DK0496314T3 - Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents
Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidlerInfo
- Publication number
- DK0496314T3 DK0496314T3 DK92100816.5T DK92100816T DK0496314T3 DK 0496314 T3 DK0496314 T3 DK 0496314T3 DK 92100816 T DK92100816 T DK 92100816T DK 0496314 T3 DK0496314 T3 DK 0496314T3
- Authority
- DK
- Denmark
- Prior art keywords
- indoles
- intermediates
- preparation
- tetrahydrocyclopenta
- hexahydrocyclopenta
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title abstract 2
- GJPJCHXDBHTUGJ-UHFFFAOYSA-N 1,2,3,3a,4,4a,8a,8b-octahydrocyclopenta[b]indole Chemical class N1C2C=CC=CC2C2C1CCC2 GJPJCHXDBHTUGJ-UHFFFAOYSA-N 0.000 title 1
- HZDXFZHFEASSBM-UHFFFAOYSA-N 1,2,3,4-tetrahydrocyclopenta[b]indole Chemical class N1C2=CC=CC=C2C2=C1CCC2 HZDXFZHFEASSBM-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 abstract 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/642,952 US5100891A (en) | 1991-01-18 | 1991-01-18 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0496314T3 true DK0496314T3 (da) | 1998-05-18 |
Family
ID=24578739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92100816.5T DK0496314T3 (da) | 1991-01-18 | 1992-01-18 | Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5100891A (OSRAM) |
| EP (1) | EP0496314B1 (OSRAM) |
| JP (1) | JP2665422B2 (OSRAM) |
| KR (1) | KR100230881B1 (OSRAM) |
| AT (1) | ATE158790T1 (OSRAM) |
| AU (1) | AU650315B2 (OSRAM) |
| BR (1) | BR9200171A (OSRAM) |
| CA (1) | CA2059610C (OSRAM) |
| CZ (1) | CZ282732B6 (OSRAM) |
| DE (1) | DE69222444T2 (OSRAM) |
| DK (1) | DK0496314T3 (OSRAM) |
| ES (1) | ES2109953T3 (OSRAM) |
| FI (2) | FI102174B (OSRAM) |
| GR (1) | GR3025318T3 (OSRAM) |
| HU (1) | HUT67027A (OSRAM) |
| IE (1) | IE920149A1 (OSRAM) |
| IL (1) | IL100693A0 (OSRAM) |
| MX (1) | MX9200206A (OSRAM) |
| NO (1) | NO178397C (OSRAM) |
| NZ (1) | NZ241305A (OSRAM) |
| PH (1) | PH31429A (OSRAM) |
| PL (2) | PL169417B1 (OSRAM) |
| RO (1) | RO112505B1 (OSRAM) |
| RU (1) | RU2077530C1 (OSRAM) |
| TW (1) | TW198024B (OSRAM) |
| ZA (1) | ZA92341B (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5298626A (en) * | 1991-01-18 | 1994-03-29 | Hoechst-Roussel Pharmaceuticals Incorporated | Select cyclopent[b]indoles |
| US5350762A (en) * | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
| US6172099B1 (en) * | 1997-07-03 | 2001-01-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Tricyclic compounds having saturated rings and medicinal compositions containing the same |
| TWI220143B (en) * | 1998-05-13 | 2004-08-11 | Solvay Pharm Gmbh | Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds and novel cyclic compounds, and intermediate products |
| UA70334C2 (en) * | 1998-10-06 | 2004-10-15 | Janssen Pharmaceutica N V Jans | BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS |
| UA69420C2 (uk) * | 1998-10-06 | 2004-09-15 | Янссен Фармацевтика Н.В. | ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ |
| JP4590102B2 (ja) * | 1998-10-06 | 2010-12-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 医薬としての三環性δ３−ピペリジン類 |
| IT1317926B1 (it) | 2000-11-03 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
| EP1654228B1 (en) | 2003-06-10 | 2008-10-22 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| US7419997B2 (en) * | 2003-06-12 | 2008-09-02 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| JP2008520741A (ja) * | 2004-11-23 | 2008-06-19 | ピーティーシー セラピューティクス， インコーポレイテッド | 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール |
