DK0972762T3 (de)
ES (2) ES2209327T3 (de)
GR (1) GR3033856T3 (de)
NO (1) NO314142B1 (de)
NZ (1) NZ271332A (de)
PT (2) PT707566E (de)
RU (1) RU2153491C2 (de)
WO (1) WO1995001960A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2166898C (en) * 1993-07-09 2004-09-07 Roger Bouillon Novel structural analogues of vitamin d
CA2206876A1 (en) * 1994-11-21 1996-05-30 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin d compounds
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
EP0771789B1 (de) * 1995-10-30 2000-02-16 F. Hoffmann-La Roche Ag 1-Alpha, 26-dihydroxy-D-homo-vitamin D3
WO1997016423A1 (en) * 1995-10-31 1997-05-09 F.Hoffmann-La Roche Ag 24-homo-26,27-hexafluoro-cholecalciferols
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
WO1998052894A1 (en) * 1997-05-23 1998-11-26 F.Hoffmann-La Roche Ag Cyclohexanediol derivatives
AU735676B2 (en) * 1997-06-10 2001-07-12 Mrc Holdings Pty Limited Method of treatment of liver tumours and pharmaceutical compositions for use therein
AUPO727097A0 (en) * 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
AU2549099A (en) * 1998-02-24 1999-09-15 Chugai Seiyaku Kabushiki Kaisha 24-hydroxyvitamin d derivatives
US6184422B1 (en) * 1998-02-26 2001-02-06 Hoffman-La Roche Inc. Cyclohexanediol derivatives
EP2340840B1 (de) * 1998-03-27 2012-08-29 Oregon Health Sciences University Gepulste Dose von einem Vitamin D Wirkstoff zur Behandlung von hyperproliferativen Hauterkrankungen
US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
DE19935771A1 (de) 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6310262B1 (en) * 1999-10-18 2001-10-30 Basilea Pharmaceutica Ag Process for preparing retiferol derivatives
JP4970682B2 (ja) * 1999-12-08 2012-07-11 ラボラトワール テラメックス ビタミンｄ前駆物質、方法及び中間体
US6191292B1 (en) * 1999-12-08 2001-02-20 Laboratoire Theramex Precursors of the A-ring of vitamin D and method and intermediates for the preparation thereof
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
AU2004247108A1 (en) * 2003-06-11 2004-12-23 Novacea, Inc Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents
US20050074443A1 (en) * 2003-10-03 2005-04-07 Treadwell Benjamin V. Methods of attenuating autoimmune disease and compositions useful therefor
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US7713951B2 (en) * 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
GB0423091D0 (en) * 2004-10-19 2004-11-17 Leuven K U Res & Dev Bioactive vitamin d analogues
US20080069814A1 (en) * 2005-01-05 2008-03-20 Novacea, Inc. Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof
CA2606517A1 (en) * 2005-04-22 2006-11-02 Novacea, Inc. Treatment, prevention and amelioration of pulmonary disorders associated with chemotherapy or radiotherapy with active vitamin d compounds or mimics thereof
AU2009206449B2 (en) * 2008-01-22 2014-04-24 Wisconsin Alumni Research Foundation 13,13-Dimethyl-des-C,D analogs of 1alpha, 25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms and methods of treating skin conditions
US8109466B2 (en) * 2008-06-23 2012-02-07 Rohr, Inc. Thrust reverser cascade assembly and AFT cascade ring with flow deflector portion
CA2750659C (en) 2009-01-27 2017-11-21 Berg Biosystems, Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG176581A1 (en) 2009-05-20 2012-01-30 Hybrigenics Sa New therapeutical uses of inecalcitol
EP3603646B1 (de) 2009-08-14 2024-04-03 BPGbio, Inc. Vitamin d3 und analoge davon zur behandlung von alopezie
EP2360145B1 (de) 2010-01-26 2012-03-21 Hybrigenics S.A. Neues Verfahren zur Isomerisierung kondensierter bicyclischer Strukturen und Herstellung von diese enthaltenden Vitamin D Analoga
PL2572204T3 (pl) 2010-05-20 2018-05-30 F.Hoffmann-La Roche Ag Odczynnik do uwalniania dla związków witaminy d
US20120015913A1 (en) 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
AU2011278352B2 (en) 2010-07-15 2016-07-21 Hybrigenics Sa Formulations of 14 - epi -analogues of vitamin D
EP2407152A1 (de) 2010-07-15 2012-01-18 Hybrigenics S.A. Formulierungen von 14-epi-Analoga von Vitamin D
WO2013072342A1 (en) 2011-11-18 2013-05-23 Roche Diagnostics Gmbh Release reagent for vitamin d compounds
EP2785687B1 (de) 2011-11-30 2019-02-20 Sandoz AG Verfahren zur herstellung von (3r-)2,4-di-abganbgsgruppen-3-methylbut-1-en
WO2013086634A1 (en) 2011-12-16 2013-06-20 Alphora Research Inc. Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof
IN2014MN01521A (de) 2011-12-29 2015-05-01 Alphora Res Inc
WO2013142999A1 (en) 2012-03-30 2013-10-03 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
CN105164108B (zh) 2013-03-14 2018-07-17 阿奎诺克斯药物（加拿大）公司 Ship1调节剂及与其相关的方法
CA2902764A1 (en) 2013-03-14 2014-09-18 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
SG11201509715UA (en) 2013-05-29 2015-12-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
GB2515128B (en) 2013-06-10 2015-05-27 Givaudan Sa Improvements in or relating to organic compounds
WO2015106293A1 (en) 2014-01-13 2015-07-16 P2 Science, Inc. Terpene-derived acids and esters and methods for preparing and using same
JP6687547B2 (ja) 2014-06-20 2020-04-22 ピー２ サイエンス，インコーポレイティド 管式又は多管式反応器における膜オゾン分解
US20170247314A1 (en) * 2014-08-06 2017-08-31 P2 Science, Inc. Fragrances from the esters of fatty acids
GB201421855D0 (en) * 2014-12-09 2015-01-21 Givaudan Sa Improvements in or relating to organic compounds
CN107787315A (zh) 2015-06-26 2018-03-09 阿奎诺克斯药物（加拿大）公司 (1s,3s,4r)‑4‑((3as,4r,5s,7as)‑4‑(氨甲基)‑7a‑甲基‑1‑亚甲基八氢‑1h‑茚‑5‑基)‑3‑(羟甲基)‑4‑甲基环己醇的乙酸盐的结晶固体形式
WO2017127753A1 (en) 2016-01-20 2017-07-27 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
JP7028457B2 (ja) 2016-06-21 2022-03-02 ピー２・サイエンス・インコーポレイテッド 過酸化物混合物の連続クエンチのためのフロースルー反応器およびそれを含む方法
US10696605B2 (en) 2016-09-16 2020-06-30 P2 Science, Inc. Uses of vanadium to oxidize aldehydes and ozonides
JP2022505298A (ja) 2018-10-19 2022-01-14 ピー２・サイエンス・インコーポレイテッド オゾニドの不均化クエンチの新規方法
CN110330522A (zh) * 2019-07-29 2019-10-15 南京海融医药科技股份有限公司 一种帕立骨化醇异构体杂质py5的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3590020C2 (de) * 1984-01-30 1995-03-09 Wisconsin Alumni Res Found In der Seitenkette ungesättigte 1-Hydroxyvitamin D-Verbindungen
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
DE3913310A1 (de) * 1989-04-20 1990-10-25 Schering Ag Spirocyclopropane in der vitamin d-reihe
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
CA2166898C (en) * 1993-07-09 2004-09-07 Roger Bouillon Novel structural analogues of vitamin d

