DK0766668T3 - Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf - Google Patents

Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf

Info

Publication number
DK0766668T3
DK0766668T3 DK95918278T DK95918278T DK0766668T3 DK 0766668 T3 DK0766668 T3 DK 0766668T3 DK 95918278 T DK95918278 T DK 95918278T DK 95918278 T DK95918278 T DK 95918278T DK 0766668 T3 DK0766668 T3 DK 0766668T3
Authority
DK
Denmark
Prior art keywords
antihistamines
polymorphs
anhydrous
morphs
pseudo
Prior art date
Application number
DK95918278T
Other languages
English (en)
Inventor
Frederick J Mccarty
Daniel R Henton
Susan I Tripp
Jill E Dewitt
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26937420&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0766668(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0766668T3 publication Critical patent/DK0766668T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
DK95918278T 1994-05-18 1995-04-28 Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf DK0766668T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24573194A 1994-05-18 1994-05-18
US41716195A 1995-04-11 1995-04-11
PCT/US1995/004942 WO1995031437A1 (en) 1994-05-18 1995-04-28 Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof

Publications (1)

Publication Number Publication Date
DK0766668T3 true DK0766668T3 (da) 2002-10-28

Family

ID=26937420

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95918278T DK0766668T3 (da) 1994-05-18 1995-04-28 Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf

Country Status (18)