| GB2422828A (en) * | 2005-02-03 | 2006-08-09 | Hunter Fleming Ltd | Tricyclic cytoprotective compounds comprising an indole residue |
| WO2013139929A1 (en) * | 2012-03-22 | 2013-09-26 | Ludwig-Maximilians-Universität München | Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging |
| KR20140013471A (ko) | 2012-07-24 | 2014-02-05 | 주식회사 쎄코 | 진공증착용 발열조립체 및 이를 구비하는 진공증착장치 |
| US10882821B1 (en) | 2017-09-26 | 2021-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3514462A (en) * | 1966-10-21 | 1970-05-26 | Upjohn Co | 1 and 2 ethoxy 3,4,5,10 - tetrahydroazepino(3,4-b) and (2,3-b)indoles and corresponding amino derivatives thereof |
| US3595874A (en) * | 1969-02-28 | 1971-07-27 | Upjohn Co | 3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols |
| BE787537A (fr) * | 1971-08-16 | 1973-02-14 | Sterling Drug Inc | Tetrahydrocarbazoles |
| SU482086A1 (ru) * | 1973-11-30 | 1976-03-15 | Всесоюзный Научно-Исследовательски% Химико-Фармацевтический Институт Им.С.Орджоникидзе | Способ получени производных 1- -амино1,2,3,4-тетрагидрокарбазола |
| JPS5111760A (OSRAM) * | 1974-06-18 | 1976-01-30 | Ayerst Mckenna & Harrison | |
| US4254134A (en) * | 1978-03-17 | 1981-03-03 | Endo Laboratories, Inc. | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles |
-
1991
- 1991-01-18 US US07/642,952 patent/US5100891A/en not_active Expired - Lifetime
-
1992
- 1992-01-15 RO RO149168A patent/RO112505B1/ro unknown
- 1992-01-15 NZ NZ241305A patent/NZ241305A/en unknown
- 1992-01-16 PL PL92293209A patent/PL169417B1/pl unknown
- 1992-01-16 CZ CS92129A patent/CZ282732B6/cs not_active IP Right Cessation
- 1992-01-16 KR KR1019920000543A patent/KR100230881B1/ko not_active Expired - Fee Related
- 1992-01-16 PL PL92296651A patent/PL167465B1/pl unknown
- 1992-01-16 FI FI920192A patent/FI102174B/fi active
- 1992-01-17 IL IL100693A patent/IL100693A0/xx unknown
- 1992-01-17 RU SU925010763A patent/RU2077530C1/ru active
- 1992-01-17 AU AU10279/92A patent/AU650315B2/en not_active Ceased
- 1992-01-17 CA CA002059610A patent/CA2059610C/en not_active Expired - Lifetime
- 1992-01-17 NO NO920235A patent/NO178397C/no unknown
- 1992-01-17 JP JP4006681A patent/JP2665422B2/ja not_active Expired - Lifetime
- 1992-01-17 HU HU9200172A patent/HUT67027A/hu unknown
- 1992-01-17 IE IE014992A patent/IE920149A1/en not_active IP Right Cessation
- 1992-01-17 ZA ZA92341A patent/ZA92341B/xx unknown
- 1992-01-17 MX MX9200206A patent/MX9200206A/es unknown
- 1992-01-18 EP EP92100816A patent/EP0496314B1/en not_active Expired - Lifetime
- 1992-01-18 DE DE69222444T patent/DE69222444T2/de not_active Expired - Lifetime
- 1992-01-18 ES ES92100816T patent/ES2109953T3/es not_active Expired - Lifetime
- 1992-01-18 DK DK92100816.5T patent/DK0496314T3/da active
- 1992-01-18 AT AT92100816T patent/ATE158790T1/de not_active IP Right Cessation
- 1992-01-21 BR BR929200171A patent/BR9200171A/pt not_active Application Discontinuation
- 1992-02-20 TW TW081101228A patent/TW198024B/zh active
- 1992-11-20 PH PH43793A patent/PH31429A/en unknown
-
1997
- 1997-11-07 GR GR970402960T patent/GR3025318T3/el unknown
-
2000
- 2000-08-10 FI FI20001775A patent/FI107919B/fi active
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