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PT707566E (pt) 2000-09-29
NO960099L (no) 1996-03-08
NO314142B1 (no) 2003-02-03
NO960099D0 (no) 1996-01-09
EP0972762B1 (de) 2003-10-01
US6548715B1 (en) 2003-04-15
JPH09500117A (ja) 1997-01-07
PT972762E (pt) 2004-02-27
US6017907A (en) 2000-01-25
RU2153491C2 (ru) 2000-07-27
AU7492794A (en) 1995-02-06
CN1103755C (zh) 2003-03-26
ES2209327T3 (es) 2004-06-16
GR3033856T3 (en) 2000-10-31
CA2166898A1 (en) 1995-01-19
EP0972762A2 (de) 2000-01-19
JP2006001944A (ja) 2006-01-05
AU699200B2 (en) 1998-11-26
ATE251133T1 (de) 2003-10-15
JP4235256B2 (ja) 2009-03-11
ES2147238T3 (es) 2000-09-01
DE69423966T2 (de) 2000-11-16
DE69433220D1 (de) 2003-11-06
CN1130899A (zh) 1996-09-11
DK0972762T3 (da) 2004-02-09
DK0707566T3 (da) 2000-09-04
EP0707566B1 (de) 2000-04-12
NZ271332A (en) 2001-03-30
WO1995001960A1 (en) 1995-01-19
JP4312183B2 (ja) 2009-08-12
EP0707566A1 (de) 1996-04-24
DE69433220T2 (de) 2004-08-19
EP0972762A3 (de) 2000-02-23
ATE191712T1 (de) 2000-04-15
CA2166898C (en) 2004-09-07

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Owner name: K.U. LEUVEN RESEARCH & DEVELOPMENT, LEUVEN, BE

Owner name: ROGER BOUILLON, HERENT, BE

Owner name: UNIVERSITEIT GENT, GENT, BE