Country Link
US (12) US20010014741A1 (da)
EP (3) EP0766668B1 (da)
JP (7) JPH10500134A (da)
CN (3) CN1907967B (da)
AT (1) ATE220667T1 (da)
AU (1) AU693892B2 (da)
CA (3) CA2189007C (da)
DE (1) DE69527429T2 (da)
DK (1) DK0766668T3 (da)
ES (1) ES2176329T3 (da)
FI (1) FI964565A (da)
HK (2) HK1098467A1 (da)
HU (1) HU227676B1 (da)
IL (3) IL113747A (da)
MX (1) MX9605613A (da)
NO (1) NO315319B1 (da)
PT (1) PT766668E (da)
WO (1) WO1995031437A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9400555D0 (en) * 1994-01-13 1994-03-09 Short Brothers Plc Boundery layer control in aerodynamic low drag structures
CA2189007C (en) * 1994-05-18 2004-03-02 Daniel R. Henton Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof
ATE226819T1 (de) * 1995-02-28 2002-11-15 Aventis Pharma Inc Arzneizubereitungen für piperidinalkanolderivate
TR200000517T2 (tr) * 1997-08-26 2000-08-21 Hoechst Marion Roussel, Inc. Piperidinoalkanol-Konjesyon azaltıcıdan oluşan kombinasyona yönelik farmasötik kompozisyon.
IN191492B (da) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
PL366576A1 (en) * 2001-04-09 2005-02-07 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
WO2002102777A2 (en) * 2001-06-18 2002-12-27 Dr. Reddy's Laboratories Ltd. NOVEL CRYSTALLINE FORMS OF 4-[4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERINDINYL]-1-HYDROXYBUTYL]-α, α-DIMETHYLBENZENE ACETIC ACID AND ITS HYDROCHLORIDE
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
ES2301662T3 (es) * 2001-07-31 2008-07-01 Texcontor Etablissement Polimorfo de clorhidrato de fexofenadina.
US20030158227A1 (en) * 2001-11-08 2003-08-21 Barnaba Krochmal Polymorphs of fexofenadine base
EP1474392A1 (en) * 2002-06-10 2004-11-10 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
JP3910907B2 (ja) * 2002-10-29 2007-04-25 新光電気工業株式会社 キャパシタ素子及びこの製造方法、半導体装置用基板、並びに半導体装置
EP1567533B1 (en) * 2003-07-03 2009-03-11 Teva Pharmaceutical Industries Ltd. Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
KR20070007196A (ko) * 2004-04-26 2007-01-12 테바 파마슈티컬 인더스트리즈 리미티드 펙소페나딘 히드로클로라이드의 결정형 및 이의 제조 방법
ITMI20041143A1 (it) * 2004-06-08 2004-09-08 Dipharma Spa Polimorfi di fexofenadina e procedimento per la loro preparazione
EP1616861A3 (en) * 2004-06-15 2006-02-08 Dipharma S.p.A. A process for the preparation of keto compounds
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
EP1685106A2 (en) * 2004-09-28 2006-08-02 Teva Pharmaceutical Industries, Inc. Fexofendadine crystal form and processes for its preparation thereof
DOP2006000274A (es) * 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
JP2009543780A (ja) * 2006-07-11 2009-12-10 ミューチュアル ファーマシューティカル カンパニー，インク． 制御放出製剤およびキット
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
EP2105134A1 (en) 2008-03-24 2009-09-30 Ranbaxy Laboratories Limited Stable amorphous fexofenadine hydrochloride
WO2010083360A2 (en) * 2009-01-16 2010-07-22 Mutual Pharmaceutical Company, Inc. Controlled-release formulations
EP2496077B1 (en) 2009-11-06 2014-08-20 Basf Se Crystalline complexes of 4-hydroxy benzoic acid and selected pesticides
US9216955B2 (en) 2010-06-15 2015-12-22 Chemelectiva S.R.L. Polymorphic form of Fexofenadine hydrochloride, intermediates and process for its preparation
IT1400965B1 (it) 2010-06-15 2013-07-05 Dipharma Francis Srl Polimorfi di fexofenadina
US9420872B2 (en) * 2010-08-23 2016-08-23 Jason Bird Apparatus and system for holding game-calling devices
JP2012087100A (ja) * 2010-10-21 2012-05-10 Sumitomo Chemical Co Ltd 形態ｉのフェキソフェナジン一塩酸塩の製造方法
CN104072402B (zh) * 2014-07-16 2016-08-17 昆山龙灯瑞迪制药有限公司 一种新结晶形式的盐酸非索非那定化合物及其制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US631375A (en) * 1899-04-12 1899-08-22 Ephraim Musselman Face-protector.
US3448152A (en) * 1966-11-03 1969-06-03 Jefferson Chem Co Inc Amine recovery
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
BE794598A (fr) 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3965257A (en) 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US4254130A (en) 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285958A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
IL63968A (en) 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
US4742175A (en) 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
JPH02213431A (ja) * 1989-02-13 1990-08-24 Kobe Steel Ltd ＳｉＣウィスカ強化Ａｌ合金複合材料
DE4034218A1 (de) 1990-10-27 1992-04-30 Merck Patent Gmbh Verfahren zur herstellung von carebastin
TW198008B (da) 1991-04-08 1993-01-11 Green Cross Corp
HU226561B1 (en) * 1992-04-10 2009-04-28 Merrell Dow Pharma Process for preparation 4-diphenylmethyl piperidine derivatives and the novel intermediates thereof
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
DE69320952T2 (de) 1992-05-11 1999-05-27 Merrell Pharma Inc Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
HU226242B1 (en) 1992-08-03 2008-07-28 Sepracor Inc Use of terfenadin carboxylic acid, their salt and optically pure isomers for the preparation of pharmaceutical compositions, and pharmaceutical compositions against allergic disorders
US5315016A (en) 1992-10-13 1994-05-24 Nycomed Dak A/S Process for preparing pure podophyllotoxin
DE69433346T2 (de) 1993-06-24 2004-09-09 Albany Molecular Research, Inc. Herstellung von Verbindungen, die in der Produktion von Piperidin-Derivaten nützlich sind
CA2254506C (en) 1993-06-24 2000-11-28 Albany Molecular Research, Inc. Piperidine derivatives and process for their production
US6147216A (en) 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
AU699559B2 (en) 1993-06-25 1998-12-10 Aventisub Ii Inc. Novel intermediates for the preparation of antihistaminic piperidine derivatives
CA2189007C (en) * 1994-05-18 2004-03-02 Daniel R. Henton Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof
US5576610A (en) 1994-07-05 1996-11-19 Motorola, Inc. Method and apparatus for determining battery characteristics
ATE226819T1 (de) * 1995-02-28 2002-11-15 Aventis Pharma Inc Arzneizubereitungen für piperidinalkanolderivate
IL134771A (en) 1995-02-28 2002-02-10 Aventis Pharma Inc Pharmaceutical compositions of piperidinoalkanol compounds in solid unit dosage form
US5574045A (en) 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
TR200000517T2 (tr) * 1997-08-26 2000-08-21 Hoechst Marion Roussel, Inc. Piperidinoalkanol-Konjesyon azaltıcıdan oluşan kombinasyona yönelik farmasötik kompozisyon.
US6214427B1 (en) * 1998-08-28 2001-04-10 General Electric Company Method of making an electronic device having a single crystal substrate formed by solid state crystal conversion
US6613906B1 (en) 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
US20020177680A1 (en) * 2000-08-23 2002-11-28 Hubbell Jeffrey A. Novel polymer compounds
US6475942B1 (en) * 2000-09-05 2002-11-05 General Electric Company Conversion of polycrystalline alumina to single crystal sapphire using molybdenum doping
PL366576A1 (en) * 2001-04-09 2005-02-07 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
US20090211514A1 (en) * 2008-02-26 2009-08-27 Lehigh University Single crystal conversion process

Also Published As

Publication number Publication date
US7666881B2 (en) 2010-02-23
CN1148849A (zh) 1997-04-30
FI964565A0 (fi) 1996-11-14
HK1137742A1 (en) 2010-08-06
PT766668E (pt) 2002-11-29
JPH10500134A (ja) 1998-01-06
CA2585705C (en) 2012-04-17
ATE220667T1 (de) 2002-08-15
IL113747A (en) 2001-05-20
IL113747A0 (en) 1995-08-31
EP0766668B1 (en) 2002-07-17
US20040014976A1 (en) 2004-01-22
AU693892B2 (en) 1998-07-09
DE69527429T2 (de) 2003-03-20
US7135571B2 (en) 2006-11-14
JP4503909B2 (ja) 2010-07-14
IL134917A (en) 2001-07-24
US20020193603A1 (en) 2002-12-19
CA2449419A1 (en) 1995-11-23
ES2176329T3 (es) 2002-12-01
HU227676B1 (en) 2011-11-28
EP0766668A1 (en) 1997-04-09
JP2002255936A (ja) 2002-09-11
CN1907967B (zh) 2012-07-04
US20070021461A1 (en) 2007-01-25
FI964565A (fi) 1996-11-14
IL134917A0 (en) 2001-05-20
US20010025106A1 (en) 2001-09-27
DE69527429D1 (de) 2002-08-22
EP1178041A1 (en) 2002-02-06
US20010012896A1 (en) 2001-08-09
US7138524B2 (en) 2006-11-21
CA2189007C (en) 2004-03-02
US7662835B2 (en) 2010-02-16
US20080167471A1 (en) 2008-07-10
JP2002316978A (ja) 2002-10-31
CA2189007A1 (en) 1995-11-23
JP2002255935A (ja) 2002-09-11
NO964859L (no) 1996-11-15
JP4503907B2 (ja) 2010-07-14
WO1995031437A1 (en) 1995-11-23
HU9603167D0 (en) 1997-01-28
US20080167469A1 (en) 2008-07-10
JP2002308850A (ja) 2002-10-23
EP2354125A1 (en) 2011-08-10
JP2002308849A (ja) 2002-10-23
HUT76134A (en) 1997-06-30
CN1907967A (zh) 2007-02-07
NO964859D0 (no) 1996-11-15
HK1098467A1 (en) 2007-07-20
CN1623985A (zh) 2005-06-08
US20070021462A1 (en) 2007-01-25
CA2585705A1 (en) 1995-11-23
US20030045721A1 (en) 2003-03-06
US20020193600A1 (en) 2002-12-19
NO315319B1 (no) 2003-08-18
MX9605613A (es) 1998-05-31
CA2449419C (en) 2011-09-06
US20020193601A1 (en) 2002-12-19
JP2010120969A (ja) 2010-06-03
US20010014741A1 (en) 2001-08-16
AU2426595A (en) 1995-12-05
JP4503908B2 (ja) 2010-07-14

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